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Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer's Disease: The Role of Antioxidants in Prevention and Treatment

Gabriela Juszczyk et al.

Summary: Chronic stress leads to oxidative stress in the brain, contributing to depression and AD. Antioxidants play a significant role in treating these diseases, with compounds like curcumin, Vitamin E, and selenium showing promising results for AD treatment, and curcumin, zinc, and selenium demonstrating potential in depression treatment.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial

Barbora Katrencikova et al.

Summary: Oxidative stress is believed to be involved in the pathophysiology of depressive disorder, with markers of oxidative stress increased and antioxidant protection decreased in pediatric and adolescent patients with DD. Supplementation with omega-3 fatty acids has been shown to reduce oxidative stress in these patients, suggesting a potential therapeutic intervention.

ANTIOXIDANTS (2021)

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Article Health Care Sciences & Services

Safflower extract improves depression in mice by inhibiting the TLR4-NLRP3 inflammation signaling pathway

Haofan Chen et al.

Summary: The study demonstrated the potential antidepressant effects of safflower extract in CUMS mice, possibly through its impact on inflammation and the TLR4-NF-kappa B-NLRP3 signaling pathway in the brain.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitive-affective and somatic symptoms

Eleonora Iob et al.

MOLECULAR PSYCHIATRY (2020)

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Article Biochemistry & Molecular Biology

Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions

Hamit Celik et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Review Pharmacology & Pharmacy

A hypothesis of monoamine (5-HT) - Glutamate/GABA long neural circuit: Aiming for fast-onset antidepressant discovery

Yun-Feng Li

PHARMACOLOGY & THERAPEUTICS (2020)

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Review Pharmacology & Pharmacy

Role of oxidative stress in depression

Shvetank Bhatt et al.

DRUG DISCOVERY TODAY (2020)

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Article Pharmacology & Pharmacy

Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC

Ke Fang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Agriculture, Multidisciplinary

Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants

Nian Zhou et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Review Endocrinology & Metabolism

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

Ygor Parladore Silva et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Multidisciplinary Sciences

Pharmacological treatment of depression: A systematic review comparing clinical practice guideline recommendations

Franciele Cordeiro Gabriel et al.

PLOS ONE (2020)

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Article Psychiatry

Symptoms of Major Depressive Disorder and Their Impact on Psychosocial Functioning in the Different Phases of the Disease: Do the Perspectives of Patients and Healthcare Providers Differ?

Michael Cronquist Christensen et al.

FRONTIERS IN PSYCHIATRY (2020)

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Review Psychiatry

Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder

Xiaojun Shao et al.

FRONTIERS IN PSYCHIATRY (2020)

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Review Medicine, Research & Experimental

Isorhamnetin: A review of pharmacological effects

Gang Gong et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Biochemistry & Molecular Biology

Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain-Liver-Gut Axis

Amritpal Singh et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Dominic S. A. Simpson et al.

ANTIOXIDANTS (2020)

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Article Biochemistry & Molecular Biology

Dietary quercetin attenuates depressive-like behaviors by inhibiting astrocyte reactivation in response to stress

Jiajia Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Pharmacology & Pharmacy

Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways

Mennat-Allah M. Hassan et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Review Neurosciences

The Bidirectional Relationship of Depression and Inflammation: Double Trouble

Eleonore Beurel et al.

NEURON (2020)

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Review Biochemistry & Molecular Biology

Neuroprotective Effect of Antioxidants in the Brain

Kyung Hee Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

Luca Colucci-D'Amato et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Unravelling the antimicrobial action of antidepressants on gut commensal microbes

Yasmina Ait Chait et al.

SCIENTIFIC REPORTS (2020)

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Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine

Dengyu Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Multidisciplinary Sciences

Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders

Jian Yang et al.

SCIENCE ADVANCES (2020)

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Review Medicine, General & Internal

Peripheral Markers of Depression

Aleksander Nobis et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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The role of vitamin C in stress-related disorders

Bettina Moritz et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

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Review Integrative & Complementary Medicine

Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

Yasaman Taheri et al.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2020)

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Article Biochemistry & Molecular Biology

Lactobacillus caseiimproves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota

Fang Gu et al.

