☆ 4.7 Review

The Potential of Senescence as a Target for Developing Anticancer Therapy

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biochemistry & Molecular Biology

Cellular senescence: all roads lead to mitochondria

Helene Martini et al.

Summary: The article discusses how the accumulation of senescent cells in multiple tissues leads to tissue dysfunction and age-related diseases, and emphasizes the important role and mechanisms of mitochondria in senescence. It also proposes the establishment of a detailed road map of mitochondrial biology to guide future research on treatments.

FEBS JOURNAL (2023)

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Article Pharmacology & Pharmacy

Extrinsic apoptosis and senescence involved in growth kinetics of seminoma to cisplatin

Yinghao Yin et al.

Summary: This study comprehensively monitored the dynamic changes of TCam-2 cells after cisplatin treatment, and found that cisplatin can induce S-phase arrest, extrinsic apoptosis, and senescence in these cells. Additionally, cisplatin also leads to DNA damage and oxidative stress, indicating its potential role in the treatment of seminoma.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2023)

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Article Geriatrics & Gerontology

Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging

Kento Takaya et al.

Summary: Cellular senescence is characterized by cell cycle arrest and the senescence-associated secretory phenotype (SASP). In this study, the association between cathepsin F (CTSF) and senescence in human fibroblasts and keratinocytes was investigated. The results showed that CTSF expression was elevated in senescence models and CTSF-positive cells were abundant in aged human epidermis and dermis. These findings suggest that CTSF could be a potential therapeutic target for aging fibroblasts and keratinocytes.

GEROSCIENCE (2023)

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Article Biochemistry & Molecular Biology

Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells

Xuhong Fan et al.

Summary: Sirt3 counters DOX-induced cell senescence by promoting autophagic flux.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2023)

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Article Biotechnology & Applied Microbiology

HIF-1α/IL-8 axis in hypoxic macrophages promotes esophageal cancer progression by enhancing PD-L1 expression

Shuai Song et al.

Summary: In this study, the influence of hypoxia-treated tumor-associated macrophages (TAMs) on the malignant phenotypes of esophageal cancer (EC) cells was examined. It was found that hypoxic macrophages contributed to the proliferation, cell cycle progression, and metastasis of EC cells. Additionally, hypoxia treatment accelerated the transformation of macrophages into M2 polarization. The upregulation of interleukin-8 (IL-8) secretion by macrophages after hypoxia treatment was found to be mediated by hypoxia-inducible factor-1 alpha (HIF-1 alpha). IL-8 secreted by hypoxic macrophages further facilitated EC cell proliferation, cell cycle progression, and metastasis by elevating programmed death 1 ligand (PD-L1) expression. The study suggests that the HIF-1 alpha/IL-8 axis in hypoxic macrophages could enhance EC advancement through upregulating PD-L1 expression, providing a novel potential target for EC treatment.

CANCER GENE THERAPY (2023)

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Article Biochemistry & Molecular Biology

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

Irene Fernandez-Duran et al.

Summary: In this study, it was revealed that caspase-4 plays a critical role in cellular senescence, dependent on gasdermin-D and tumor suppressor p53. This pathway is conserved in the cellular response to oncogenic stress.

CELL DEATH AND DIFFERENTIATION (2022)

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Article Oncology

Lung cancer cells expressing a shortened CDK16 3 ' UTR escape senescence through impaired miR-485-5p targeting

Qi Jia et al.

Summary: The study discovered that the expression of CDK16 is regulated by APA and miR-485-5p, making it a potential target for prosenescence therapy for lung cancer.

MOLECULAR ONCOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells

Pallavi Chaturvedi et al.

Summary: This study demonstrates that the immunotherapeutic HCW9218 can enhance the activity of immune cells, reduce TIS tumor cells, and improve the efficacy of docetaxel and gemcitabine plus nab-paclitaxel in the treatment of melanoma and pancreatic tumors. HCW9218 eliminates TIS cancer cells by reducing the immunosuppressive tumor microenvironment and enhancing immune cell infiltration and cytotoxicity, while also reducing side effects caused by chemotherapy.

MOLECULAR THERAPY (2022)

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Article Biochemistry & Molecular Biology

Complete loss of miR-200 family induces EMT associated cellular senescence in gastric cancer

Liang Yu et al.

