Real-Time PCR Quantification of 87 miRNAs from Cerebrospinal Fluid: miRNA Dynamics and Association with Extracellular Vesicles after Severe Traumatic Brain Injury

Article Biochemistry & Molecular Biology

miRNATissueAtlas2: an update to the human miRNA tissue atlas

Andreas Keller et al.

Summary: The updated resource provides sequencing data of 188 tissue samples from six humans and 58 samples from Tabula Muris collection, totaling 87,252 non-coding RNAs, to shed light on organ specificity in the non-coding transcriptome.

NUCLEIC ACIDS RESEARCH (2022)

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Article Clinical Neurology

Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant

Taylor E. Branyan et al.

Summary: The study identifies miR-20a-3p as a potential therapeutic for stroke and reveals different expression levels of this microRNA in astrocytes of different genders and age groups. Results show that miR-20a-3p has more neuroprotective effects when expressed in neurons, and intravenous injections of miR-20a-3p mimic significantly improve stroke outcomes.

TRANSLATIONAL STROKE RESEARCH (2022)

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Article Neurosciences

Baicalein ameliorates oxidative stress and brain injury after intracerebral hemorrhage by activating the Nrf2/ARE pathway via miR-106a-5p/PHLPP2 axis

Jilei Tang et al.

Summary: Baicalein (BAI) has been shown to be effective in protecting against brain injury after intracerebral hemorrhage (ICH) by activating the Nrf2/ARE pathway, inhibiting oxidative stress, improving neurobehavioral scores, reducing brain edema and blood-brain barrier permeability, as well as mitigating neuronal apoptosis and pathological injury.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles from Human Cerebrospinal Fluid Are Effectively Separated by Sepharose CL-6B-Comparison of Four Gravity-Flow Size Exclusion Chromatography Methods

Vedrana Krusic Alic et al.

Summary: Extracellular vesicles (EVs) are cell-secreted membranous nanoparticles present in body fluids with great diagnostic potential. This study compared four types of size exclusion chromatography (SEC) techniques to isolate EVs from the cerebrospinal fluid (CSF) of patients with severe traumatic brain injury. It was found that Sepharose CL-6B was the most effective method for isolating EVs from CSF and separating them from lipoproteins.

BIOMEDICINES (2022)

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Article Microbiology

miR-451a Regulates Neuronal Apoptosis by Modulating 14-3-3ζ-JNK Axis upon Flaviviral Infection

Surajit Chakraborty et al.

Summary: In this study, the role of miRNA in promoting flavivirus-induced neuronal apoptosis was evaluated. It was found that miR-451a promotes neuronal cell death by targeting the 14-3-3 zeta protein. This discovery provides a potential therapeutic target for improving disease outcomes in flavivirus-induced encephalitis.

MSPHERE (2022)

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Article Neurosciences

HIF-1α protects PC12 cells from OGD/R-induced cell injury by regulating autophagy flux through the miR-20a-5p/KIF5A axis

Jing-Wei Cao et al.

Summary: HIF-1 alpha protects PC12 cells from OGD/R-induced cell injury by regulating autophagy flux through the miR-20a-5p/KIF5A axis.

ACTA NEUROBIOLOGIAE EXPERIMENTALIS (2022)

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Review Biochemistry & Molecular Biology

Systematic Review of the Diagnostic and Clinical Utility of Salivary microRNAs in Traumatic Brain Injury (TBI)

Matthew I. Hiskens et al.

Summary: This systematic review investigates the diagnostic or prognostic ability of microRNAs extracted from saliva in traumatic brain injury (TBI). Early data suggests that salivary microRNAs may assist with TBI diagnosis, but further research with consistent methods and larger patient populations is necessary to evaluate their diagnostic and prognostic potential.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

MicroRNA-223 Attenuates Stretch-Injury-Induced Apoptosis in Brain Microvascular Endothelial Cells by Regulating RhoB Expression

Yingliang Liu et al.

