4.5 Review

Radiation-induced pulmonary fibrosis: roles of therapy-induced senescence and microRNAs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

The radiobiology of TGFβ

Mary Helen Barcellos-Hoff

Summary: Ionizing radiation not only kills cancer cells by inducing DNA damage, but also activates transforming growth factor beta (TGF-β) to alter the tumor microenvironment, promoting malignancy and immune evasion.

SEMINARS IN CANCER BIOLOGY (2022)

Article Oncology

Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury

Yi Li et al.

Summary: Exosomal miR-466f-3p derived from mMSCs exhibits anti-fibrotic properties and prevents radiation-induced EMT and lung fibrosis through inhibition of AKT/GSK3 beta pathway and c-MET.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Multidisciplinary Sciences

Serum RNA biomarkers for predicting survival in non-human primates following thoracic radiation

Jared M. May et al.

Summary: In this study, miRNome analysis was performed to determine the differential expression of miRNA in non-human primate serum after radiation exposure. The results showed that miRNAs have the potential to determine radiation dose and predict survival or complications early following irradiation. Further experiments and development of a serum miRNA assay are needed to validate these findings and improve survival rates.

SCIENTIFIC REPORTS (2022)

Article Respiratory System

Transcriptional inhibition of miR-486-3p by BCL6 upregulates Snail and induces epithelial-mesenchymal transition during radiation-induced pulmonary fibrosis

Ziyan Yan et al.

Summary: This study reveals that ionizing radiation (IR) induces pulmonary fibrosis by altering the content of miR-486-3p and inducing epithelial mesenchymal transition (EMT). IR decreases the levels of miR-486-3p, which is closely related to the occurrence of radiation-induced pulmonary fibrosis (RIPF). The transcription factor BCL6 is activated by IR, inhibiting the transcription of miR-486-3p and decreasing its content, which in turn increases the content of the target gene slug and triggers EMT.

RESPIRATORY RESEARCH (2022)

Article Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Radiation-Induced Lung InjuryviamiRNA-214-3p

Xudan Lei et al.

Summary: This study demonstrates that MSC-derived EVs can alleviate pulmonary radiation injury by transferring miR-214-3p, offering new strategies to mitigate lung damage caused by radiation therapy.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Article Biochemistry & Molecular Biology

MiRNA-155-5p inhibits epithelium-to-mesenchymal transition (EMT) by targeting GSK-3β during radiation-induced pulmonary fibrosis

Duo Wang et al.

Summary: This study demonstrated the critical role of miR-155-5p in radiation-induced EMT and RIPF, with its regulation through the GSK-3 beta/NF-kappa B pathway. The downregulation of miR-155-5p induced EMT and contributed to RIPF formation, while ectopic expression of miR-155-5p alleviated RIPF in mice. These findings provide further insights into the regulation of RIPF and potential therapeutic targets.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Review Medical Laboratory Technology

Long and short non-coding RNA and radiation response: a review

Jared M. May et al.

Summary: Noncoding RNAs play crucial roles in cellular processes and stress response, serving as biomarkers of disease progression. They modulate radiosensitivity of cells by competitively binding DNA, mRNA, proteins, and other ncRNAs. Noncoding RNAs have great potential as future therapeutic tools and clinical diagnostic assays in radiation research.

TRANSLATIONAL RESEARCH (2021)

Article Multidisciplinary Sciences

Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence

Elena Zoico et al.

Summary: This study demonstrated the senolytic effect of quercetin on pre-adipocytes and adipocytes in vitro, highlighting its ability to reduce cellular senescence by decreasing beta-galactosidase activity, suppressing ROS, and inhibiting inflammatory cytokines. Additionally, quercetin treatment led to a downregulation of miR-155-5p expression, modulating NF-kappa B activity and showing a trend towards upregulation of SIRT-1, suggesting a potential key mechanism of action for quercetin in reducing adipose tissue aging.

SCIENTIFIC REPORTS (2021)

Article Oncology

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy

Pataje G. Prasanna et al.

Summary: Cellular senescence is crucial in suppressing tumor growth, but radiation and chemotherapy can lead to accumulation of senescent cells in both tumor and normal tissues, potentially promoting tumor relapse and resistance to treatment. Targeting cellular senescence could be important in the fight against cancer.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Cell Biology

Potential role of senescent macrophages in radiation-induced pulmonary fibrosis

Lulu Su et al.

Summary: The study suggests that ionizing radiation may induce macrophage senescence, leading to sustained high secretion of SASP in pulmonary macrophages, which may stimulate a fibrotic phenotype in pulmonary fibroblasts.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

Identification of miRNA signatures associated with radiation-induced late lung injury in mice

Claude J. Rogers et al.

PLOS ONE (2020)

Review Oncology

Radiation-induced Adaptive Response: New Potential for Cancer Treatment

C. Norman Coleman et al.

CLINICAL CANCER RESEARCH (2020)

Review Medical Laboratory Technology

Cellular senescence and radiation-induced pulmonary fibrosis

Yonghan He et al.