Summary: The miR-200 family plays a crucial role in maintaining the epithelial phenotype in gastric cancer, but its suppression in late-stage gastric tumors leads to EMT and affects prognosis.

ONCOGENE (2022)

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Article Oncology

Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies

Hanxin Liu et al.

Summary: The tumor microenvironment plays a major role in the malignancy and therapeutic resistance of cancer, with intercellular communication contributing to this process. Immune evasion, extracellular matrix remodeling, and therapy-induced senescence (TIS) all contribute to cancer resistance and disease progression. The senescence-associated secretory phenotype (SASP) of senescent cells drives inflammation and promotes tumor relapse and distant metastasis. selectively removing senescent cells may be a promising strategy to prevent drug resistance associated with the remodelled tumor microenvironment.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Oncology

ATF4-mediated microRNA-145/HDAC4/p53 axis affects resistance of colorectal cancer cells to 5-fluorouracil by regulating autophagy

Lin Zhao et al.

Summary: This study revealed the clinical significance of the ATF4-mediated miR-145/HDAC4/p53 axis in colorectal cancer (CRC). The axis promotes autophagy and chemoresistance in CRC cells by inhibiting miR-145 expression and activating the HDAC4/p53 pathway.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2022)

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Article Dermatology

HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre-Basal Cell Carcinoma through p16 and p53

Xuming Zhu et al.

Summary: The study highlights the crucial roles of HDAC1 and HDAC2 in maintaining proliferation and survival of adult epidermal and basal cell carcinoma progenitors. Deletion of these genes leads to various abnormalities and cell loss, which can be partially rescued by p16 and p53 deletion. Therapeutic efficacy of HDAC1/2 inhibition may depend on the mutational status of p53 and p16.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Biology

Autophagy regulates X-ray radiation-induced premature senescence through STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells

Yu-Ting Tian et al.

Summary: This study found that ionizing radiation can induce premature senescence and autophagy in lung adenocarcinoma cells. Autophagy regulates X-ray radiation-induced premature senescence through the STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

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Article Cell Biology

TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms

Lu Guo et al.

Summary: Alternative splicing (AS) plays a crucial role in the progression of triple-negative breast cancer (TNBC), especially in maintaining the stemness of breast cancer stem cells (BCSCs). The splicing regulator TAR DNA-binding protein-43 (TDP43) and its partner serine-arginine-rich splicing factor 3 (SRSF3) are identified as important factors in regulating CD44 variant AS isoforms (CD44v) and BCSC stemness. Mechanistically, SRSF3 stabilizes TDP43 mRNA by inhibiting nonsense-mediated decay (NMD), thereby maintaining the abundance of CD44v.

CELL DEATH & DISEASE (2022)

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Article Multidisciplinary Sciences

Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis

Yukinari Haraoka et al.

Summary: The study demonstrates that oncogenic cells can be eliminated through oncogene-induced senescence, but this behavior can be altered by a p53 mutation, leading to promotion rather than suppression of tumorigenesis. The findings provide important insights into the initial step of tumor formation.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

A novel 4′-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/STAT3 pathways in non-small-cell lung cancer without any adverse effects in mice

Akash Sabarwal et al.

Summary: The therapeutic toxicity and resistance to currently available treatment options are major challenges in lung cancer management. A novel fisetin analogue, 3b, has shown improved anti-cancer activity against lung cancer cells both in vitro and in vivo, without apparent toxicity, supporting its further development as a potential anti-lung cancer agent.

FASEB JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells

Theodoros Eleftheriadis et al.

Summary: Gliflozins, such as dapagliflozin, can inhibit cell senescence pathways and prevent renal tubular epithelial cell (RPTEC) senescence. High glucose induces oxidative stress and leads to a senescence-associated secretory phenotype. Dapagliflozin reduces glucose consumption and inhibits related pathways, effectively preventing cell senescence. Investigating the effects of gliflozins on cell senescence has potential significance for the treatment of diabetic nephropathy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells

David Rysanek et al.

Summary: The accumulation of senescent cells in tissues is involved in the development of several age-related diseases. This study explores the potential of using BCL-2 inhibitors to eliminate senescent cells and overcome drug resistance. Combining BCL-2 inhibitors shows promising synergistic effects in eliminating senescent cells and may allow for the use of lower doses of drugs.

