☆ 4.7 Review

No country for old antibiotics! Antimicrobial peptides (AMPs) as next-generation treatment for skin and soft tissue infection

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Review Pharmacology & Pharmacy

Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides

Xiaofang Luo et al.

Summary: This review explores the historical background, research trends, technological advancements, challenges, and future perspectives in the development and applications of antimicrobial peptides (AMPs) as potential therapeutic molecules. Vital questions regarding pharmaceutical production, the slow and steady journey, the importance of oral bioavailability, and the drug resistance possibilities of AMPs were raised and addressed. Therefore, this study is believed to provide a profound understanding of the past, current, and future scenarios on the therapeutic impacts of peptide drugs.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2023)

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Review Pharmacology & Pharmacy

Peptide-drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?

Chen Fu et al.

Summary: Peptide-drug conjugates (PDCs) are the next generation of targeted therapeutics that have enhanced cellular permeability and improved drug selectivity. PDCs have been developed for cancer, COVID-19, and metabolic diseases, but face challenges in stability, bioactivity, and long development time. This review summarizes the components and functions of PDCs and discusses strategies for improving their permeability, targeting, and stability. The future direction of PDCs includes coupling with toxin or supramolecular nanostructures. Clinical trials and drug delivery modes for PDCs are also discussed.

ACTA PHARMACEUTICA SINICA B (2023)

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Editorial Material Ophthalmology

Dapsone for the treatment of acne vulgaris: do the risks outweigh the benefits?

Selami Aykut Temiz et al.

Summary: Dapsone is a drug used to treat leprosy and acne. It has antimicrobial, anti-inflammatory, and antioxidant effects. However, dapsone treatment may cause various side effects.

CUTANEOUS AND OCULAR TOXICOLOGY (2022)

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Review Biochemistry & Molecular Biology

The tryptophan connection: cyclic peptide natural products linked via the tryptophan side chain

Jonathan A. Swain et al.

Summary: This review explores the isolation, bioactivity, first total synthesis, and biosynthesis of tryptophan-linked cyclic peptide natural products, highlighting their diversity and significance in research and synthesis studies.

NATURAL PRODUCT REPORTS (2022)

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Article Cell & Tissue Engineering

Healing Mechanisms in Cutaneous Wounds: Tipping the Balance

Adam J. Singer

Summary: Cutaneous wound healing is a complex process that occurs in four stages: hemostasis, inflammation, proliferation, and remodeling. Postnatal wound healing often leads to scar tissue formation, while regenerative healing can restore the wound to an uninjured state with minimal scarring. This review focuses on the pathophysiology of acute burn wounds and discusses reparative and regenerative healing mechanisms, as well as the development of novel approaches and therapeutics using components of regenerative healing.

TISSUE ENGINEERING PART B-REVIEWS (2022)

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Review Biotechnology & Applied Microbiology

Indolicidin revisited: biological activity, potential applications and perspectives of an antimicrobial peptide not yet fully explored

Jaqueline Batista Araujo et al.

Summary: The emergence of multidrug-resistant microorganisms and tumors poses a serious threat to public health. Indolicidin, a natural peptide with broad biological activity against various bacteria, fungi, and viruses, shows promising potential for application in medical, biomedical, and food industries. However, further research and interdisciplinary collaboration are needed to optimize the peptide and develop novel formulations to combat existing and future diseases.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2022)

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Review Materials Science, Biomaterials

Recent advances in the design of antimicrobial peptide conjugates

Amanda R. P. Silva et al.

Summary: This review discusses the design and application of conjugates of antimicrobial peptides (AMPs) with other molecules to enhance their therapeutic efficacy. It also explores the use of in silico tools in creating new AMPs and AMPs' conjugates and evaluates the future development of AMPs' conjugates in the context of antimicrobial resistance.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Medicine, Research & Experimental

Mechanisms of gram-positive vancomycin resistance (Review)

Samy Selim

Summary: Vancomycin-resistant bacteria (VRB) are increasingly complex and difficult to treat, with resistance mechanisms associated with gene evolution and various environmental and animal settings.

BIOMEDICAL REPORTS (2022)

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Article Engineering, Environmental

Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication

Nadia A. Samak et al.

Summary: In this study, cyclic dodecapeptides rich in Arg-Trp were synthesized and immobilized on an RGO/MnO2 nanocomposite, showing excellent antimicrobial activity and ability to degrade biofilms.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Review Biochemistry & Molecular Biology

The Role of Antimicrobial Peptides as Antimicrobial and Antibiofilm Agents in Tackling the Silent Pandemic of Antimicrobial Resistance

Bruno S. Lopes et al.

Summary: Antibiotic resistance caused by ESKAPE pathogens resulted in more than one million deaths globally in 2019. The use of antimicrobial peptides (AMPs) is crucial in combating this crisis, but their stability and potential toxic side effects need to be addressed. Developing new AMP analogues and using a one health approach, along with phage therapies and breakthroughs in antimicrobial peptide synthesis, can help tackle the problem of antimicrobial resistance (AMR).

MOLECULES (2022)

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Review Dermatology

Emerging treatment strategies in wound care

Marjan Mirhaj et al.

