4.7 Review

Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

Nanomedical approaches in the realm of rheumatoid arthritis

Andrei-Flavius Radu et al.

Summary: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder characterized by bone and cartilage damage in the synovium, resulting in joint impairment and increased mortality rate. Despite recent improvements in RA treatment, only a small fraction of patients achieve clinical remission without ongoing immunosuppressive drugs. Research on RA nano therapies has increased due to their potential advantages over traditional systemic treatments. Nanotherapeutic techniques, specifically drug delivery nano systems, offer new approaches to overcome the limitations of existing treatments by precisely delivering therapeutic drugs to affected sites.

AGEING RESEARCH REVIEWS (2023)

Review Engineering, Biomedical

Mechanochemistry of collagen

Seyed Mohammad Siadat et al.

Summary: Collagen is a unique family of proteins that provide mechanical support to biological tissues. Its formation and remodeling mechanisms are not fully understood, but they play a critical role in vertebrates' survival.

ACTA BIOMATERIALIA (2023)

Review Biochemistry & Molecular Biology

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Qing Yao et al.

Summary: Osteoarthritis (OA) is a chronic degenerative joint disorder that affects more than 500 million people worldwide. It is now recognized as a whole-joint disorder caused by biochemical and cellular alterations in the synovial joint tissues. The lack of understanding of the pathological mechanism has hindered the development of a cure for OA. Therefore, it is crucial to study the signaling pathways and key molecules involved in OA pathogenesis for the development of therapeutic strategies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Article Allergy

Inflammaging and Osteoarthritis

Francesca Motta et al.

Summary: Osteoarthritis is a prevalent disease in the elderly population, and the role of inflammaging in its development has been explored. Inflammaging affects immune response and cartilage degradation, and may serve as a potential therapeutic target.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2023)

Review Rheumatology

Blood and urine biomarkers in osteoarthritis - an update on cartilage associated type II collagen and aggrecan markers

Anne C. Bay-Jensen et al.

Summary: This narrative review emphasizes the importance of using biomarkers in blood or urine to understand osteoarthritis, specifically focusing on type II collagen and aggrecan. While several markers have been developed, there is still a lack of in vitro diagnostics.

CURRENT OPINION IN RHEUMATOLOGY (2022)

Review Endocrinology & Metabolism

Osteogenesis Imperfecta: Mechanisms and Signaling Pathways Connecting Classical and Rare OI Types

Milena Jovanovic et al.

Summary: Osteogenesis imperfecta (OI) is a diverse genetic and phenotypic skeletal disorder characterized by bone fragility, growth deficiency, and skeletal deformity. Research focuses on defects in collagen, abnormal bone mineralization, different inheritance patterns, and various genetic mutations related to OI.

ENDOCRINE REVIEWS (2022)

Review Immunology

LncRNAs and Rheumatoid Arthritis: From Identifying Mechanisms to Clinical Investigation

Wentao Huang et al.

Summary: Rheumatoid arthritis (RA) is a chronic autoinflammatory disease that causes synovial hyperplasia, pannus formation, articular cartilage damage, and bone matrix destruction. Recent studies have shown the importance of long non-coding RNAs (LncRNAs) in mediating the development and progression of RA, highlighting the potential of LncRNAs in diagnosis and therapy.

FRONTIERS IN IMMUNOLOGY (2022)

Review Engineering, Biomedical

The immune microenvironment in cartilage injury and repair

Muzhe Li et al.

Summary: The limited ability of articular cartilage to repair itself is hindered by inflammatory problems. Immune response plays a crucial role in both promoting cartilage repair and accelerating cartilage degradation. Multi-dimensional regulation of the inflammatory microenvironment is needed for cartilage regeneration.

ACTA BIOMATERIALIA (2022)

Article Allergy

Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings

Maria Sokolova et al.

