The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System

Article Biochemistry & Molecular Biology

Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model

Nikita Mikhailov et al.

Summary: Piezo1 channels play a role in migraine pain generation and there may be differences in mechanosensitivity between trigeminal and somatic nerves.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Identification of Piezo1 channels in perivascular adipose tissue (PVAT) and their potential role in vascular function

Taylor R. Miron et al.

Summary: The research found that Piezo1 is present and functional in the isolated rat aorta and mesenteric artery, but this channel does not directly cause vascular contraction, regardless of the presence of PVAT.

PHARMACOLOGICAL RESEARCH (2022)

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Article Cell Biology

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-I3-catenin mechanotransduction complex

Jing Wang et al.

Summary: The mechanically activated Piezo channel is connected to the actin cytoskeleton via the cadherin-O-catenin mechanotransduction complex, enabling mechanosensitivity. Disruption of specific interactions impairs Piezo channel function.

CELL REPORTS (2022)

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Review Immunology

Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation

Hailin Liu et al.

Summary: Mechanical damage is a predisposing factor for inflammation, and the newly discovered mechanically sensitive ion channel Piezo1 plays a vital role in the occurrence and progression of chronic inflammatory diseases. The transduction of damaging mechanical signals into inflammatory signals can be inhibited to improve the outcome of inflammation, and the pharmacology of Piezo1 shows promising prospects.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis

Huascar Pedro Ortuste Quiroga et al.

Summary: Piezo1 plays a crucial role in myogenic differentiation, with its activation enhancing myoblast fusion and its knockout suppressing fusion. These findings suggest that Piezo1 deregulation may impact muscle aging and degenerative diseases.

CELLS (2022)

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Article Chemistry, Medicinal

Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): APromising Therapeutic Target and Its Modulators

Hairong Tang et al.

Summary: Piezo1 is a mechanosensitive channel that plays important physiological roles and is associated with various pathological conditions. Targeting and modulating Piezo1 have shown potential therapeutic effects, making it a promising drug target for diseases.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Biotechnology & Applied Microbiology

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration

Jinna Wu et al.

Summary: Abnormal mechanical load is a significant risk factor for intervertebral disc degeneration (IDD) and cellular senescence plays a crucial role in this process. This study reveals the molecular mechanism underlying mechano-induced cellular senescence and IDD progression, highlighting the positive feedback loop between NF-kappa B and periostin. Additionally, neutralizing antibodies against periostin can interrupt this loop.

MOLECULAR THERAPY (2022)

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Article Clinical Neurology

Single Impact Injury of Vertebral Endplates Without Structural Disruption, Initiates Disc Degeneration Through Piezo1 Mediated Inflammation and Metabolism Dysfunction

Zhengang Sun et al.

Summary: This in vitro experimental study aimed to establish an axial impact injury model of intervertebral disc (IVD) and investigate whether a single impact injury without endplate structural disruption could initiate intervertebral disc degeneration (IDD), as well as the roles of Piezo1 in this process. The study found that both fracture of the endplate and a single impact injury without structural impairment could initiate IDD, possibly mediated by activation of Piezo1-induced inflammation and abnormal energy metabolism of IVD cells.

SPINE (2022)

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Article Cell Biology

The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance

Ryo Nakamichi et al.

Summary: This study reveals how mechanical stress affects physical performance by regulating PIEZO1 in tendons. The researchers found that tendon-specific knock-in mice with the gain-of-function variant R2482H Piezo1 had higher jumping abilities and faster running speeds due to enhanced tendon anabolism and increased expression of tendon-specific transcription factors. This finding suggests that PIEZO1 could be a potential target for enhancing physical performance.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells

Yundong Peng et al.

Summary: Skeletal muscle stem cells, also known as satellite cells, play a crucial role in postnatal muscle growth and regeneration. This study reveals that Piezo1, a mechanosensitive ion channel, is essential for maintaining the quiescence and preventing senescence of muscle stem cells. Absence of Piezo1 leads to premature activation of these cells, impairs their proliferation and differentiation, and significantly hinders skeletal muscle regeneration. The inactivation of Piezo1 results in compensatory up-regulation of T-type voltage-gated Ca2+ channels, which increases the influx of Ca2+ and induces NOX4 expression through cPKC. The elevated expression of NOX4 in Piezo1-deficient cells leads to increased levels of reactive oxygen species (ROS) and DNA damage, causing P53-dependent cellular senescence and cell death. The study also highlights the importance of the P53/P21-axis in mediating the cellular defects caused by the absence of Piezo1. This research sheds light on the critical role of Piezo1-mediated mechano-signaling in maintaining the quiescence and preventing senescence of muscle stem cells, and suggests that reduced mechano-signaling during aging may contribute to the accumulation of senescent cells and the decline of muscle stem cell numbers in geriatric individuals.

