☆ 4.7 Review

Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Oncology

Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression

Danhui Ma et al.

Summary: Fucoidan, a natural sulfated polysaccharide extracted from brown algae, effectively inhibits the progression of hepatocellular carcinoma by causing the overexpression of lncRNA LINC00261.

FRONTIERS IN ONCOLOGY (2021)

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Review Cell Biology

Molecular mechanism of cell ferroptosis and research progress in regulation of ferroptosis by noncoding RNAs in tumor cells

Bumin Xie et al.

Summary: Ferroptosis is a newly identified form of regulated cell death characterized by iron-dependent accumulation of lipid reactive oxygen species, closely related to various diseases and tumor treatment. Noncoding RNAs play a crucial role in regulating the molecular mechanism of ferroptosis in tumor cells.

CELL DEATH DISCOVERY (2021)

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Article Environmental Sciences

Protective effects of selenium yeast against cadmium-induced necroptosis through miR-26a-5p/PTEN/PI3K/AKT signaling pathway in chicken kidney

Huijie Chen et al.

Summary: Se-Y was found to antagonize Cd-induced necroptosis in chicken kidneys by regulating the miR-26a-5p/PTEN/PI3K/AKT signaling pathway and HSPs, reducing oxidative stress and providing important protective effects.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Cell Biology

MicroRNA-29b-3p promotes 5-fluorouracil resistance via suppressing TRAF5-mediated necroptosis in human colorectal cancer

Shuimei Wu et al.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4

Chong Bao et al.

Summary: The study demonstrates that miR-670-3p suppresses ferroptosis in human glioblastoma cells by targeting ACSL4, and inhibiting miR-670-3p may serve as an alternative or adjuvant strategy in the treatment of glioblastoma. Increased chemosensitivity to TMZ was observed in U87MG and A172 cells treated with miR-670-3p inhibitor, indicating a potential therapeutic effect.

FREE RADICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines

Kazuo Tomita et al.

Summary: The study found that miR-7-5p controls radioresistance by generating ROS, leading to ferroptosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Plant Sciences

Cochlioquinone derivative CoB1 induces cytostatic autophagy in lung cancer through miRNA-125b and Foxp3

Nana Xu et al.

Summary: This study demonstrated the inhibitory effect of CoB1 on lung cancer cells by inducing cytostatic autophagy both in vitro and in vivo. CoB1 exerted its effects by blocking the PI3K/Akt1/mTOR signaling pathway, activating the TAK1/MKK4/JNK/Smad axis, inducing miR-125b expression, reducing Foxp3 expression, and ultimately inducing autophagy.

PHYTOMEDICINE (2021)

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Article Cell Biology

MicroRNA-494 Regulates Endoplasmic Reticulum Stress in Endothelial Cells

Namita Chatterjee et al.

Summary: The study demonstrates the functional role of miR-494 in ER stress, showing that its expression is affected by ER stress inducers and hyperglycemia. Pre-treatment with miR-494 can mitigate ER stress induced by ER stress inducers and increase cell viability. It is suggested that ER stress-driven miR-494 may function in a feedback inhibitory loop.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs

Yuan Zhi et al.

Summary: Ferroptosis is a newly identified form of regulated cell death associated with iron metabolism and oxidative stress, selectively removing cancer cells by regulating non-coding RNAs. The role of circular RNAs in controlling ferroptosis and carcinogenesis is highlighted as valuable and warrants further research and exploration in cancer therapeutics.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

TFEB Signalling-Related MicroRNAs and Autophagy

Davide Cora et al.

Summary: TFEB, an oncogenic transcription factor, is a key regulator of genes controlling lysosomal biogenesis, autophagy, and vesicle flux. Its activation is modulated by stress factors, with miRNAs playing a role in post-transcriptional regulation. miRNAs are involved in various cellular processes and are important in autophagy.

BIOMOLECULES (2021)

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Article Andrology

MiRNA-124 regulates the sensitivity of renal cancer cells to cisplatin-induced necroptosis by targeting the CAPN4-CNOT3 axis

Qingyan Mao et al.