FOOD & FUNCTION (2020)

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Article Clinical Neurology

Gut Microbiota Regulates Depression-Like Behavior in Rats Through the Neuroendocrine-Immune-Mitochondrial Pathway

Shuhan Liu et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2020)

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Article Neurosciences

The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression

Darren W. Roddy et al.

BIOLOGICAL PSYCHIATRY (2019)

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Article Endocrinology & Metabolism

Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade

Wenqi Gao et al.

METABOLIC BRAIN DISEASE (2019)

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Review Biochemistry & Molecular Biology

Quercetin and Related Chromenone Derivatives as Monoamine Oxidase Inhibitors: Targeting Neurological and Mental Disorders

Priyanka Dhiman et al.

MOLECULES (2019)

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Review Biochemistry & Molecular Biology

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Dong Xu et al.

MOLECULES (2019)

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Article Nutrition & Dietetics

Maternal Flavonoids Intake Reverts Depression-Like Behaviour in Rat Female Offspring

Ana Laura de la Garza et al.

NUTRIENTS (2019)

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Article Psychiatry

Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers in postmenopausal women: a cross-sectional study

Maryam Abshirini et al.

ANNALS OF GENERAL PSYCHIATRY (2019)

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Article Behavioral Sciences

Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury

Morteza Kosari-Nasab et al.

BEHAVIOURAL PHARMACOLOGY (2019)

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Article Endocrinology & Metabolism

Rutin alleviates cadmium-induced neurotoxicity in Wistar rats: involvement of modulation of nucleotide-degrading enzymes and monoamine oxidase

Ganiyu Oboh et al.

METABOLIC BRAIN DISEASE (2019)

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Review Biochemistry & Molecular Biology

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Anju Singh et al.

MOLECULES (2019)

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Review Neurosciences

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

Ronald S. Duman et al.

NEURON (2019)

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Article Medicine, Research & Experimental

Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice

Zhongfei Shen et al.

MEDICAL SCIENCE MONITOR (2019)

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Review Psychiatry

Is the HPA Axis as Target for Depression Outdated, or Is There a New Hope?

Andreas Menke

FRONTIERS IN PSYCHIATRY (2019)

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Review Psychiatry

Cytokine Research in Depression: Principles, Challenges, and Open Questions

Hubertus Himmerich et al.

FRONTIERS IN PSYCHIATRY (2019)

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Article Medicine, Research & Experimental

Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone

Jing Song et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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Review Immunology

The Role of Inflammation in Depression and Fatigue

Chieh-Hsin Lee et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Psychiatry

COX-2 Inhibitors, Aspirin, and Other Potential Anti-Inflammatory Treatments for Psychiatric Disorders

Norbert Mueller

FRONTIERS IN PSYCHIATRY (2019)

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Article Chemistry, Medicinal

Involvement of l-arginine-nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice

Benneth Ben-Azu et al.

DRUG DEVELOPMENT RESEARCH (2019)

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Article Chemistry, Physical

Rutin as promising drug for the treatment of Parkinson's disease: an assessment of MAO-B inhibitory potential by docking, molecular dynamics and DFT studies

Faizul Azam et al.

MOLECULAR SIMULATION (2019)

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Article Biochemistry & Molecular Biology

Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action

Supawadee Daodee et al.

MOLECULES (2019)

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Review Nutrition & Dietetics

Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency

Amit Kumar Singh et al.

NUTRIENTS (2019)

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Review Nutrition & Dietetics

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

Wijdan M. Dabeek et al.

NUTRIENTS (2019)

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Review Biochemistry & Molecular Biology

Linking What We Eat to Our Mood: A Review of Diet, Dietary Antioxidants, and Depression

Qingyi Huang et al.

ANTIOXIDANTS (2019)

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Article Neurosciences

Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-B and IDO-1

Priyansha Choubey et al.