REDOX BIOLOGY (2022)

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Article Medicine, Research & Experimental

Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice

Sandip M. Swain et al.

Summary: Pancreatic fibrosis, a complication of chronic pancreatitis and pancreatic cancer, is caused by increased pancreatic duct pressure. Activation of Piezo1 and TRPV4 leads to activation of pancreatic stellate cells, resulting in pressure-induced chronic pancreatitis and fibrosis.

JCI INSIGHT (2022)

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Review Cell Biology

Extracellular matrix in intervertebral disc: basic and translational implications

Shuo Zhang et al.

Summary: Intervertebral disc degeneration is a common spinal disorder that causes neck pain or low back pain. The extracellular matrix (ECM) in healthy discs plays a crucial role in maintaining their structural integrity and supporting cell viability. However, with degeneration and aging, the ECM of the intervertebral disc undergoes structural degeneration and content loss, leading to a deterioration of the disc microenvironment. Understanding the physiology and pathology of ECM in the disc can provide new insights into potential strategies for disc regeneration.

CELL AND TISSUE RESEARCH (2022)

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Article Biology

The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration

Kotaro Hirano et al.

Summary: The calcium ion channel PIEZO1 regulates muscle satellite cells (MuSCs) by controlling cell division, promoting proliferation and regenerative functions. Deleting Piezo1 in MuSCs delays myofibre regeneration after injury, indicating its crucial role in muscle regeneration.

LIFE SCIENCE ALLIANCE (2022)

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Article Nanoscience & Nanotechnology

Piezo1 Response to Shear Stress Is Controlled by the Components of the Extracellular Matrix

Austin Lai et al.

Summary: This study investigates the influence of extracellular matrix (ECM) composition on the mechanosensitivity of the Piezo1 ion channel in response to hemodynamic forces. The presence of ECM proteins does not affect the sensitivity of Piezo1 to shear stress, but different ECM proteins regulate Piezo1 sensitivity depending on the shear stress level. These findings demonstrate that ECM/integrin interactions play a role in Piezo1 mechanosensitivity and provide new insights into how Piezo1 senses shear stress.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Medicine, Research & Experimental

A Piezo1/KLF15/IL-6 axis mediates immobilization- induced muscle atrophy

Yu Hirata et al.

Summary: This study reveals that the upregulation of KLF15 and IL-6, as well as the decrease in intracellular Ca2+ concentration, are involved in muscle atrophy induced by immobility. This finding has been validated in both mouse models and human samples.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Multidisciplinary Sciences

Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states

Nuoying Ma et al.

Summary: This study reveals the morphological heterogeneity of muscle stem cells (MuSCs) and their different functional states. The shift between these states, regulated by the sensing protein Piezo1, promotes tissue regeneration. Activation of Piezo1 increases the responsiveness of MuSCs, while deletion of Piezo1 decreases their responsiveness. These findings enhance our understanding of how stem cells respond to injury and identify Piezo1 as a key regulator of the essential stem cell states for regeneration.

SCIENCE ADVANCES (2022)

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Review Biochemistry & Molecular Biology

Structure, kinetic properties and biological function of mechanosensitive Piezo channels

Xiang-Zhi Fang et al.

Summary: Mechanotransduction, Piezo channels, and their mutations play crucial roles in various biological processes, including touch sensation, balance, and cardiovascular regulation. The kinetics of Piezo channels are critical for normal physiological functions. Mutations in Piezo genes have been linked to hereditary human disorders.

CELL AND BIOSCIENCE (2021)

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Article Multidisciplinary Sciences

A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

Bo Shen et al.

Summary: Stromal cells in adult bone marrow expressing leptin receptor are a critical source of growth factors for haematopoietic stem cells. Among these cells, those expressing osteogenic growth factor osteolectin are poised for osteogenesis, while those near sinusoids are primed for adipogenesis. Mechanical stimulation is crucial for the maintenance of the peri-arteriolar niche for osteogenesis and lymphopoiesis.

NATURE (2021)

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Article Cell Biology

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

Jiahao He et al.

