期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 94, 期 1, 页码 259-279出版社
IOS PRESS
DOI: 10.3233/JAD-221274
关键词
Alzheimer's disease; brain atrophy; cognitive decline; hippocampus; longitudinal studies; magnetic resonance imaging
This study examined the clinical utility of automated volumetry in a well-defined and biomarker-classified longitudinal predementia cohort. The results showed that individuals with positive A/T/N classification had smaller entorhinal cortex and hippocampus compared to those with negative classification. Longitudinally, participants with SCD A+ and MCI A+ had greater hippocampal atrophy compared to controls, and this atrophy was also observed in A+/T-/N- and A+/T+orN+ individuals.
Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer's disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort. Methods: We used Automatic Segmentation of Hippocampal Subfields (ASHS) to determine MTL morphometry from MRI. We harmonized scanner effects using the recently developed longitudinal ComBat. Subjects were classified according to the A/T/N system, and as normal controls (NC), subjective cognitive decline (SCD), or mild cognitive impairment (MCI). Positive or negative values of A, T, and N were determined by cerebrospinal fluid measurements of the A beta(42/40) ratio, phosphorylated and total tau. From 406 included subjects, longitudinal data was available for 206 subjects by stage, and 212 subjects by A/T/N. Results: Compared to A-/T-/N- at baseline, the entorhinal cortex, anterior and posterior hippocampus were smaller in A+/T+orN+. Compared to NC A- at baseline, these subregions were also smaller in MCI A+. Longitudinally, SCD A+ and MCI A+, and A+/T-/N- and A+/T+orN+, had significantly greater atrophy compared to controls in both anterior and posterior hippocampus. In the entorhinal and parahippocampal cortices, longitudinal atrophy was observed only in MCI A+ compared to NC A-, and in A+/T-/N- and A+/T+orN+ compared to A-/T-/N-. Conclusion: We found MTL neurodegeneration largely consistent with existing models, suggesting that harmonized MRI volumetry may be used under conditions that are common in clinical multi-center cohorts.
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