Summary: Wound healing is a complex process, and the current treatment strategies face challenges. Dressings and skin substitutes are the most effective, convenient, and cost-effective method for treating chronic wounds, and advances in materials science offer hope for treatment. There is a need to improve current treatment strategies to meet the increasing demands of the aging population and diabetes-related wounds.

INTERNATIONAL WOUND JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

Suhasini Mallick et al.

Summary: The treatment of chronic wound infections involves the complex interaction of immunity and host processes, with the formation of biofilm contributing to antimicrobial resistance. Nanomaterials are being developed as a non-conventional antimicrobial approach to disrupt and remove biofilms, improving wound healing effectiveness. Extensive research is focusing on various nanoplatforms, including metallic and nonmetallic nanoparticles, to enhance the treatment of chronic wounds.

NANOMATERIALS (2022)

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Article Pediatrics

Non-bullous Impetigo: Incidence, Prevalence, and Treatment in the Pediatric Primary Care Setting in Italy

Elisa Barbieri et al.

Summary: This study evaluated the incidence, prevalence, and management of children with non-bullous impetigo in Italy. The prevalence of NBI in Italian children is lower than the global estimate and is decreasing over time. Overprescription of systemic antibiotics poses a threat to antimicrobial resistance diffusion.

FRONTIERS IN PEDIATRICS (2022)

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Article Biotechnology & Applied Microbiology

Acceleration of Healing in Full-Thickness Wound by Chitosan-Binding bFGF and Antimicrobial Peptide Modification Chitosan Membrane

Lin Hou et al.

Summary: This study reports a multifunctional composite wound dressing loaded with chitosan-binding bFGF and antimicrobial peptides. The dressing exhibited excellent antibacterial activity, effectively inhibiting the growth of bacteria, and accelerated wound healing. Cell experiments and animal experiments demonstrated the positive effects of the composite dressing on cell growth and tissue repair.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Microbiology

Inducible Clindamycin-Resistant Staphylococcus aureus Strains in Africa: A Systematic Review

Muluneh Assefa

Summary: There is a high prevalence of inducible clindamycin resistance among S. aureus isolates in Africa, especially in MRSA strains. Regular screening, prudent use of clindamycin, and molecular detection and genotyping of resistant genes are urgently needed.

INTERNATIONAL JOURNAL OF MICROBIOLOGY (2022)

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Review Chemistry, Medicinal

Melittin: A Natural Peptide with Expanded Therapeutic Applications

Ruchi Tiwari et al.

Summary: This review article summarizes the therapeutic applications, mechanism of action, and recent research progress of melittin (MEL), a component of bee venom. It is found that MEL exerts multiple effects on the cellular functions of infected cells.

NATURAL PRODUCTS JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Fast killing kinetics, significant therapeutic index, and high stability of melittin-derived antimicrobial peptide

Reza Akbari et al.

Summary: The study evaluated the activity, toxicity, stability, and structure of MDP1 and MDP2. The results showed that MDP1 and MDP2 had fast killing kinetics, low hemolytic and cytotoxic effects, and high stability. Based on these findings, MDP1 could be considered as a drug lead for treating septicemia infections in mice.

AMINO ACIDS (2022)

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Review Agriculture, Dairy & Animal Science

The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production

Di Wu et al.

Summary: Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities and can indirectly protect hosts by modulating immune responses. They are considered a promising antibiotic substitute in animal production for improving growth performance, intestinal health, and immunity.

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

The dual interaction of antimicrobial peptides on bacteria and cancer cells; mechanism of action and therapeutic strategies of nanostructures

Atefeh Parchebafi et al.

Summary: Microbial infection and cancer are major causes of global mortality. Cationic antimicrobial peptides (AMPs) have dual antimicrobial and anticancer activities and are considered the best choice. Improving the efficacy and stability of AMPs is still necessary, and various strategies such as nano-carrier application can enhance their effects.

MICROBIAL CELL FACTORIES (2022)

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Article Chemistry, Multidisciplinary

Photochemical Optimization of a Silver Nanoprism/Graphene Oxide Nanocomposite?s Antibacterial Properties

Joselyn Benalcazar et al.

Summary: This study investigates how to optimize the antibacterial properties of nano-composites by varying the irradiation wavelength during the synthesis process. The authors transformed silver nanoparticles into narrow-sized anisotropically flat silver nanoprisms and anchored them to graphene oxide. They found a synergistic effect between the silver nanoprisms and the oxygen functional groups of the graphene oxide, resulting in enhanced antibacterial activity of the nanocomposite.

ACS OMEGA (2022)

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Article Biology

Matching amino acids membrane preference profile to improve activity of antimicrobial peptides

Shanghyeon Kim et al.

Summary: The improved antimicrobial peptide WCopWs demonstrates that matching the amino acid membrane preference profile can enhance insertion and activity, providing a potential solution to the problem of weak activity in antimicrobial peptides.

COMMUNICATIONS BIOLOGY (2022)

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Editorial Material Dermatology

Antibiotic Stewardship in Dermatology-Reducing the Risk of Prolonged Antimicrobial Resistance in Skin

Margaret A. MacGibeny et al.

JAMA DERMATOLOGY (2022)

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Article Medicine, General & Internal

Chronic wounds

Vincent Falanga et al.

