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The Role of Smoking in the Mechanisms of Development of Chronic Obstructive Pulmonary Disease and Atherosclerosis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Respiratory System

Comorbid Heart Disease in Patients with COPD is Associated with Increased Hospitalization and Mortality - A 15-Year Follow-Up

Maaike Giezeman et al.

Summary: The study aimed to examine the association between comorbid heart disease and hospitalization and mortality in COPD patients. The findings showed that COPD patients with heart disease had a higher risk of hospitalization and mortality, mainly due to cardiovascular and other causes. Therefore, there is a need for strong primary and secondary prevention of cardiovascular disease in COPD patients.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2023)

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Article Immunology

HSP60 regulates the cigarette smoke-induced activation of TLR4-NF-?B-MyD88 signalling pathway and NLRP3 inflammasome

Guochun Ou et al.

Summary: This study reveals the upregulation of HSP60 expression in COPD and its involvement in the activation of TLR4-MyD88-NF-kappa B signaling pathway and NLRP3 inflammasome, suggesting its potential role in COPD pathogenesis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Involvement of the Innate Immune System in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Stanislav Kotlyarov

Summary: Chronic obstructive pulmonary disease (COPD) is a common disease characterized by progressive airflow limitation due to chronic inflammation in the bronchi. The mechanisms of the innate immune system play a role in the pathogenesis of COPD, leading to chronic inflammation and lung tissue damage.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Gastroenterology & Hepatology

Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide

Hsin-Chih Lai et al.

Summary: The study found that gut microbiota composition significantly affects cigarette smoking-induced COPD development, and fecal microbiota transplantation can restore COPD pathogenesis. A beneficial bacterium Parabacteroides goldsteinii was isolated and shown to ameliorate COPD, with its derived active component having anti-inflammatory effects and ameliorating COPD through inhibition of lung inflammation and regulation of host metabolism.

GUT (2022)

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Article Endocrinology & Metabolism

Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement

Lorenzo M. Donini et al.

Summary: Loss of skeletal muscle mass and function is common in individuals with obesity. The co-existence of excess adiposity and low muscle mass/function, known as sarcopenic obesity (SO), negatively impacts patient outcomes. However, the lack of a universally established definition and diagnostic criteria for SO hampers prevention and treatment efforts.

OBESITY FACTS (2022)

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Review Biochemistry & Molecular Biology

Role of Short-Chain Fatty Acids Produced by Gut Microbiota in Innate Lung Immunity and Pathogenesis of the Heterogeneous Course of Chronic Obstructive Pulmonary Disease

Stanislav Kotlyarov

Summary: Chronic obstructive pulmonary disease (COPD) is a widespread and socially significant disease, and its development is related to the innate immune system. The regulation of the lung immune system is connected to the gut microbiota, which produces short-chain fatty acids (SCFAs) that play a role in this connection. Nutritional disturbances and changes in the gut microbiota can lead to a decrease in SCFAs production and affect lung immunity. The metabolic and immune axis between the lungs and gut plays an important role in the pathogenesis of COPD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Substance Abuse

Evolution of the global smoking epidemic over the past half century: strengthening the evidence base for policy action

Xiaochen Dai et al.

Summary: This study provides a recent assessment of smoking levels worldwide based on the methods used in the Global Burden of Disease Study. Despite a decline in global smoking prevalence, smoking remains a significant health burden globally.

TOBACCO CONTROL (2022)

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Article Medicine, General & Internal

The Influence of Prior Statin Use on the Prevalence and Exacerbation of Chronic Obstructive Pulmonary Disease in an Adult Population

Joo-Hee Kim et al.

Summary: Although previous statin use did not have a significant association with the occurrence of COPD, it was found to decrease the risk of acute exacerbations in COPD patients, with a greater effect seen with the use of lipophilic statins.

FRONTIERS IN MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Estrogen Receptor-β Agonists Modulate T-Lymphocyte Activation and Ameliorate Left Ventricular Remodeling During Chronic Heart Failure

Rachel Rosenzweig et al.

Summary: The study identified the activation of ER-alpha signaling in CD4(+) T cells during ischemic heart failure and demonstrated the potential of using ER beta agonist OSU-ERb-012 to inhibit T cells and reduce left ventricular remodeling. Treatment with OSU-ERb-012 effectively inhibited proliferation and proinflammatory cytokine expression in T cells, leading to improved cardiac outcomes in a mouse model.

