Evaluation of the Antiviral Efficacy of Subcutaneous Nafamostat Formulated with Glycyrrhizic Acid against SARS-CoV-2 in a Murine Model

Article Medicine, General & Internal

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

Takuya Tada et al.

Summary: This study found that the Omicron variant has significantly reduced sensitivity to neutralization by vaccines and vaccine-elicited antibodies. However, a booster immunization can enhance the neutralizing effect against Omicron. In addition, individuals with a history of prior SARS-CoV-2 infection showed increased neutralizing activity against Omicron. Different monoclonal antibodies showed varying effectiveness against the Omicron variant.

EBIOMEDICINE (2022)

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Article Biochemistry & Molecular Biology

A Novel Computational Approach for the Discovery of Drug Delivery System Candidates for COVID-19

Taeheum Cho et al.

Summary: A drug delivery system (DDS) was developed through computational methods to provide stable drug release for treating COVID-19, selecting glycyrrhizin as a carrier and converting NM into micelle nanoparticles. The spherical particle morphology and stability of the NPs were confirmed with TEM, DLS, and zeta potential measurements, showing more than 90% loading efficiency of NM using UV spectrum analysis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

Anti-SARS-CoV-2 Natural Products as Potentially Therapeutic Agents

Cheorl-Ho Kim

Summary: Research on COVID-19 is focused on collaborative searches for effective drugs, with current exploration into various treatment methods including drug screening and vaccine development. Studies have also found that SARS-CoV-2 infects host cells by recognizing specific neuraminic acids and membrane proteins.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Glycyrrhizic Acid for COVID-19: Findings of Targeting Pivotal Inflammatory Pathways Triggered by SARS-CoV-2

Wenjiang Zheng et al.

Summary: The study suggests that glycyrrhizic acid may inhibit COVID-19 through its anti-oxidant, anti-viral, and anti-inflammatory effects, as well as its ability to activate the immune system. Targeted therapy for specific pathways is a predominant strategy to inhibit the cytokine storms triggered by SARS-CoV-2 infection.

FRONTIERS IN PHARMACOLOGY (2021)

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Letter Infectious Diseases