True grit and brain: Trait grit mediates the connection of DLPFC functional connectivity density to posttraumatic growth following COVID-19

Background: There is increasing interest in identifying factors to predict posttraumatic growth (PTG), a positive psychological response following traumatic events (e.g., the COVID-19 pandemic). Grit, a psychological trait of perseverance and passion to pursue long-term goals, has emerged as a promising predictor for PTG. This study aimed to examine the functional connectivity markers of grit and the potential brain-grit mechanism in pre-dicting PTG.Methods: Baseline brain imaging scans and grit scale and other controlling measures were administered in 100 normal young adults before the COVID-19 pandemic, and follow-up PTG measurement was obtained during the period of community-level outbreak. Whole-brain correlation analysis and prediction analysis were used to identify the brain regions whose functional connectivity density (FCD) related to individuals' grit scores. Mediation analyses were performed to explore the mediation relation between FCD, grit and PTG.Results: Grit was positively related to FCD in the right dorsolateral prefrontal cortex (DLPFC), a core hub implicated in self-regulation and reward-motivation processes. Furthermore, grit mediated the effect of right DLPFC FCD on COVID-related PTG. These results survived controlling for self-control and family socioeconomic status.Limitations: Our study is limited by only one-session neuroimaging data and self-reported behavioral measures in a sample of normal adults.Conclusions: This study indicates grit and right DLPFC FCD as neuropsychological contributors for the devel-opment of PTG. It deepens our understanding of the neural bases of grit, and may have clinical potential to develop targeted brain interventions aimed at improving grit to raise PTG and mental health during the pandemic.

Automated summary

This study aimed to explore the relationship between grit and posttraumatic growth (PTG), and investigate the associated brain mechanism. The results showed a positive association between grit and functional connectivity density (FCD) in the right dorsolateral prefrontal cortex (DLPFC), and grit mediated the effect of right DLPFC FCD on COVID-related PTG.