CIRCULATION-HEART FAILURE (2022)

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Article Multidisciplinary Sciences

Cardiovascular predictors of mortality and exacerbations in patients with COPD

Peter Alter et al.

Summary: Cardiovascular comorbidities are predictors of mortality but not exacerbation risk in patients with chronic obstructive pulmonary disease.

SCIENTIFIC REPORTS (2022)

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Review Physiology

Pathogenesis of (smoking-related) non-communicable diseases-Evidence for a common underlying pathophysiological pattern

Wolfgang Kopp

Summary: Non-communicable diseases, such as diabetes and cardiovascular diseases, are major causes of death worldwide. Lifestyle factors and physiological dysregulation play crucial roles in the development of these diseases, including smoking-related diseases. Understanding the common pathophysiological pattern can provide insights into disease comorbidities and guide future research.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Primary Health Care

A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy

Trinh T. Nguyen et al.

Summary: There is increasing evidence that sex hormones may impact the development of obstructive lung disease. This study found that bilateral oophorectomy is associated with a higher risk of obstructive lung disease, particularly in certain subgroups. Therefore, unless there is clear evidence of a high genetic risk of ovarian cancer, it is recommended to avoid oophorectomy in premenopausal women.

NPJ PRIMARY CARE RESPIRATORY MEDICINE (2022)

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Review Medicine, General & Internal

Analysis of pathogenesis and drug treatment of chronic obstructive pulmonary disease complicated with cardiovascular disease

Xiao-Fang Li et al.

Summary: COPD is a chronic airflow limitation disease caused by cigarette smoke and toxic gases. It is closely associated with cardiovascular disease, and the two conditions increase the risk of exacerbations and mortality. Chronic inflammation in the lungs leads to lung destruction and vascular dysfunction, promoting the development of CVD.

FRONTIERS IN MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Identification and verification of immune-related biomarkers and immune infiltration in diabetic heart failure

Zuoquan Zhong et al.

Summary: This study identified immune-related core genes and immune infiltrating cells associated with diabetic heart failure. The findings provide new insights into the pathogenesis of diabetic heart failure.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Medicine, General & Internal

Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019

Saeid Safiri et al.

Summary: This study reports the global, regional, and national burden of chronic obstructive pulmonary disease (COPD) and its risk factors from 1990 to 2019. The findings indicate that although the burden of COPD has decreased, it still remains a significant public health problem worldwide. Preventive measures should focus on smoking cessation, improving air quality, and reducing occupational exposure to further reduce the burden of COPD.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4+T Lymphocytes During Ischemic Heart Failure

Vinay Kumar et al.

Summary: CD4+ T cells become pathological during heart failure, and the expression of tumor necrosis factor alpha (TNF-α) and tumor necrosis factor receptor 1 (TNFR1) increases in these activated cells. The study shows that TNFR1 plays a crucial role in suppressing prosurvival and proliferative signals in CD4+ T cells during heart failure, without altering their pathological activity.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2022)

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Review Biochemistry & Molecular Biology

Immune Function of Endothelial Cells: Evolutionary Aspects, Molecular Biology and Role in Atherogenesis

Stanislav Kotlyarov

Summary: Atherosclerosis is a prevalent disease that is closely associated with cardiovascular diseases. Endothelial cells play a crucial role in the development of atherosclerosis, and a better understanding of their functions and interactions can improve early diagnosis and treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Effects of Cigarette Smoke Exposure on the Gut Microbiota and Liver Transcriptome in Mice Reveal Gut-Liver Interactions

Lei Meng et al.

Summary: Cigarette smoke exposure has detrimental effects on health, particularly on the gut-liver axis. This study evaluated the adverse effects of cigarette smoke exposure on mice and explored the effects on gut microbiota and liver gene expression. The findings revealed that cigarette smoke exposure caused abnormal physiological indices, liver injury, and disorders in gut microbiota and liver transcriptome, especially in lipid metabolism. The study highlighted the key role of gut microbiota in liver damage and metabolism caused by cigarette smoke exposure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Small Molecules Targeting Oxidative Stress in the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Comprehensive Review

Hamad Ghaleb Dailah

Summary: Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), and antioxidants can be used for its treatment.

MOLECULES (2022)

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Review Environmental Sciences

The Effect of Smoking Cessation on Body Weight and Other Metabolic Parameters with Focus on People with Type 2 Diabetes Mellitus

Stamatina Driva et al.