Summary: This study evaluated the protective effect of miR-223 on brain microvascular endothelial cells (BMECs) after stretch injury (SI). The results demonstrated that miR-223 can alleviate SI-induced apoptosis of BMECs, and this anti-apoptotic effect is partially achieved by inhibiting the expression of RhoB. Moreover, miR-223 may play a role in maintaining the integrity of the blood-brain barrier (BBB) during traumatic brain injury (TBI).

BRAIN SCIENCES (2022)

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Article Critical Care Medicine

Prognostic Research in Traumatic Brain Injury: Markers, Modeling, and Methodological Principles

Isabel R. A. Retel Helmrich et al.

Summary: Prognostic assessment in traumatic brain injury is important in clinical care, with interest in new biomarkers and other prognostic indicators for improved prediction models. Methodological issues and guidelines for research focus on transparent reporting and modern approaches to enhance prognostic research. Collaboration among multiple centers is crucial for improving prognostic research in TBI.

JOURNAL OF NEUROTRAUMA (2021)

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Article Neurosciences

HDAC9 Silencing Exerts Neuroprotection Against Ischemic Brain Injury via miR-20a-Dependent Downregulation of NeuroD1

Liangjun Zhong et al.

Summary: HDAC9 plays a role in ischemic brain injury through the miR-20a/NeuroD1 signaling pathway, with its silencing showing potential to attenuate ischemic brain damage.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Critical Care Medicine

Diagnosing Level of Consciousness: The Limits of the Glasgow Coma Scale Total Score

Yelena G. Bodien et al.

Summary: The study found that the Glasgow Coma Scale (GCS) total score may not accurately reflect level of consciousness and various Disorders of Consciousness (DoC) diagnoses could be associated with different GCS total scores. To improve classification of traumatic brain injury (TBI) patients and inform future clinical trials, clinicians and investigators should consider individual subscale behaviors and more comprehensive assessments when evaluating TBI severity.

JOURNAL OF NEUROTRAUMA (2021)

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Article Behavioral Sciences

The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury

Megan E. Huibregtse et al.

Summary: Blood biomarkers can provide objective measures in traumatic brain injury (TBI) assessment and predict recovery duration. Proteomic markers, often examined in research, have short half-lives due to degradation, while emerging biomarkers like microRNA and extracellular vesicles can better reflect the genetic and metabolic alterations following TBI.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Article Neurosciences

Enrichment of the erythrocyte miR-451a in brain extracellular vesicles following impairment of the blood-brain barrier

Nasser Nassiri Koopaei et al.

Summary: Extracellular RNAs, including miRNA, are present in biofluids and are stabilized by being bound within ribonucleoprotein complexes or packaged into extracellular vesicles (EVs). This study revealed that under conditions of a disrupted blood-brain barrier, EVs and their contents can be transferred from the peripheral circulation to the central nervous system.

NEUROSCIENCE LETTERS (2021)

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Letter Neurosciences

miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3

Lili Zhao et al.

NEUROSCIENCE BULLETIN (2021)

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Review Biochemical Research Methods

Understanding extracellular vesicle and nanoparticle heterogeneity: Novel methods and considerations

William Phillips et al.

Summary: Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by cells, playing a role in intercellular communication and various physiological and pathological processes. Current size-based isolation methods are not optimal, and proteomic analysis may offer alternative approaches for EV purification.

PROTEOMICS (2021)

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Article Biochemistry & Molecular Biology

A Highly Predictive MicroRNA Panel for Determining Delayed Cerebral Vasospasm Risk Following Aneurysmal Subarachnoid Hemorrhage

Wang-Xia Wang et al.

