4.7 Article

TgMORN2, a MORN Family Protein Involved in the Regulation of Endoplasmic Reticulum Stress in Toxoplasma gondii

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress

Anastasiya Klebanovych et al.

Summary: ER distribution relies on microtubules, and disruption of ER homeostasis activates the unfolded protein response, leading to ER remodeling. UFL1 and C53 interact with gamma-tubulin ring complex proteins and regulate microtubule nucleation in response to ER stress. These findings reveal a novel mechanism for alleviating ER stress through stimulation of centrosomal microtubule nucleation.
Review Biochemistry & Molecular Biology

Membrane occupation and recognition nexus (MORN) motif controls protein localization and function

Jinrun Zhou et al.

Summary: The MORN motif is a widely expressed protein sequence in different organisms and has been found to have multiple functions in various diseases and physiological processes.

FEBS LETTERS (2022)

Article Parasitology

Depletion of Toxoplasma adenine nucleotide translocator leads to defects in mitochondrial morphology

Yihan Wu et al.

Summary: This study identified and characterized the ANT protein in T. gondii. Depletion of TgANT inhibited parasite growth, impaired mitochondrial and apicoplast biogenesis, and resulted in abnormal cell division.

PARASITES & VECTORS (2022)

Article Microbiology

Involvement of Urm1, a Ubiquitin-Like Protein, in the Regulation of Oxidative Stress Response of Toxoplasma gondii

Qianqian Tan et al.

Summary: In this study, the role of TgURM1 in Toxoplasma gondii was characterized. It was found that TgURM1 plays a pivotal role in parasite survival, particularly in invasion, replication, and virulence. Additionally, TgURM1 was involved in the oxidative stress response through urmylation, and its interaction with TgAHP1 under oxidative stress conditions was identified.

MICROBIOLOGY SPECTRUM (2022)

Article Biochemistry & Molecular Biology

Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics

Yaqin Deng et al.

Summary: The study revealed that Rab18 plays a crucial role in oleic acid-induced lipid droplet accumulation in myoblast cells by interacting with PLIN2 and ACSL3 to regulate lipid droplet dynamics. Loss of Rab18 function leads to reduced triacylglycerol levels and fewer but larger lipid droplets, while overexpression of Rab18 results in elevated triacylglycerol content and an increased number of lipid droplets. Lipid droplet-associated Rab18 forms a complex with PLIN2 and ACSL3, demonstrating its critical role in lipid droplet accumulation and dynamics in myoblast cells.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

Article Biochemistry & Molecular Biology

Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species

Ludek Koreny et al.

Summary: Through spatial proteomics and high-resolution microscopy, this study reveals molecular conservation of all conoid substructures throughout the phylum Apicomplexa, including in Plasmodium species. It also shows that Plasmodium has equivalent conoid structures in all zoite forms, with molecular differentiation between different stages.

PLOS BIOLOGY (2021)

Article Cell Biology

Nogo-A Is Critical for Pro-Inflammatory Gene Regulation in Myocytes and Macrophages

H. M. Arif Ullah et al.

Summary: Nogo-A is found to be associated with muscle diseases, with its upregulation leading to an increase in CHOP, IL-6, and TNF-alpha levels, while its downregulation results in a decrease in these markers. Furthermore, the role of Nogo-A in muscle and bone marrow macrophages can modulate inflammatory responses, and deletion of Nogo-A can alleviate muscle inflammation, serving as a potential therapeutic target for improving muscle diseases.
Article Biochemistry & Molecular Biology

Toxoplasma gondii UBL-UBA Shuttle Protein DSK2s Are Important for Parasite Intracellular Replication

Heng Zhang et al.

Summary: DSK2b is a novel UBL-UBA shuttle protein that plays an important role in the degradation of ubiquitinated proteins and the synchronous cell division of T. gondii.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Rab7a modulates ER stress and ER morphology

Duarte Mateus et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

Review Medicine, Research & Experimental

Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites

Luca Galluzzi et al.

FUTURE SCIENCE OA (2017)

Article Multidisciplinary Sciences

RTN1 mediates progression of kidney disease by inducing ER stress

Ying Fan et al.

NATURE COMMUNICATIONS (2015)

Review Oncology

Microtubules and their role in cellular stress in cancer

Amelia L. Parker et al.

FRONTIERS IN ONCOLOGY (2014)

Article Cell Biology

Rab10 GTPase regulates ER dynamics and morphology

Amber R. English et al.

NATURE CELL BIOLOGY (2013)

Article Neurosciences

A Model of Toxic Neuropathy in Drosophila Reveals a Role for MORN4 in Promoting Axonal Degeneration

Martha R. C. Bhattacharya et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Cell Biology

RNG1 is a Late Marker of the Apical Polar Ring in Toxoplasma gondii

Johnson Q. Tran et al.

CYTOSKELETON (2010)

Review Cell Biology

Regulation of basal cellular physiology by the homeostatic unfolded protein response

D. Thomas Rutkowski et al.

JOURNAL OF CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

A decade of epigenetic research in Toxoplasma gondii

Stacy E. Dixon et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2010)

Article Microbiology

TgMORN1 Is a Key Organizer for the Basal Complex of Toxoplasma gondii

Aoife T. Heaslip et al.

PLOS PATHOGENS (2010)

Article Microbiology

GAP45 Phosphorylation Controls Assembly of the Toxoplasma Myosin XIV Complex

Stacey D. Gilk et al.

EUKARYOTIC CELL (2009)

Article Microbiology

MORN1 has a conserved role in asexual and sexual development across the Apicomplexa

David J. P. Ferguson et al.

EUKARYOTIC CELL (2008)

Review Parasitology

The cell cycle and Toxoplasma gondii cell division: Tightly knit or loosely stitched?

Marc-Jan Gubbels et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2008)

Article Biochemistry & Molecular Biology

Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii

Jana Narasimhan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis

Keizo Tokuhiro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Translational control and the unfolded protein response

Ronald C. Wek et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Article Parasitology

Quantitative dissection of clone-specific growth rates in cultured malaria parasites

Heather B. Reilly et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2007)

Article Cell Biology

A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus

Marc-Jan Gubbels et al.

JOURNAL OF CELL SCIENCE (2006)

Article Biochemistry & Molecular Biology

Nogo-B is a new physiological substrate for MAPKAP-K2

S Rousseau et al.

BIOCHEMICAL JOURNAL (2005)

Article Multidisciplinary Sciences

A membrane protein required for dislocation of misfolded proteins from the ER

BN Lilley et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii

JR Radke et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2001)