Summary: Chronic wounds are wounds that do not heal within an expected time frame due to prolonged dysregulated inflammation. Advances in understanding the cellular and molecular aspects of basic science and innovative treatment modalities have improved the management of chronic wounds. However, gaps still exist in scientific knowledge, highlighting the need for further research to enhance understanding of chronic wounds.

NATURE REVIEWS DISEASE PRIMERS (2022)

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Article Biochemistry & Molecular Biology

Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome

Zimfira Z. Khairullina et al.

Summary: New antimicrobial compounds were designed and synthesized by conjugating desmycosin and fragments of oncocin, showing binding to E. coli ribosomes and inhibiting bacterial protein synthesis. These compounds demonstrated activity against some macrolide-resistant bacteria strains.

BIOCHEMISTRY-MOSCOW (2022)

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Article Pharmacology & Pharmacy

Electrospun fibers loaded with antimicrobial peptides for treatment of wound infections

Tobias Kielholz et al.

Summary: The resistance of clinically relevant bacteria against antibiotics highlights the need for novel therapeutics, especially for the treatment of wound infections. This study successfully developed drug-loaded wound dressings using electrospinning techniques, and demonstrated their antimicrobial activity against typical wound-associated pathogens.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

The Antimicrobial Peptide 1018-K6 Interacts Distinctly with Eukaryotic and Bacterial Membranes, the Basis of Its Specificity and Bactericidal Activity

Rosa Luisa Ambrosio et al.

Summary: Since the misuse of antibiotics has led to drug resistance, the search for alternative antimicrobial substances has become crucial. Antimicrobial peptide 1018-K6 has shown significant bactericidal and antibiofilm activity against various pathogenic bacteria, including antibiotic-resistant strains.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing

Qiqi Liu et al.

Summary: A core-shell structured nanoplatform was developed to co-load ciprofloxacin and tumor necrosis factor-alpha small interfering RNA for treating bacterial-infected wounds. The released silver ions and ciprofloxacin inhibited the growth of bacterial pathogens. Macrophage cells internalized the loaded siTNF-alpha, silencing the expression of inflammatory cytokines and promoting wound healing. In vivo, the infected wounds almost completely disappeared after treatment with the nanoplatform, and no suppuration symptoms were observed. The nanoplatform showed negligible side effects, highlighting its potential for clinical wound infections.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Medicinal

Development of Antimicrobial Peptide-Antibiotic Conjugates to Improve the Outer Membrane Permeability of Antibiotics Against Gram-Negative Bacteria

Ruka Yamauchi et al.

Summary: Antibiotics are not effective against certain Gram-negative bacteria due to their low permeability to the outer membrane. The coadministration of antibiotics and antimicrobial peptides is a strategy to enhance their antibacterial activity, but their different pharmacokinetics may limit their efficacy in clinical settings. This study introduced antimicrobial peptide-antibiotic conjugates as a novel approach to improve the antimicrobial activity of antibiotics with low outer membrane permeability.

ACS INFECTIOUS DISEASES (2022)

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Article Integrative & Complementary Medicine

Management of folliculitis decalvans with ayurveda- A case report

Shankar Gautam et al.

Summary: This case report presents a 24-year-old male patient with patchy hair loss in the scalp region accompanied by scale formation, itching, and pain for 2 months. After treatment, complete remission of folliculitis decalvans (FD) was achieved, with new hair growth over the scalp.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2022)

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Review Biophysics

Tryptophan, more than just an interfacial amino acid in the membrane activity of cationic cell-penetrating and antimicrobial peptides

Sonia Khemaissa et al.

Summary: Trp is unique among the amino acids due to its involvement in various noncovalent interactions, including electrostatic, hydrophobic, pi-pi, pi-cation, pi-anion, and pi-ion pair interactions. This review focuses on the less explored role of Trp in membranotropic peptides, specifically its effects on CPP internalization and AMP activity, as well as its interactions with lipids, glycoconjugates, and extracellular matrix components. Understanding the physico-chemical properties and extensive interactions of Trp is essential for designing future membranotropic peptides with antimicrobial or cell-penetrating activity.

QUARTERLY REVIEWS OF BIOPHYSICS (2022)

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Review Pharmacology & Pharmacy

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Yunjiang Jiang et al.

Summary: AMPs and SMAMPs have attracted significant enthusiasm in the past thirty years due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. Despite challenges inherent to current design strategies slowing down the clinical translational development of AMPs and SMAMPs, these challenges have triggered efforts to redesign and repurpose AMPs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Letter Dermatology

Guidelines for the management of hidradenitis suppurativa: recommendations supported by the Centre of Evidence of the French Society of Dermatology

A. Bertolotti et al.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

Stephen K. Burley et al.

Summary: RCSB PDB, as the US data center for the global PDB archive, provides free access to 3D macromolecular structure data for millions of users worldwide, including educators, students, and the general public, integrating over 40 external biodata resources. The redesigned website now features improved search functionality and easier access to PDB data, showcasing new structures relevant to the understanding and addressing of the COVID-19 pandemic.

NUCLEIC ACIDS RESEARCH (2021)

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Review Immunology

Molecular Dynamics for Antimicrobial Peptide Discovery

Nicholas Palmer et al.