Summary: Smokers with diabetes mellitus can substantially lower their risks of microvascular and macrovascular diabetic complications, particularly cardiovascular disease, by quitting smoking. However, post-smoking-cessation weight gain may negate some of the benefits of quitting smoking and discourage further attempts to quit. Weight gain can transiently exacerbate diabetes and worsen glycemic control and metabolic profile.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Editorial Material Cardiac & Cardiovascular Systems

Is It the Heart or the Lung? Sometimes It Is Both

Sanjay Sethi

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

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Article Medicine, General & Internal

Mortality Risk Assessment in Peripheral Arterial Disease-The Burden of Cardiovascular Risk Factors over the Years: A Single Center's Experience

Viviana Aursulesei Onofrei et al.

Summary: Atherosclerosis is the underlying cause of cardiovascular complications in patients with peripheral artery disease (PAD). This study identified hypertension, dyslipidemia, diabetes mellitus, and smoking as important factors associated with unfavorable prognosis. Patients in the high-intermediate and high-risk mortality group had higher lipid levels and fasting blood glucose levels, which correlated positively with the ankle-brachial index value.

DIAGNOSTICS (2022)

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Article Cardiac & Cardiovascular Systems

CD4+ T-lymphocytes exhibit biphasic kinetics post-myocardial infarction

Vinay Kumar et al.

Summary: CD4(+) T-cells exhibit different activation patterns during myocardial infarction and heart failure, promoting left-ventricular remodeling, and temporal immunomodulation may be important for ischemic heart failure.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Respiratory System

Possible association of high-density lipoprotein cholesterol levels with trunk muscle deficits and decrease in energy expenditure in patients with or at risk for COPD: A pilot study

Toru Shirahata et al.

Summary: This study investigated the associations between serum biomarkers and muscle measurements as well as energy expenditure indices in patients with chronic obstructive pulmonary disease (COPD). The results showed that high-density lipoprotein cholesterol (HDL-C) levels were significantly correlated with muscle areas, densities, and total energy expenditure (TEE). Only low-density lipoprotein cholesterol (LDL-C) levels were correlated with physical activity level (PAL).

RESPIRATORY INVESTIGATION (2022)

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Article Respiratory System

Sarcopenia is associated with cardiovascular risk in men with COPD, independent of adiposity

Ah Young Leem et al.

Summary: This study found a significant association between sarcopenia and increased risk for atherosclerotic cardiovascular disease in men with chronic obstructive pulmonary disease, independent of central obesity and fat mass. High ASCVD risk was particularly associated with sarcopenia in participants with moderate to very severe airflow limitation.

RESPIRATORY RESEARCH (2022)

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Article Respiratory System

Imbalanced prostanoid release mediates cigarette smoke-induced human pulmonary artery cell proliferation

Abdullah A. Alqarni et al.

Summary: In this study, the researchers investigated the effects of cigarette smoke extract (CSE) on cell proliferation and pulmonary vascular remodeling. The results showed that CSE can induce imbalanced prostanoid release, contributing to pulmonary vascular remodeling. These findings have important implications for understanding the pathogenesis of pulmonary hypertension in COPD and identifying new therapeutic targets.

RESPIRATORY RESEARCH (2022)

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Article Medicine, General & Internal

No Independent Influence of Statins on the Chronic Obstructive Pulmonary Disease Exacerbation Rate: A Cohort Observation Study Over 10 Years

Josef Yayan et al.

Summary: This study investigated the independent influence of statins on COPD exacerbation rate, and the results showed that statins have no effect on the exacerbation rate or mortality in COPD patients.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

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Review Oncology

Metabolic reprogramming in macrophage responses

Yang Liu et al.

Summary: Macrophages are key regulators of tissue homeostasis, involved in tissue development, repair, and defense against pathogens. TAMs play a crucial role in the tumor microenvironment, impacting tumor initiation, growth, invasion, and metastasis. The metabolic characteristics of macrophages influence their phenotype and function, with pro-inflammatory M1 macrophages relying on glycolysis and anti-inflammatory M2 macrophages more dependent on mitochondrial OXPHOS.

BIOMARKER RESEARCH (2021)

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Article Medicine, General & Internal

Statin prescription in patients with chronic obstructive pulmonary disease and risk of exacerbations: a retrospective cohort study in the Clinical Practice Research Datalink

Margaret C. Smith et al.

Summary: A retrospective cohort study in England found that the use of statins in people with COPD was not associated with a decreased risk of COPD exacerbation, contrary to previous observational studies.

