Hybrid Hydrogel Loaded with Chlorhexidine??-CD-MSN Composites as Wound Dressing

Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Multiple Stimuli-Responsive MXene-Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Xin Yang et al.

Summary: A novel MXene-based hydrogel drug delivery system for efficient treatment of deep chronic wounds is introduced in the study. This system demonstrates multiple response capability and controllable drug delivery ability, reducing toxic side effects of drugs and promoting wound healing process. The practical performance of the system in treating rat models indicates great prospect in clinical wound healing and related biomedical fields.

SMALL (2022)

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Article Engineering, Biomedical

Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

Wanyi Zhou et al.

Bioactive Materials (2022)

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Article Chemistry, Multidisciplinary

Treatment of Wound Infections in a Mouse Model Using Zn2+-Releasing Phage Bound to Gold Nanorods

Huan Peng et al.

Summary: Infections caused by drug-resistant bacteria are difficult to treat, but a study found that engineered phage-nanomaterial conjugates can effectively treat infected wounds caused by Gram-negative pathogens in mice. The treatment rapidly reduced bacterial load and promoted wound healing, outperforming standard-of-care antibiotics. The phage-nanomaterial treatment also worked against a strain resistant to last-line antibiotics, with no detectable toxicity or systemic effects.

ACS NANO (2022)

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Article Biotechnology & Applied Microbiology

GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing

Meng Yuan et al.

Summary: Clinical work and research on diabetic wound repair are challenging, and conventional wound dressings have limited efficacy. Sustained release of biomolecules from biological wound dressings, such as cell-derived exosomes, shows promise for wound healing. A methacrylate gelatin microneedle patch was developed to achieve transdermal and controlled release of exosomes and tazarotene for diabetic wound repair. The patch demonstrated therapeutic effects by promoting cell migration and angiogenesis.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Polymer Science

Recent Progress in Electrospun Polyacrylonitrile Nanofiber-Based Wound Dressing

Chang Huang et al.

Summary: Bleeding control is crucial in healthcare, which has led to advancements in wound dressing research and development. Electrospun polyacrylonitrile nanofibers offer excellent properties for wound dressings, showing great potential in manufacturing.

POLYMERS (2022)

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Article Engineering, Biomedical

De novo strategy with engineering a multifunctional bacterial cellulose-based dressing for rapid healing of infected wounds

Chen Zhou et al.

Summary: A multifunctional dressing consisting of collagen I and an antibacterial agent has been developed to treat and promote the healing of infected wounds. The dressing showed excellent antibacterial properties and cell compatibility, and significantly improved water retention compared to existing options.

BIOACTIVE MATERIALS (2022)

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Review Nanoscience & Nanotechnology

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Ping Zhao et al.

Summary: This article introduces the research progress and application of electrospun nanofibrous membranes for periodontitis treatment. Electrospun nanofibrous membranes have a large specific surface area and high porosity, which can improve the absorption capacity of proteins, promote the expression of specific genes, improve cell adhesion properties, and prevent fibroblasts from passing through the barrier membrane. Currently, various nanofibrous membranes with antibacterial, anti-inflammatory, and tissue regeneration properties have been prepared for periodontal treatment. Electrospinning has unique advantages in periodontal treatment and has potential for further development in the future.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Engineering, Biomedical

Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

Chen-Yu Zou et al.

Summary: Bio-adhesive polysaccharide-based hydrogels with improved mechanical properties and bio-adhesion have been developed. These hydrogels exhibit excellent biocompatibility, antibacterial property and pro-healing bioactivity. They show superior hemostatic performance and promote infected wound healing due to their enhanced adhesive properties and procoagulant activity.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

Lin Jin et al.

Summary: This study developed a band-aid with a core-shell structure to modulate vascularization and the immune microenvironment, leading to scarless wound healing. The band-aid released H2S and a growth factor, which controlled macrophage polarization and inhibited excessive inflammation, thereby promoting skin cell proliferation and facilitating wound healing.

