期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 93, 期 1, 页码 211-224出版社
IOS PRESS
DOI: 10.3233/JAD-221126
关键词
Alzheimer's disease; amyloid; gene-environment interaction; mice; social behavior; social environment
Altered social behavior could be an early indicator of A-beta pathology in female J20 mice. Co-housing with wild type mice can have a positive influence on this social phenotype.
Background: Altered social behavior is one of the symptoms of Alzheimer's disease (AD) that results in social withdrawal and loneliness and provides a major burden on patients and their relatives. Furthermore, loneliness is associated with an increased risk to develop AD and related dementias. Objective: We aimed to investigate if altered social behavior is an early indicator of amyloid-beta (A beta) pathology in J20 mice, and if co-housing with wild type (WT) mice can positively influence this social phenotype. Methods: The social phenotype of group-housed mice was assessed using an automated behavioral scoring system for longitudinal recordings. Female mice were housed in a same-genotype (4 J20 or WT mice per colony) or mixed-genotype (2 J20mice + 2 WT mice) colony. At 10 weeks of age, their behavior was assessed for five consecutive days. Results: J20 mice showed increased locomotor activity and social sniffing, and reduced social contact compared to WT mice housed in same-genotype colonies. Mixed-genotype housing reduced the social sniffing duration of J20 mice, increased social contact frequency of J20 mice, and increased nest hide by WT mice. Conclusion: Thus, altered social behavior can be used as an early indicator ofA beta-pathology in female J20 mice. Additionally, when co-housed with WT mice, their social sniffing phenotype is not expressed and their social contact phenotype is reduced. Our findings highlight the presence of a social phenotype in the early stages of AD and indicate a role for social environment variation in the expression of social behavior of WT and J20 mice.
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