B cells: The many facets of B cells in allergic diseases

B cells play a key role in our immune system through their ability to produce antibodies, suppress a proinflammatory state, and contribute to central immune tolerance. We aim to provide an in-depth knowledge of the molecular biology of B cells, including their origin, developmental process, types and subsets, and functions. In allergic diseases, B cells are well known to induce and maintain immune tolerance through the production of suppressor cytokines such as IL-10. Similarly, B cells protect against viral infections such as severe acute respiratory syndrome coronavirus 2 that caused the recent coronavirus disease 2019 pandemic. Considering the unique and multifaceted functions of B cells, we hereby provide a comprehensive overview of the current knowledge of B-cell biology and its clinical applications in allergic diseases, organ transplantation, and cancer. (J Allergy Clin Immunol 2023;152:567-81.)

Automated summary

B cells play a crucial role in the immune system by producing antibodies, suppressing inflammation, and contributing to immune tolerance. This article aims to provide an in-depth understanding of the molecular biology of B cells, including their origin, development, types and subsets, and functions. Additionally, the importance of B cells in clinical applications such as allergic diseases, organ transplantation, and cancer is discussed.