Summary: Autoantibodies such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) are key markers of rheumatoid arthritis (RA) and can impact disease course and progression. The identification of new autoantibodies and advancements in diagnostic techniques have led to a decrease in the seronegative patient population. Autoantibodies not only play a role in the pathogenesis of RA but also directly influence disease progression and radiographic outcomes.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

Article Immunology

Pain-like behavior in the collagen antibody-induced arthritis model is regulated by lysophosphatidic acid and activation of satellite glia cells

Jie Su et al.

Summary: Lysophosphatidic acid (LPA) plays an important role in rheumatoid arthritis-associated pain, and its signaling affects joint inflammation and neuropathic pain. In a experimental model, neutralizing antibody and receptor inhibitor reverse pain-like behavior without affecting joint inflammation. LPA synthesizing enzyme is upregulated in dorsal root ganglia (DRG) neurons, and Lpar1 receptor deficiency blocks pronociceptive neurochemical changes in DRG. LPA regulates pain-like behavior through LPA(1) receptor on satellite glia cells (SGCs) in DRG.

BRAIN BEHAVIOR AND IMMUNITY (2022)

Article Medicine, Research & Experimental

In-depth bibliometric analysis and current scientific mapping research in the context of rheumatoid arthritis pharmacotherapy

Andrei-Flavius Radu et al.

Summary: Rheumatoid arthritis is a chronic autoimmune disorder, and pharmacotherapy plays a crucial role in its treatment. This study provides a comprehensive analysis of RA pharmacotherapy in terms of scientific impact, current research status, and trends, which is important for improving disease outcomes.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Medicine, General & Internal

Highlighting the Benefits of Rehabilitation Treatments in Hip Osteoarthritis

Andrei-Flavius Radu et al.

Summary: The study highlights the benefits of combining rehabilitation treatment and drug therapy in patients with early-stage hip osteoarthritis. The results showed significant improvements in hip joint function, daily activities, and joint mobility in patients who complied with the rehabilitation treatment. This research provides guidance for the treatment options of early-stage hip osteoarthritis patients.

MEDICINA-LITHUANIA (2022)

Review Engineering, Biomedical

The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration

Zhi Peng et al.

Summary: Osteoarthritis (OA) is a leading cause of disability and socioeconomic loss globally, with current pharmacological treatments mainly palliative. Focus is shifting towards targeting cartilage extracellular matrix (ECM) destruction and abnormal homeostasis in OA for regenerative therapies, using potential biomarkers and preclinical studies to identify pathological stages.

BIOMATERIALS (2021)

Review Rheumatology

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

Philip R. Coryell et al.

Summary: The development of osteoarthritis (OA) is correlated with an increase in senescent cells in joint tissues, with senescence-associated secretory phenotype (SASP) implicated in cartilage degradation and OA. Developing therapeutics like senolytics or senomorphics to eliminate or alter senescent cells may halt the progression and pathogenesis of OA.

NATURE REVIEWS RHEUMATOLOGY (2021)

Review Biochemistry & Molecular Biology

Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects

Lourdes Alcaide-Ruggiero et al.

Summary: Various collagen subtypes are present in hyaline articular cartilage, with type II, IX, and XI collagens being the main and most abundant. All collagens, regardless of abundance, play a key role in healthy cartilage. Evaluating collagen fibrils in repaired cartilage tissue is essential in determining tissue quality and whether it can be classified as hyaline cartilage.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Sequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration

Dongtak Lee et al.

Summary: The study demonstrates the synergistic effect of releasing BMP-2 and ALN in a sequential manner for enhanced bone regeneration. By combining these two bioactive molecules, the collagen-hydroxyapatite composite scaffolds significantly increase osteogenic activity, showing potential for application in cell-free tissue engineering.

SCIENTIFIC REPORTS (2021)

Review Neurosciences

Transmembrane Collagens in Neuromuscular Development and Disorders

Tomoko Wakabayashi

Summary: Neuromuscular development is a complex process involving interactions among various molecules, with transmembrane collagens like collagen XXV playing a role in motor axon growth and collagen XIII contributing to neuromuscular junction formation. These transmembrane collagens are not only conserved in mammals but also present in other organisms, with documented functions in motor innervation.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Article Orthopedics

Genetically predicted circulating levels of copper and zinc are associated with osteoarthritis but not with rheumatoid arthritis

J. Zhou et al.

Summary: Genetically determined copper and zinc status were positively associated with osteoarthritis, particularly increasing the risk of localized OA, while an increase in calcium levels decreased the risk of localized OA.