Summary: miR-124 is upregulated by cisplatin in renal cancer cells, reducing sensitivity to cisplatin. CAPN4 is a direct target of miR-124, and its overexpression reverses the effects of miR-124 on cisplatin sensitivity and necroptosis. CAPN4 can interact with and promote the degradation of CNOT3, and upregulating CNOT3 can reverse the cisplatin-resistant phenotype.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Article Biochemistry & Molecular Biology

Rutin attenuates Sorafenib-induced Chemoresistance and Autophagy in Hepatocellular Carcinoma by regulating BANCR/miRNA-590-5P/OLR1 Axis

Meng Zhou et al.

Summary: This study found that rutin can regulate autophagy by modulating the BANCR/miRNA-590-5P/OLR1 axis, potentially enhancing sensitivity to chemotherapy in hepatocellular carcinoma.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Oncology

The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer

Yujing Zhang et al.

Summary: Despite the lack of full understanding of the exact mechanism for treating digestive cancer, research on the relationship between ER stress and microRNAs has risen in recent years. miRNAs play crucial roles in cancer cell proliferation, invasion, and apoptosis by affecting the expression of genes related to cancer cell signaling, making them important targets for developing new therapeutic strategies for digestive cancer.

JOURNAL OF CANCER (2021)

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Review Biochemistry & Molecular Biology

Traditional Chinese medicine (TCM) as a source of new anticancer drugs

Chang-liang Yao et al.

Summary: Traditional Chinese medicine (TCM)-derived drugs include both single chemical entities and multi-component preparations, playing a significant role in the healthcare system in China. This article discusses the research and development process, molecular mechanisms, and clinical evaluation of some exemplificative anticancer drugs based on TCM, as well as their potential integration in western medicine.

NATURAL PRODUCT REPORTS (2021)

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Article Chemistry, Applied

Anticancer Effect of Natural Product Sulforaphane by Targeting MAPK Signal through miRNA-1247-3p in Human Cervical Cancer Cells

Meng Luo et al.

Summary: Sulforaphane inhibits proliferation and promotes apoptosis of HeLa cells by regulating miR1247-3p and activating the MAPK pathway, providing experimental evidence for its potential in cervical cancer treatment.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

miRDB: an online database for prediction of functional microRNA targets

Yuhao Chen et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Hematology

HIF-1α (Hypoxia-Inducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383

Ela Karshovska et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Article Chemistry, Applied

A methoxylated quercetin glycoside harnesses HCC tumor progression in a TP53/miR-15/miR-16 dependent manner

Rana Ahmed Youness et al.

NATURAL PRODUCT RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Anticancer Activities of the Quinone-Methide Triterpenes Maytenin and 22-β-hydroxymaytenin Obtained from Cultivated Maytenus ilicifolia Roots Associated with Down-Regulation of miRNA-27a and miR-20a/miR-17-5p

Camila Hernandes et al.

MOLECULES (2020)

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Review Geriatrics & Gerontology

The roles of MTOR and miRNAs in endothelial cell senescence

Eng-Soon Khor et al.

BIOGERONTOLOGY (2020)

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Article Cell Biology

Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway

Yinbao Qi et al.

CELL CYCLE (2020)

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Article Medicine, Research & Experimental

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer

Yadong Xie et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Biotechnology & Applied Microbiology

MicroRNA-126 Inhibit Viability of Colorectal Cancer Cell by Repressing mTOR Induced Apoptosis and Autophagy

Li Wei et al.

ONCOTARGETS AND THERAPY (2020)

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Article Pharmacology & Pharmacy

(-)-Sativan Inhibits Tumor Development and Regulates miR-200c/PD-L1 in Triple Negative Breast Cancer Cells

Fu Peng et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Oncology

Toosendanin Suppresses Glioma Progression Property and Induces Apoptosis by Regulating miR-608/Notch Axis

Qiong Wang et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Cell Biology

MicroRNA-381-3p Functions as a Dual Suppressor of Apoptosis and Necroptosis and Promotes Proliferation of Renal Cancer Cells

Cong Zhao et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Medicine, Research & Experimental

Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p

Songbo Fu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Biochemistry & Molecular Biology

Jack of all trades? The versatility of RNA in DNA double-strand break repair

Ruth F. Ketley et al.

GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR (2020)

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Article Hematology

DEPTOR is a microRNA-155 target regulating migration and cytokine production in diffuse large B-cell lymphoma cells

Ewa Jablonska et al.

