期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 326, 期 -, 页码 225-231出版社
ELSEVIER
DOI: 10.1016/j.jad.2023.01.100
关键词
Cognition; Obesity; Leptin; JAK; STAT; Bariatric surgery; Signaling pathway; Inflammation
Determining the role of changes in leptin signaling on cognitive function after bariatric surgery can aid in the development of therapeutic approaches targeting cognitive dysfunction in obese individuals. Although several studies have explored cognition post bariatric surgery and leptin changes, the integration of leptin signaling effects in relation to cognition post surgery has not been considered as a key aspect. This review highlights potential correlations and proposes the improvement of cognitive function through the amelioration of the leptin Janus kinase/Signal transducer and activator of transcription (JAK/STAT) signaling pathway by reversing inflammatory processes.
Determining whether changes in leptin signaling plays a role in the improvement of cognitive function post-bariatric surgery may aid in the understanding and development of novel therapeutic approaches targeting cognitive dysfunction through the greater understanding of processes connecting obesity and brain health. Several studies have explored the effects of cognition post bariatric surgery, and others have studied leptin and its changes post surgery. However the amalgamation of the effects of leptin signaling in relation to cognition post bariatric surgery have yet to be considered as key tools in the understanding of cognitive dysfunction in obese subjects with leptin resistance or insensitivity. This review serves to highlight the potential correlations, to further elucidate the effect of improved leptin signaling on cognition post bariatric surgery, and to propose a direct cause for the improvement of cognitive function via the amelioration of the leptin Janus kinase/Signal transducer and activator of transcription (JAK/STAT) signaling pathway as a result of the reversal of inflam-matory processes involved in diseased individuals.
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