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The Role of the Oral Microbiome in the Development of Diseases

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Gut-derived β-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis

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Summary: Peripheral beta-amyloid (A beta), including gut-derived A beta, is believed to contribute to the formation of A beta plaques in the brain, and the gut microbiota has an impact on Alzheimer's disease (AD) through the gut-brain axis. This study investigated the potential interactions among gut-derived A beta, gut microbiota, and AD pathogenesis. The results showed that the gut is a critical source of A beta in the brain, and gut microbiota can upregulate A beta production in the gut, potentially contributing to AD pathogenesis.

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Oral Microbial Signatures of Tobacco Chewers and Oral Cancer Patients in India

Shriya Sawant et al.

Summary: Dysbiosis of the oral microbiome is linked to oral cancer, and tobacco chewing is a risk factor associated with oral dysbiosis. This study investigated the oral bacterial diversity of Indian oral cancer patients and tobacco chewers, identifying potential biomarkers for the Indian population. The results showed differences in the abundance of certain bacterial genera between the study groups, and functional predictions highlighted gene expression variations related to specific metabolic processes.

PATHOGENS (2023)

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Responsiveness to pulmonary rehabilitation in COPD is associated with changes in microbiota

Sara Melo-Dias et al.

Summary: Pulmonary rehabilitation (PR) can alter the composition of oral microbiota, which is associated with the effectiveness of PR for COPD management. It increases the abundance of beneficial bacteria Prevotella melaninogenica and decreases harmful bacteria Streptococcus and Lautropia.

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Review Food Science & Technology

Aggregatibacter actinomycetemcomitans as the Aetiological Cause of Rheumatoid Arthritis: What Are the Unsolved Puzzles?

Sung Cheng Looh et al.

Summary: Leukotoxin A (LtxA) is a major virulence factor of the oral bacterium Aggregatibacter actinomycetemcomitans (Aa) and has been found to be associated with elevated levels of anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients. LtxA targets leukocytes and triggers an influx of extracellular calcium, leading to hypercitrullination. Although the model-based evidence is yet to be established, the interaction of LtxA with the host immune system has sparked interest in its role in RA.

TOXINS (2022)

Review Immunology

More Than Just a Periodontal Pathogen -the Research Progress on Fusobacterium nucleatum

Yuanxin Chen et al.

Summary: Fusobacterium nucleatum is a common oral opportunistic bacterium associated with periodontal diseases, halitosis, dental pulp infection, oral cancer, and systemic diseases. This study evaluated the progress in research on epidemiological evidence, pathogenic mechanisms, and treatment methods related to F. nucleatum in oral and systemic diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Biochemistry & Molecular Biology

Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment

Mattia Di Stefano et al.

Summary: The oral cavity harbors a complex microbial community, which can lead to periodontal damage. Periodontal disease is a common chronic inflammatory condition globally, with diverse clinical manifestations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Immunology

Limosilactobacillus (Lactobacillus) fermentum ALAL020, a Probiotic Candidate Bacterium, Produces a Cyclic Dipeptide That Suppresses the Periodontal Pathogens Porphyromonas gingivalis and Prevotella intermedia

Tomomi Kawai et al.

Summary: Periodontal disease is caused by oral microbiota imbalance, and the use of antibiotics and disinfectants for treatment can lead to drug-resistant bacteria and allergies. Studies have found that probiotics have potential as an alternative therapy for periodontitis, but the mechanism is not clear. This study identified and analyzed a cyclic dipeptide produced by a probiotic strain, which showed antibacterial activity against periodontal pathogens. This discovery may contribute to a better understanding of the antibacterial mechanism and prevention of periodontal disease.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Immunology

Probiotic Species in the Management of Periodontal Diseases: An Overview

Yuwei Zhang et al.

Summary: Periodontal diseases, common chronic inflammatory diseases of the oral cavity, can be effectively prevented and treated by probiotics through regulating periodontal microbiota or host immune responses. Probiotics have promising potential in the treatment of oral diseases, but further research and exploration are needed for their practical application in periodontal health.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Biochemistry & Molecular Biology

Interactive Relationships between Intestinal Flora and Bile Acids

Xiaohua Guo et al.

Summary: The microbial community in the digestive tract and bile acids have a mutual relationship, which may be involved in the pathogenesis of various diseases such as inflammatory bowel disease, colorectal cancer, etc.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Editorial Material Immunology

Editorial: The Human Microbiota in Periodontitis

Marcela Hernandez et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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The Microbiome in COPD: Emerging Potential for Microbiome-Targeted Interventions

Laura Millares et al.

International Journal of Chronic Obstructive Pulmonary Disease (2022)

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The airway microbiome in COPD, bronchiectasis and bronchiectasis-COPD overlap

Pei Yee Tiew et al.