Summary: Antimicrobial resistance is a growing concern, with only two new classes of antibiotics approved for human use since the 1960s. Molecular dynamics simulation is a valuable tool for understanding antibiotic mechanisms and can lay the groundwork for new antibiotic discovery. Antimicrobial peptides show promise in combating resistance due to their lower tendency to induce resistance compared to small-molecule antibiotics.

INFECTION AND IMMUNITY (2021)

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Review Biochemistry & Molecular Biology

Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action

Rachita Dash et al.

Summary: Thanatin, an AMP with broad-spectrum activity, shows high potency in inhibiting the growth of bacteria and fungi at considerably low concentrations. Recent interest has been focused on understanding its modes of action, in vivo activity, and therapeutic potential against drug-resistant pathogens. Further research is needed to develop novel molecules for treating infections.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Microbiology

Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs)

Gabrielle S. Dijksteel et al.

Summary: Antimicrobial peptides show potential as alternatives to antibiotics, but face challenges in clinical implementation. To improve the success rate of AMPs in clinical trials, strategies need to be developed, emphasizing lessons learned from these trials.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Medicine, Research & Experimental

Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota

Michelle Mouritzen et al.

Summary: LFcinB treatment has shown significant positive effects on diabetic wound healing, including increased keratinocyte migration, reduced bacterial diversity, enhanced angiogenesis, and improved collagen deposition.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

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Article Engineering, Biomedical

Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations

Payel Das et al.

Summary: The combination of deep learning and molecular dynamics simulations enables the rapid discovery of antimicrobial peptides with low toxicity and high potency against a variety of Gram-positive and Gram-negative pathogens.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Nanoscience & Nanotechnology

Synergistic and On-Demand Release of Ag-AMPs Loaded on Porous Silicon Nanocarriers for Antibacteria and Wound Healing

Yao Jin et al.

Summary: The study developed a dual synergistic antibacterial platform based on AgNPs and AMP, showing excellent antibacterial effect with on-demand release ability. PSiMPs as a carrier efficiently loaded AgNPs and AMP, releasing Ag+ and AMP under bacterial infection conditions, promoting wound healing by synergistic antibacterial efficiency.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes

Shikun Wei et al.

Summary: This study developed a hydrogel system for the treatment of chronic infected wounds, which can effectively regulate inflammation and enhance collagen deposition and angiogenesis by using antimicrobial peptides and PRP. The hydrogel showed sustained-release capacity, anti-bacterial activity against pathogenic strains, and promoted fibroblast cells proliferation and migration. Additionally, the hydrogel accelerated wound healing in diabetic mouse infection, leading to improved collagen deposition, reduced bacterial load, and balanced inflammatory response.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Medicinal

Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates

Weiwei Shi et al.

Summary: This study introduces a new type of antibiotic, VPCs, which show enhanced activity against vancomycin resistant bacteria and effectiveness against Gram-negative bacteria, providing a novel strategy for vancomycin modification and glycopeptide antibiotics synthesis.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

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Review Pharmacology & Pharmacy

Vehicles for Drug Delivery and Cosmetic Moisturizers: Review and Comparison

Tanya M. Barnes et al.

Summary: The article discusses the use of topical therapeutic products for dermatological conditions, such as eczema and psoriasis, and emphasizes the importance of choosing the right topical vehicles based on the size and properties of the skin to optimize treatment effectiveness and patient compliance. Regulatory rules governing topical product claims in Australia and worldwide are also briefly examined.

PHARMACEUTICS (2021)

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Review Biotechnology & Applied Microbiology

Systematic Review of the Application of Perinatal Derivatives in Animal Models on Cutaneous Wound Healing

Melanie Pichlsberger et al.

Summary: The review discusses the beneficial effects of perinatal derivatives in wound healing, highlighting the various factors that can influence their efficacy in preclinical models.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing

Denis C. Szondi et al.

Summary: Arginase is a crucial enzyme in the skin that plays a role in cell detoxification, proliferation, and collagen production, while balancing pro- and anti-inflammatory responses during wound healing. Dysfunctionalities in the ARG pathways can impede the healing process and contribute to chronic wounds.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Nanoscience & Nanotechnology

Antimicrobial Peptide-Loaded Pectolite Nanorods for Enhancing Wound-Healing and Biocidal Activity of Titanium

Lan Zhang et al.

Summary: Titanium is commonly used in medical implants due to its mechanical strength and biocompatibility. Recent studies have focused on developing coatings to enhance the properties of Ti implants, with Ca- and Si-based ceramic coatings being able to release ions to improve bone integration. However, the high degradation rates of these ceramics may reduce cell viability, requiring the use of polymeric or protein-based coatings to modulate degradation while maintaining stability and biocompatibility.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Medicinal

Computational Methods and Tools in Antimicrobial Peptide Research

Pietro G. A. Aronica et al.

Summary: The evolution of antibiotic-resistant bacteria has led to an increase in untreatable diseases, highlighting the urgent need for alternative treatment methods. Antimicrobial peptides (AMPs) have attracted significant interest, with their design and development aided by molecular models and computational approaches can aid experimental studies in this area.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)

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Article Materials Science, Biomaterials

Hyaluronic acid nanofiber mats loaded with antimicrobial peptide towards wound dressing applications

Qianwen Yang et al.

