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Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation
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Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer
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MATRIX BIOLOGY (2019)
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Structure and dynamics of GPCR signaling complexes
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Scaffolding protein IQGAP1: an insulin-dependent link between caveolae and the cytoskeleton in primary human adipocytes?
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IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway
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Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography
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NATURE CELL BIOLOGY (2016)
The Structural Basis for Cdc42-Induced Dimerization of IQGAPs
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Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer
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The BioPlex Network: A Systematic Exploration of the Human Interactome
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IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development
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The biology of IQGAP proteins: beyond the cytoskeleton
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EMBO REPORTS (2015)
IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes
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IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)
Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors
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MOLECULAR CANCER RESEARCH (2015)
IQGAP1: Insights into the function of a molecular puppeteer
Alex M. Abel et al.
MOLECULAR IMMUNOLOGY (2015)
IQGAPs choreograph cellular signaling from the membrane to the nucleus
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TRENDS IN CELL BIOLOGY (2015)
Role of ErbB Receptors in Cancer Cell Migration and Invasion
Aline Appert-Collin et al.
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Hepatocyte Growth Factor-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier
Yufeng Tian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Transforming growth factor- inhibits IQ motif containing guanosine triphosphatase activating protein 1 expression in lung fibroblasts via the nuclear factor-B signaling pathway
Chuanyue Zong et al.
MOLECULAR MEDICINE REPORTS (2015)
A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions
Sally Fram et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis
Inmaculada Banon-Rodriguez et al.
EMBO JOURNAL (2014)
IQGAP1 Regulates Endothelial Barrier Function via EB1-Cortactin Cross Talk
Yufeng Tian et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells
Ying Yang et al.
PLOS ONE (2014)
G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion
Michael E. Feigin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury
Takashi Kohno et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)
Platelet-derived growth factors and their receptors: Structural and functional perspectives
Po-Han Chen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration
Suyong Choi et al.
EMBO JOURNAL (2013)
KISS1R Induces Invasiveness of Estrogen Receptor-Negative Human Mammary Epithelial and Breast Cancer Cells
Donna Cvetkovic et al.
ENDOCRINOLOGY (2013)
A Labile Pool of IQGAP1 Disassembles Endothelial Adherens Junctions
Zhiguo Yuan et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
IQGAP1 Protein Regulates Nuclear Localization of β-Catenin via Importin-β5 Protein in Wnt Signaling
Toshiyasu Goto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex
Guillaume Jacquemet et al.
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IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver
Chunsheng Liu et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Activated Cdc42-Bound IQGAP1 Determines the Cellular Endocytic Site
Toshihide Kimura et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors
Katherine L. Jameson et al.
NATURE MEDICINE (2013)
IQGAP1 plays an important role in the cell proliferation of multiple myeloma via the MAP kinase (ERK) pathway
Yongyong Ma et al.
ONCOLOGY REPORTS (2013)
β-Arrestin2 Regulates Lysophosphatidic Acid-Induced Human Breast Tumor Cell Migration and Invasion via Rap1 and IQGAP1
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PLOS ONE (2013)
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia
M. Bhattacharya et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)
IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation
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CELLULAR SIGNALLING (2012)
Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition
Damien Lemoine et al.
CHEMICAL REVIEWS (2012)
Rho Isoform-specific Interaction with IQGAP1 Promotes Breast Cancer Cell Proliferation and Migration
Darren E. Casteel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
A conserved role of IQGAP1 in regulating TOR complex 1
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JOURNAL OF CELL SCIENCE (2012)
Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension
Hector Y. Caro-Gonzalez et al.
JOURNAL OF CELL SCIENCE (2012)
The Cytoskeletal Adaptor Protein IQGAP1 Regulates TCR-Mediated Signaling and Filamentous Actin Dynamics
Jacquelyn A. Gorman et al.
JOURNAL OF IMMUNOLOGY (2012)
IQGAP1 Interacts with Components of the Slit Diaphragm Complex in Podocytes and Is Involved in Podocyte Migration and Permeability In Vitro
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PLOS ONE (2012)
Angiopoietin-1 Requires IQ Domain GTPase-Activating Protein 1 to Activate Rac1 and Promote Endothelial Barrier Defense
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload
Mauro Sbroggio et al.
CARDIOVASCULAR RESEARCH (2011)
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
Andrei Glinka et al.
EMBO REPORTS (2011)
Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis
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FREE RADICAL RESEARCH (2011)
MAPK Scaffold IQGAP1 Binds the EGF Receptor and Modulates Its Activation
Dean E. McNulty et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
IQGAP1 Protein Binds Human Epidermal Growth Factor Receptor 2 (HER2) and Modulates Trastuzumab Resistance
Colin D. White et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
IQGAP1 Regulates NR2A Signaling, Spine Density, and Cognitive Processes
Can Gao et al.
JOURNAL OF NEUROSCIENCE (2011)
RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1
Yan Wu et al.
MOLECULAR MEDICINE REPORTS (2011)
GPR54 (KISS1R) Transactivates EGFR to Promote Breast Cancer Cell Invasiveness
Mateusz Zajac et al.
PLOS ONE (2011)
IQGAP1 Is a Novel CXCR2-Interacting Protein and Essential Component of the Chemosynapse
Nicole F. Neel et al.