BMJ OPEN (2021)

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Review Immunology

Regulatory T Cells in Chronic Heart Failure

Yuzhi Lu et al.

Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Public, Environmental & Occupational Health

Relationship between smoking and the incidence of sarcopenia: The SarcoPhAge cohort

M. Locquet et al.

Summary: The study revealed that smokers are more likely to develop sarcopenia, with a significantly higher risk of both sarcopenia and severe sarcopenia compared to non-smokers.

PUBLIC HEALTH (2021)

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Article Multidisciplinary Sciences

High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism

Yoon Ok Jang et al.

Summary: High-fiber diets can influence cigarette smoking-exposed emphysema mice by modulating gut microbiota and metabolites, slowing down pathological changes and inflammatory responses. Different types of dietary fiber can also impact gut microbiota diversity and metabolism.

SCIENTIFIC REPORTS (2021)

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Review Cardiac & Cardiovascular Systems

Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies

Kathryn A. McGurk et al.

Summary: There is a need for new biomarkers of atherosclerotic cardiovascular disease, with recent studies highlighting circulating ceramides as potential indicators of coronary artery disease, type-2 diabetes and insulin resistance. Ceramides are highly regulated by enzymatic reactions throughout the body in terms of their activity and metabolism, including production, degradation and transport. Genetic studies have shown that DNA variants in genes involved in ceramide biosynthesis play a key role in influencing heritable, circulating ceramide levels.

ATHEROSCLEROSIS (2021)

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Review Biochemistry & Molecular Biology

Arginine-dependent immune responses

Adria-Arnau Lindez et al.

Summary: Arginine plays a crucial role in regulating immune responses and its adequate supply is important for improving immune function. The availability, synthesis, and catabolism of arginine are interrelated aspects that affect immune cell biology profoundly. Disruption or perversion of arginine metabolism is implicated in various pathologies, from infectious diseases to autoimmunity and cancer.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Cardiac & Cardiovascular Systems

Immune Cells and Immunotherapy for Cardiac Injury and Repair

Joel G. Rurik et al.

Summary: Cardiac injury remains a major cause of morbidity and mortality worldwide, with a lack of understanding on why the heart fails to fully recover function after acute injury and why progressive heart failure frequently ensues. Recent studies have brought to light the significant contributions of the immune system to normal cardiac function and response to injury, offering promise for new treatment avenues for cardiac disease through immune modifying therapies.

CIRCULATION RESEARCH (2021)

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Review Cell Biology

Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Du Xiang et al.

Summary: Premenopausal women have lower risk of cardiovascular disease compared to men, while postmenopausal women have higher risk. Estrogen has a protective effect on the cardiovascular system by regulating oxidative stress, offering potential strategies for treating menopausal women with cardiovascular diseases.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Respiratory System

The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD

Qing Song et al.

Summary: COPD is a common chronic respiratory disease with smoking as a main risk factor. Recent research indicates that pulmonary vascular endothelial cell apoptosis plays a role in the pathogenesis of COPD.

RESPIRATORY RESEARCH (2021)

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Article Hematology

Macrophages in Atherosclerosis Regression

Tessa J. Barrett

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Article Pharmacology & Pharmacy

Skeletal muscle area and density are associated with lipid and lipoprotein cholesterol levels: The Multi-Ethnic Study of Atherosclerosis

Chantal A. Vella et al.

JOURNAL OF CLINICAL LIPIDOLOGY (2020)

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Review Oncology

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

Corry-Anke Brandsma et al.

JOURNAL OF PATHOLOGY (2020)

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Article Respiratory System

Statin Use and the Risk of Subsequent Hospitalized Exacerbations in COPD Patients with Frequent Exacerbations

Chieh-Mo Lin et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2020)

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Article Physiology

Protective Effects of Short-Chain Fatty Acids on Endothelial Dysfunction Induced by Angiotensin II

Inaki Robles-Vera et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Respiratory System

FEV1 is a stronger mortality predictor than FVC in patients with moderate COPD and with an increased risk for cardiovascular disease

Andras Bikov et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2020)

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Review Cell Biology

The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability

Tiewei Li et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Cardiac & Cardiovascular Systems

Effect of nitric oxide reduction on arterial thrombosis

Dario Costa et al.

SCANDINAVIAN CARDIOVASCULAR JOURNAL (2019)

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Article Multidisciplinary Sciences

NLRP3 inflammasome activity is upregulated in an in-vitro model of COPD exacerbation

Noy Nachmias et al.