Summary: This study developed a new type of EPL-loaded nanofiber mat using hyaluronic acid (HA) instead of starch, showing excellent antibacterial properties and biocompatibility, which may be potentially used for treating chronic wounds.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Polymer Science

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Sibusiso Alven et al.

Summary: The management of chronic wounds is challenging due to factors such as malnutrition, diseases, and bacterial infection. Wound dressings formulated from a combination of biopolymers and synthetic polymers show promising properties, especially when prepared using electrospinning technique.

POLYMERS (2021)

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Review Polymer Science

Hyaluronic Acid-Based Scaffolds as Potential Bioactive Wound Dressings

Sibusiso Alven et al.

Summary: The negative factors that lead to delayed and prolonged wound healing, such as microbial pathogens and excess wound exudates, pose challenges for currently used wound dressings, necessitating improvements. Biopolymers offer interesting properties suitable for the design of wound dressings.

POLYMERS (2021)

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Article Pharmacology & Pharmacy

In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria

Parvin Askari et al.

Summary: The study found that melittin could not exhibit antimicrobial activity at its safe dose, which hinders its application in clinical practice.

BMC PHARMACOLOGY & TOXICOLOGY (2021)

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Review Biochemistry & Molecular Biology

Recent Developments in Free Energy Calculations for Drug Discovery

Edward King et al.

Summary: The grand challenge of structure-based drug design lies in accurately predicting binding free energies. Molecular dynamics simulations have enabled the modeling of conformational changes in the binding process, leading to the calculation of thermodynamic quantities for estimating binding affinities. Various approaches, including MM-PBSA, LIE, and alchemical methods, have been widely used to model molecular recognition for drug discovery and lead optimization.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Health Care Sciences & Services

Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds

Andreea Barbu et al.

Summary: Chronic wounds pose a major public health issue with high costs globally. An ideal wound dressing should possess various characteristics such as adhesion, non-antigenicity, biocompatibility, semi-permeability, and biodegradability. This paper explores the use of biopolymer materials, specifically alginate forms, in advanced wound healing applications, focusing on hydrogels, nanofibers networks, and 3D-scaffolds.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Review Dermatology

Topical Antibacterials in Dermatology

Debabrata Bandyopadhyay

Summary: Topical antibacterials are commonly used for superficial skin infections such as acne and impetigo, but bacterial resistance is a growing concern. Additionally, contact dermatitis limits the use of certain antibacterial agents.

INDIAN JOURNAL OF DERMATOLOGY (2021)

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Review Immunology

Pathogenicity and virulence of Staphylococcus aureus

Gordon Y. C. Cheung et al.

Summary: Staphylococcus aureus is a common pathogen causing a range of diseases, with treatment complicated by antibiotic resistance and lack of an effective vaccine. Understanding the role of S. aureus virulence factors can help in developing anti-virulence strategies to combat the challenges posed by this pathogen.

VIRULENCE (2021)

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Article Pharmacology & Pharmacy

Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo

Albert Bolatchiev et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2020)

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Article Microbiology

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes

Sae Aoki et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of vancomycin resistance

Peter J. Stogios et al.

PROTEIN SCIENCE (2020)

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Review Chemistry, Physical

Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Parteek Prasher et al.

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Vancomycin Resistance is Overcome by Conjugation of Polycationic Peptides

Florian Umstatter et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Medicine, Research & Experimental

Pharmacodynamic Effects of Topical Omiganan in Patients With Mild to Moderate Atopic Dermatitis in a Randomized, Placebo-Controlled, Phase II Trial

Tessa Niemeyer-van der Kolk et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)

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Review Biochemistry & Molecular Biology

Understanding and modelling the interactions of peptides with membranes: from partitioning to self-assembly

Charles H. Chen et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)

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Article Microbiology

Resistance Evolution Against Antimicrobial Peptides in Staphylococcus aureus Alters Pharmacodynamics Beyond the MIC

Baydaa El Shazely et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Immunology

Defensins: A Double-Edged Sword in Host Immunity

Dan Xu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Antimicrobial peptides as therapeutic agents: opportunities and challenges

Margit Mahlapuu et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components

F. Savini et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

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Article Biochemistry & Molecular Biology

Versatile Polypeptide-Functionalized Plasmonic Paper as Synergistic Biocompatible and Antimicrobial Nanoplatform

Leopold Tie et al.

MOLECULES (2020)

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Highly synergistic antimicrobial activity of magainin 2 and PGLa peptides is rooted in the formation of supramolecular complexes with lipids

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SCIENTIFIC REPORTS (2020)

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The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics

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Antimicrobial Peptide Induced-Stress RendersStaphylococcus aureusSusceptible to Toxic Nucleoside Analogs

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FRONTIERS IN IMMUNOLOGY (2020)

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An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

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PHARMACEUTICS (2020)

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Covalent Grafting of Antimicrobial Peptides onto Microcrystalline Cellulose

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ACS APPLIED BIO MATERIALS (2020)

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Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides

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FRONTIERS IN MEDICAL TECHNOLOGY (2020)

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North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations Part I: Diagnosis, evaluation, and the use of complementary and procedural management

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Simulation-Guided Rational de Novo Design of a Small Pore-Forming Antimicrobial Peptide

