4.6 Article

Colchicine in High-risk Patients with Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3): Rationale and design of a multicenter randomized placebo-controlled trial

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Inflammatory cytokines, high-sensitivity C-reactive protein, and risk of one-year vascular events, death, and poor functional outcome after stroke and transient ischemic attack

S. Coveney et al.

Summary: The study found that inflammatory cytokines IL-6, IL-8, and hsCRP independently predicted one-year recurrent vascular events, with IL-6 and hsCRP also predicting one-year fatality. This suggests that baseline inflammatory cytokines can predict late recurrence and supports the rationale for randomized trials of anti-inflammatory agents for prevention after stroke, indicating targeted therapy to high-risk patients with high baseline inflammation may be beneficial.

INTERNATIONAL JOURNAL OF STROKE (2022)

Article Immunology

Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study

Jiejie Li et al.

Summary: The study found that IL-6 and YKL-40 were independently associated with recurrent stroke and poor functional outcome, and improved risk classification of clinical risk algorithms.

JOURNAL OF NEUROINFLAMMATION (2022)

Article Pharmacology & Pharmacy

Effect of different doses of colchicine on high sensitivity C-reactive protein in patients with acute minor stroke or transient ischemic attack: A pilot randomized controlled trial

Baoshi Yuan et al.

Summary: This study aimed to test the effect of colchicine at different doses on hsCRP levels after stroke. The results showed that early treatment with low dose of colchicine reduced hsCRP levels in patients with acute minor ischemic stroke and TIA.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Article Clinical Neurology

Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) - study protocol for a randomised controlled trial

Peter Kelly et al.

Summary: CONVINCE is a multi-center international Phase 3 clinical trial investigating the effect of low-dose colchicine on recurrent vascular events in patients with non-severe, non-cardioembolic stroke and TIA. The study will provide high-quality randomized data assessing the efficacy and safety of colchicine anti-inflammatory therapy for secondary prevention after stroke.

EUROPEAN STROKE JOURNAL (2021)

Article Medicine, General & Internal

Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA

Yongjun Wang et al.

Summary: This study compared ticagrelor and clopidogrel for the secondary prevention of stroke in Chinese patients with minor ischemic stroke or TIA who carried CYP2C19 loss-of-function alleles. The results showed that ticagrelor was associated with a modestly lower risk of stroke at 90 days compared to clopidogrel, with no difference in severe or moderate bleeding risk between the two treatment groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Clinical Neurology

Residual Risk and Its Risk Factors for Ischemic Stroke with Adherence to Guideline-Based Secondary Stroke Prevention

Yuesong Pan et al.

Summary: Despite adherence to guideline-based secondary stroke prevention, there is still a significant residual risk of recurrent stroke at 12 months. Future research should focus on reducing this residual risk.

JOURNAL OF STROKE (2021)

Review Cardiac & Cardiovascular Systems

Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials

Aernoud T. L. Fiolet et al.

Summary: This meta-analysis indicates that low-dose colchicine reduces the risk of major adverse cardiovascular events, myocardial infarction, stroke, and the need for coronary revascularization in patients with coronary disease. There was no difference in all-cause mortality, with fewer cardiovascular deaths but more non-cardiovascular deaths.

EUROPEAN HEART JOURNAL (2021)

Article Clinical Neurology

Residual Inflammatory Risk Predicts Poor Prognosis in Acute Ischemic Stroke or Transient Ischemic Attack Patients

Jiejie Li et al.

Summary: Residual inflammatory risk only may predict recurrent stroke and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack, especially in those with large-artery atherosclerosis.

STROKE (2021)

Review Clinical Neurology

Inflammation and Stroke Risk: A New Target for Prevention

Peter J. Kelly et al.

Summary: Inflammation plays a key role in the pathogenesis of stroke, and anti-inflammatory agents have shown benefits for secondary prevention in patients with coronary disease. By reviewing observational studies and randomized controlled trials, the potential implications of anti-inflammatory therapy on stroke prevention are discussed.

STROKE (2021)

Review Clinical Neurology

Interleukin-6, C-reactive protein, fibrinogen, and risk of recurrence after ischaemic stroke: Systematic review and meta-analysis

J. J. McCabe et al.

Summary: This study conducted a systematic review and meta-analysis on the association between blood inflammatory markers and the risk of recurrent stroke or major vascular events (MVEs) after stroke. The findings indicated that CRP and fibrinogen were associated with recurrent stroke and MVEs, while IL-6 showed some trends but not statistically significant associations. Substantial methodological heterogeneity among studies was identified, highlighting the need for individual-patient pooled analysis and standardization of methods to determine the prognostic role of blood inflammatory markers.

EUROPEAN STROKE JOURNAL (2021)

Article Medicine, General & Internal

Colchicine in Patients with Chronic Coronary Disease

Stefan M. Nidorf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Anticytokine Agents Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis

Paul M. Ridker

CIRCULATION RESEARCH (2019)

Article Medicine, General & Internal

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

Jean-Claude Tardif et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Clinical Neurology

Anti-inflammatory approaches to ischaemic stroke prevention

Peter J. Kelly et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

Review Cardiac & Cardiovascular Systems

The NLRP3 inflammasome in acute myocardial infarction

Stefano Toldo et al.

NATURE REVIEWS CARDIOLOGY (2018)

Article Medicine, General & Internal

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA

S. Claiborne Johnston et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack

Yongjun Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Paul M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Pharmacology & Pharmacy

Rhabdomyolysis in a patient treated with colchicine and atorvastatin

Abdurrahman Tufan et al.

ANNALS OF PHARMACOTHERAPY (2006)

Article Pharmacology & Pharmacy

Colchicine myotoxicity: Case reports and literature review

K Wilbur et al.

PHARMACOTHERAPY (2004)

Article Clinical Neurology

Cytoskeletal myotoxicity from simvastatin and colchicine

SK Baker et al.

MUSCLE & NERVE (2004)