PLOS ONE (2011)
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
Sonia Sharma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1
Matthew J. Smith et al.
EMBO JOURNAL (2010)
IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation
Feng Chen et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2010)
Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion
Hiroyuki Hayashi et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Proteomic Identification of CD44 Interacting Proteins
Spyros S. Skandalis et al.
IUBMB LIFE (2010)
Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin
Samantha A. Oblander et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2010)
Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases
Shuying Liu et al.
CANCER CELL (2009)
Gα12-Mediated Pathway Promotes Invasiveness of Nasopharyngeal Carcinoma by Modulating Actin Cytoskeleton Reorganization
Shu-Chen Liu et al.
CANCER RESEARCH (2009)
ADP-Ribosylation Factor 6 Regulates Glioma Cell Invasion through the IQ-Domain GTPase-Activating Protein 1-Rac1-Mediated Pathway
Bo Hu et al.
CANCER RESEARCH (2009)
IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis
Colin D. White et al.
FEBS LETTERS (2009)
Ras Subcellular Localization Defines Extracellular Signal-Regulated Kinase 1 and 2 Substrate Specificity through Distinct Utilization of Scaffold Proteins
Berta Casar et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
The role of CXC chemokines and their receptors in cancer
Jo Vandercappellen et al.
CANCER LETTERS (2008)
A dual role for IQGAP1 in regulating exocytosis
Eric N. Rittmeyer et al.
JOURNAL OF CELL SCIENCE (2008)
Mapping the integrin-linked kinase interactome using SILAC
Iveta Dobreva et al.
JOURNAL OF PROTEOME RESEARCH (2008)
IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis
Rosana D. Meyer et al.
PLOS ONE (2008)
N-cadherin regulates cytoskeletally associated lQGAP1/ERK signaling and memory formation
Christina Schrick et al.
NEURON (2007)
IQGAP1 binds Rap1 and modulates its activity
Ha-Won Jeong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
IQGAP1 modulates activation of B-Raf
Jian-Guo Ren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
IQGAP1 regulates adult neural progenitors in vivo and vascular endothelial growth factor-triggered neural progenitor migration in vitro
Laurent Balenci et al.
JOURNAL OF NEUROSCIENCE (2007)
Receptor tyrosine kinases: mechanisms of activation and signaling
Stevan R. Hubbard et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth
Shujie Wang et al.
JOURNAL OF CELL SCIENCE (2007)
IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly
Lorena B. Bensenor et al.
JOURNAL OF CELL SCIENCE (2007)
Characterization of IQGAP1-containing complexes in NK-like cells: Evidence for Rac 2 and RACK1 association during homotypic adhesion
Xiaobo Meng et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas
Peixin Dong et al.
CANCER LETTERS (2006)
Protein tyrosine phosphatases: from genes, to function, to disease
Nicholas K. Tonks
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis
Minako Yamaoka-Tojo et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to β1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II
Kazuhide Takahashi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
The receptor protein-tyrosine phosphatase PTPμ interacts with IQGAP1
PJ Phillips-Mason et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility
SS Kholmanskikh et al.
NATURE NEUROSCIENCE (2006)
IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2
S Ikeda et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Self-association of IQGAP1 - Characterization and functional sequelae
JG Ren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation-dependent interactions of α-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4
M Nuriya et al.
JOURNAL OF NEUROCHEMISTRY (2005)
IQGAP1 is a scaffold for mitogen-activated protein kinase signaling
M Roy et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation
I Kratchmarova et al.
SCIENCE (2005)
Requirement of protein phosphatase 2A for recruitment of IQGAP1 to Rac-bound β1 integrin
K Suzuki et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
IQGAP1: A key regulator of adhesion and migration
J Noritake et al.
JOURNAL OF CELL SCIENCE (2005)
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression
LYW Bourguignon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mitotic dissociation of IQGAP1 from Rac-bound β1-integrin is mediated by protein phosphatase 2A
E Nakajima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate sertoli-germ cell adherens junction dynamics in the testis
WY Lui et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
IQGAP1 binds ERK2 and modulates its activity
M Roy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact
J Noritake et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation
M Yamaoka-Tojo et al.
CIRCULATION RESEARCH (2004)
EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells
JA Bryant et al.
CANCER BIOLOGY & THERAPY (2004)
Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments
G Izumi et al.
JOURNAL OF CELL BIOLOGY (2004)
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
T Watanabe et al.
DEVELOPMENTAL CELL (2004)
IQGAP1 promotes cell motility and invasion
JM Mataraza et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
IQGAP proteins are integral components of cytoskeletal regulation
MW Briggs et al.
EMBO REPORTS (2003)
IQGAP2 functions as a GTP dependent effector protein in thrombin-induced platelet cytoskeletal reorganization
VA Schmidt et al.
BLOOD (2003)
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
B Blagoev et al.
NATURE BIOTECHNOLOGY (2003)
Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1
ZG Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line
L Xie et al.
BREAST CANCER RESEARCH (2003)
The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin
R Ruiz-Velasco et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Regulation and targets of receptor tyrosine kinases
T Pawson
EUROPEAN JOURNAL OF CANCER (2002)
Complex formation of IQGAP1 with E-cadherin/catenin during cohort migration of carcinoma cells - Its possible association with localized release from cell-cell adhesion
Y Shimao et al.
VIRCHOWS ARCHIV (2002)
Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts
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