PSYCHOPHARMACOLOGY (2019)

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Article Neurosciences

COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats

Qiqi Song et al.

NEUROPHARMACOLOGY (2019)

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Article Microbiology

GABA-modulating bacteria of the human gut microbiota

Philip Strandwitz et al.

NATURE MICROBIOLOGY (2019)

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Article Biology

Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress

Juying Zhong et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2019)

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Article Chemistry, Medicinal

A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice

Khadeeja Khan et al.

DRUG RESEARCH (2019)

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Review Clinical Neurology

Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

Makoto Naoi et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

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Review Clinical Neurology

Neural basis of major depressive disorder: Beyond monoamine hypothesis

Shuken Boku et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2018)

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Article Biochemistry & Molecular Biology

The Microbiota-Inflammasome Hypothesis of Major Depression

Antonio Inserra et al.

BIOESSAYS (2018)

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Article Biochemistry & Molecular Biology

Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway

Yunyi Dai et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2018)

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Review Neurosciences

Brain structure alterations in depression: Psychoradiological evidence

Fei-Fei Zhang et al.

CNS NEUROSCIENCE & THERAPEUTICS (2018)

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Article Psychiatry

Variation of genes involved in oxidative and nitrosative stresses in depression

Paulina Wigner et al.

EUROPEAN PSYCHIATRY (2018)

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Review Clinical Neurology

Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications

Jordi Olloquequi et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2018)

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Article Neurosciences

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

Daniel Lindqvist et al.

NEUROPSYCHOPHARMACOLOGY (2018)

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Article Neurosciences

Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK

T. H. Wang et al.

NEUROSCIENCE (2018)

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Article Cell Biology

Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers

Elena Alberdi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Chemistry, Medicinal

Ameliorative Effect of Quercetin and Rutin via Modulation o f Hypothalamic-Pituitary-Adrenal Axis and Regulation of Fasting Glucose in Chronic Stress -Induced Prediabetes

Mustajab Quraishi et al.

PHARMACOGNOSY MAGAZINE (2018)

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Review Psychiatry

Copper in depressive disorder: A systematic review and meta-analysis of observational studies

Ni Mengmei et al.

PSYCHIATRY RESEARCH (2018)

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Review Behavioral Sciences

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

Julia K. Gjerstad et al.

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2018)

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Article Biotechnology & Applied Microbiology

Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions

Tomas Herraiz et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Article Neurosciences

TLR4-NF-κB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice

Yihe Wang et al.

NEURAL PLASTICITY (2018)

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Review Neurosciences

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

Josh Allen et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Review Biochemistry & Molecular Biology

13 reasons why the brain is susceptible to oxidative stress

James Nathan Cobley et al.

REDOX BIOLOGY (2018)

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Article Psychiatry

Cerebrospinal fluid monoamine metabolite concentrations in depressive disorder: A meta-analysis of historic evidence

Shintaro Ogawa et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms

Alyssa Moore et al.

MOLECULES (2018)

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Article Endocrinology & Metabolism

Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone

Sara Cristiane Barauna et al.

METABOLIC BRAIN DISEASE (2018)

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Article Multidisciplinary Sciences

Prevalence of Depression in the Community from 30 Countries between 1994 and 2014

Grace Y. Lim et al.

SCIENTIFIC REPORTS (2018)

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Review Biotechnology & Applied Microbiology

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

Soo Liang Ooi et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Article Psychiatry

BDNF Plasma Levels and BDNF Exon IV Promoter Methylation as Predictors for Antidepressant Treatment Response

Klaus Lieb et al.

FRONTIERS IN PSYCHIATRY (2018)

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Review Cell Biology

Polyphenols-gut microbiota interplay and brain neuromodulation

Stefania Filosa et al.

NEURAL REGENERATION RESEARCH (2018)

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Article Medicine, General & Internal

Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study

Md Rabiul Islam et al.