Summary: The study identified that Piezo1 channel is overexpressed in myofibroblasts of hypertrophic scar (HS) tissues and plays a regulatory role in fibroblasts, thus participating in HS formation. Piezo1 activity enhances various cellular biological behaviors in response to mechanical stretch in dermal fibroblasts, including proliferation, motility, and differentiation. Additionally, blocking Piezo1 with GsMTx4 peptide injection protected rats from stretch-induced HS formation, suggesting Piezo1 as a potential therapeutic target for HS.

CELL DEATH & DISEASE (2021)

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Review Biotechnology & Applied Microbiology

A New Hope in Spinal Degenerative Diseases: Piezo1

Daxue Zhu et al.

Summary: Piezo1 protein, a newly discovered mechanosensitive ion channel protein, plays a vital role in transmitting mechanical signals on the cell membrane and mammalian biomechanics. Studies have shown that piezo1 is expressed in multiple systems and affects cell functions by receiving external mechanical stimulation, promoting the development of lumbar degenerative diseases.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Biology

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

Jesse R. Holt et al.

Summary: Mechanically activated ion channel PIEZO1 regulates keratinocyte migration and wound healing, with Piezo1 knockout mice exhibiting faster wound closure and gain-of-function mice displaying slower wound closure. The spatiotemporal dynamics of PIEZO1 channels play a key role in controlling tissue-scale events beyond wound healing.

ELIFE (2021)

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Article Physiology

Mechanosensitive Piezo1 in Periodontal Ligament Cells Promotes Alveolar Bone Remodeling During Orthodontic Tooth Movement

Yukun Jiang et al.

Summary: The Piezo1 channel plays a critical role in mediating bone formation and osteoclastic activities during orthodontic tooth movement, particularly on the tension side. Inhibition of Piezo1 function leads to reduced expression of osteogenesis-associated transcription factors and disruptions in bone remodeling processes.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Neurosciences

Differential effects of the Piezo1 agonist Yoda1 in the trigeminovascular system: An electrophysiological and intravital microscopy study in rats

Antonina Dolgorukova et al.

Summary: Migraine is associated with the activation and sensitization of the trigeminovascular system. Piezo1, expressed in endothelial cells and trigeminal ganglion neurons, may play a role in both vascular and neuronal activation. Activation of Piezo1 channels can modulate both neuronal firing and vascular dilation, providing new evidence for its involvement in migraine pathogenesis.

EXPERIMENTAL NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

Whasil Lee et al.

Summary: The study reveals that interleukin-1 affects the expression and function of Piezo1 gene in osteoarthritis, leading to a detrimental calcium-driven feed-forward mechanism that can be targeted for intervention.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Editorial Material Physiology

A crucial physiological role of Piezo1 channel in differentiation rather than proliferation during myogenesis

Ming Jie Wang et al.

ACTA PHYSIOLOGICA (2021)

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Article Physiology

Time window effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation

Alessandra Bosutti et al.

Summary: Chemical activation of Piezo1 channels enhances the differentiation of skeletal muscle precursors, while showing no significant impact on adult muscle fibers and neuromuscular junctions. This suggests a potential new strategy for promoting muscle regeneration.

ACTA PHYSIOLOGICA (2021)

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Article Peripheral Vascular Disease

Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients

Jing Liao et al.

Summary: Emerging studies have shown that Piezo1 plays crucial roles in regulating vascular tone and intracellular calcium homeostasis. Activation of Piezo1 leads to an increase in [Ca2+](i) through both intracellular release and extracellular influx mechanisms. The enhanced expression and activity of Piezo1 contribute to abnormal elevation of [Ca2+](i) and proliferation in idiopathic PAH-PASMCs.

HYPERTENSION (2021)

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Article Gastroenterology & Hepatology

Mechanical stimulation activates Piezo1 to promote mucin2 expression in goblet cells

Yan Xu et al.

Summary: The study revealed that mechanical stimulation can promote mucin secretion and mucin2 expression in intestinal goblet cells. Piezo1, as a mechanoreceptor, plays a key role in these processes by regulating mucin2 expression through the Erk/Ca2+ pathway.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Physiology

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

Mayumi Matsunaga et al.

Summary: Odontoblasts play crucial roles in dentin formation and sensory transduction. Mechanical stimulation induces intracellular Ca2+ signaling through Piezo1 channels, promoting intercellular communication and regulating dentinogenesis. Understanding the role of Piezo1 channels in odontoblast function may provide insights into dentin sensitivity and mineralization processes.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Engineering, Biomedical

Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans

Fabian S. Passini et al.

