Evolution-Informed Strategies for Combating Drug Resistance in Cancer

The ever-changing nature of cancer poses the most difficult challenge oncologists face today. Cancer's remarkable adaptability has inspired many to work toward understanding the evolutionary dynamics that underlie this disease in hopes of learning new ways to fight it. Eco-evolutionary dynamics of a tumor are not accounted for in most standard treatment regimens, but exploiting them would help us combat treatment-resistant effectively. Here, we outline several notable efforts to exploit these dynamics and circumvent drug resistance in cancer.

Automated summary

The ever-changing nature of cancer poses significant challenges to oncologists, who are working to understand the evolutionary dynamics of the disease in order to develop new treatment strategies. Exploiting the eco-evolutionary dynamics of tumors can help combat treatment resistance effectively. This article outlines several notable efforts to exploit these dynamics and overcome drug resistance in cancer.