期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 635, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2023.122703
关键词
Dendritic cell; Polymer; Target; Receptor; Immunity
This paper reviews and compares DC surface receptors and their specific coupling natural ligands and antibodies, describes reaction mechanisms, and demonstrates the synergistic effects of immune adjuvants. Moreover, extracellular-targeting antigen-delivery strategies and intracellular stimulus responses are reviewed to promote the rational design of polymer delivery systems.
Cancer immunity is dependent on dynamic interactions between T cells and dendritic cells (DCs). Polymer-based nanoparticles target DC receptors to improve anticancer immune responses. In this paper, DC surface receptors and their specific coupling natural ligands and antibodies are reviewed and compared. Moreover, reaction mechanisms are described, and the synergistic effects of immune adjuvants are demonstrated. Also, extracellular-targeting antigen-delivery strategies and intracellular stimulus responses are reviewed to promote the rational design of polymer delivery systems.
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