PLOS ONE (2019)

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Review Immunology

The Metabolic Signature of Macrophage Responses

Antonella Viola et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review

Rupert Bauersachs et al.

CARDIOVASCULAR THERAPEUTICS (2019)

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Article Multidisciplinary Sciences

Extracellular adenosine triphosphate is associated with airflow limitation severity and symptoms burden in patients with chronic obstructive pulmonary disease

Iva Hlapcic et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, General & Internal

Mortality of patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study

Seon Cheol Park et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2019)

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Review Cardiac & Cardiovascular Systems

Immunity and Inflammation in Atherosclerosis

Dennis Wolf et al.

CIRCULATION RESEARCH (2019)

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Review Respiratory System

Effectiveness of long-term using statins in COPD - a network meta-analysis

Yongbin Lu et al.

RESPIRATORY RESEARCH (2019)

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Article Primary Health Care

Association between Cigarette Smoking and Sarcopenia according to Obesity in the Middle-Aged and Elderly Korean Population: The Korea National Health and Nutrition Examination Survey (2008-2011)

Yoonjoo Jo et al.

KOREAN JOURNAL OF FAMILY MEDICINE (2019)

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Article Public, Environmental & Occupational Health

Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease A Prospective Cohort Study of Men

Joanna Kaluza et al.

EPIDEMIOLOGY (2018)

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Article Critical Care Medicine

Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events

Ken M. Kunisaki et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Article Hematology

Plasma Ceramides: A Novel Predictor of Major Adverse Cardiovascular Events After Coronary Angiography

Jeffrey W. Meeusen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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Review Medicine, Research & Experimental

Nitric oxide bioavailability dysfunction involves in atherosclerosis

Jing-yi Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Respiratory System

The effects of smoking on vascular endothelial growth factor and inflammation markers: A case-control study

Merve Guzeldulger Ugur et al.

CLINICAL RESPIRATORY JOURNAL (2018)

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Article Biochemistry & Molecular Biology

A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure

Jarrod Sonett et al.

FASEB JOURNAL (2018)

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Article Peripheral Vascular Disease

Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?

Matthew F. Yuyun et al.

MICROVASCULAR RESEARCH (2018)

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Article Cardiac & Cardiovascular Systems

High risk of subclinical atherosclerosis in COPD exacerbator phenotype

Adolfo Domenech et al.

RESPIRATORY MEDICINE (2018)

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Article

Phytochemicals as modulators of M1-M2 macrophages in inflammation

Uzma Saqib et al.

Oncotarget (2018)

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Article Biochemistry & Molecular Biology

Oxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages

Oscar J. Lara-Guzman et al.

REDOX BIOLOGY (2018)

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Review Immunology

Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity

Christoph Konradt et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

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Article Respiratory System

Regional heterogeneity in response of airway epithelial cells to cigarette smoke

Hario Baskoro et al.

BMC PULMONARY MEDICINE (2018)

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Article Medicine, General & Internal

Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study

Su Hwan Lee et al.

JOURNAL OF CLINICAL MEDICINE (2018)

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Review Respiratory System

Cardiovascular disease and COPD: dangerous liaisons?

Klaus F. Rabe et al.

EUROPEAN RESPIRATORY REVIEW (2018)

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Article Biochemical Research Methods

Central and peripheral airway nitric oxide in patients with stable and exacerbated chronic obstructive pulmonary disease

Zsofia Lazar et al.

JOURNAL OF BREATH RESEARCH (2018)

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Review Cardiac & Cardiovascular Systems

COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series)

Francesca Polverino et al.

PULMONARY CIRCULATION (2018)

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Review Psychiatry

Body weight and mortality in COPD: focus on the obesity paradox

Francesco Spelta et al.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2018)

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Review Respiratory System

Defining the relationship between COPD and CVD: what are the implications for clinical practice?

Ann D. Morgan et al.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2018)

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Article Respiratory System

Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men

Joanna Kaluza et al.

THORAX (2017)

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Review Oncology

Statins reduce all-cause mortality in chronic obstructive pulmonary disease: an updated systematic review and meta-analysis of observational studies

Wen-Feng Li et al.

ONCOTARGET (2017)

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Article Oncology

Role of the inflammasome in chronic obstructive pulmonary disease (COPD)

Chiara Colarusso et al.

