期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms24108573
关键词
SARS-CoV-2; genomic surveillance Spain; laboratory network RELECOV; VOCs; lineages; national QCA; mutation; phylogeny
The Spanish laboratory network for coronavirus (RELECOV) was created to enhance genomic surveillance of SARS-CoV-2 in Spain. Through the development of quality control assessments and the analysis of viral genomes, the network has improved detection, monitoring, and characterization of the virus, contributing to valuable public health surveillance.
Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required to contribute to meaningful surveillance in public health. In this context, the network of Spanish laboratories for coronavirus (RELECOV) was created with the main goal of promoting actions to speed up the detection, analyses, and evaluation of SARS-CoV-2 at a national level, partially structured and financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024). A SARS-CoV-2 sequencing quality control assessment (QCA) was developed to evaluate the network's technical capacity. QCA full panel results showed a lower hit rate for lineage assignment compared to that obtained for variants. Genomic data comprising 48,578 viral genomes were studied and evaluated to monitor SARS-CoV-2. The developed network actions showed a 36% increase in sharing viral sequences. In addition, analysis of lineage/sublineage-defining mutations to track the virus showed characteristic mutation profiles for the Delta and Omicron variants. Further, phylogenetic analyses strongly correlated with different variant clusters, obtaining a robust reference tree. The RELECOV network has made it possible to improve and enhance the genomic surveillance of SARS-CoV-2 in Spain. It has provided and evaluated genomic tools for viral genome monitoring and characterization that make it possible to increase knowledge efficiently and quickly, promoting the genomic surveillance of SARS-CoV-2 in Spain.
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