Summary: This study found that tenocytes detect mechanical forces through the mechanosensitive ion channel PIEZO1, influencing tendon stiffness and strength. Humans carrying specific mutations in PIEZO1 may exhibit higher athletic performance.

NATURE BIOMEDICAL ENGINEERING (2021)

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Proceedings Paper Green & Sustainable Science & Technology

Revealing the hiden mystery of Piezo: A phylogenetic study

Chenyang Jia

Summary: Piezo proteins are crucial mechanical-responsive ion channel proteins in the normal physiological process. By constructing an evolutionary tree of the Piezo1 gene, researchers can analyze the evolution of Piezo genes, predict the direction of gene mutation, and map pathogenic mutation sites. This evolutionary perspective analysis of the Piezo 1 gene may be valuable for future disease diagnosis and individualized therapy.

2020 INTERNATIONAL SYMPOSIUM ON ENERGY ENVIRONMENT AND GREEN DEVELOPMENT (2021)

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Article Cell & Tissue Engineering

Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells

Guangdao Zhang et al.

Summary: The mechanosensitive ion channel Piezo1 is believed to play a crucial role in transducing mechanical signals induced by LIPUS to regulate cell migration and proliferation. Experimental results indicate that Piezo1 can modulate intracellular calcium levels in response to LIPUS stimulation, affecting the growth processes of cells.

BONE RESEARCH (2021)

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Article Endocrinology & Metabolism

Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation

Gretl Hendrickx et al.

Summary: The skeleton is a dynamic tissue that continuously adapts to mechanical stimuli. Piezo1 plays a critical role in bone formation, specifically in endochondral ossification. Deletion of Piezo1 may lead to osteoporosis and spontaneous fractures.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

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Article Neurosciences

Piezo1 regulates calcium oscillations and cytokine release from astrocytes

Maria Velasco-Estevez et al.

GLIA (2020)

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Article Medicine, Research & Experimental

Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes

Genlai Du et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Article Ophthalmology

Piezo channel plays a part in retinal ganglion cell damage

Wataru Morozumi et al.

EXPERIMENTAL EYE RESEARCH (2020)

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Article Multidisciplinary Sciences

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Lijun Wang et al.

NATURE COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Satellite cells in ageing: use it or lose it

William Chen et al.

OPEN BIOLOGY (2020)

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Article Biology

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-satenin

Taifeng Zhou et al.

ELIFE (2020)

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Review Cell Biology

Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing

Laura Forcina et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis

Erika Sugisawa et al.

CELL (2020)

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Article Immunology

Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway

Yi Sun et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Physiology

Disruption of membrane cholesterol organization the of PIEZO1 channel clusters

Pietro Ridone et al.

JOURNAL OF GENERAL PHYSIOLOGY (2020)

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Article Biophysics

Piezo1 Forms Specific, Functionally Important Interactions with Phosphoinositides and Cholesterol

Amanda Buyan et al.

BIOPHYSICAL JOURNAL (2020)

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Article Multidisciplinary Sciences

Identification of PIEZO1 as a potential prognostic marker in gliomas

Wenjianlong Zhou et al.

SCIENTIFIC REPORTS (2020)

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Review Multidisciplinary Sciences

Discoveries in structure and physiology of mechanically activated ion channels

J. M. Kefauver et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

Xuekun Fu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Cell & Tissue Engineering

Molecular mechanosensors in osteocytes

Lei Qin et al.

BONE RESEARCH (2020)

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Article Cell & Tissue Engineering

Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation

Bing Shu et al.

BONE RESEARCH (2020)

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Article Cell & Tissue Engineering

Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice

Huiling Cao et al.

BONE RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Study on the mechanism of excessive apoptosis of nucleus pulposus cells induced by shRNA-Piezo1 under abnormal mechanical stretch stress

Qining Yang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Multidisciplinary Sciences

Dietary fatty acids fine-tune Piezo1 mechanical response

Luis O. Romero et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

Emily E. Friedrich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Endocrinology & Metabolism

Mechanosensitive Ion Channel Piezo1 Regulates Diet-Induced Adipose Inflammation and Systemic Insulin Resistance

Can Zhao et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Review Hematology

Force Sensing by Piezo Channels in Cardiovascular Health and Disease

David J. Beech et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Article Multidisciplinary Sciences

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Angel G. Solis et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Force-induced conformational changes in PIEZO1

Yi-Chih Lin et al.

NATURE (2019)

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Article Biology

Stimulation of Piezo1 by mechanical signals promotes bone anabolism

Xuehua Li et al.

