4.7 Article

Enhanced dissolution rate of nimodipine through ?-lactoglobulin based formulation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

A Comparative Study between A Protein Based Amorphous Formulation and Other Dissolution Rate Enhancing Approaches: A Case Study with Rifaximin

Xuezhi Zhuo et al.

Summary: This study compared the feasibility of using proteins as co-formers in amorphous solid dispersions (ASDs) with traditional synthetic polymers and a nanocrystalline formulation. The whey protein beta-lactoglobulin (BLG) demonstrated the highest glass transition temperature and improved dissolution rate and drug solubility compared to the polymer-based ASD systems and the nanocrystalline formulation.

PHARMACEUTICS (2023)

Article Medicine, Research & Experimental

Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Aleksei Kabedev et al.

Summary: This study investigates the impact of drug loading on the stability of protein-stabilized amorphous formulations, finding a second glass transition temperature at drug loadings higher than 40-50%. The simulations suggest that the mechanisms of drug stabilization by proteins involve reduced mobility of drug molecules in the first drug shell and hydrogen-bond networks.

MOLECULAR PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

Patterns of drug release as a function of drug loading from amorphous solid dispersions: A comparison of five different polymers.

Sugandha Saboo et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Article Pharmacology & Pharmacy

Whey proteins as stabilizers in amorphous solid dispersions

Jaya Mishra et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Article Pharmacology & Pharmacy

Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery - An update

Scott V. Jermain et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Pharmacology & Pharmacy

Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions

Matthias Manne Knopp et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

Article Pharmacology & Pharmacy

Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions

Matthias Manne Knopp et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

Article Chemistry, Applied

Mesoporous drug carrier systems for enhanced delivery rate of poorly water-soluble drug: nimodipine

Anna Kiwilsza et al.

JOURNAL OF POROUS MATERIALS (2015)

Article Polymer Science

Poly(vinylpyrrolidone) - A Versatile Polymer for Biomedical and Beyond Medical Applications

Mirela Teodorescu et al.

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING (2015)

Review Pharmacology & Pharmacy

Refining stability and dissolution rate of amorphous drug formulations

Holger Grohganz et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

Review Pharmacology & Pharmacy

Fundamental aspects of solid dispersion technology for poorly soluble drugs

Yanbin Huang et al.

ACTA PHARMACEUTICA SINICA B (2014)

Review Pharmacology & Pharmacy

Drug precipitation inhibitors in supersaturable formulations

Sen Xu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Review Pharmacology & Pharmacy

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

Laura M. Ensign et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)