ONCOTARGET (2017)

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Article Respiratory System

Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study

Ji Hye Park et al.

BMC PULMONARY MEDICINE (2017)

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Article Respiratory System

The role of cyclooxygenase-2 in the protection against apoptosis in vascular endothelial cells induced by cigarette smoking

Zhihui Shi et al.

JOURNAL OF THORACIC DISEASE (2017)

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Article Biochemistry & Molecular Biology

Cigarette smoke extract counteracts atheroprotective effects of high laminar flow on endothelial function

Sindy Giebe et al.

REDOX BIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Macrophage phagocytosis cracking the defect code in COPD

Jamil Jubrail et al.

BIOMEDICAL JOURNAL (2017)

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Article Multidisciplinary Sciences

Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells

Jack E. Teasdale et al.

SCIENTIFIC REPORTS (2017)

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Article Biophysics

Shear-Induced Nitric Oxide Production by Endothelial Cells

Krishna Sriram et al.

BIOPHYSICAL JOURNAL (2016)

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Review Pharmacology & Pharmacy

Statin Effects on Exacerbation Rates, Mortality, and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease: A Review of Prospective Studies

Meredith L. Howard et al.

PHARMACOTHERAPY (2016)

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Review Biotechnology & Applied Microbiology

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

Yuri V. Bobryshev et al.

BIOMED RESEARCH INTERNATIONAL (2016)

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Article Respiratory System

Prevalence of comorbidities according to predominant phenotype and severity of chronic obstructive pulmonary disease

Gianna Camiciottoli et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2016)

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Article Multidisciplinary Sciences

Structural and functional characterization of endothelial microparticles released by cigarette smoke

Karina A. Serban et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

The implication of cigarette smoking and cessation on macrophage cholesterol efflux in coronary artery disease patients

Wei Song et al.

JOURNAL OF LIPID RESEARCH (2015)

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Article Oncology

Simvastatin promotes alveolar epithelial cell proliferation and attenuates cigarette smoke-induced emphysema in rats

Shuyue Xia et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Multidisciplinary Sciences

The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research

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SCIENTIFIC REPORTS (2015)

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Article Obstetrics & Gynecology

Impact of smoking on estrogenic efficacy

X. Ruan et al.

CLIMACTERIC (2015)

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Article Cardiac & Cardiovascular Systems

Cigarette smoke condensate affects monocyte interaction with endothelium

I. Giunzioni et al.

ATHEROSCLEROSIS (2014)

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Article Biochemistry & Molecular Biology

Smoking and Atherosclerosis: Mechanisms of Disease and New Therapeutic Approaches

Gerasimos Siasos et al.

CURRENT MEDICINAL CHEMISTRY (2014)

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Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD

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NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Cell Biology

Endogenous Ceramide Contributes to the Transcytosis of oxLDL across Endothelial Cells and Promotes Its Subendothelial Retention in Vascular Wall

Wenjing Li et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

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A study on particles and some microbial markers in waterpipe tobacco smoke

P. Markowicz et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2014)

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Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan

Yasuhiro Yamauchi et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2014)

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Molecular mechanisms that influence the macrophage M1-M2 polarization balance

Nan Wang et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Role of alveolar macrophages in chronic obstructive pulmonary disease

Ross Vlahos et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Monocytes and macrophages: developmental pathways and tissue homeostasis

Florent Ginhoux et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Statin Use and Risk of COPD Exacerbation Requiring Hospitalization

Meng-Ting Wang et al.

AMERICAN JOURNAL OF MEDICINE (2013)

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Cardiovascular Disease in COPD Mechanisms

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CHEST (2013)

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Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy

Benjamin B. Davis et al.

EUROPEAN RESPIRATORY JOURNAL (2013)

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Toxicological effects of cigarette smoke on Ana-1 macrophages in vitro

Fengjiao Yuan et al.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2013)

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Effects of Cigarette Smoking on HDL Quantity and Function: Implications for Atherosclerosis

Bai-mei He et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2013)

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Article Cell Biology

Increased Serum ox-LDL Levels Correlated with Lung Function, Inflammation, and Oxidative Stress in COPD

Yongchun Shen et al.

MEDIATORS OF INFLAMMATION (2013)

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Ceramide Expression and Cell Homeostasis in Chronic Obstructive Pulmonary Disease

Maria C. Scarpa et al.

RESPIRATION (2013)

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Smad3 mediates cigarette smoke extract (CSE) induction of VEGF release by human fetal lung fibroblasts

Maha Farid et al.

