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Review
Biochemistry & Molecular Biology
Riccardo Fiorentino et al.
Summary: Due to the progression of lipid abnormalities from childhood to adulthood, it is crucial to identify and treat children and adolescents with dyslipidemia early on. This is important in order to reduce cardiovascular risk, delay the development of fatty streaks, slow down the progression of atherosclerosis, and reverse atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Deokho Lee et al.
Summary: This study demonstrated for the first time the protective effect of NMN in cardiovascular disease-induced retinal ischemia in a mouse model, suppressing retinal dysfunction and pathological gliosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jana Zlacka et al.
Summary: Inhibition of glycolysis in endothelial cells combined with growth factor receptor blockade shows promise as an antiangiogenic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elena Tretyakova et al.
Summary: The incidence of diabetes has increased significantly in the past decade, resulting in higher rates of morbidity and mortality globally. In this study, a series of quinopimaric acid derivatives were synthesized and evaluated for their inhibitory effects on alpha-Glucosidase (alpha-GLy), a therapeutic target for type 2 diabetes. The results showed that some of the synthesized compounds exhibited good inhibitory activities against alpha-GLy, suggesting their potential as alternative therapies for type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Imma Forzano et al.
Summary: Tirzepatide is a new molecule that combines the dual agonism of GIP and GLP-1 receptors to control blood glucose levels. It has been shown to improve glycemic control in patients with diabetes and also has beneficial effects on blood pressure and cholesterol levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Diana-Carina Iovanovici et al.
Summary: Sacubitril/valsartan is a pharmaceutical strategy that increases natriuretic peptide levels and shows significant improvement in heart failure patients. It reduces morbidity and mortality through mechanisms like reverse cardiac remodeling and has benefits even for patients with preserved ejection fraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Deokho Lee et al.
Summary: The study suggests that NMN administration offers protection against retinal ischemia/reperfusion injury by suppressing inflammation, protecting retinal neuronal cells, and activating the antioxidant pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
