The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System

Since the recent discovery of the mechanosensitive Piezo1 channels, many studies have addressed the role of the channel in various physiological or even pathological processes of different organs. Although the number of studies on their effects on the musculoskeletal system is constantly increasing, we are still far from a precise understanding. In this review, the knowledge available so far regarding the musculoskeletal system is summarized, reviewing the results achieved in the field of skeletal muscles, bones, joints and cartilage, tendons and ligaments, as well as intervertebral discs.

Automated summary

Since the discovery of Piezo1 channels, studies have investigated their role in various physiological and pathological processes in different organs. However, our understanding of their effects on the musculoskeletal system is still limited. This review summarizes the current knowledge regarding their impact on skeletal muscles, bones, joints and cartilage, tendons and ligaments, and intervertebral discs.