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Nanofiber Dressings Topically Delivering Molecularly Engineered Human Cathelicidin Peptides for the Treatment of Biofilms in Chronic Wounds

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MOLECULAR PHARMACEUTICS (2019)

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Review Microbiology

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NATURE REVIEWS MICROBIOLOGY (2019)

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Reassessing the Host Defense Peptide Landscape

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FRONTIERS IN CHEMISTRY (2019)

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Editorial Material Dermatology

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BIOTECHNOLOGY LETTERS (2019)

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FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

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Evaluation of the Antifungal and Wound-Healing Properties of a Novel Peptide-Based Bioadhesive Hydrogel Formulation

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The role of molecular simulations in understanding the mechanisms of cell-penetrating peptides

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DRUG DISCOVERY TODAY (2019)

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EXPERT OPINION ON DRUG DISCOVERY (2019)

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Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

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Biofunctions of antimicrobial peptide-conjugated alginate/hyaluronic acid/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Facile and efficient encapsulation of antimicrobial peptides via crosslinked DNA nanostructures and their application in wound therapy

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The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

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NATURE COMMUNICATIONS (2019)

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Peptide Design Principles for Antimicrobial Applications

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PHYSIOLOGICAL REVIEWS (2019)

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Antimicrobial peptides activity in the skin

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SKIN RESEARCH AND TECHNOLOGY (2019)

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Helicobacter pylori Ribosomal Protein-A2 Peptide/Silk Fibroin Nanofibrous Composites as Potential Wound Dressing

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Antimicrobial peptides under clinical investigation

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Topical Gentamicin for the Treatment of Genetic Skin Diseases

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Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

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BMC MICROBIOLOGY (2018)

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Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo

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BRITISH JOURNAL OF PHARMACOLOGY (2018)

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Membrane interactions of microgels as carriers of antimicrobial peptides

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Conjugates and nano-delivery of antimicrobial peptides for enhancing therapeutic activity

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Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment

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The interfacial electrostatic potential modulates the insertion of cell-penetrating peptides into lipid bilayers

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An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds.

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VALUE IN HEALTH (2018)

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Efficacy and Safety of Ozenoxacin Cream for Treatment of Adult and Pediatric Patients With Impetigo A Randomized Clinical Trial

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JAMA DERMATOLOGY (2018)

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NATURE REVIEWS DISEASE PRIMERS (2018)

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Antimicrobial Peptides: Interaction With Model and Biological Membranes and Synergism With Chemical Antibiotics

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FRONTIERS IN CHEMISTRY (2018)

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Smart Bandages: The Future of Wound Care

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TRENDS IN BIOTECHNOLOGY (2018)

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Antibiotics-Peptide Conjugates Against Multidrug-Resistant Bacterial Pathogens

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CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)

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Biocompatible antimicrobial electrospun nanofibers functionalized with epsilon-poly-L-lysine

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Management of complicated skin and soft tissue infections with a special focus on the role of newer antibiotics

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INFECTION AND DRUG RESISTANCE (2018)

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Novel vancomycin-peptide conjugate as potent antibacterial agent against vancomycin-resistant Staphylococcus aureus

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INFECTION AND DRUG RESISTANCE (2018)

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Treatment of severe skin and soft tissue infections: a review

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CURRENT OPINION IN INFECTIOUS DISEASES (2018)

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Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential

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JOURNAL OF CONTROLLED RELEASE (2017)

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Development of novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial and antibiofilm activities against multidrug-resistant bacteria

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DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

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Antimicrobial peptide Epinecidin-1 promotes complete skin regeneration of methicillin-resistant Staphylococcus aureus infected burn wounds in a swine model

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ONCOTARGET (2017)

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Article Chemistry, Medicinal

Membrane-Active Amphipathic Peptide WRL3 with in Vitro Antibiofilm Capability and in Vivo Efficacy in Treating Methicillin-Resistant Staphylococcus aureus Burn Wound Infections

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ACS INFECTIOUS DISEASES (2017)

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Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound

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NPJ BIOFILMS AND MICROBIOMES (2017)

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Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses

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Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

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Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications

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Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes

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Delivery systems for antimicrobial peptides

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ADVANCES IN COLLOID AND INTERFACE SCIENCE (2017)

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Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure

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CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

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Multi-biofunction of antimicrobial peptide-immobilized silk fibroin nanofiber membrane: Implications for wound healing

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Molecular mechanisms of membrane targeting antibiotics

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

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One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model

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BIOMATERIALS (2016)

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Mechanisms and consequences of bacterial resistance to antimicrobial peptides

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DRUG RESISTANCE UPDATES (2016)

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The staphylococcal surface-glycopolymer wall teichoic acid (WTA) is crucial for complement activation and immunological defense against Staphylococcus aureus infection

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IMMUNOBIOLOGY (2016)

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Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections

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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

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Review Immunology

Antimicrobial Peptides : An Emerging Category of Therapeutic Agents

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FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2016)

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Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides

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ACS INFECTIOUS DISEASES (2016)

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Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity

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SCIENTIFIC REPORTS (2016)

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Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration

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SCIENTIFIC REPORTS (2016)

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Review Biochemistry & Molecular Biology