Summary: This study demonstrates the potential of a custom designed miRNA panel in predicting the risk of DCV in aSAH patients. The differential expression of selected miRNAs in CSF and plasma before the occurrence of DCV events highlights the early predictive capability of this panel. Additionally, the prediction accuracy reached 87% in a separate testing cohort, indicating the strong applications of this miRNA panel in clinical management of aSAH patients.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Biology

Extracellular Vesicles as Biomarkers and Therapeutic Tools: From Pre-Clinical to Clinical Applications

Maria Chiara Ciferri et al.

Summary: Extracellular vesicles (EVs) are membrane-bound vesicles released by all cell types, playing a crucial role in intercellular communication and serving as biomarkers for various diseases. EVs isolated from stem/progenitor cells exhibit innate immunosuppressive and anti-inflammatory properties, making them potential vehicles for drug delivery.

BIOLOGY-BASEL (2021)

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Review Critical Care Medicine

Association of cerebrospinal fluid protein biomarkers with outcomes in patients with traumatic and non-traumatic acute brain injury: systematic review of the literature

Carlos A. Santacruz et al.

Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.

CRITICAL CARE (2021)

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Review Medicine, General & Internal

MicroRNAs as potential biomarkers for the diagnosis of Traumatic Brain Injury: A systematic review and meta-analysis

Qian Zhou et al.

Summary: miRNAs could be potential diagnostic markers in TBI patients, panels of multiple miRNAs could improve the diagnostic accuracy of TBI, and miRNAs detected in blood and brain tissue display high accuracy for TBI diagnosis.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

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Article Critical Care Medicine

Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics

Matthew Hemphill et al.

JOURNAL OF NEUROTRAUMA (2020)

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Review Neurosciences

MicroRNAs: The New Challenge for Traumatic Brain Injury Diagnosis

Enrica Pinchi et al.

CURRENT NEUROPHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Apoptotic cell-derived exosomes: messages from dying cells

Ramesh Kakarla et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke

Feifei Ma et al.

SCIENCE SIGNALING (2020)

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Article Geriatrics & Gerontology

miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2

Yeong-Jin Kim et al.

EXPERIMENTAL GERONTOLOGY (2020)

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Article Neurosciences

Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers

Grant C. O'Connell et al.

BRAIN INJURY (2020)

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Article Cell Biology

Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity

Yanyan Feng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Critical Care Medicine

Severe Traumatic Brain Injury Induces Early Changes in the Physical Properties and Protein Composition of Intracranial Extracellular Vesicles

Janja Kuharic et al.

JOURNAL OF NEUROTRAUMA (2019)

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Article Biochemistry & Molecular Biology

Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR-219a-5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1

Jing Yan et al.

JOURNAL OF NEUROCHEMISTRY (2019)

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Article Toxicology

Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Lin Feng et al.

PARTICLE AND FIBRE TOXICOLOGY (2019)

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Review Neurosciences

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

Si Yun Ng et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Biochemistry & Molecular Biology

Japanese Encephalitis Virus-induced let-7a/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation

Sriparna Mukherjee et al.

JOURNAL OF NEUROCHEMISTRY (2019)

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Article Multidisciplinary Sciences

Expression profile of plasma microRNAs and their roles in diagnosis of mild to severe traumatic brain injury

Xiaojing Qin et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

MicroRNA isolation and quantification in cerebrospinal fluid: A comparative methodical study

Alena Kopkova et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

MicroRNA-451a overexpression induces accelerated neuronal differentiation of Ntera2/D1 cells and ablation affects neurogenesis in microRNA-451a(-/-) mice

Christa Trattnig et al.

PLOS ONE (2018)

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Review Orthopedics

Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities

Ye Xiong et al.

CHINESE JOURNAL OF TRAUMATOLOGY (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Oncology

A methodological procedure for evaluating the impact of hemolysis on circulating microRNAs

Sara Pizzamiglio et al.

ONCOLOGY LETTERS (2017)

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Article Critical Care Medicine

MicroRNAs as Novel Biomarkers for the Diagnosis and Prognosis of Mild and Severe Traumatic Brain Injury

Valentina Di Pietro et al.

