期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 94, 期 3, 页码 1133-1144出版社
IOS PRESS
DOI: 10.3233/JAD-230187
关键词
Alzheimer's disease; amyloid; cognition; occipital lobe; prognosis
This study found that additional occipital amyloid-beta deposition is associated with poor baseline language function and rapid cognitive deterioration in patients with Alzheimer's disease.
Background: Clinical significance of additional occipital amyloid-beta (A beta) plaques in Alzheimer's disease (AD) remains unclear. Objective: In this study, we investigated the effect of regional A beta deposition on cognition in patients on the AD continuum, especially in the occipital region. Methods: We retrospectively reviewed the medical record of 208 patients with AD across the cognitive continuum (non-dementia and dementia). Multivariable linear regression analyses were performed to determine the effect of regional A beta deposition on cognitive function. A linear mixed model was used to assess the effect of regional deposition on longitudinal changes in Mini-Mental State Examination (MMSE) scores. Additionally, the patients were dichotomized according to the occipital-to-global A beta deposition ratio (ratio <= 1, A beta-OCC- group; ratio >1, A beta-OCC+ group), and the same statistical analyses were applied for between-group comparisons. Results: Regional A beta burden itself was not associated with baseline cognitive function. In terms of A beta-OCC group effect, the A beta-OCC+ group exhibited a poorer cognitive performance on language function compared to the A beta-OCC- group. High A beta retention in each region was associated with a rapid decline in MMSE scores, only in the dementia subgroup. Additionally, A beta-OCC+ individuals exhibited a faster annual decline in MMSE scores than A beta-OCC- individuals in the non-dementia subgroup (beta = -0.77, standard error [SE] = 0.31, p = 0.013). Conclusion: The present study demonstrated that additional occipital A beta deposition was associated with poor baseline language function and rapid cognitive deterioration in patients on the AD continuum.
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