EXPERIMENTAL HEMATOLOGY (2020)

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Review Oncology

Regulation of breast cancer metastasis signaling by miRNAs

Belinda J. Petri et al.

CANCER AND METASTASIS REVIEWS (2020)

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Article Cell Biology

miRNA-182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury

Yunsheng Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Medicine, Research & Experimental

Targeting miRNAs by natural products: A new way for cancer therapy

Beilei Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Pharmacology & Pharmacy

Luteolin mediated targeting of protein network and microRNAs in different cancers: Focus on JAK -STAT, NOTCH, mTOR and TRAIL-mediated signaling pathways

Ammad Ahmad Farooqi et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Pharmacology & Pharmacy

miRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells

Sara Carpi et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Oncology

Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting IAPs via miR-22-3p

Feiyu Chen et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

MicroRNA-1911-3p targets mEAK-7 to suppress mTOR signaling in human lung cancer cells

Daniela Baccelli Mendonca et al.

HELIYON (2020)

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Article Medicine, Research & Experimental

The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer

Wu Sun et al.

THERANOSTICS (2020)

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Article Oncology

TGFβ signaling-induced miRNA participates in autophagic regulation by targeting PRAS40 in mesenchymal subtype of glioblastoma

Yingbin Xie et al.

CANCER BIOLOGY & MEDICINE (2020)

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Article Oncology

Dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells

Lei Chen et al.

JOURNAL OF CANCER (2020)

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Article Biochemistry & Molecular Biology

SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2

Ning Zhang et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Cell Biology

Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR-146b-5p and lncRNA-AFAP1-AS1

Jingkai Zhou et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Multidisciplinary Sciences

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Xia Sheng et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

MiR-200c downregulates HIF-1 and inhibits migration of lung cancer cells

Yuree Byun et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2019)

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Review Oncology

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Marek Samec et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

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Article Biotechnology & Applied Microbiology

TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway

Tao Huang et al.

DISEASE MARKERS (2019)

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Article Multidisciplinary Sciences

MicroRNA-126 regulates Hypoxia-Inducible Factor-1α which inhibited migration, proliferation, and angiogenesis in replicative endothelial senescence

Matilde Alique et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma

Beilei Zhang et al.

CANCER LETTERS (2019)

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Review Pharmacology & Pharmacy

Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics

Md Asaduzzaman Khan et al.

DRUG DISCOVERY TODAY (2019)

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Review Biochemistry & Molecular Biology

MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

Solmaz Shirjang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Oncology

c-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma

Pie-Che Chen et al.

CANCERS (2019)

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Article Cell Biology

Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy

Alessandra Stacchiotti et al.

CELLS (2019)

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Review Cell Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lian-Jiu Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Cell Biology

miR-223 overexpression inhibits doxorubicin-induced autophagy by targeting FOXO3a and reverses chemoresistance in hepatocellular carcinoma cells

Yue Zhou et al.

CELL DEATH & DISEASE (2019)

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Article Biochemistry & Molecular Biology

Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/-catenin, JAK-STAT pathways, and microRNAs

Ulku Ozbey et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation

Joe S. Matarlo et al.

CELL CHEMICAL BIOLOGY (2019)

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Article Oncology

Resistance to paclitaxel is associated with a variant of the gene BCL2 in multiple tumor types

Rotem Ben-Hamo et al.

NPJ PRECISION ONCOLOGY (2019)

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Article Medicine, Research & Experimental

C-myc/miR-150/EPG5 axis mediated dysfunction of autophagy promotes development of non-small cell lung cancer

Hui Li et al.

THERANOSTICS (2019)

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Review Biochemistry & Molecular Biology

mTORC1 pathway in DNA damage response

Yinxing Ma et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

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Article Medicine, Research & Experimental

Sulforaphane promotes apoptosis, and inhibits proliferation and self-renewal of nasopharyngeal cancer cells by targeting STAT signal through miRNA-124-3p

Xiqing Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Biochemistry & Molecular Biology

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

Meiying Luo et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Article Biochemistry & Molecular Biology

Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107

Eng-Soon Khor et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

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Review Oncology

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

Shang Yao et al.