OSTEOARTHRITIS AND CARTILAGE (2021)

Review Medicine, General & Internal

Role of Gelatinases MMP-2 and MMP-9 in Healthy and Complicated Pregnancy and Their Future Potential as Preeclampsia Biomarkers

Asparuh Nikolov et al.

Summary: Gelatinases MMP-2 and MMP-9 play crucial roles in vascular and uteroplacental remodeling during healthy pregnancy, but dysregulation may lead to abnormal vasodilation and placental formation in preeclampsia. Understanding the functions of MMP-2 and MMP-9 in uterine and vascular remodeling could aid in predicting and managing preeclampsia effectively.

DIAGNOSTICS (2021)

Review Biochemistry & Molecular Biology

Quality Control of Procollagen in Cells

Shinya Ito et al.

Summary: Collagen, the most abundant protein in mammals, has a unique triple-helical structure formed by Gly-Xaa-Yaa repeats, crucial for its functions such as bone strength and signal transduction. The quality control of collagen biosynthesis in the endoplasmic reticulum is maintained by heat shock protein 47, mutations affecting this process can lead to collagen destabilization and degradation.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 (2021)

Article Rheumatology

A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?

Ali Mobasheri et al.

Summary: OA is the most common form of arthritis causing pain and disability, with no approved disease modifying drugs. Collagen hydrolyzates are increasingly popular as supplements for joint health, but their efficacy in treating advanced joint disease remains uncertain. The White Paper aims to encourage research and development of collagen-based supplements for musculoskeletal diseases, emphasizing the need for scientific innovation and collaboration.

CURRENT RHEUMATOLOGY REPORTS (2021)

Review Immunology

Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes

Zewen Wu et al.

Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Cell Biology

Post-Adipose-Derived Stem Cells (ADSC) Stimulated by Collagen Type V (Col V) Mitigate the Progression of Osteoarthritic Rabbit Articular Cartilage

Isabele Camargo Brindo da Cruz et al.

Summary: The study found that ADSC stimulated by Col V can significantly increase Col II in the degenerative area of OA rabbits, regulating the expression of cartilage-related genes, making it a promising target for OA treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Medicine, General & Internal

Collagen Biosynthesis, Processing, and Maturation in Lung Ageing

Ceylan Onursal et al.

Summary: Collagen is a key component of the extracellular matrix and plays a crucial role in the pathogenesis of chronic lung diseases. Age-related alterations in collagen composition and crosslinking may contribute to the development of lung diseases in elderly individuals.

FRONTIERS IN MEDICINE (2021)

Review Immunology

Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

Shuang Liu et al.

Summary: Rheumatoid arthritis is characterized by systemic synovitis and joint destruction due to imbalances in pro-inflammatory and anti-inflammatory cytokines. Understanding the signaling pathways and inhibitors is crucial for the development of therapeutic targets and new drugs for RA.

CLINICAL IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Collagen's primary structure determines collagen:HSP47 complex stoichiometry

Elena T. Abraham et al.

Summary: Collagens require the specific chaperone HSP47 for proper folding and secretion. This study characterized high-affinity binding sites for HSP47 using a collagen II peptide library and revealed the importance of large hydrophobic amino acids such as phenylalanine in enhancing binding strength. The crystal structures of HSP47 bound to peptides containing phenylalanine or leucine showed local conformational rearrangements and altered binding stoichiometry, providing insight into the formation of higher oligomeric complexes at promiscuous collagen-binding sites.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Biotechnology & Applied Microbiology

Collagen Mimetic Peptides

Yujia Xu et al.

