期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms24119695
关键词
Alzheimer's disease; 5XFAD; sleep disturbance; reactive astrogliosis; GABA
This study examined the relationship between sleep disturbances and regional neuron and astrocyte pathologies in Alzheimer's disease (AD). The findings showed that 5XFAD mice demonstrated reduced NREM and REM sleep duration and bout counts, as well as decreased theta EEG power frequency during REM sleep. Sleep disturbances were correlated with the number and ratio of GFAP-positive astrocytes in sleep-promoting brain regions. This study reveals the link between neurotoxic reactive astrogliosis and sleep disturbances in AD.
Sleep disturbances, a debilitating symptom of Alzheimer's disease (AD), are associated with neuropathological changes. However, the relationship between these disturbances and regional neuron and astrocyte pathologies remains unclear. This study examined whether sleep disturbances in AD result from pathological changes in sleep-promoting brain areas. Male 5XFAD mice underwent electroencephalography (EEG) recordings at 3, 6, and 10 months, followed by an immunohistochemical analysis of three brain regions associated with sleep promotion. The findings showed that 5XFAD mice demonstrated reduced duration and bout counts of nonrapid eye movement (NREM) sleep by 6 months and reduced duration and bout counts of rapid eye movement (REM) sleep by 10 months. Additionally, peak theta EEG power frequency during REM sleep decreased by 10 months. Sleep disturbances correlated with the total number of GFAP-positive astrocytes and the ratio of GFAP- and GABA-positive astrocytes across all three sleep-associated regions corresponding to their roles in sleep promotion. The presence of GABRD in sleep-promoting neurons indicated their susceptibility to inhibition by extrasynaptic GABA. This study reveals that neurotoxic reactive astrogliosis in NREM and REM sleep-promoting areas is linked to sleep disturbances in 5XFAD mice, which suggests a potential target for the treatment of sleep disorders in AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据