SAGE OPEN MEDICINE (2018)

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Article Psychiatry

C-reactive protein, brain-derived neurotrophic factor, interleukin-2, and stressful life events in drug-naive first-episode and recurrent depression: A cross-sectional study

Jitendra Jeenger et al.

INDIAN JOURNAL OF PSYCHIATRY (2018)

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Review Clinical Neurology

Neuronal connectivity in major depressive disorder: a systematic review

Katharina Helm et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2018)

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Article Neurosciences

Research Paper: Protective Effects of Morin Hydrate on Acute Stress-Induced Behavioral and Biochemical Alterations in Mice

Elizabeth Toyin Olonode et al.

BASIC AND CLINICAL NEUROSCIENCE (2018)

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Review Cell Biology

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity

Przemyslaw Kowianski et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2018)

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Article Neurosciences

Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria

Juan A. Godoy et al.

MOLECULAR NEUROBIOLOGY (2017)

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Review Neurosciences

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

Gerwyn Morris et al.

MOLECULAR NEUROBIOLOGY (2017)

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Article Biochemistry & Molecular Biology

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition

J. Keller et al.

MOLECULAR PSYCHIATRY (2017)

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Review Neurosciences

Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders

Ebrahim Haroon et al.

NEUROPSYCHOPHARMACOLOGY (2017)

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Article Psychiatry

Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder

Qingzhong Wang et al.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2017)

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Article Biochemistry & Molecular Biology

Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice

Yamin Wang et al.

JOURNAL OF NEUROCHEMISTRY (2017)

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Article Neurosciences

Rutin alleviates chronic unpredictable stress-induced behavioral alterations and hippocampal damage in mice

Arun Parashar et al.

NEUROSCIENCE LETTERS (2017)

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Article Psychology, Biological

Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress

Vineet Mehta et al.

PHYSIOLOGY & BEHAVIOR (2017)

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Review Clinical Neurology

The recent progress in animal models of depression

Qingzhong Wang et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2017)

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Article Endocrinology & Metabolism

Oxidative stress, inflammation and treatment response in major depression

Daniel Lindqvist et al.

PSYCHONEUROENDOCRINOLOGY (2017)

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Article Multidisciplinary Sciences

Quercetin metabolism by fecal microbiota from healthy elderly human subjects

Motoi Tamura et al.

PLOS ONE (2017)

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Article Behavioral Sciences

Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice

Erika Meyer et al.

BEHAVIOURAL BRAIN RESEARCH (2017)

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Review Pharmacology & Pharmacy

Oxidative Stress and the Central Nervous System

Samina Salim

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

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Article Pharmacology & Pharmacy

The gut microbiota: A key factor in the therapeutic effects of (poly) phenols

Juan Carlos Espin et al.

BIOCHEMICAL PHARMACOLOGY (2017)

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Article Medicine, Research & Experimental

Neurotoxic effects of silver nanoparticles and the protective role of rutin

Mona M. Ahmed et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Psychiatry

Illness seventy and biomarkers in depression: Using a unidimensional rating scale to examine BDNF

Marco A. Caldieraro et al.

COMPREHENSIVE PSYCHIATRY (2017)

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Article Neurosciences

Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis

Enver Ahmet Demir et al.

ACTA NEUROPSYCHIATRICA (2016)

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Article Nutrition & Dietetics

Estimated intake and major food sources of flavonoids among US adults: changes between 1999-2002 and 2007-2010 in NHANES

Kijoon Kim et al.

EUROPEAN JOURNAL OF NUTRITION (2016)

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Article Neurosciences

Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis

Enver Ahmet Demir et al.

ACTA NEUROPSYCHIATRICA (2016)

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Article Neurosciences

Mitochondrial Dysfunction in Depression

Yashika Bansal et al.

CURRENT NEUROPHARMACOLOGY (2016)

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Review Chemistry, Medicinal

Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine

Seyed Fazel Nabavi et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

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Article Clinical Neurology

Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder

Emiko Aizawa et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

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Review Psychology, Clinical

N-Acetylcysteine in Depressive Symptoms and Functionality: A Systematic Review and Meta-Analysis

Brisa S. Fernandes et al.

