4.7 Review

Cholinergic Antagonists and Behavioral Disturbances in Neurodegenerative Diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity

Marta Lavrador et al.

Summary: This study aimed to provide a comprehensive list of drugs with documented affinity for muscarinic receptors, in order to address the gaps in anticholinergic burden tools. A literature review and database search were conducted to identify these tools and evaluate the drugs included in them. A universal list of 133 drugs with anticholinergic activity, categorized by their affinity for different subtypes of muscarinic receptors and their ability to cross the blood-brain barrier, was developed. The proportion of drugs with confirmed antagonism varied among the tools, highlighting the need for further validation in different clinical settings.

PHARMACEUTICS (2023)

Article Geriatrics & Gerontology

Neuropsychiatric Symptoms as Predictor of Poor Clinical Outcome in Patients With Vascular Cognitive Impairment

Yoni C. P. Sep et al.

Summary: This study examines the association between neuropsychiatric symptoms (NPS) and clinical outcomes in memory clinic patients with possible Vascular Cognitive Impairment (VCI). The findings reveal that NPS are common in this patient group and are associated with institutionalization, mortality, and cognitive deterioration. The association between NPS and clinical outcomes varies depending on the severity of cognitive impairment.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2022)

Review Pharmacology & Pharmacy

Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review

Angela Lisibach et al.

Summary: This study aimed to compare different anticholinergic burden scales in terms of quality and their associations with clinical outcomes. Out of 1297 records, 19 ABS and 104 validation studies were identified, but validation studies for newer scales are lacking. The most investigated clinical outcomes were delirium, cognition, mortality, and falls, but they showed contradicting results.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Review Psychology, Clinical

Prevalence of psychotropic polypharmacy in nursing home residents with dementia: a meta-analysis

Dylan J. Jester et al.

Summary: The study found that the use of psychotropic polypharmacy is common among nursing home residents with dementia, with one-third receiving two or more medications concurrently, and one-eighth receiving three or more medications. Factors such as geographic region, sample size, or study year have little impact on the prevalence of psychotropic polypharmacy, with only male gender being associated with a higher use of two or more psychotropic medications concurrently.

INTERNATIONAL PSYCHOGERIATRICS (2021)

Article Clinical Neurology

Current use of anticholinergic medications in a large naturalistic sample of psychiatric patients

Sermin Toto et al.

Summary: This study aimed to analyze the prevalence and type of pharmacodynamic anticholinergic drug-drug interactions in psychiatric patients. The investigation revealed a high prevalence of anticholinergic drug use in psychiatric patients, with younger patients and those with longer inpatient stays being more likely to simultaneously take combinations of these drugs.

JOURNAL OF NEURAL TRANSMISSION (2021)

Article Medicine, General & Internal

Prevalence of Central Nervous System-Active Polypharmacy Among Older Adults With Dementia in the US

Donovan T. Maust et al.

Summary: In 2018, 13.9% of older adults with dementia in the US were prescribed medications consistent with CNS-active polypharmacy. This polypharmacy may increase the risk of cognitive impairment, falls, and death in these patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Review Geriatrics & Gerontology

Interventions to Reduce Anticholinergic Burden in Adults Aged 65 and Older: A Systematic Review

Athagran Nakham et al.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2020)

Article Geriatrics & Gerontology

Apathy and anxiety are early markers of Alzheimer's disease

Maurits Johansson et al.

NEUROBIOLOGY OF AGING (2020)

Review Psychiatry

The role of nicotinic cholinergic neurotransmission in delusional thinking

Michael Caton et al.

NPJ SCHIZOPHRENIA (2020)

Article Geriatrics & Gerontology

Using electronic health records to estimate the prevalence of agitation in Alzheimer disease/dementia

Rachel Halpern et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2019)

Article Geriatrics & Gerontology

Threshold for a Reduction in Anticholinergic Burden to Decrease Behavioral and Psychological Symptoms of Dementia

Yacine Jaidi et al.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2019)

Article Pharmacology & Pharmacy

DEFEAT-polypharmacy: deprescribing anticholinergic and sedative medicines feasibility trial in residential aged care facilities

Nagham Ailabouni et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2019)

Review Pharmacology & Pharmacy

Targeting Muscarinic Acetylcholine Receptors for the Treatment of Psychiatric and Neurological Disorders

Sean P. Moran et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Review Neurosciences

Anticholinergic Drugs in Geriatric Psychopharmacology

Jorge Lopez-Alvarez et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Geriatrics & Gerontology

Reduction of the Anticholinergic Burden Makes It Possible to Decrease Behavioral and Psychological Symptoms of Dementia

Yacine Jaidi et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2018)

Review Pharmacology & Pharmacy

Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy

Stuti Verma et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2018)

Article Geriatrics & Gerontology

Risk of hospitalization associated with anticholinergic medication for patients with dementia

Shuichi Watanabe et al.