AGING-US (2022)

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Article Cell Biology

Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts

Yuri Lee et al.

Aging-US (2022)

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Article Cell Biology

Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

Fraser R. Millar et al.

Summary: Targeting Toll-like receptor 2 (TLR2), a key regulator of oncogene-induced senescence, can impede early lung cancer progression by activating cell intrinsic cell cycle arrest pathways and the proinflammatory SASP. This discovery suggests TLR2 as a potential therapeutic target for lung cancer.

CELL REPORTS (2022)

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Article Biochemistry & Molecular Biology

CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma

Monserrat Gerardo-Ramirez et al.

Summary: Osteosarcoma is the most common type of pediatric bone tumor. Research shows that CD44 plays an important role in drug resistance of osteosarcoma cells, and abnormal expression of CD44 leads to molecular alterations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis

Pei-Wei Weng et al.

Summary: Osteoarthritis (OA) is a common disease in older individuals that causes significant social and economic burden. However, there is currently no effective noninvasive treatment for OA. Recent studies have shown that chondrocyte senescence is a key mechanism in the development of OA. GDF15, a protein involved in cellular senescence, is highly expressed in early OA and has been linked to the progression of the disease. Inhibiting GDF15 may slow down the progression of OA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Essential role for STAT3/FOXM1/ATG7 signaling-dependent autophagy in resistance to Icotinib

Xin Lyu et al.

Summary: The resistance to icotinib treatment is associated with the autophagy mechanism induced by the STAT3/FOXM1/ATG7 signaling, providing new insights into the potential clinical value of ATG7-dependent autophagy in icotinib treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Therapy-induced senescence promotes breast cancer cells plasticity by inducing Lipocalin-2 expression

Jorge Morales-Valencia et al.

Summary: Exposure to cytotoxic drugs can lead to the acquisition of aggressive and metastatic properties in cancer cells. The senescence-associated secretory phenotype (SASP) plays a role in this process, but the specific mechanisms involved are poorly understood. This study identifies Lipocalin-2 (LCN2) as a critical regulator of SASP-induced cellular plasticity in breast cancer cells, and suggests that targeting LCN2 may prevent the emergence of aggressive tumors following chemotherapy.

ONCOGENE (2022)

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Article Biochemistry & Molecular Biology

Inhibition of Autophagy Promotes the Elimination of Liver Cancer Stem Cells by CD133 Aptamer-Targeted Delivery of Doxorubicin

Wang Yin et al.

Summary: This study aimed to overcome drug resistance in liver cancer caused by cancer stem cells by using a CD133 aptamer for targeted delivery of Doxorubicin and enhancing the treatment efficacy through autophagy inhibition. The results showed that CD133 aptamer-guided delivery of Doxorubicin resulted in a higher concentration of Doxorubicin in liver cancer stem cells. The combinatorial treatment strategy of CD133 aptamer-Doxorubicin conjugates and an autophagy inhibitor showed a significantly higher elimination of liver cancer stem cells in vitro.

BIOMOLECULES (2022)

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Article Cell Biology

Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage

Dingfu Du et al.

Summary: Using senotherapies such as metformin and dasatinib and quercetin (DQ) can protect the ovaries from damage caused by platinum-based chemotherapy, improving ovarian function, oocyte quality, fertility, as well as reducing fibrosis and DNA damage. The combination of metformin and DQ is more effective than using them individually.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Multidisciplinary Sciences

Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer

Joyce Lee et al.

Summary: This study reveals that TNBCs with elevated MYC expression are resistant to immune checkpoint inhibitor therapy, but this resistance can be overcome by restoring interferon signaling and targeting specific molecules. This finding has important implications for improving the outcomes of patients with TNBC treated with immune checkpoint inhibitors.

NATURE COMMUNICATIONS (2022)

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Article Cell & Tissue Engineering

Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming

Chenxiang Xi et al.

Summary: The METTL3-METTL14 complex plays a crucial role in biological processes. Mettl14 enhances the generation of induced pluripotent stem cells independent of m(6)A and promotes senescence-associated secretory phenotype gene expression.

STEM CELL REPORTS (2022)

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Article Immunology

Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment

Heidi Braumueller et al.