Summary: The airway microbiome composition in COPD and bronchiectasis is relatively comparable, with certain microbial dominance associated with disease severity and exacerbations. However, the role of the microbiome in bronchiectasis-COPD overlap remains understudied.

CLINICAL RESPIRATORY JOURNAL (2021)

Review Infectious Diseases

Periodontal disease in seropositive rheumatoid arthritis: scoping review of the epidemiological evidence

Nik-Madihah Nik-Azis et al.

Summary: There is a difference in the prevalence and severity of PD between ACPA-positive and ACPA-negative RA patients, but reports on the different manifestations of PD between the two RA subsets remains inconclusive.
Review Biochemistry & Molecular Biology

Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients

Heidelinde Sammallahti et al.

Summary: Pancreatic cancer and the microbiota have complex interactions, with the microbiota playing a significant role in the development of pancreatic cancer, although the mechanisms are not completely clear. Dysbiosis may lead to the development of pancreatic cancer by altering host metabolism and immune responses. Additionally, the microbiota may also influence the efficacy of pancreatic cancer treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Developmental Biology

Histopathological and immunohistochemical study of periodontal changes in chronic smokers

Gabriel Valeriu Popa et al.

Summary: Periodontal disease is a global pandemic that can influence the progression of systemic diseases, with smoking playing a significant role in changing the clinical aspects and disease progression of periodontal disease.

ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY (2021)

Article Immunology

Dynamic Alterations of Oral Microbiota Related to Halitosis in Preschool Children

Yu Zhang et al.

Summary: The composition and abundance of oral microbiota differed significantly between the halitosis and control groups even before the onset of clinical halitosis manifestations. The halitosis prediction model based on tongue coating microbiome biomarkers indicated microbial shifts prior to the onset of halitosis. This could be helpful for timely detection and intervention of halitosis in children.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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R/G Value-A Numeric Index of Individual Periodontal Health and Oral Microbiome Dynamics

Lucie Najmanova et al.

Summary: The dysbiosis of oral microbiome can precede the clinical signs of periodontal disease, and evaluating the individual taxonomic composition of OM can provide prediction for the risk of developing periodontitis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Immunology

The Oral Microbiome in Periodontal Health

Magdalena Lenartova et al.

Summary: The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can be biased, as the clinically periodontally healthy subjects may already have dysbiosis; By characterizing the OM in young individuals with good oral hygiene, distinct clusters corresponding to different health states were identified, with two possible oral types representing microbial succession.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Immunology

Transcriptional Activity of Predominant Streptococcus Species at Multiple Oral Sites Associate With Periodontal Status

Daniel Belstrom et al.

Summary: The study demonstrates that the transcriptional activity of predominant Streptococcus species is influenced by specific ecological conditions and the presence of periodontitis in the oral microbiota. Certain Streptococcus species show higher transcriptional activity in saliva in orally healthy individuals and lower activity in patients with periodontitis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID

John P. Haran et al.

Summary: In a study, it was found that patients with long COVID had higher abundance of bacteria in the oral microbiome that can induce inflammation, such as Prevotella and Veillonella genera. These microbes may be related to the development of ongoing symptoms in patients, and the oral microbiome of long COVID patients resembled that of patients with chronic fatigue syndrome.

JCI INSIGHT (2021)

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Risk of incident cardiovascular disease in people with periodontal disease: A systematic review and meta-analysis

Harriet Larvin et al.

Summary: The study showed that there is a modest but consistently increased risk of cardiovascular disease in populations with periodontal disease. Higher risk in men and individuals with severe periodontal disease suggests targeted interventions could be beneficial.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2021)

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J. Wu et al.

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The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems

Jesse R. Willis et al.

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A Review of the Role of Probiotic Supplementation in Dental Caries

Bhagavathi Sundaram Sivamaruthi et al.

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The Role of Oral Microbiota in Intra-Oral Halitosis

Katarzyna Hampelska et al.

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How Periodontal Disease and Presence of Nitric Oxide Reducing Oral Bacteria Can Affect Blood Pressure

Pamela Pignatelli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Kelly S. Swanson et al.

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Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

Malgorzata Kozak et al.

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The Effect of Probiotics on Halitosis: a Systematic Review and Meta-analysis

Jun-Il Yoo et al.

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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview

Zahra Heidari et al.

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L. Nibali et al.

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In vitro beneficial effects of Streptococcus dentisani as potential oral probiotic for periodontal diseases

Adelaida Esteban-Fernandez et al.

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Ester Saus et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

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Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

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Rodrigo Lopez et al.

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Eamonn M. M. Quigley

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