4.7 Article

Association between Taxonomic Composition of Gut Microbiota and Host Single Nucleotide Polymorphisms in Crohn's Disease Patients from Russia

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MDPI
DOI: 10.3390/ijms24097998

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Crohn's disease; microbiota; SNP

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Crohn's disease (CD) is a chronic inflammatory bowel disease with unknown causes. Genetic predisposition and imbalanced gut microbiota play important roles in the development of CD. In this study, the composition of gut microbiota and genotypes of 24 single nucleotide polymorphisms (SNP) associated with CD were analyzed. Significant differences were observed in the allele frequencies and gut microbiota composition between CD patients and controls. Two different types of gut microbiota communities were identified in CD patients.
Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease of unknown etiology. Genetic predisposition and dysbiotic gut microbiota are important factors in the pathogenesis of CD. In this study, we analyzed the taxonomic composition of the gut microbiota and genotypes of 24 single nucleotide polymorphisms (SNP) associated with the risk of CD. The studied cohorts included 96 CD patients and 24 healthy volunteers from Russia. Statistically significant differences were found in the allele frequencies for 8 SNPs and taxonomic composition of the gut microbiota in CD patients compared with controls. In addition, two types of gut microbiota communities were identified in CD patients. The main distinguishing driver of bacterial families for the first community type are Bacteroidaceae and unclassified members of the Clostridiales order, and the second type is characterized by increased abundance of Streptococcaceae and Enterobacteriaceae. Differences in the allele frequencies of the rs9858542 (BSN), rs3816769 (STAT3), and rs1793004 (NELL1) were also found between groups of CD patients with different types of microbiota communities. These findings confirm the complex multifactorial nature of CD.

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