Evaluation of cytotoxic, antifungal, and larvicidal activities of different bis-sulfonamide Schiff base compounds

Schiff bases (imines or azomethines) are versatile ligands synthesized from the condensation of amino compounds with active carbonyl groups and used for many pharmaceutical and medicinal applications. In our study, we aimed to determine the cytotoxic, antifungal and larvicidal activities of biologically potent bis-sulfonamide Schiff base derivatives that were re-synthesized by us. For this aim, 16 compounds were re-synthesized and tested for their cytotoxic, antifungal and larvicidal properties. Among this series, compounds A1B2, A1B4, A4B2, A4B3, and A4B4 were shown to have cytotoxic activity against tested cancer lung cell line (A549). The most potent antifungal activity was observed in compounds A2B1 and A2B2 against all fungi. A1B1 showed the strongest larvicidal effect at all concentrations at the 72nd h (100% mortality). These obtained results demonstrate that these type of bis-substituted compounds might be used as biologically potent pharmacophores against different types of diseases.

Automated summary

In our study, we synthesized and tested the cytotoxic, antifungal, and larvicidal activities of bis-sulfonamide Schiff base derivatives. Among the 16 compounds tested, A1B2, A1B4, A4B2, A4B3, and A4B4 showed cytotoxic activity against lung cancer cells. A2B1 and A2B2 exhibited the strongest antifungal activity against all tested fungi, while A1B1 had the highest larvicidal effect. These results suggest that these bis-substituted compounds could be promising pharmacophores for various diseases.