TOXICOLOGY LETTERS (2013)

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Macrophages in atherosclerosis: a dynamic balance

Kathryn J. Moore et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Comorbidities and Risk of Mortality in Patients with Chronic Obstructive Pulmonary Disease

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

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Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota

Jane L. Benjamin et al.

INFLAMMATORY BOWEL DISEASES (2012)

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Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS-/- mice and human smokers

J. L. Wright et al.

INHALATION TOXICOLOGY (2012)

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Editorial Material Oncology

Mortality Attributable to Tobacco by Selected Countries Based on the WHO Global Report

Kota Katanoda et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2012)

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Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Chao Cao et al.

PLOS ONE (2012)

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Microbiological components in mainstream and sidestream cigarette smoke

Lennart Larsson et al.

TOBACCO INDUCED DISEASES (2012)

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Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

Rina Takamiya et al.

FEBS OPEN BIO (2012)

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Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice

M. A. Hassan Talukder et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

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Article Critical Care Medicine

The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema

Jeffrey J. Atkinson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Article Critical Care Medicine

Statin Reverses Smoke-induced Pulmonary Hypertension and Prevents Emphysema but Not Airway Remodeling

Joanne L. Wright et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction

Silvia S. Barbieri et al.

CARDIOVASCULAR RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Macrophages in the Pathogenesis of Atherosclerosis

Kathryn J. Moore et al.

CELL (2011)

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Is Atherosclerotic Heart Disease in COPD a Distinct Phenotype?

S. F. Paul Man et al.

CHEST (2011)

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ATP-Binding Cassette Transporters A1 and G1, HDL Metabolism, Cholesterol Efflux, and Inflammation: Important Targets for the Treatment of Atherosclerosis

Dan Ye et al.

CURRENT DRUG TARGETS (2011)

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Phenotypic modulation of macrophages in response to plaque lipids

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CURRENT OPINION IN LIPIDOLOGY (2011)

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TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease

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NATURE (2011)

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Review Biochemistry & Molecular Biology

The role of nitric oxide in prostaglandin biology; update

Sangwon F. Kim

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2011)

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The role of female hormones on lung function in chronic lung diseases

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BMC WOMENS HEALTH (2011)

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Nitric Oxide Synthase Isoenzyme Expression and Activity in Peripheral Lung Tissue of Patients with Chronic Obstructive Pulmonary Disease

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

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Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

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Review Medicine, General & Internal

Systematic review of the evidence relating FEV1 decline to giving up smoking

Peter N. Lee et al.

BMC MEDICINE (2010)

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Increased Risk of Myocardial Infarction and Stroke Following Exacerbation of COPD

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CHEST (2010)

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ATP and the pathogenesis of COPD

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EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

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Defective macrophage phagocytosis of bacteria in COPD

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EUROPEAN RESPIRATORY JOURNAL (2010)

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The cardiopulmonary continuum systemic inflammation as 'common soil' of heart and lung disease

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INTERNATIONAL JOURNAL OF CARDIOLOGY (2010)

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Functional regulation of vascular and platelet activity during thrombosis by nitric oxide and endothelial nitric oxide synthase

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THROMBOSIS AND HAEMOSTASIS (2010)

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Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death

Michal Levy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

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Article Biochemistry & Molecular Biology

The Role of Interleukin-1β in Murine Cigarette Smoke-induced Emphysema and Small Airway Remodeling

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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)

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Nitric oxide and airway epithelial barrier function: Regulation of tight junction proteins and epithelial permeability

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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)

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The Effects of Smoking Cessation on the Risk of Chronic Obstructive Pulmonary Disease Exacerbations

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JOURNAL OF GENERAL INTERNAL MEDICINE (2009)

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Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease

Yuji Higashimoto et al.

RESPIRATORY MEDICINE (2009)

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Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig

Elisabet Ferrer et al.

RESPIRATORY RESEARCH (2009)

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Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

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Article Cardiac & Cardiovascular Systems

Underdiagnosis of myocardial infarction in COPD - Cardiac Infarction Injury Score (CIIS) in patients hospitalised for COPD exacerbation

Pal H. Brekke et al.

RESPIRATORY MEDICINE (2008)

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Association between muscular strength and mortality in men:: prospective cohort study

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BMJ-BRITISH MEDICAL JOURNAL (2008)

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The use of statins and lung function in current and former smokers

Jean I. Keddissi et al.

