Associations of Accelerometer-Measured Physical Activity and Sedentary Time With All-Cause Mortality by Genetic Predisposition for Longevity

The goal of this study was to examine associations between accelerometer-measured physical activity (PA) and sedentary time (ST) with mortality by a genetic risk score (GRS) for longevity. Among 5,446 women, (mean [SD]: age, 78.2 [6.6] years), 1,022 deaths were observed during 33,350 person-years of follow-up. Using multivariable Cox proportional hazards models, higher light PA and moderate to vigorous PA were associated with lower mortality across all GRS for longevity categories (low/ medium/high; all Ptrend < .001). Higher ST was associated with higher mortality (Ptrend across all GRS categories < .001). Interaction tests for PA and ST with the GRS were not statistically significant. Findings support the importance of higher PA and lower ST for reducing mortality risk in older women, regardless of genetic predisposition for longevity.

Automated summary

The aim of this study was to investigate the relationship between accelerometer-measured physical activity (PA) and sedentary time (ST) with mortality risk, considering a genetic risk score (GRS) for longevity. Among 5,446 women, aged 78.2 (SD: 6.6) years, 1,022 deaths occurred during the 33,350 person-years of follow-up. The findings revealed that higher levels of light and moderate to vigorous PA were associated with reduced mortality risk, regardless of GRS category. Conversely, higher sedentary time was linked to increased mortality risk, independent of GRS category. The interaction tests between PA and ST with GRS were not statistically significant.