Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems

A dual-target strategy was designed for the application of lignin nanoparticles in the lipase mediated biosynthesis of novel 3-O-ethyl-L-ascorbyl-6-ferulate and 3-O-ethyl-L-ascorbyl-6-palmitate and in their successive solvent-shift encapsulation in order to improve stability and antioxidant activity against temperature and pH-dependent degradation. The loaded lignin nanoparticles were fully characterized in terms of kinetic release, radical scavenging activity and stability under pH 3 and thermal stress (60 C-?), showing improved antioxidant activity and high efficacy in the protection of ascorbic acid esters from degradation.

Automated summary

A dual-target strategy was developed using lignin nanoparticles for the biosynthesis of novel ascorbic acid esters and their encapsulation, resulting in improved stability and antioxidant activity. The loaded lignin nanoparticles showed increased antioxidant activity and effectively protected ascorbic acid esters from degradation.