A methodology to abridge microdosimetric distributions without a significant loss of the spectral information needed for the RBE computation in carbon ion therapy

Article Instruments & Instrumentation

Clonogenic Survival RBE Calculations in Carbon Ion Therapy: The Importance of the Absolute Values of α and β in the Photon Dose-Response Curve and a Strategy to Mitigate Their Anticorrelation

Alessio Parisi et al.

Summary: The computation of the relative biological effectiveness (RBE) plays a crucial role in cancer radiotherapy treatments. This study examines the impact of alpha/beta ratio and the absolute values of alpha and beta on the RBE calculations for different LET carbon ions. The findings also propose a theory-based strategy to mitigate the anticorrelation between alpha and beta during the fit of the photon dose-response biological data.

QUANTUM BEAM SCIENCE (2023)

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Article Engineering, Biomedical

On the calculation of the relative biological effectiveness of ion radiation therapy using a biological weighting function, the microdosimetric kinetic model (MKM) and subsequent corrections (non-Poisson MKM and modified MKM)

Alessio Parisi et al.

Summary: This study systematically analyzed various biological weighting functions and microdosimetric models, revealing a common issue of overestimation of RBE values at high linear energy transfer. The importance of improving model accuracy was emphasized.

PHYSICS IN MEDICINE AND BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines

Alessio Parisi et al.

Summary: This article presents the design and application of the Mayo Clinic Florida MKM (MCF MKM) and compares it with the local effect model (LEM). Through extensive benchmarking and predictions with in vitro data, it is found that the MCF MKM can be reliably used for RBE calculations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Engineering, Biomedical

The Mayo Clinic Florida microdosimetric kinetic model of clonogenic survival: formalism and first benchmark against in vitro and in silico data

Alessio Parisi et al.

Summary: The study developed a new model to accurately describe cell survival under different linear energy transfer conditions, which is of great importance for cancer radiotherapy treatment planning.

PHYSICS IN MEDICINE AND BIOLOGY (2022)

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Review Physics, Applied

Physics and biomedical challenges of cancer therapy with accelerated heavy ions

Marco Durante et al.

Summary: Carbon ions represent a promising combination of physical and biological advantages for radiotherapy, with clinical results showing potential breakthroughs. However, the cost-effectiveness and comparison to proton therapy centers continue to be a topic of debate in the clinical community. Research towards smaller, cheaper machines with more effective beam delivery is seen as necessary to make particle therapy more affordable and fully exploit the clinical benefits.

NATURE REVIEWS PHYSICS (2021)

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Review Engineering, Biomedical