期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms24129829
关键词
mitosis; ribosomal DNA (rDNA); nucleolus; nuclear envelope; vacuole; lysosome; TOR; lipid metabolism; autophagy; nucleophagy
The morphology of the nucleus is typically spherical in eukaryotic cells, but it can change during cell migration and division. This is important because abnormal nuclear morphology is associated with cancer and aging, and targeting nuclear shaping pathways and proteins can be used in therapies. Recent evidence also suggests a connection between nuclear shape and lysosomal function in tumor cells.
The morphology of the nucleus is roughly spherical in most eukaryotic cells. However, this organelle shape needs to change as the cell travels through narrow intercellular spaces during cell migration and during cell division in organisms that undergo closed mitosis, i.e., without dismantling the nuclear envelope, such as yeast. In addition, the nuclear morphology is often modified under stress and in pathological conditions, being a hallmark of cancer and senescent cells. Thus, understanding nuclear morphological dynamics is of uttermost importance, as pathways and proteins involved in nuclear shaping can be targeted in anticancer, antiaging, and antifungal therapies. Here, we review how and why the nuclear shape changes during mitotic blocks in yeast, introducing novel data that associate these changes with both the nucleolus and the vacuole. Altogether, these findings suggest a close relationship between the nucleolar domain of the nucleus and the autophagic organelle, which we also discuss here. Encouragingly, recent evidence in tumor cell lines has linked aberrant nuclear morphology to defects in lysosomal function.
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