Design and Application of Antimicrobial Peptide Conjugates

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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In Vitro Spectrum of Pexiganan Activity When Tested against Pathogens from Diabetic Foot Infections and with Selected Resistance Mechanisms

Robert K. Flamm et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

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Blood culture-based diagnosis of bacteraemia: state of the art

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CLINICAL MICROBIOLOGY AND INFECTION (2015)

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Co-spinning of Silver Nanoparticles with Nisin Increases the Antimicrobial Spectrum of PDLLA: PEO Nanofibers

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CURRENT MICROBIOLOGY (2015)

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Bacteria-Targeting Conjugates Based on Antimicrobial Peptide for Bacteria Diagnosis and Therapy

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MOLECULAR PHARMACEUTICS (2015)

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Letter Medicine, General & Internal

Methemoglobinemia as a Complication of Topical Dapsone

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NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Levofloxacin and Indolicidin for Combination Antimicrobial Therapy

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CURRENT DRUG DELIVERY (2015)

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Challenges in the Treatment of Chronic Wounds

Robert G. Frykberg et al.

ADVANCES IN WOUND CARE (2015)

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LTX-109 Is a Novel Agent for Nasal Decolonization of Methicillin-Resistant and -Sensitive Staphylococcus aureus

Anna C. Nilsson et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

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The Frog Skin-Derived Antimicrobial Peptide Esculentin-1a(1-21)NH2 Promotes the Migration of Human HaCaT Keratinocytes in an EGF Receptor-Dependent Manner: A Novel Promoter of Human Skin Wound Healing?

Antonio Di Grazia et al.

PLOS ONE (2015)

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Correction Biochemistry & Molecular Biology

Efficacy of the designer antimicrobial peptide SHAP1 in wound healing and wound infection (vol 46, pg 2333, 2014)

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AMINO ACIDS (2014)

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Temporins A and B Stimulate Migration of HaCaT Keratinocytes and Kill Intracellular Staphylococcus aureus

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

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Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America

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CLINICAL INFECTIOUS DISEASES (2014)

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A potential wound-healing-promoting peptide from salamander skin

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FASEB JOURNAL (2014)

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A short peptide from frog skin accelerates diabetic wound healing

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FEBS JOURNAL (2014)

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Article Biochemistry & Molecular Biology

A potential wound healing-promoting peptide from frog skin

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

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Novel Anti-Microbial Peptide SR-0379 Accelerates Wound Healing via the PI3 Kinase/Akt/mTOR Pathway

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PLOS ONE (2014)

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A Small Peptide with Potential Ability to Promote Wound Healing

Jing Tang et al.

PLOS ONE (2014)

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Comparison of Biofilm Formation between Major Clonal Lineages of Methicillin Resistant Staphylococcus aureus

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PLOS ONE (2014)

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1,25-Dihydroxyvitamin D3 Induces LL-37 and HBD-2 Production in Keratinocytes from Diabetic Foot Ulcers Promoting Wound Healing: An In Vitro Model

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PLOS ONE (2014)

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Article Cell Biology

Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trial

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WOUND REPAIR AND REGENERATION (2014)

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Multifunctional self-assembled cationic peptide nanostructures efficiently carry plasmid DNA in vitro and exhibit antimicrobial activity with minimal toxicity

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JOURNAL OF MATERIALS CHEMISTRY B (2014)

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Article Microbiology

Evaluation of a Nisin-Eluting Nanofiber Scaffold To Treat Staphylococcus aureus-Induced Skin Infections in Mice

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

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Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

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The multiple roles of histidine in protein interactions

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PHARMACEUTICALS (2013)

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Characterization and evaluation of silver release from four different dressings used in burns care

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BURNS (2012)

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Review Biotechnology & Applied Microbiology

Antimicrobial peptides: key components of the innate immune system

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CRITICAL REVIEWS IN BIOTECHNOLOGY (2012)

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Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery

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Current Computer-Aided Drug Design (2012)

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Accelerating resistance, inadequate antibacterial drug pipelines and international responses

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Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation

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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Biochemistry & Molecular Biology

Mechanism of Elongation Factor-G-mediated Fusidic Acid Resistance and Fitness Compensation in Staphylococcus aureus

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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)

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Bacterial skin and soft tissue infections: review of the epidemiology, microbiology, aetiopathogenesis and treatment

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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2012)

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Designing antimicrobial peptides: form follows function

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Enhanced Membrane Pore Formation through High-Affinity Targeted Antimicrobial Peptides

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PLOS ONE (2012)

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Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection

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PLOS ONE (2012)

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Review Cell Biology

A review of the scientific evidence for biofilms in wounds

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WOUND REPAIR AND REGENERATION (2012)

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β-Lactam-host defence peptide conjugates as antibiotic prodrug candidates targeting resistant bacteria

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RSC ADVANCES (2012)

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Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates

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CARBOHYDRATE RESEARCH (2011)

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Review Cell Biology

Defensins in innate immunity

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CELL AND TISSUE RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Role of host-defence peptides in eye diseases

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CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

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Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF

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EUROPEAN JOURNAL OF IMMUNOLOGY (2011)

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Article Infectious Diseases

Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved

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INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2011)

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Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes

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JOURNAL OF DERMATOLOGICAL SCIENCE (2011)

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Review Biotechnology & Applied Microbiology

The expanding scope of antimicrobial peptide structures and their modes of action

Leonard T. Nguyen et al.

