期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms24055001
关键词
molecular mechanisms; neurogenic inflammation
Neurogenic inflammation is the result of nerve endings and mediators' activity in the skin, leading to inflammatory reactions. TRPV-ion channels' activation increases the release of inflammatory mediators and contributes to the maintenance of cutaneous neurogenic inflammation. Understanding the molecular mechanisms of neuropeptide and neurotransmitter receptors in cutaneous cells can aid in developing effective treatments for inflammatory skin disorders.
The skin, including the hypodermis, is the largest body organ and is in constant contact with the environment. Neurogenic inflammation is the result of the activity of nerve endings and mediators (neuropeptides secreted by nerve endings in the development of the inflammatory reaction in the skin), as well as interactions with other cells such as keratinocytes, Langerhans cells, endothelial cells and mast cells. The activation of TRPV-ion channels results in an increase in calcitonin gene-related peptide (CGRP) and substance P, induces the release of other pro-inflammatory mediators and contributes to the maintenance of cutaneous neurogenic inflammation (CNI) in diseases such as psoriasis, atopic dermatitis, prurigo and rosacea. Immune cells present in the skin (mononuclear cells, dendritic cells and mast cells) also express TRPV1, and their activation directly affects their function. The activation of TRPV1 channels mediates communication between sensory nerve endings and skin immune cells, increasing the release of inflammatory mediators (cytokines and neuropeptides). Understanding the molecular mechanisms underlying the generation, activation and modulation of neuropeptide and neurotransmitter receptors in cutaneous cells can aid in the development of effective treatments for inflammatory skin disorders.
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