PSYCHOGERIATRICS (2018)

Article Geriatrics & Gerontology

Risk of hospitalization associated with anticholinergic medication for patients with dementia

Shuichi Watanabe et al.

PSYCHOGERIATRICS (2018)

Article Neurosciences

Anticholinergic Burden and Risk of Stroke and Death in People with Different Types of Dementia

Edwin C. K. Tan et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Clinical Neurology

The Vascular Impairment of Cognition Classification Consensus Study

Olivia A. Skrobot et al.

ALZHEIMERS & DEMENTIA (2017)

Article Clinical Neurology

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

Qing-Fei Zhao et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

Article Geriatrics & Gerontology

Anticholinergic Medication Burden and 5-Year Risk of Hospitalization and Death in Nursing Home Elderly Residents With Coronary Artery Disease

Davide L. Vetrano et al.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2016)

Article Psychiatry

Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia

Allison R. Kaup et al.

JAMA PSYCHIATRY (2016)

Review Cell Biology

Multivariate models of subjective caregiver burden in dementia: A systematic review

Jacqueline van der Lee et al.

AGEING RESEARCH REVIEWS (2014)

Article Neurosciences

Striatal Cholinergic Neurotransmission Requires VGLUT3

Alexandra B. Nelson et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Geriatrics & Gerontology

Multiple Anticholinergic Medication Use and Risk of Hospital Admission for Confusion or Dementia

Lisa M. Kalisch Ellett et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2014)

Review Geriatrics & Gerontology

What is frontotemporal dementia?

Alexander Kurz et al.

MATURITAS (2014)

Article Geriatrics & Gerontology

Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study

M. E. Peters et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2013)

Article Clinical Neurology

α-Synucleinopathy phenotypes

Heather McCann et al.

PARKINSONISM & RELATED DISORDERS (2013)

Article Pathology

Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease-Like Pathology and Cognitive Decline

Rodrigo Medeiros et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Multidisciplinary Sciences

The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

Benoit Poulin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Pharmacology & Pharmacy

Association between prescribing of antimuscarinic drugs and antimuscarinic adverse effects in older people

Clare V Bostock et al.

Expert Review of Clinical Pharmacology (2010)

Review Geriatrics & Gerontology

Memantine Therapy of Behavioral Symptoms in Community-Dwelling Patients with Moderate to Severe Alzheimer's Disease

George T. Grossberg et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2009)

Review Pharmacology & Pharmacy

A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

Steven C. Leiser et al.

PHARMACOLOGY & THERAPEUTICS (2009)

Article Pharmacology & Pharmacy

Efficacy of memantine on behavioral and psychological symptoms related to dementia: A systematic meta-analysis

Ian D. Maidment et al.

ANNALS OF PHARMACOTHERAPY (2008)

Article Medicine, General & Internal

The anticholinergic risk scale and anticholinergic adverse effects in older persons

James L. Rudolph et al.

ARCHIVES OF INTERNAL MEDICINE (2008)

Article Geriatrics & Gerontology

Galantamine in frontotemporal dementia and primary progressive aphasia

A. Kertesz et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2008)

Article Geriatrics & Gerontology

Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study

Martin Steinberg et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2008)

Article Multidisciplinary Sciences

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

W. Y. Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Pharmacology & Pharmacy

Drugs with anticholinergic properties as a risk factor for psychosis in patients affected by Alzheimer's disease

I. Cancelli et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)

Article Pharmacology & Pharmacy

Heterogeneity and complexity of native brain nicotinic receptors

Cecilia Gotti et al.

BIOCHEMICAL PHARMACOLOGY (2007)

Article Geriatrics & Gerontology

Preliminary findings: Behavioral worsening on donepezil in patients with frontotemporal dementia

Mario F. Mendez et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2007)

Review Biotechnology & Applied Microbiology

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

Juergen Wess et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Review Clinical Neurology

Behavioural changes and psychological symptoms in dementia disorders

I McKeith et al.

LANCET NEUROLOGY (2005)

Review Pharmacology & Pharmacy

Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's Disease

JW Clader et al.

CURRENT PHARMACEUTICAL DESIGN (2005)

Article Geriatrics & Gerontology

Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia

A Wallin et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2003)

Article Behavioral Sciences

Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies

JA Court et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2001)