SEMINARS IN CANCER BIOLOGY (2018)

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Article

Steviol, a natural product inhibits proliferation of the gastrointestinal cancer cells intensively

Junming Chen et al.

Oncotarget (2018)

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Article Medicine, Research & Experimental

Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer

Yue Wu et al.

MEDICAL SCIENCE MONITOR (2018)

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Article Cell Biology

MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway

Wei Zhang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Genetics & Heredity

Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma

Xiuhua Xu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2018)

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Article Multidisciplinary Sciences

A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression

Deepak Poudyal et al.

SCIENTIFIC REPORTS (2018)

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Article Cell Biology

MicroRNA-495-3p inhibits multidrug resistance by modulating autophagy through GRP78/mTOR axis in gastric cancer

Sheng Chen et al.

CELL DEATH & DISEASE (2018)

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Article Oncology

被撤回的出版物: MiR-101 reduces cell proliferation and invasion and enhances apoptosis in endometrial cancer via regulating PI3K/Akt/mTOR (Retracted article. See vol. 30, pg. 275, 2021)

Suxia Zhang et al.

CANCER BIOMARKERS (2018)

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Article Immunology

miR-199a-5p inhibits proliferation and induces apoptosis in hemangioma cells through targeting HIF1A

Yang Wang et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2018)

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Article Oncology

p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage

Hangjun Gong et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

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Review Oncology

Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention

Mohammad Alam Jafri et al.

SEMINARS IN CANCER BIOLOGY (2017)

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Article Oncology

microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer

Aijun Yang et al.

ONCOLOGY LETTERS (2017)

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Article Oncology

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway

Ai-Mei Gao et al.

ONCOTARGET (2017)

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Article Medicine, Research & Experimental

MicroRNA-200c Inhibits Epithelial-Mesenchymal Transition by Targeting the BMI-1 Gene Through the Phospho-AKT Pathway in Endometrial Carcinoma Cells In Vitro

Fengling Li et al.

MEDICAL SCIENCE MONITOR (2017)

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Article Biochemistry & Molecular Biology

miRNA-223 suppresses FOX01 and functions as a potential tumor marker in breast cancer

Y-T. Wei et al.

CELLULAR AND MOLECULAR BIOLOGY (2017)

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Article Cell Biology

Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells

Beibei Bie et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

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Review Biochemistry & Molecular Biology

AKT/PKB Signaling: Navigating the Network

Brendan D. Manning et al.

CELL (2017)

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Article Oncology

miR-132 upregulation promotes gastric cancer cell growth through suppression of FoxO1 translation

Wei Li et al.

TUMOR BIOLOGY (2016)

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Article Oncology

MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcriptional inactivation of EIF4EBP1

Maria Lee et al.

ONCOTARGET (2016)

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Article Medicine, Research & Experimental

MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1

Yunjun Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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Article Oncology

A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1

Fan Wang et al.

CANCER BIOLOGY & THERAPY (2016)

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Review Oncology

miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1

Yue-Bin Zeng et al.

CANCER CELL INTERNATIONAL (2016)

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Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

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Article Biochemistry & Molecular Biology

Inhibition of microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt/FOXO1 pathway

Hongmei Xu et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2016)

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Article Oncology

miRNA-149 promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia

Sheng-jin Fan et al.

LEUKEMIA RESEARCH (2016)

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Article Immunology

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

Mireille Ouimet et al.

NATURE IMMUNOLOGY (2016)

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Article Oncology

miR-1908 Overexpression Inhibits Proliferation, Changing Akt Activity and p53 Expression in Hypoxic NSCLC Cells

Yuefeng Ma et al.

ONCOLOGY RESEARCH (2016)

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Article Oncology

MicroRNA-21 Regulates the Proliferation, Differentiation, and Apoptosis of Human Renal Cell Carcinoma Cells by the mTOR-STAT3 Signaling Pathway

Tao Liang et al.

ONCOLOGY RESEARCH (2016)

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Article Multidisciplinary Sciences

MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells

Aihong Mao et al.

SCIENTIFIC REPORTS (2016)

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Article Oncology

MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1

Jung-Hee Lee et al.

CANCER RESEARCH (2015)

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Article Cell Biology

Bufalin Inhibits the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosarcoma Cells through Mir-148a

Yuewen Chang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

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Article Chemistry, Medicinal

Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells

Ming-De Yan et al.

