HBV Enhances Sorafenib Resistance in Hepatocellular Carcinoma by Reducing Ferroptosis via SRSF2-Mediated Abnormal PCLAF Splicing

Article Cell Biology

Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis

Qidi Zhang et al.

Summary: Exosomal miR-222 promotes liver fibrosis by inhibiting TFRC and TFRC-induced ferroptosis in HBV-infected hepatocytes. This study reveals the significance of miR-222 and TFRC in the process of liver fibrosis.

CELL BIOLOGY AND TOXICOLOGY (2023)

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Article Endocrinology & Metabolism

KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway

Kai Wang et al.

Summary: KIAA0101 is overexpressed in glioma tissues and cells, and high expression indicates a poor prognosis for glioma patients. Silencing KIAA0101 inhibits cell proliferation, migration, invasion, and promotes apoptosis in glioma cells. Additionally, KIAA0101 knockdown reduces glycolytic flux and inhibits the PI3K/AKT/mTOR pathway in glioma cells.

METABOLIC BRAIN DISEASE (2022)

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Review Ecology

The role of alternative splicing in adaptation and evolution

Jukka-Pekka Verta et al.

Summary: Regulation of gene expression is crucial in evolutionary processes, and alternative splicing has an important but unexplored role in adaptation. Recent studies have shown the independent evolution of alternative splicing and transcript levels, providing diverse paths for selection.

TRENDS IN ECOLOGY & EVOLUTION (2022)

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Article Cell Biology

PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis

Xiaowei Liu et al.

Summary: PCLAF is overexpressed in neuroblastoma and is associated with poor prognosis. Knocking down PCLAF restricts neuroblastoma cell proliferation and affects cell cycle-related pathways. PCLAF accelerates the G1/S transition of neuroblastoma cell cycle by activating the E2F1/PTTG1 signaling pathway.

CELL DEATH & DISEASE (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.

CELL (2022)

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Article Oncology

Canonical WNT Signaling Activated by WNT7B Contributes to L-HBs-Mediated Sorafenib Resistance in Hepatocellular Carcinoma by Inhibiting Mitophagy

Li-Juan Liu et al.

Summary: Hepatitis B virus (HBV) plays a role in sorafenib resistance in hepatocellular carcinoma (HCC) through the overexpression of WNT7B, which increases cell proliferation and metastasis in HCC and reduces sorafenib-induced mitophagy.

CANCERS (2022)

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Review Oncology

RNA splicing: a dual-edged sword for hepatocellular carcinoma

Anjali Kashyap et al.

Summary: RNA splicing is a fundamental process that brings diversity at the transcriptome and proteome levels. Aberrant regulation of RNA splicing is associated with various diseases, including cancer. In hepatocellular carcinoma (HCC), multiple splicing events have been observed, which directly affect tumor progression and patient survival.

MEDICAL ONCOLOGY (2022)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Article Medicine, Research & Experimental

YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Ruize Gao et al.

Summary: The study reveals the critical role of YAP/TAZ in suppressing ferroptosis and establishing Sorafenib resistance in hepatocellular carcinoma (HCC). This highlights YAP/TAZ-based rewiring strategies as potential approaches to overcome HCC therapy resistance. The findings provide new insights into improving the efficacy of current therapies in cancer treatment.

EMBO MOLECULAR MEDICINE (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Gastroenterology & Hepatology

Translatomic profiling reveals novel self-restricting virus-host interactions during HBV infection

Shilin Yuan et al.

Summary: This study identified multiple self-restricting HBV-host interactions, including a negative feedback mechanism of SRSF2-HpZ/P'. Targeting host splicing machinery might represent a strategy to intervene in HBV-host interactions.

JOURNAL OF HEPATOLOGY (2021)

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Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma

Xiao-Cui Wei et al.

Summary: The study focused on how HBc promotes Doxorubicin resistance in HCC. Results showed that HBc increased the expression of exosomal miR-135a-5p, leading to anti-apoptosis, cell proliferation, and chemotherapy resistance in HCC.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Article Oncology

Effects of Antiviral Therapy on HBV Reactivation and Survival in Hepatocellular Carcinoma Patients Undergoing Hepatic Artery Infusion Chemotherapy

Shousheng Liu et al.

Summary: HBV reactivation is more likely to occur in HBsAg-positive HCC patients undergoing HAIC without antiviral prophylaxis. Regular monitoring of HBV DNA and antiviral prophylaxis are suggested to prevent HBV reactivation and prolong the overall survival of these patients.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Proliferating cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors

Li-Juan Liu et al.

Summary: GI cancers are a leading cause of death globally due to their poor prognosis, making it urgent to investigate potential molecular targets for prediction, diagnosis, prognosis, and therapy. PCLAF, a key factor in cell proliferation and apoptosis, plays a significant role in GI cancers by contributing to various malignant properties. It is also implicated in other cancers and autoimmune diseases through dysregulation of multiple signaling pathways. Suppression of PCLAF/PCNA interaction or PCLAF expression may be a promising therapeutic strategy for GI cancers.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

TRERNA1 upregulation mediated by HBx promotes sorafenib resistance and cell proliferation in HCC via targeting NRAS by sponging miR-22-3p

Wei Song et al.

