Pregnancy outcomes following recurrent miscarriage

BackgroundRecurrent miscarriage affects 1-2% of the population, and the literature has focussed on causes, treatment, and live birth rate.AimThis study aimed to assess the reproductive outcomes for patients who attended a specialist recurrent miscarriage clinic for investigation and treatment.MethodsProspective analysis of all patients who attended a recurrent miscarriage clinic from January 2014 to January 2021.ResultsOf the 488 patients who attended a specialist clinic, 318 had a further pregnancy with 299 included in this study. The median age was 37 years, with 55.6% having a previous live birth. The subsequent live birth rate was 75.3%, 22.0% had a further pregnancy loss, 1.7% had an ongoing pregnancy, and 1% attended another institution after the second trimester. The rate of preeclampsia was 2.2%, pregnancy-induced hypertension was 2.2%, fetal growth restriction was 5.3%, preterm birth <= 34 weeks was 1.8%, and preterm birth > 34 weeks < 37 weeks was 6.6%.ConclusionPatients who attend a dedicated recurrent miscarriage clinic for investigation and treatment have a high live birth rate in a subsequent pregnancy. A subsequent pregnancy following recurrent pregnancy loss does not appear to be associated with an increased risk of adverse pregnancy outcomes.

Automated summary

This study aimed to assess the reproductive outcomes for patients who attended a specialist recurrent miscarriage clinic. The study found that patients treated at the clinic had a high live birth rate in subsequent pregnancies, and recurrent pregnancy loss did not appear to be associated with an increased risk of adverse pregnancy outcomes.