Summary: Collagen mimetic peptides (CMPs) have been utilized since the late 1960s as a molecular tool for studying collagen and developing novel collagen mimetic biomaterials. Recent advancements have focused on producing heterotrimeric CMPs and CMPs capable of forming collagen-like higher order molecular assemblies. The interdisciplinary field of CMP research has seen significant growth and progress in understanding collagen structure and properties.

BIOENGINEERING-BASEL (2021)

Review Rheumatology

Soluble biological markers in osteoarthritis

Jean-Charles Rousseau et al.

Summary: Current research on cartilage markers focuses on structural components of the matrix, with a second generation of degradation markers developed against specific enzymes. High-throughput technologies allow detection of new markers and improved understanding of OA metabolic changes, enhancing patient selection and clinical trial evaluations.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2021)

Review Pathology

Blood and urinary collagen markers in osteoarthritis: markers of tissue turnover and disease activity

Anne Christine Bay-Jensen et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2020)

Review Dermatology

Collagen supplementation for skin health: A mechanistic systematic review

Meisam Barati et al.

JOURNAL OF COSMETIC DERMATOLOGY (2020)

Article Materials Science, Biomaterials

Collagen Type I and II Blend Hydrogel with Autologous Mesenchymal Stem Cells as a Scaffold for Articular Cartilage Defect Repair

Claire Kilmer et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Article Engineering, Biomedical

Design and evaluation of collagen-inspired mineral-hydrogel nanocomposites for bone regeneration

Akhil Patel et al.

ACTA BIOMATERIALIA (2020)

Review Nanoscience & Nanotechnology

Collagen: quantification, biomechanics and role of minor subtypes in cartilage

Benjamin J. Bielajew et al.

NATURE REVIEWS MATERIALS (2020)

Review Pharmacology & Pharmacy

Chondrocyte dedifferentiation and osteoarthritis (OA)

Edith Charlier et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Biotechnology & Applied Microbiology

Salicin inhirits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis

Feng Gao et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Review Materials Science, Biomaterials

Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications

Xinhua Liu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Biochemistry & Molecular Biology

Drug-Loaded Elastin-Like Polypeptide-Collagen Hydrogels with High Modulus for Bone Tissue Engineering

Pallabi Pal et al.

MACROMOLECULAR BIOSCIENCE (2019)

Review Cell Biology

Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis

Qinghua Fang et al.

MEDIATORS OF INFLAMMATION (2019)

Review Biochemistry & Molecular Biology

Complexity of type IV collagens: from network assembly to function

Yuexin Wu et al.

BIOLOGICAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Mechanics and structural stability of the collagen triple helix

Michael W. H. Kirkness et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2019)

Article Rheumatology

Adipokines: New Therapeutic Target for Osteoarthritis?

Chenxi Xie et al.

CURRENT RHEUMATOLOGY REPORTS (2019)

Review Chemistry, Multidisciplinary

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Anna Sorushanova et al.

ADVANCED MATERIALS (2019)

Review Engineering, Biomedical

Biomaterials for articular cartilage tissue engineering: Learning from biology

A. R. Armiento et al.

ACTA BIOMATERIALIA (2018)

Article Medical Laboratory Technology

Aggrecanase degradation of type III collagen is associated with clinical knee pain

A. C. Bay-Jensen et al.

CLINICAL BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Cartilage diseases

Yamini Krishnan et al.

MATRIX BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis

Nikolaos A. Afratis et al.

MATRIX BIOLOGY (2018)

Review Rheumatology

Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis

Jane Falconer et al.

ARTHRITIS & RHEUMATOLOGY (2018)

Article Biology

The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis

Elizabeth A. Lawrence et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2018)

Article Biochemistry & Molecular Biology

A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation

Yunyun Luo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biochemistry & Molecular Biology

Matrix Metalloproteinase Gene Activation Resulting from Disordred Epigenetic Mechanisms in Rheumatoid Arthritis

Yasuto Araki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Type XIX collagen: A new partner in the interactions between tumor cells and their microenvironment

Jean-Baptiste Oudart et al.

MATRIX BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients

Ritva Heljasvaara et al.