MARINE DRUGS (2015)

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Article Toxicology

p53-p66shc/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma

Jingyue Yang et al.

TOXICOLOGY LETTERS (2015)

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Article Geriatrics & Gerontology

MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies

Xiaoyang Ye et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

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Article Oncology

Hypoxia-induced autophagy reduces. radiosensitivity by the HIF-1α/miR-210/Bcl-2 pathway in colon cancer cells

Yong Sun et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Review Oncology

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

K. Musilova et al.

LEUKEMIA (2015)

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Article Oncology

Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S

Hengyou Weng et al.

CANCER RESEARCH (2014)

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Article Cell Biology

MicroRNA-22 Induces Endothelial Progenitor Cell Senescence by Targeting AKT3

Yue Zheng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)

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Article Oncology

FOXO1-dependent DNA damage repair is regulated by JNK in lung cancer cells

Yinghua Ju et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Article Multidisciplinary Sciences

A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

Fan Yang et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

被撤回的出版物: MicroRNA-33b Suppresses Migration and Invasion by Targeting c-Myc in Osteosarcoma Cells (Retracted article. See vol. 17, 2022)

Ning Xu et al.

PLOS ONE (2014)

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Article Obstetrics & Gynecology

miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells

Wakana Abe et al.

HUMAN REPRODUCTION (2013)

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Article Multidisciplinary Sciences

MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells

Xiangyan Li et al.

PLOS ONE (2013)

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Article Biochemistry & Molecular Biology

MicroRNA-1291-mediated silencing of IRE1α enhances Glypican-3 expression

Marion Maurel et al.

RNA (2013)

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Article Biochemistry & Molecular Biology

Glutaminolysis Activates Rag-mTORC1 Signaling

Raul V. Duran et al.

MOLECULAR CELL (2012)

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Article Multidisciplinary Sciences

Downregulation of miR-205 Modulates Cell Susceptibility to Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells

Shiyo Muratsu-Ikeda et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines

Ho-Shin Gwak et al.

PLOS ONE (2012)

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Article Oncology

Specific Pomegranate Juice Components as Potential Inhibitors of Prostate Cancer Metastasis

Lei Wang et al.

TRANSLATIONAL ONCOLOGY (2012)

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Article Cell Biology

Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair

Libing Song et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2012)

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Review Biochemistry & Molecular Biology

Akt, FoxO and regulation of apoptosis

Xinbo Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

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Article Endocrinology & Metabolism

MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1

Ting Zhao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

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Article Biochemistry & Molecular Biology

p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

N. R. Christoffersen et al.

CELL DEATH AND DIFFERENTIATION (2010)

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Article Biology

The Modified High-Density Survival Assay is the Useful Tool to Predict the Effectiveness of Fractionated Radiation Exposure

Yoshikazu Kuwahara et al.

JOURNAL OF RADIATION RESEARCH (2010)

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Article Multidisciplinary Sciences

Unregulated miR-96 Induces Cell Proliferation in Human Breast Cancer by Downregulating Transcriptional Factor FOXO3a

Huanxin Lin et al.

PLOS ONE (2010)

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Article Oncology

p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs

Emmanuel Petroulakis et al.

CANCER CELL (2009)

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Article Oncology

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

Meredith E. Crosby et al.

CANCER RESEARCH (2009)

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Article Biochemistry & Molecular Biology

MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation

K-H Lee et al.

ONCOGENE (2009)

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Article Chemistry, Medicinal

Ellagitannin (BJA3121), an Anti-proliferative Natural Polyphenol Compound, can Regulate the Expression of MiRNAs in HepG(2) Cancer Cells

Xiao-Yun Wen et al.

PHYTOTHERAPY RESEARCH (2009)

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Review Biochemistry & Molecular Biology

FOXOs, cancer and regulation of apoptosis

Z. Fu et al.

ONCOGENE (2008)

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Article Oncology

PRAS40 deregulates apoptosis in malignant melanoma

SubbaRao V. Madhunapantula et al.

CANCER RESEARCH (2007)

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Article Multidisciplinary Sciences

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

H Tran et al.

SCIENCE (2002)

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