ELIFE (2019)

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Article Biochemistry & Molecular Biology

The mechanosensitive Piezo1 channel: a three-bladed propeller-like structure and a lever-like mechanogating mechanism

Qiancheng Zhao et al.

FEBS JOURNAL (2019)

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Review Pharmacology & Pharmacy

Piezo Ion Channels in Cardiovascular Mechanobiology

Dominique Douguet et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

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Article Respiratory System

Piezo1 induced apoptosis of type II pneumocytes during ARDS

Guo-Peng Liang et al.

RESPIRATORY RESEARCH (2019)

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Article Multidisciplinary Sciences

Structure of the mechanically activated ion channel Piezol

Kei Saotome et al.

NATURE (2018)

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Article Clinical Neurology

Phenotype variability and histopathological findings in patients with a novel DNM2 mutation

Shuyun Chen et al.

NEUROPATHOLOGY (2018)

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Review Physiology

Bacterial Mechanosensors

Charles D. Cox et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

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Meeting Abstract Biophysics

Cytoskeleton-Associated Proteins Modulate the Tension Sensitivity of Piezo1

Charles D. Cox et al.

BIOPHYSICAL JOURNAL (2018)

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Review Developmental Biology

Regulation and phylogeny of skeletal muscle regeneration

Meryem B. Baghdadi et al.

DEVELOPMENTAL BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

PIEZO1 Channel Is a Potential Regulator of Synovial Sarcoma Cell-Viability

Takahisa Suzuki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Multidisciplinary Sciences

Structure and mechanogating mechanism of the Piezol channel

Qiancheng Zhao et al.

NATURE (2018)

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Article Multidisciplinary Sciences

Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

Joelle M. -J. Romac et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Voltage gating of mechanosensitive PIEZO channels

Mirko Moroni et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

Yanfeng Wang et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation

Masaki Tsuchiya et al.

NATURE COMMUNICATIONS (2018)

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Article Genetics & Heredity

Identification of novel PIEZO1 variants using prenatal exome sequencing and correlation to ultrasound and autopsy findings of recurrent hydrops fetalis

Ilina Datkhaeva et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2018)

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Article Biochemistry & Molecular Biology

Structure of the mechanosensitive OSCA channels

Mingfeng Zhang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

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Article Biology

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

Swetha E. Murthy et al.

ELIFE (2018)

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Article Biology

Piezo's membrane footprint and its contribution to mechanosensitivity

Christoph A. Haselwandter et al.

ELIFE (2018)

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Article Neurosciences

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

Christiane Wetzel et al.

NATURE NEUROSCIENCE (2017)

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Article Medicine, Research & Experimental

被撤回的出版物: Piezo1 protein induces the apoptosis of human osteoarthritis-derived chondrocytes by activating caspase-12, the signaling marker of ER stress (Retracted article. See vol. 42, pg. 3640, 2018)

Xiao-Fei Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

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Article Dentistry, Oral Surgery & Medicine

Role of Piezo Channels in Ultrasound-stimulated Dental Stem Cells

Qianhua Gao et al.

JOURNAL OF ENDODONTICS (2017)

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Article Chemistry, Multidisciplinary

Mechanical Stimulation of Piezo1 Receptors Depends on Extracellular Matrix Proteins and Directionality of Force

Benjamin M. Gaub et al.

NANO LETTERS (2017)

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Review Cell Biology

Piezos thrive under pressure: mechanically activated ion channels in health and disease

Swetha E. Murthy et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology

Thomas M. Suchyna

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2017)

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Review Cell Biology

How cells channel their stress: Interplay between Piezo1 and the cytoskeleton

Jamison L. Nourse et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

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Article Multidisciplinary Sciences

A protein interaction mechanism for suppressing the mechanosensitive Piezo channels

Tingxin Zhang et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

Baptiste Rode et al.

NATURE COMMUNICATIONS (2017)

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Article Biology

Structure-based membrane dome mechanism for Piezo mechanosensitivity

Yusong R. Guo et al.

ELIFE (2017)

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Review Endocrinology & Metabolism

Osteocyte Mechanobiology

Yuhei Uda et al.

CURRENT OSTEOPOROSIS REPORTS (2017)

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Article Multidisciplinary Sciences

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1

K. M. Lawrence et al.

SCIENTIFIC REPORTS (2017)

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Article Biophysics

GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels

Radhakrishnan Gnanasambandam et al.

BIOPHYSICAL JOURNAL (2017)

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Article Multidisciplinary Sciences

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

Charles D. Cox et al.

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The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System

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