Summary: The study revealed that upregulation of TRERNA1 induced by HBx not only promoted HCC cell proliferation by regulating the cell cycle and correlated with poor prognosis, but also increased sorafenib resistance in HCC cells. This suggests that TRERNA1 may serve as a potential tumor biomarker and therapeutic target in HCC.

MOLECULAR THERAPY (2021)

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Article Cell Biology

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

Qiujie Wang et al.

Summary: The study revealed that GSTZ1 enhances sorafenib-induced ferroptosis by inhibiting the NRF2/GPX4 axis in HCC cells, and the combination therapy of sorafenib and GPX4 inhibitor RSL3 may be a promising strategy in HCC treatment.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Structural basis of human transcription-DNA repair coupling

Goran Kokic et al.

Summary: Transcription-coupled DNA repair removes bulky DNA lesions and protects cells from UV irradiation. It involves stalling of Pol II at a DNA lesion, recruitment of repair factors, and the use of elongation factors to repair DNA while continuing transcription.

NATURE (2021)

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Article Medicine, Research & Experimental

Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis

Liang Pan et al.

Summary: Curcumin inhibits the growth, migration, and invasion of prostate cancer cells by regulating the miR-30a-5p/PCLAF axis, leading to increased apoptosis of the cells.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Geriatrics & Gerontology

Alternative splicing in Alzheimer's disease

Giuseppe Biamonti et al.

Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, with approximately 20% of people over 80 affected. Recent studies have shown that Alternative Splicing is involved in gene expression reprogramming and splicing abnormalities in AD tissues. While the molecular causes of AD are still poorly understood, therapeutic approaches targeting aberrant AS regulation offer potential new treatments.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2021)

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Article Biology

Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice

Chang Zhang et al.

COMMUNICATIONS BIOLOGY (2020)

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Article Cell Biology

Prognostic value and underlying mechanism of KIAA0101 in hepatocellular carcinoma: database mining and co-expression analysis

Weiyu Xu et al.

AGING-US (2020)

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Article Pharmacology & Pharmacy

Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis

Chan-Yen Kuo et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2020)

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Review Biotechnology & Applied Microbiology

The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy

Yuechen Zhao et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

CKLF1 Enhances Inflammation-Mediated Carcinogenesis and Prevents Doxorubicin-Induced Apoptosis via IL6/STAT3 Signaling in HCC

Youyi Liu et al.

CLINICAL CANCER RESEARCH (2019)

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Article Cell Biology

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping

Heegyum Moon et al.

CELLS (2019)

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O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancer

Yan Chen et al.

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Serine/arginine rich splicing factor 2 expression and clinic pathological features indicating a prognostic factor in human hepatocellular carcinoma patients

Pingan Wang et al.

CANCER BIOMARKERS (2018)

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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold et al.

CELL (2018)

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Fraction and incidence of liver cancer attributable to hepatitis B and C viruses worldwide

Delphine Maucort-Boulch et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

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LANCET (2018)

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PCNA-associated factor P15(PAF), targeted by FOXM1, predicts poor prognosis in high-grade serous ovarian cancer patients

Chengjuan Jin et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

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Review Oncology

Role of ferroptosis in hepatocellular carcinoma

Jianhua Nie et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

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Article Gastroenterology & Hepatology

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Victoria Tovar et al.

GUT (2017)

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Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma

Lijuan Liu et al.

ONCOTARGET (2017)

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Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines

Yuki Haga et al.

PLOS ONE (2017)

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SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion

Heegyum Moon et al.

BMB REPORTS (2017)

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SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development

Chunling Luo et al.

CANCER RESEARCH (2017)

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Article Gastroenterology & Hepatology

Metallothionein-1G Facilitates Sorafenib Resistance Through Inhibition of Ferroptosis

Xiaofang Sun et al.

HEPATOLOGY (2016)

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Review Gastroenterology & Hepatology

Molecular Mechanism and Prediction of Sorafenib Chemoresistance in Human Hepatocellular Carcinoma

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Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression

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Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

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limma powers differential expression analyses for RNA-sequencing and microarray studies

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Aberrant Regulation of Alternative Pre-mRNA Splicing in Hepatocellular Carcinoma

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Identification of natural splice variants of SAMHD1 in virus- infected HCC

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ONCOLOGY REPORTS (2014)

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Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

Christophe Louandre et al.

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Expression of KIAA0101 protein is associated with poor survival of esophageal cancer patients and resistance to cisplatin treatment in vitro

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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia-Pacific trial

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Variant 1 of KIAA0101, overexpressed in hepatocellular carcinoma, prevents doxorubicin-induced apoptosis by inhibiting p53 activation

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NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma

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HBV Enhances Sorafenib Resistance in Hepatocellular Carcinoma by Reducing Ferroptosis via SRSF2-Mediated Abnormal PCLAF Splicing

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