BIOACTIVE MATERIALS (2022)

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Review Pharmacology & Pharmacy

Mesoporous silica nanoparticles for pulmonary drug delivery

Alba Garcia-Fernandez et al.

Summary: Respiratory diseases have become a major clinical concern worldwide and nanomedicine shows promise in overcoming the limitations of current lung therapies by enhancing drug bioavailability and reducing side effects. However, more efforts are needed to achieve effective pulmonary drug delivery despite the different approaches that have been developed.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Engineering, Biomedical

A multifunctional hydrogel coating to direct fibroblast activation and infected wound healing via simultaneously controllable photobiomodulation and photodynamic therapies

Ye He et al.

Summary: This study explores the PBM concept using 660 nm laser-triggered photodynamic therapy (PDT) to simplify the material system and achieve antibacterial activity and biological modulation effects. The research combines PBM with a PDT-based material system to develop a hydrogel coating with antibacterial activity and fibroblast activation ability.

BIOMATERIALS (2021)

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Article Biotechnology & Applied Microbiology

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

Zohaib Akram et al.

Summary: The study synthesized and characterized chlorhexidine-loaded mesoporous silica nanoparticles grafted with poly-L-glycolic acid, and tested their in vitro drug release, cytotoxicity, and antimicrobial capacity in different pH environments. The experimental nanoparticles demonstrated low cytotoxicity and high antibacterial efficacy, showing potential for use in adhesive and restorative dentistry.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Engineering, Biomedical

Multi-functional silica-based mesoporous materials for simultaneous delivery of biologically active ions and therapeutic biomolecules

Hui Zhu et al.

Summary: In summary, mesoporous silica-based materials, especially MBGs, are promising for biomedical applications due to their bioactivity, biocompatibility, tunable composition, and controllable nanoporosity. Research has shown that MBGs can be doped with therapeutic ions and loaded with specific biomolecules to achieve controllable drug release kinetics. Co-delivery of ions and biomolecules using MBGs can offer synergistic effects for improved therapeutic outcomes.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Immobilization of molecular catalysts on electrode surfaces using host-guest interactions

Laurent Severy et al.

Summary: The study demonstrates a non-covalent 'click' chemistry approach to reversibly bind molecular electrocatalysts to electrode surfaces through host-guest complexation. This efficient method enables the replacement and reuse of molecular catalysts, enhancing the attractiveness of electrosynthetic systems.

NATURE CHEMISTRY (2021)

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Article Nanoscience & Nanotechnology

Novel Diabetic Foot Wound Dressing Based on Multifunctional Hydrogels with Extensive Temperature-Tolerant, Durable, Adhesive, and Intrinsic Antibacterial Properties

Hou Liu et al.

Summary: This study developed a temperature-tolerant antibacterial hydrogel dressing with excellent properties, effectively promoting the healing of diabetic foot ulcers (DFUs).

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Dopamine-Substituted Multidomain Peptide Hydrogel with Inherent Antimicrobial Activity and Antioxidant Capability for Infected Wound Healing

Mubashir Hussain et al.

Summary: The study introduces a dopamine-substituted multidomain peptide (DAP) hydrogel with antimicrobial activity, strong adhesion, and ROS scavenging properties, showing promising results in accelerating wound closure and restoring normal tissue structure in mice wound healing experiments.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

An injectable mesoporous silica-based analgesic delivery system prolongs the duration of sciatic nerve block in mice with minimal toxicity

Haiyan Wang et al.

Summary: The study developed novel injectable anesthetic nanocomposites based on mesoporous silica, showing long-lasting pain relief in mice with minimal toxicity.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

In Vivo Tracking of the Degradation of Mesoporous Silica through 89Zr Radio-Labeled Core-Shell Nanoparticles

Elisa Bindini et al.

Summary: A novel method was reported to track the in vivo degradation of mesoporous silica nanoparticles, showing that these nanoparticles have fast degradation kinetics in vivo.

SMALL (2021)

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Article Nanoscience & Nanotechnology