CHEST (2007)

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Article Biochemistry & Molecular Biology

Smoking alters alveolar macrophage recognition and phagocytic ability

Sandra Hodge et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2007)

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Vascular endothelial growth factor: an angiogenic factor reflecting airway inflammation in healthy smokers and in patients with bronchitis type of chronic obstructive pulmonary disease?

Nikoletta Rovina et al.

RESPIRATORY RESEARCH (2007)

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Review Cardiac & Cardiovascular Systems

Role of Kruppel-like transcription factors in endothelial biology

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CIRCULATION RESEARCH (2007)

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Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke

S. Patrick Nana-Sinkam et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

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Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1β release through a dye uptake-independent pathway

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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Toll-like receptor 4 in atherosclerosis

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2007)

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Toll-like receptor 4 deficiency causes pulmonary emphysema

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JOURNAL OF CLINICAL INVESTIGATION (2006)

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Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD:: morphological impact of VEGFR-2 inhibition

JA Marwick et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)

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Article Respiratory System

Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages

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RESPIRATORY RESEARCH (2006)

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Cytokine and chemokine expression in cigarette smoke-induced lung injury in guinea pigs

S Kubo et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

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Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs

LH Lee et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)

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COPD and incident cardiovascular disease hospitalizations and mortality: Kaiser permanente medical care program

S Sidney et al.

CHEST (2005)

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Cardiovascular morbidity and mortality in COPD

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CHEST (2005)

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Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients

D Droemann et al.

RESPIRATORY RESEARCH (2005)

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Mitochondrial ceramide and the induction of apoptosis

LJ Siskind

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2005)

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Review Pharmacology & Pharmacy

Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors

V Mollace et al.

PHARMACOLOGICAL REVIEWS (2005)

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Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

I Petrache et al.

NATURE MEDICINE (2005)

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Endogenous nitric oxide activation protects against cigarette smoking induced apoptosis in endothelial cells

M Raveendran et al.

FEBS LETTERS (2005)

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Article Biochemistry & Molecular Biology

Regulation of amiloride-sensitive Na+ transport by basal nitric oxide

KA Hardiman et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2004)

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Article Cardiac & Cardiovascular Systems

Flow-dependent regulation of endothelial toll-like receptor 2 expression through inhibition of SP1 activity

S Dunzendorfer et al.

CIRCULATION RESEARCH (2004)

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Article Critical Care Medicine

Early emphysema in patients with anorexia nervosa

HO Coxson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

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Article Critical Care Medicine

Tumor necrosis factor-α drives 70% of cigarette smoke-induced emphysema in the mouse

A Churg et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

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Article Medicine, General & Internal

Mortality in relation to smoking: 50 years' observations on male British doctors

R Doll et al.

BMJ-BRITISH MEDICAL JOURNAL (2004)

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Article Physiology

Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts:: implications for lung inflammation and cancer

CA Martey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)

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Review Cardiac & Cardiovascular Systems

New markers of inflammation and endothelial cell activation - Part I

PE Szmitko et al.

CIRCULATION (2003)

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Article Critical Care Medicine

Enhanced expression of vascular endothelial growth factor in pulmonary arteries of smokers and patients with moderate chronic obstructive pulmonary disease

S Santos et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

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iNOS activity is essential for endothelial stress gene expression protecting against oxidative damage

K Hemmrich et al.

JOURNAL OF APPLIED PHYSIOLOGY (2003)

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TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS

S Zeuke et al.

CARDIOVASCULAR RESEARCH (2002)

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Expression of toll-like receptors in human atherosclerotic lesions - A possible pathway for plaque activation

K Edfeldt et al.

CIRCULATION (2002)

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Smoking diminishes the beneficial effect of statins: Observations from the landmark trials

HJ Milionis et al.

ANGIOLOGY (2001)

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Article Critical Care Medicine

Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema

Y Kasahara et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

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Article Medicine, Research & Experimental

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

Y Kasahara et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

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Review Cell Biology

Lipid rafts and signal transduction

K Simons et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)

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Article Biochemistry & Molecular Biology

Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells

DC Li et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)

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Article Critical Care Medicine

Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways

M Ichinose et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

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Article Critical Care Medicine

The relationship between chronic hypoxemia and activation of the tumor necrosis factor-α system in patients with chronic obstructive pulmonary disease

N Takabatake et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

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Article Critical Care Medicine

Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease - The Lung Health Study

PD Scanlon et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

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