TRENDS IN BIOTECHNOLOGY (2011)

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Review Biochemistry & Molecular Biology

A play in four acts: Staphylococcus aureus abscess formation

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TRENDS IN MICROBIOLOGY (2011)

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Review Biochemistry & Molecular Biology

Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity

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BIOCHIMIE (2010)

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Article Immunology

Human β-defensin 3 has immunosuppressive activity in vitro and in vivo

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EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

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Injury Is a Major Inducer of Epidermal Innate Immune Responses during Wound Healing

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

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Article Infectious Diseases

Mandell, Douglas, and Bennett's principles and practice of infectious diseases

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LANCET INFECTIOUS DISEASES (2010)

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Review Dermatology

Fusidic acid in dermatology: an updated review

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EUROPEAN JOURNAL OF DERMATOLOGY (2010)

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Review Biochemistry & Molecular Biology

Mechanisms of Antimicrobial, Cytolytic, and Cell-Penetrating Peptides: From Kinetics to Thermodynamics

Paulo F. Almeida et al.

BIOCHEMISTRY (2009)

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Article Immunology

Mupirocin Resistance

Jean B. Patel et al.

CLINICAL INFECTIOUS DISEASES (2009)

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Article Dermatology

Topical Antibiotics in Dermatology: Emerging Patterns of Resistance

Dirk M. Elston

DERMATOLOGIC CLINICS (2009)

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Article Infectious Diseases

Skin and soft tissue infection: microbiology and epidemiology

Matthew S. Dryden

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2009)

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Article Biotechnology & Applied Microbiology

Human beta-defensin-3 promotes wound heating in infected diabetic wounds

Tobias Hirsch et al.

JOURNAL OF GENE MEDICINE (2009)

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Review Microbiology

Waves of resistance: Staphylococcus aureus in the antibiotic era

Henry F. Chambers et al.

NATURE REVIEWS MICROBIOLOGY (2009)

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Review Biotechnology & Applied Microbiology

Mechanism of action of and resistance to quinolones

Anna Fabrega et al.

MICROBIAL BIOTECHNOLOGY (2009)

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Article Biophysics

The Activity of the Amphipathic Peptide δ-Lysin Correlates with Phospholipid Acyl Chain Structure and Bilayer Elastic Properties

Antje Pokorny et al.

BIOPHYSICAL JOURNAL (2008)

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Review Infectious Diseases

Bacterial skin and soft tissue infections in adults: A review of their epidemiology, pathogenesis, diagnosis, treatment and site of care

Vincent Ki et al.

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY (2008)

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Article Immunology

Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?

Kyle J. Popovich et al.

CLINICAL INFECTIOUS DISEASES (2008)

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Article Immunology

Topical versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double-Blinded, Multicenter Trial of Pexiganan Cream

Benjamin A. Lipsky et al.

CLINICAL INFECTIOUS DISEASES (2008)

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Article Dermatology

Local antibiotics in dermatology

Carlo Gelmetti

DERMATOLOGIC THERAPY (2008)

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Article Microbiology

Differential roles of sortase-anchored surface proteins and wall teichoic acid in Staphylococcus aureus nasal colonization

Christopher Weidenmaier et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2008)

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Article Biochemistry & Molecular Biology

The preference of tryptophan for membrane interfaces - Insights from n-methylation of tryptophans in gramicidin channels

Haiyan Sun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Dermatology

In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37

Marta Carretero et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

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Review Chemistry, Medicinal

Wound healing dressings and drug delivery systems: A review

Joshua S. Boateng et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

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Review Infectious Diseases

Alternative mechanisms of action of cationic antimicrobial peptides on bacteria

John D. F. Hale et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2007)

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Review Pharmacology & Pharmacy

Topical clindamycin in the management of acne vulgaris

David R. P. Guay

EXPERT OPINION ON PHARMACOTHERAPY (2007)

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Article Dermatology

Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines

Francois Niyonsaba et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Review Immunology

Cationic host defense (antimicrobial) peptides

KL Brown et al.

CURRENT OPINION IN IMMUNOLOGY (2006)

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Review Biochemistry & Molecular Biology

Tryptophan- and arginine-rich antimicrobial peptides: Structures and mechanisms of action

David I. Chan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)

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Article Immunology

Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37

S Tokumaru et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Biochemistry & Molecular Biology

Investigating the importance of the flexible hinge in caerin 1.1: Solution structures and activity of two synthetically modified caerin peptides

TL Pukala et al.

BIOCHEMISTRY (2004)

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Article Dermatology

The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium

JD Heilborn et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)

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Article Surgery

Temporin A as a prophylactic agent against methicillin sodium-susceptible and methicillin sodium-resistant Staphylococcus epidermidis vascular graft infection

R Ghiselli et al.

JOURNAL OF VASCULAR SURGERY (2002)

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Article Biochemistry & Molecular Biology

Antimicrobial activity of short arginine- and tryptophan-rich peptides

MB Strom et al.

JOURNAL OF PEPTIDE SCIENCE (2002)

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Review Biochemistry & Molecular Biology

Mode of action of membrane active antimicrobial peptides

Y Shai

BIOPOLYMERS (2002)

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