The PI3K/AKT Signaling Pathway and Caspase-3 in Alzheimer's Disease: Which One Is the Beginner?

One of the main players in apoptosis during Alzheimer's disease progression are different members of caspase family of proteases. The most well-known member of this family is caspase-3, in which alterations of its levels have been detected in samples from Alzheimer's disease patients. There are numerous intracellular factors involved in regulation of cellular apoptosis through regulation of caspase-3 activity, the most important of which is the PI3K/AKT signaling pathway. This commentary tries to highlight the probable relations between PI3K/AKT signaling pathway and caspase-3 in Alzheimer's disease.

Automated summary

One of the main players in apoptosis during Alzheimer's disease progression are different members of caspase family of proteases, with caspase-3 being the most well-known. The PI3K/AKT signaling pathway is the most important intracellular factor involved in regulating caspase-3 activity. This commentary aims to highlight the possible relations between the PI3K/AKT signaling pathway and caspase-3 in Alzheimer's disease.