TRANSLATIONAL RESEARCH (2019)

Article Biotechnology & Applied Microbiology

Microarray analysis of miRNA expression profiles following whole body irradiation in a mouse model

Molykutty J. Aryankalayil et al.

BIOMARKERS (2018)

Article Biology

Radiation-Induced Long Noncoding RNAs in a Mouse Model after Whole-Body Irradiation

Molykutty J. Aryankalayil et al.

RADIATION RESEARCH (2018)

Review Biochemistry & Molecular Biology

Role of MicroRNAs in TGF-β Signaling Pathway-Mediated Pulmonary Fibrosis

Hara Kang

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biotechnology & Applied Microbiology

miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-β Receptor II

Qian Zhang et al.

MOLECULAR THERAPY (2017)

Article Biochemistry & Molecular Biology

MicroRNA-27a-3p Is a Negative Regulator of Lung Fibrosis by Targeting Myofibroblast Differentiation

Huachun Cui et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways

Jin Shang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Review Biochemistry & Molecular Biology

Cellular senescence and tumor promotion: Is aging the key?

Natalia Loaiza et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2016)

Article Oncology

Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model

Eun Joo Chung et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

Article Biochemistry & Molecular Biology

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression

R. Rupaimoole et al.

ONCOGENE (2016)

Article Cell Biology

CBX7 and miR-9 are part of an autoregulatory loop controlling p16INK4a

Ana O'Loghlen et al.

AGING CELL (2015)

Article Biochemistry & Molecular Biology

Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition

Xiao Xiao et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2015)

Article Pathology

The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis

Chunlian Liang et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2015)

Article Multidisciplinary Sciences

Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis

Jiaolong Wang et al.

SCIENTIFIC REPORTS (2015)

Article Pharmacology & Pharmacy

MicroRNAs as potential targets for progressive pulmonary fibrosis

Subbiah Rajasekaran et al.

FRONTIERS IN PHARMACOLOGY (2015)

Review Biochemistry & Molecular Biology

The Long and Short of MicroRNA

Luke A. Yates et al.

Article Cell Biology

Up-Regulated Expression of miR-23a/b Targeted the Pro-Apoptotic Fas in Radiation-Induced thymic Lymphoma

Bailong Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2013)

Article Oncology

Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis

Deborah E. Citrin et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Biochemistry & Molecular Biology

Angiotensin signalling in pulmonary fibrosis

Bruce D. Uhal et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Review Hematology

miR-210: The Master Hypoxamir

Yuk C. Chan et al.

MICROCIRCULATION (2012)

Article Multidisciplinary Sciences

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

Muller Fabbri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

miR-29 Is a Major Regulator of Genes Associated with Pulmonary Fibrosis

Leah Cushing et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Article Rheumatology

Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway

Christina Bergmann et al.

ANNALS OF THE RHEUMATIC DISEASES (2011)

Review Urology & Nephrology

MicroRNAs as mediators and therapeutic targets in chronic kidney disease

Johan M. Lorenzen et al.

NATURE REVIEWS NEPHROLOGY (2011)

Article Biochemistry & Molecular Biology

Negative regulation of the tumor suppressor p53 gene by microRNAs

M. Kumar et al.

ONCOGENE (2011)

Review Medical Laboratory Technology

MicroRNAs in idiopathic pulmonary fibrosis

Kusum V. Pandit et al.

TRANSLATIONAL RESEARCH (2011)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Review Biochemistry & Molecular Biology

MicroRNAs and the regulation of fibrosis

Xiaoying Jiang et al.

FEBS JOURNAL (2010)

Review Cell Biology

The essence of senescence

Thomas Kuilman et al.

GENES & DEVELOPMENT (2010)

Article Immunology

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

Gang Liu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Review Oncology

Therapy-Induced Senescence in Cancer

Jonathan A. Ewald et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

Article Oncology

VASCULAR INJURY AFTER WHOLE THORACIC X-RAY IRRADIATION IN THE RAT

S. N. Ghosh et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2009)

Article Oncology

RENIN-ANGIOTENSIN SYSTEM SUPPRESSION MITIGATES EXPERIMENTAL RADIATION PNEUMONITIS

Swarajit N. Ghosh et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2009)

Review Immunology

Pulmonary fibrosis: pathogenesis, etiology and regulation

M. S. Wilson et al.

MUCOSAL IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy

Qiang Wang et al.

FASEB JOURNAL (2008)

Article Oncology

Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: A randomized controlled trial

Eric P. Cohen et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2008)

Article Biochemistry & Molecular Biology

The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis

Melanie Koenigshoff et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2007)

Article Oncology

Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury

John E. Moulder et al.

SEMINARS IN RADIATION ONCOLOGY (2007)

Review Biochemistry & Molecular Biology

Matrix metalloproteinases (MMPs): Chemical-biological functions and (Q)SARs

Rajeshwar P. Verma et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Critical Care Medicine

Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis

M Selman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Article Medical Laboratory Technology

The renin-angiotensin system in experimental radiation nephropathy

EP Cohen et al.

JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2002)