JOURNAL OF CLINICAL PSYCHIATRY (2016)

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Article Chemistry, Medicinal

Myricitrin Ameliorates 6-Hydroxydopamine-Induced Dopaminergic Neuronal Loss in the Substantia Nigra of Mouse Brain

Heung Deok Kim et al.

JOURNAL OF MEDICINAL FOOD (2016)

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Review Biochemistry & Molecular Biology

BDNF isoforms: a round trip ticket between neurogenesis and serotonin?

Rocio Beatriz Foltran et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Article Endocrinology & Metabolism

The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice

Xuefeng Yu et al.

METABOLIC BRAIN DISEASE (2016)

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Article Cell Biology

Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease

Matin Ramezani et al.

NEURAL REGENERATION RESEARCH (2016)

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Article Neurosciences

Protective effects of myricetin on chronic stress-induced cognitive deficits

Qi-Min Wang et al.

NEUROREPORT (2016)

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Review Cell Biology

ROS and ROS-Mediated Cellular Signaling

Jixiang Zhang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Psychiatry

Inflammatory cytokines and nuclear factor-kappa B activation in adolescents with bipolar and major depressive disorders

David J. Miklowitz et al.

PSYCHIATRY RESEARCH (2016)

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Article Psychiatry

Evaluation of malondialdehyde, superoxide dismutase and catalase activity and their diagnostic value in drug naive, first episode, non-smoker major depression patients and healthy controls

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PSYCHIATRY RESEARCH (2016)

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Article Psychiatry

Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder

Meng-Chang Tsai et al.

PSYCHIATRY RESEARCH (2016)

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Review Nutrition & Dietetics

Myricetin: A Dietary Molecule with Diverse Biological Activities

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NUTRIENTS (2016)

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Article Medicine, General & Internal

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NATURE REVIEWS DISEASE PRIMERS (2016)

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Article Biochemistry & Molecular Biology

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats

Shuangchan Wu et al.

FOOD & FUNCTION (2016)

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Article Immunology

Altered fecal microbiota composition in patients with major depressive disorder

Haiyin Jiang et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

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Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

Jessica M. Yano et al.

CELL (2015)

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A meta-analysis of changes in brain activity in clinical depression

Susan M. Palmer et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2015)

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Review Immunology

Immune mechanisms linked to depression via oxidative stress and neuroprogression

Nataliia Bakunina et al.

IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress

Zegang Ma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Review Clinical Neurology

Biochemical markers subtyping major depressive disorder

Hiroshi Kunugi et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2015)

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Article Medicine, Research & Experimental

Vitamin C as an adjuvant for treating major depressive disorder and suicidal behavior, a randomized placebo-controlled clinical trial

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TRIALS (2015)

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Review Physiology

Stress, glucocorticoid hormones, and hippocampal neural progenitor cells: implications to mood disorders

Tomoshige Kino

FRONTIERS IN PHYSIOLOGY (2015)

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Blood BDNF Level Is Gender Specific in Severe Depression

Anatoly Kreinin et al.

PLOS ONE (2015)

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A Meta-Analysis of Oxidative Stress Markers in Depression

Tao Liu et al.

PLOS ONE (2015)

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Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis

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Article Psychology, Clinical

The Efficacy of Adjunctive N-Acetylcysteine in Major Depressive Disorder: A Double-Blind, Randomized, Placebo-Controlled Trial

Michael Berk et al.

JOURNAL OF CLINICAL PSYCHIATRY (2014)

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Article Pharmacology & Pharmacy

Quercetin mitigates Adriamycin-induced anxiety- and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats

Sameha Merzoug et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2014)

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Article Geriatrics & Gerontology

Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease

Yannick Vermeiren et al.

