Transcatheter Left Atrial Appendage Exclusion Preclinical and Early Clinical Results With the Laminar Device

Article Cardiac & Cardiovascular Systems

Left atrial appendage sealing performance of the Amplatzer Amulet and Watchman FLX device

Kasper Korsholm et al.

Summary: This study compared the left atrial appendage (LAA) sealing properties of two devices, Amplatzer Amulet and Watchman FLX, using cardiac computed tomography (CT) follow-up. The results showed that the Watchman FLX device achieved a significantly higher rate of complete LAA occlusion compared to the Amplatzer Amulet device. The FLX group also had smaller visible leaks. Further studies with clinical outcomes are needed to better understand the differences in device design.

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Left atrial appendage occlusion vs novel oral anticoagulation for stroke prevention in atrial fibrillation: rationale and design of the multicenter randomized occlusion-AF trial

Kasper Korsholm et al.

Summary: The Occlusion-AF trial aims to compare left atrial appendage occlusion (LAAO) with novel oral anticoagulants (NOACs) in reducing the combined endpoint of stroke, systemic embolism, major bleeding, and all-cause mortality in patients with atrial fibrillation (AF) and a recent ischemic stroke or transient ischemic attack (TIA).

AMERICAN HEART JOURNAL (2022)

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Letter Cardiac & Cardiovascular Systems

First-in-Human Experience With the Amplatzer Steerable Delivery Sheath for Left Atrial Appendage Closure

Jacqueline Saw et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2021)

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Article Cardiac & Cardiovascular Systems

Primary Outcome Evaluation of a Next-Generation Left Atrial Appendage Closure Device Results From the PINNACLE FLX Trial

Saibal Kar et al.

Summary: The study evaluated the safety and effectiveness of the next-generation WATCHMAN FLX LAA closure device in patients with nonvalvular atrial fibrillation. The results showed a low incidence of adverse events and a high incidence of anatomic closure.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial

Dhanunjaya Lakkireddy et al.

Summary: The Amulet occluder was found to be noninferior to the Watchman device in terms of safety and effectiveness for stroke prevention among patients with nonvalvular atrial fibrillation, and was superior in terms of left atrial appendage occlusion. However, procedure-related complications were higher with the Amulet occluder and decreased with operator experience.

CIRCULATION (2021)

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Editorial Material Cardiac & Cardiovascular Systems