MATRIX BIOLOGY (2017)

Review Cell Biology

Articular cartilage and joint development from embryogenesis to adulthood

Rebekah S. Decker

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

Review Cell Biology

MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment

Wei Seong Toh et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

Review Cell Biology

The minor collagens in articular cartilage

Yunyun Luo et al.

PROTEIN & CELL (2017)

Review Cell & Tissue Engineering

Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine

Rebekah M. Samsonraj et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

Review Cell Biology

Aging and osteoarthritis: Central role of the extracellular matrix

Maryam Rahmati et al.

AGEING RESEARCH REVIEWS (2017)

Article Anatomy & Morphology

Type V Collagen in Health, Disease, and Fibrosis

Ki M. Mak et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2016)

Article Biophysics

Nanomechanics of Type I Collagen

Sameer Varma et al.

BIOPHYSICAL JOURNAL (2016)

Article Dermatology

Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility

Georgios Theocharidis et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

Review Biotechnology & Applied Microbiology

Molecular genetics of the COL2A1-related disorders

Hao Deng et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2016)

Review Rheumatology

Ageing and the pathogenesis of osteoarthritis

Richard F. Loeser et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Article Cell Biology

Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

Katja M. Heinemeier et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

Vanessa J. Craig et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

Article Chemistry, Multidisciplinary

Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite scaffolds for superior bone tissue regeneration

Elaine Quinlan et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Review Medicine, Research & Experimental

Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes

Morena Scotece et al.

LIFE SCIENCES (2015)

Review Rheumatology

Cartilage damage in osteoarthritis and rheumatoid arthritis-two unequal siblings

Thomas Pap et al.

NATURE REVIEWS RHEUMATOLOGY (2015)

Article Rheumatology

Physicochemical and Biomechanical Stimuli in Cell-Based Articular Cartilage Repair

Holger Jahr et al.

CURRENT RHEUMATOLOGY REPORTS (2015)

Article Biochemistry & Molecular Biology

Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER

Daniela Zwolanek et al.

BIOCHEMICAL JOURNAL (2014)

Article Endocrinology & Metabolism

Type III Collagen Regulates Osteoblastogenesis and the Quantity of Trabecular Bone

Susan W. Volk et al.

CALCIFIED TISSUE INTERNATIONAL (2014)

Review Pharmacology & Pharmacy

Cellular and molecular mechanisms of cartilage damage and repair

Joanna C. Sherwood et al.

DRUG DISCOVERY TODAY (2014)

Article Biochemistry & Molecular Biology

Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils

Matthias Chiquet et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Article Chemistry, Multidisciplinary

Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes

Adolfo Lopez-Noriega et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Review Biochemistry & Molecular Biology

The structure and function of the pericellular matrix of articular cartilage

Rebecca E. Wilusz et al.

MATRIX BIOLOGY (2014)

Article Multidisciplinary Sciences

Structural basis of collagen fiber degradation by cathepsin K

Adeleke H. Aguda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Cell & Tissue Engineering

Anti-Inflammatory Strategies in Cartilage Repair

Ying Zhang et al.

TISSUE ENGINEERING PART B-REVIEWS (2014)

Article Biochemistry & Molecular Biology

Drosophila type XV/XVIII collagen mutants manifest integrin mediated mitochondrial dysfunction, which is improved by cyclosporin A and losartan

Ryusuke Momota et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Collagen XVI in health and disease

Susanne Graessel et al.

MATRIX BIOLOGY (2013)

Review Orthopedics

Cell-based approaches to joint surface repair: a research perspective

A. J. Roelofs et al.

OSTEOARTHRITIS AND CARTILAGE (2013)

Review Engineering, Biomedical

Collagen for bone tissue regeneration

Ana Marina Ferreira et al.

ACTA BIOMATERIALIA (2012)

Article Medical Laboratory Technology

MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis

S. S. Veidal et al.

CLINICAL BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Collagen XIII: A type II transmembrane protein with relevance to musculoskeletal tissues, microvessels and inflammation

Anne Heikkinen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

Szymon W. Manka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Multidisciplinary Sciences

Unlike Bone, Cartilage Regeneration Remains Elusive

Daniel J. Huey et al.

