4.7 Article

Rational Exploration of Novel SDHI Fungicide through an Amide-?-ketonitrile Bioisosteric Replacement Strategy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Agriculture, Multidisciplinary

Comprehensive Overview of Carboxamide Derivatives as Succinate Dehydrogenase Inhibitors

Bo Luo et al.

Summary: This review summarizes the importance of carboxamide derivatives as SDHIs and the structure-activity relationships of their antifungal activities. It also introduces the reasons behind SDHIs resistance and potential solutions, as well as prospects the development trend of SDHIs fungicides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Agriculture, Multidisciplinary

Design, Synthesis, Anti-Tomato Spotted Wilt Virus Activity, and Mechanism of Action of Thienopyrimidine-Containing Dithioacetal Derivatives

Yanju Wang et al.

Summary: This study prepared and tested a series of compounds with anti-TSWV activities, among which compound35 showed promising curative and protective effects. The anti-TSWV activity of compound35 was associated with defense-related enzyme activities, enhanced photosynthesis, and reduced stress response.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Agriculture, Multidisciplinary

Silicon-Containing Complex II Acaricides-Design, Synthesis, and Pharmacological Optimization

Cong Zhou et al.

Summary: Bioisosteric replacement is a powerful strategy in life science research. The substitution of carbon with silicon has shown positive effects on efficacy and safety properties in pharmaceutical and crop protection research. The application of carbon-silicon substitution has led to the discovery of new silicon-containing analogues with improved acaricidal activity. This review discusses molecular design, synthesis, and structure-activity relationships in carbon-silicon bioisosteric substitution.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors

Shuqi Li et al.

Summary: Succinate dehydrogenase inhibitors (SDHIs) are a rapidly growing class of new fungicides with high activity and a broad spectrum. By inhibiting the activity of succinate dehydrogenase, they disrupt mitochondrial respiration and kill pathogenic fungi, making them popular among major pesticide companies worldwide for research and development.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Azo-incorporating Increases Inhibitory Activity of Succinate Dehydrogenase

Wen Fu et al.

Summary: This study introduced a new fungicide developed using azo groups, with compound 9d showing improved antifungal activity and enzyme inhibition towards succinate dehydrogenase. The results suggest a new strategy for pesticide discovery through the incorporation of azobenzene derivatives.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Synthesis and Biological Activity of Novel Antifungal Leads: 3,5-Dichlorobenzyl Ester Derivatives

Shaoqing Du et al.

Summary: Research has identified a series of ester compounds with significant antifungal activity, among which compound 5 showed remarkable inhibition against Botrytis cinerea and Rhizoctonia solani. Esterification can maintain the fungicidal activity of target compounds.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Expanding the Chemical Space of Succinate Dehydrogenase Inhibitors via the Carbon-Silicon Switch Strategy

Ge Wei et al.

Summary: The carbon-silicon switch strategy has been effectively utilized to synthesize novel SDH inhibitors with enhanced fungicidal activity. The resulting compounds showed promising potential in disease control experiments and may serve as candidate fungicides in the future.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Synthesis, Antibacterial Activity, and Mechanisms of Novel 6-Sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole Derivatives

Sikai Wu et al.

Summary: A series of novel 6-sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. The established CoMFA models were used to analyze and design compounds with higher activities, revealing their mechanisms of action in disease resistance.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agronomy

Design, synthesis and antifungal/anti-oomycete activity of pyrazolyl oxime ethers as novel potential succinate dehydrogenase inhibitors

Minlong Wang et al.

Summary: Innovative pyrazolyl oxime ethers were designed to discover SDHI compounds with a novel bridge, showing substantial differences in biological activities between Z- and E-isomers against fungi and oomycetes. These novel compounds have the potential for future SDHI development, and the strategy of replacing an amide bond with oxime ether may provide an alternative option in SDHI fungicide discovery.