NEUROBIOLOGY OF AGING (2014)

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Article Neurosciences

Elevated Monoamine Oxidase A Binding During Major Depressive Episodes Is Associated with Greater Severity and Reversed Neurovegetative Symptoms

Lina Chiuccariello et al.

NEUROPSYCHOPHARMACOLOGY (2014)

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LACK OF BDNF EXPRESSION THROUGH PROMOTER IV DISTURBS EXPRESSION OF MONOAMINE GENES IN THE FRONTAL CORTEX AND HIPPOCAMPUS

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Review Behavioral Sciences

Oxidative & nitrosative stress in depression: Why so much stress?

Steven Moylan et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2014)

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The Different Roles of Glucocorticoids in the Hippocampus and Hypothalamus in Chronic Stress-Induced HPA Axis Hyperactivity

Li-Juan Zhu et al.

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Article Clinical Neurology

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Adrian L. Lopresti et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2014)

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Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes

Ji Hye Yang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

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Review Neurosciences

BDNF signaling and survival of striatal neurons

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FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

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Cellular uptake of quercetin and luteolin and their effects on monoamine oxidase-A in human neuroblastoma SH-SY5Y cells

Yauhen Bandaruk et al.

TOXICOLOGY REPORTS (2014)

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Article Medicine, General & Internal

So depression is an inflammatory disease, but where does the inflammation come from?

Michael Berk et al.

BMC MEDICINE (2013)

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Defective NF-kB Transcription Factor as the Mediator of Inflammatory Responses: A Study on Depressed Iranian Medical Students

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CLINICAL LABORATORY (2013)

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Current Place of Monoamine Oxidase Inhibitors in the Treatment of Depression

Kenneth I. Shulman et al.

CNS DRUGS (2013)

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Diagnostic accuracy of serum brain derived neurotrophic factor concentration in antidepressant naive patients with first major depression episode

Dalibor Karlovic et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2013)

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Article Neurosciences

QUERCETIN SUPPRESS MICROGLIAL NEUROINFLAMMATORY RESPONSE AND INDUCE ANTIDEPRESSENT-LIKE EFFECT IN OLFACTORY BULBECTOMIZED RATS

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NEUROSCIENCE (2013)

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Review Neurosciences

INFLAMMATORY CYTOKINES IN DEPRESSION: NEUROBIOLOGICAL MECHANISMS AND THERAPEUTIC IMPLICATIONS

J. C. Felger et al.

NEUROSCIENCE (2013)

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Article Nutrition & Dietetics

Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study

Mostafa Amr et al.

NUTRITION JOURNAL (2013)

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Article Clinical Neurology

Mitochondrial dysfunction, oxidative stress, and major depressive disorder

Edward H. Tobe

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2013)

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Article Behavioral Sciences

The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system

Linlin Zhen et al.

BEHAVIOURAL BRAIN RESEARCH (2012)

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Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW 264.7 Macrophages

Van Anh Vo et al.

BIOMOLECULES & THERAPEUTICS (2012)

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Article Clinical Neurology

Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD)

Asuka Katsuki et al.

CNS SPECTRUMS (2012)

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Article Psychiatry

Dietary Restrictions and Drug Interactions With Monoamine Oxidase Inhibitors

David A. Flockhart

JOURNAL OF CLINICAL PSYCHIATRY (2012)

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Article Chemistry, Medicinal

Chemical Modification of the Multitarget Neuroprotective Compound Fisetin

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JOURNAL OF MEDICINAL CHEMISTRY (2012)

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Article Biochemistry & Molecular Biology

Neuroprotective Effect of Quercetin Against Hydrogen Peroxide-induced Oxidative Injury in P19 Neurons

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Article Neurosciences

NADPH Oxidase Mediates Depressive Behavior Induced by Chronic Stress in Mice

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JOURNAL OF NEUROSCIENCE (2012)

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Article Neurosciences

RUTIN PREVENTS COGNITIVE IMPAIRMENTS BY AMELIORATING OXIDATIVE STRESS AND NEUROINFLAMMATION IN RAT MODEL OF SPORADIC DEMENTIA OF ALZHEIMER TYPE

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NEUROSCIENCE (2012)

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Review Biology

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse

Jacob P. R. Jacobsen et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2012)

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Article Psychiatry

Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features

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PSYCHIATRY RESEARCH (2012)

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Article Psychiatry

Where in the Brain Is Depression?