JOURNAL OF NEUROTRAUMA (2017)

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Article Nanoscience & Nanotechnology

Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation

Emma A. Mol et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Article Neurosciences

MicroRNA-144 modulates oxidative stress tolerance in SH-SY5Y cells by regulating nuclear factor erythroid 2-related factor 2-glutathione axis

Chunlei Zhou et al.

NEUROSCIENCE LETTERS (2017)

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Article Oncology

MiR-144 promotes β-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury

Liqian Sun et al.

ONCOTARGET (2017)

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Review Cell & Tissue Engineering

Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors

Michael Galgano et al.

CELL TRANSPLANTATION (2017)

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Editorial Material Cell Biology

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

Erik R. Abels et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury

Ting Yang et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Review Biochemistry & Molecular Biology

Multiple Roles of Peroxiredoxins in Inflammation

Bernard Knoops et al.

MOLECULES AND CELLS (2016)

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Review Neurosciences

Extracellular vesicles round off communication in the nervous system

Vivian Budnik et al.

NATURE REVIEWS NEUROSCIENCE (2016)

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Article Biochemistry & Molecular Biology

Distribution of miRNA expression across human tissues

Nicole Ludwig et al.

NUCLEIC ACIDS RESEARCH (2016)

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Article Multidisciplinary Sciences

A Panel of Serum MiRNA Biomarkers for the Diagnosis of Severe to Mild Traumatic Brain Injury in Humans

Manish Bhomia et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage

Zhao Yang et al.

MOLECULAR IMMUNOLOGY (2015)

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Review Biochemistry & Molecular Biology

General hallmarks of microRNAs in brain evolution and development

Wei Chen et al.

RNA BIOLOGY (2015)

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Article Medicine, Legal

Detection of hypoxia markers in the cerebellum after a traumatic frontal cortex injury: a human postmortem gene expression analysis

K. Schober et al.

INTERNATIONAL JOURNAL OF LEGAL MEDICINE (2015)

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Article Chemistry, Analytical

Distribution Profiling of Circulating MicroRNAs in Serum

Jonathan Ashby et al.

ANALYTICAL CHEMISTRY (2014)

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Review Biochemistry & Molecular Biology

Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128

Yogita K. Adlakha et al.

MOLECULAR CANCER (2014)

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Article Critical Care Medicine

More than Cell Dust: Microparticles Isolated from Cerebrospinal Fluid of Brain Injured Patients Are Messengers Carrying mRNAs, miRNAs, and Proteins

Silke Patz et al.

JOURNAL OF NEUROTRAUMA (2013)

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Review Biochemical Research Methods

Assessing sample and miRNA profile quality in serum and plasma or other biofluids

Thorarinn Blondal et al.

METHODS (2013)

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Review Immunology

New perspectives on central and peripheral immune responses to acute traumatic brain injury

Mahasweta Das et al.

JOURNAL OF NEUROINFLAMMATION (2012)

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Article Neurosciences

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

Sabrina M. Lehmann et al.

NATURE NEUROSCIENCE (2012)

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Article Neurosciences

Peroxisome Proliferator-Activated Receptor δ Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury

Ke-Jie Yin et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Critical Care Medicine

Human Traumatic Brain Injury Alters Plasma microRNA Levels

John B. Redell et al.

JOURNAL OF NEUROTRAUMA (2010)

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Review Anesthesiology

Monitoring intracranial pressure in traumatic brain injury

Martin Smith

ANESTHESIA AND ANALGESIA (2008)

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Article Biochemistry & Molecular Biology

Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells

Timothy J. Tavender et al.

BIOCHEMICAL JOURNAL (2008)

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Real-Time PCR Quantification of 87 miRNAs from Cerebrospinal Fluid: miRNA Dynamics and Association with Extracellular Vesicles after Severe Traumatic Brain Injury

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