4.5 Article

White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia

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JOURNAL OF ALZHEIMERS DISEASE
卷 94, 期 2, 页码 695-707

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IOS PRESS
DOI: 10.3233/JAD-221209

关键词

Alzheimer's disease; amyloid-beta; executive function; memory; tau; white matter hyperintensities

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This study found that white matter hyperintensity (WMH) volume can moderate the association between AD biomarkers and cognition, with a quadratic effect between WMH and A beta on memory; however, there was no interaction between linear or quadratic effects of WMH and A beta on executive function; additionally, there was no interaction between WMH volume and tau-PET on cognitive measures.
Background: Alzheimer's disease (AD) and cerebrovascular disease are common, co-existing pathologies in older adults. Whether the effects of cerebrovascular disease and AD biomarkers on cognition are additive or synergistic remains unclear. Objective: To examine whether white matter hyperintensity (WMH) volume moderates the independent association between each AD biomarker and cognition. Methods: In 586 older adults without dementia, linear regressions tested the interaction between amyloid-beta (A beta) positron emission tomography (PET) andWMHvolume on cognition, independent of tau-PET. We also tested the interaction between tau-PET and WMH volume on cognition, independent of A beta-PET. Results: Adjusting for tau-PET, the quadratic effect of WMH interacted with A beta-PET to impact memory. There was no interaction between either the linear or quadratic effect ofWMHand A beta-PET on executive function. There was no interaction between WMH volume and tau-PET on either cognitive measure. Conclusion: Results suggest that cerebrovascular lesions act synergistically with A beta to affect memory, independent of tau, highlighting the importance of incorporating vascular pathology into biomarker assessment of AD.

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