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CURRENT PSYCHIATRY REPORTS (2012)

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Article Psychiatry

Role of antioxidants in generalised anxiety disorder and depression

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Indian Journal of Psychiatry (2012)

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Review Psychology, Experimental

The novel object recognition memory: neurobiology, test procedure, and its modifications

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COGNITIVE PROCESSING (2012)

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Article Biochemistry & Molecular Biology

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

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HUMAN MOLECULAR GENETICS (2011)

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Article Biochemistry & Molecular Biology

Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment

M. L. Molendijk et al.

MOLECULAR PSYCHIATRY (2011)

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Review Biochemistry & Molecular Biology

The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?

G. MacQueen et al.

MOLECULAR PSYCHIATRY (2011)

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Article Biochemistry & Molecular Biology

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

C. Anacker et al.

MOLECULAR PSYCHIATRY (2011)

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Article Neurosciences

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

Jonas Hannestad et al.

NEUROPSYCHOPHARMACOLOGY (2011)

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Article Neurosciences

Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells

Namiko Suematsu et al.

NEUROSCIENCE LETTERS (2011)

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Article Plant Sciences

The Anti-Immobility Effect of Hyperoside on the Forced Swimming Test in Rats is Mediated by the D2-Like Receptors Activation

Juliana Schulte Haas et al.

PLANTA MEDICA (2011)

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Review Pharmacology & Pharmacy

Immune system to brain signaling: Neuropsychopharmacological implications

Lucile Capuron et al.

PHARMACOLOGY & THERAPEUTICS (2011)

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Article Multidisciplinary Sciences

Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo

Conor Liston et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Review Clinical Neurology

Glucocorticoids, cytokines and brain abnormalities in depression

Patricia A. Zunszain et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

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Article Medicine, Research & Experimental

Antidepressant-like Effect of Kaempferol and Quercitirin, Isolated fromOpuntia ficus-indicavar.saboten

Soo-Hyun Park et al.

Experimental Neurobiology (2011)

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Article Chemistry, Multidisciplinary

Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo

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ACTA PHARMACOLOGICA SINICA (2010)

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Article Behavioral Sciences

Lack of promoter IV-driven BDNF transcription results in depression-like behavior

K. Sakata et al.

GENES BRAIN AND BEHAVIOR (2010)

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Article Biochemistry & Molecular Biology

Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats

Kyuichi Kawabata et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2010)

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Article Neurosciences

Functional Polymorphism of Cyclooxygenase-2 Gene (G-765C) in Depressive Patients

Piotr Galecki et al.

NEUROPSYCHOBIOLOGY (2010)

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Article Multidisciplinary Sciences

Reversal of hippocampal neuronal maturation by serotonergic antidepressants

Katsunori Kobayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Multidisciplinary Sciences

Distinct 3′UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)

Anthony G. Lau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Multidisciplinary Sciences

Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior

Ja Wook Koo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Review Clinical Neurology

Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice

Pravinkumar Bhutada et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2010)

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Article Psychiatry

Increased xanthine oxidase in the thalamus and putamen in depression

Tanja Maria Michel et al.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2010)

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Article Neurosciences

Structural changes in the hippocampus in major depressive disorder: contributions of disease and treatment

Nikolai V. Malykhin et al.

JOURNAL OF PSYCHIATRY & NEUROSCIENCE (2010)

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Article Neurosciences

Rutin protects the neural damage induced by transient focal ischemia in rats

Mohd. Moshahid Khan et al.