SCIENCE (2012)

Review Biochemistry & Molecular Biology

New Hope for the Treatment of Osteoarthritis Through Selective Inhibition of MMP-13

N. -G. Li et al.

CURRENT MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

ADAMTS-4 and ADAMTS-5: Key Enzymes in Osteoarthritis

Priyanka Verma et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2011)

Article Genetics & Heredity

The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities

Angela Moncada-Pazos et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2011)

Article Cell Biology

Collagens

Marion K. Gordon et al.

CELL AND TISSUE RESEARCH (2010)

Article Biochemistry & Molecular Biology

Type III Collagen, a Fibril Network Modifier in Articular Cartilage

Jiann-Jiu Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

Effect of adiponectin on ATDC5 proliferation, differentiation and signaling pathways

T. Delessa Challa et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)

Article Rheumatology

Adiponectin is a potential catabolic mediator in osteoarthritis cartilage

Eun Ha Kang et al.

ARTHRITIS RESEARCH & THERAPY (2010)

Review Biochemistry & Molecular Biology

Collagen Structure and Stability

Matthew D. Shoulders et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Differences in Chain Usage and Cross-linking Specificities of Cartilage Type V/XI Collagen Isoforms with Age and Tissue

Jiann-Jiu Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Type XIV Collagen Regulates Fibrillogenesis PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE

Heather L. Ansorge et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Sport Sciences

The Basic Science of Articular Cartilage: Structure, Composition, and Function

Alice J. Sophia Fox et al.

SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH (2009)

Article Biochemistry & Molecular Biology

Trimerization of collagen IX α-chains does not require the presence of the COL1 and NC1 domains

Juha Jaalinoja et al.

BIOCHEMICAL JOURNAL (2008)

Review Medicine, General & Internal

Articular cartilage: structure, injuries and review of management

Abhijit M. Bhosale et al.

BRITISH MEDICAL BULLETIN (2008)

Article Biochemistry & Molecular Biology

Collagen turnover in normal and degenerate human intervertebral discs as determined by the racemization of aspartic acid

Sarit-Sara Sivan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Engineering, Biomedical

Self-assembled collagen-human mesenchymal stem cell microspheres for regenerative medicine

Barbara P. Chan et al.

BIOMATERIALS (2007)

Article Endocrinology & Metabolism

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis

Rebecca Hjorten et al.

Review Peripheral Vascular Disease

Type IV collagen-derived angiogenesis inhibitors

Thomas M. Mundel et al.

MICROVASCULAR RESEARCH (2007)

Review Medical Laboratory Technology

Review: Collagen markers in early arthritic diseases

KA Elsaid et al.

CLINICA CHIMICA ACTA (2006)

Article Biochemistry & Molecular Biology

The new collagen gene COL27A1 contains SOX9-responsive enhancer elements

E Jenkins et al.

MATRIX BIOLOGY (2005)

Article Biochemistry & Molecular Biology

A novel marker of tissue junctions, collagen XXII

M Koch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Pharmacology & Pharmacy

Collagens -: structure, function, and biosynthesis

K Gelse et al.

ADVANCED DRUG DELIVERY REVIEWS (2003)

Article Biochemistry & Molecular Biology

Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils

A Kassner et al.

MATRIX BIOLOGY (2003)

Article Biochemistry & Molecular Biology

The C5 domain of Col6A3 is cleaved off from the Col6 fibrils immediately after secretion

T Aigner et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Endocrinology & Metabolism

Developmental distribution of collagen type XII in cartilage: Association with articular cartilage and the growth plate

KE Gregory et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2001)

Article Orthopedics

Composition and structure of articular cartilage - A template for tissue repair

AR Poole et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2001)

Article Biochemistry & Molecular Biology

Effect of collagen turnover on the accumulation of advanced glycation end products

N Verzijl et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)