PEST MANAGEMENT SCIENCE (2021)

Article Agriculture, Multidisciplinary

Synthesis, Fungicidal Activity, and Mechanism of Action of Pyrazole Amide and Ester Derivatives Based on Natural Products L-Serine and Waltherione Alkaloids

Xuewen Hua et al.

Summary: New green fungicides developed through structural optimization of natural products can effectively address the low safety and high pathogen resistance issues associated with traditional fungicides. In this study, a series of L-serine-derived pyrazole amide and waltherione alkaloid-derived pyrazole ester derivatives were synthesized based on the pyrazole amide compound h-I-9 with excellent fungicidal activity. Compound II-5 exhibited good inhibition against Physalospora piricola, potentially causing damage to cell membranes and vacuoles and producing blue fluorescence in treated hyphae. Additionally, compounds 1-3 and 1-4 showed potential as succinate dehydrogenase (SDH) inhibitors against Alternaria sp.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Discovery of Novel Pyrazole Carboxylate Derivatives Containing Thiazole as Potential Fungicides

Dongguo Xia et al.

Summary: Novel pyrazole carboxylate derivatives containing a flexible thiazole backbone were successfully synthesized and evaluated for their antifungal bioactivities. Compound 24 showed excellent bioactivities against Botrytis cinerea and Sclerotinia sclerotiorum, while compound 15 exhibited remarkable antifungal activity against Valsa mali. Compounds 3, 15, and 24 are promising antifungal candidates worthy of further fungicide development.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Novel Pyrazole-4-acetohydrazide Derivatives Potentially Targeting Fungal Succinate Dehydrogenase: Design, Synthesis, Three-Dimensional Quantitative Structure-Activity Relationship, and Molecular Docking

Xiaobin Wang et al.

Summary: It has been found that the pyrazole-4-acetohydrazide derivatives targeting fungal SDH have high antifungal efficacy, with significantly superior performance compared to existing fungicides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement

Cong Zhou et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study

Han Wang et al.

LETTERS IN DRUG DESIGN & DISCOVERY (2019)

Article Agriculture, Multidisciplinary

Novel 1,3,4-Oxadiazole-2-carbohydrazides as Prospective Agricultural Antifungal Agents Potentially Targeting Succinate Dehydrogenase

Yuan-Yuan Wu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Agronomy

Physicochemical property guidelines for modern agrochemicals

Yu Zhang et al.

PEST MANAGEMENT SCIENCE (2018)

Article Agriculture, Multidisciplinary

Structure-Based Discovery of Potential Fungicides as Succinate Ubiquinone Oxidoreductase Inhibitors

Li Xiong et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

Article Chemistry, Organic

Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety

Nabo Sun et al.

CHINESE JOURNAL OF ORGANIC CHEMISTRY (2017)

Article Agriculture, Multidisciplinary

Discovery of Potent Succinate-Ubiquinone Oxidoreductase Inhibitors via Pharmacophore-linked Fragment Virtual Screening Approach

Li Xiong et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

Daniel Ken Inaoka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Biochemistry & Molecular Biology

Catalytic mechanisms of complex II enzymes: A structural perspective

T. M. Iverson

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2013)

Article Agronomy

Cyflumetofen, a novel acaricide - its mode of action and selectivity

Naotaka Hayashi et al.

PEST MANAGEMENT SCIENCE (2013)

Review Multidisciplinary Sciences

Emerging fungal threats to animal, plant and ecosystem health

Matthew C. Fisher et al.

NATURE (2012)

Review Biochemistry & Molecular Biology

The quinone-binding and catalytic site of complex II

Elena Maklashina et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Review Biochemistry & Molecular Biology

The mitochondrial respiratory chain

Peter R. Rich et al.

ESSAYS IN BIOCHEMISTRY: MITOCHONDRIAL FUNCTION (2010)

Review Chemistry, Multidisciplinary

Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

Stefan Braese et al.

CHEMICAL REVIEWS (2009)