BRAIN RESEARCH (2009)

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Article Cell Biology

Rutin Supplementation in the Diet has Protective Effects Against Toxicant-Induced Hippocampal Injury by Suppression of Microglial Activation and Pro-Inflammatory Cytokines

Tomoko Koda et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2009)

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Article Plant Sciences

Rat electropharmacograms of the flavonoids rutin and quercetin in comparison to those of moclobemide and clinically used reference drugs suggest antidepressive and/or neuroprotective action

Wilfried Dimpfel

PHYTOMEDICINE (2009)

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Article Multidisciplinary Sciences

Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex

Kazuko Sakata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemistry & Molecular Biology

Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression

Hiroyuki Sakakibara et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2008)

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Review Clinical Neurology

Monoamine Oxidase Inhibitors: A Modern Guide to an Unrequited Class of Antidepressants

Stephen M. Stahl et al.

CNS SPECTRUMS (2008)

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Article Pharmacology & Pharmacy

Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice:: Evidence for the involvement of the serotonergic and noradrenergic systems

Daniele G. Machado et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Review Pharmacology & Pharmacy

Health effects of quercetin: From antioxidant to nutraceutical

Agnes W. Boots et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Review Clinical Neurology

A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression

Andre Russowsky Brunoni et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2008)

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Article Chemistry, Medicinal

Antidepressant and antistress activity of GC-MS characterized lipophilic extracts of Ginkgo biloba leaves

Satyan S. Kalkunte et al.

PHYTOTHERAPY RESEARCH (2007)

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Article Biotechnology & Applied Microbiology

Dissecting the human BDNF locus:: Bidirectional transcription, complex splicing, and multiple promoters

Priit Pruunsild et al.

GENOMICS (2007)

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Article Neurosciences

Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus

Christopher S. Rex et al.

JOURNAL OF NEUROSCIENCE (2007)

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Article Clinical Neurology

Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems

Asli Sarandol et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2007)

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Article Psychiatry

Elevated monoamine oxidase A levels in the brain - An explanation for the monoamine imbalance of major depression

Jeffrey H. Meyer et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)

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Article Pharmacology & Pharmacy

Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models

Hiroyuki Sakakibara et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2006)

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Article Multidisciplinary Sciences

Leptin: A potential novel antidepressant

XY Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Psychiatry

Increased serum levels of 8-hydroxy-2 '-deoxyguanosine in clinical depression

MJ Forlenza et al.

PSYCHOSOMATIC MEDICINE (2006)

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Article Endocrinology & Metabolism

Glucocorticoids, depression, and mood disorders: structural remodeling in the brain

BS McEwen

METABOLISM-CLINICAL AND EXPERIMENTAL (2005)

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Review Pharmacology & Pharmacy

Increasing hippocampal neurogenesis: A novel mechanism for antidepressant drugs

JE Malberg et al.

CURRENT PHARMACEUTICAL DESIGN (2005)

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Article Plant Sciences

Flavonoids of St. John's Wort reduce HPA axis function in the rat

V Butterweck et al.

PLANTA MEDICA (2004)

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Article Medicine, General & Internal

The epidemiology of major depressive disorder - Results from the National Comorbidity Survey Replication (NCS-R).

RC Kessler et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

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Article Geriatrics & Gerontology

Hippocampal volume and antidepressant response in geriatric depression

MH Hsieh et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2002)

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Article Neurosciences

Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: Requirement for ERK activation coupled to CREB and upregulation of Arc synthesis

SW Ying et al.

JOURNAL OF NEUROSCIENCE (2002)

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Article Agriculture, Multidisciplinary

Monoamine oxidase B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don

MH Lee et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)

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Review Clinical Neurology

The immune system, depression and the action of antidepressants

BE Leonard

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2001)

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Article Clinical Neurology

Antioxidative enzyme activities and lipid peroxidation in major depression:: alterations by antidepressant treatments

M Bilici et al.

JOURNAL OF AFFECTIVE DISORDERS (2001)

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Article Clinical Neurology

Lower serum vitamin E concentrations in major depression - Another marker of lowered antioxidant defenses in that illness

M Maes et al.

JOURNAL OF AFFECTIVE DISORDERS (2000)

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