Summary: More than half of colorectal cancer patients develop distant metastasis and up to 48% of patients have peritoneal carcinomatosis. Tumor cells of peritoneal carcinomatosis exhibit senescence and stem cell features. A murine model demonstrated that the peritoneal metastatic site induces senescence and stemness in tumor cells, independent of oncogene activation or therapy. Additionally, senescence-associated secretory phenotype (SASP) factors in peritoneal carcinomatosis lead to immunosenescence in the tumor microenvironment, contributing to the resistance of peritoneal carcinomatosis to current therapies.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263

Ibrahim Y. Abdelgawad et al.

Summary: The research found that DOX-induced senescence demonstrates similar phenotypes between EA.hy926 cells and HUVECs, but they respond differently to ABT-263.

CELLS (2022)

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Article Geriatrics & Gerontology

Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions

Agata Gluchowska et al.

Summary: Atherosclerosis is a common age-related disease characterized by intense immunological activity. Senescent vascular smooth muscle cells (VSMCs) secrete increased number of extracellular vesicles (senEVs) that modulate the cytokine milieu by influencing immune cell activity.

GEROSCIENCE (2022)

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Article Immunology

Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes

Yingze Li et al.

Summary: In the aged and fibrotic left atrium, replicative senescence of atrial fibroblasts (AFs) plays a significant role in the pathogenesis of atrial fibrillation. The downregulation of Ezh2, a histone methyltransferase, is identified as a key regulator of AFs' replicative senescence. This finding may have implications for future treatments of atrial fibrosis in the elderly.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Article Cell Biology

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

Rebeca Uceda-Castro et al.

Summary: Breast cancer brain metastasis (BCBM) is difficult to treat with immunotherapies due to the unique immune landscape of the brain and the "cold" nature of breast cancer. However, inducing senescence in BCBM cells with doxorubicin can improve the efficacy of anti-PD1 immunotherapy by recruiting PD1-expressing T cells to the brain.

CELL REPORTS MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Resolvin E1 attenuates doxorubicin-induced cardiac fibroblast senescence: A key role for IL-1β

Jenaro A. Espitia-Corredor et al.

Summary: Cardiac fibroblasts (CFs) undergo senescence in reaction to different stressors, leading to a poor prognosis of cardiac disease. Doxorubicin (Doxo) induces CFs senescence by triggering IL-1 beta secretion and a potent pro-inflammatory response. However, Resolvin E1 (RvE1), a lipid derivative resolutive mediator, has not been used before to prevent CFs senescence. This study shows that RvE1 can prevent Doxo-induced CFs senescence by reducing IL-1 beta secretion.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

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Article Oncology

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells

Alberta Palazzo et al.

Summary: Cancer cells arising from senescent cells display more aggressive features and resistance to drugs. A molecular signature of these cells can serve as a prognostic marker for several human cancers.

CANCER LETTERS (2022)

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Article Oncology

Hsa-microRNA-370-3p targeting Snail and Twist1 suppresses IL-8/STAT3-driven hepatocellular carcinoma metastasis

Siqi Peng et al.

Summary: In this study, the researchers found that interleukin-8 (IL-8) promotes metastasis and invasion in hepatocellular carcinoma (HCC) by downregulating miR-370-3p expression and activating the STAT3 pathway. MiR-370-3p directly interacts with Snail and Twist1, attenuating the protumoral effects of IL-8 on liver cancer cells. Patients with high levels of miR-370-3p and low levels of IL-8 had longer overall survival, indicating the diagnostic and therapeutic potential of miR-370-3p in HCC metastasis.

CANCER SCIENCE (2022)

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LncRNA FGD5-AS1 potentiates autophagy-associated doxorubicin resistance by regulating the miR-154-5p/WNT5A axis in osteosarcoma

Dan Fei et al.

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CELL BIOLOGY INTERNATIONAL (2022)

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Article Cell Biology

Protective roles of cytoplasmic p21Cip1/Waf1 in senolysis and ferroptosis of lung cancer cells

Akira Koyanagi et al.

Summary: Cytoplasmic p21 protein in therapy-induced lung cancer cells plays a protective role in cell death, mainly by inhibiting cellular senescence and promoting ferroptosis. Loss of p21 protein increases the sensitivity of lung cancer cells to therapy.

CELL PROLIFERATION (2022)

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Article Biochemistry & Molecular Biology

A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways

Nikolay N. Kalitin et al.

Summary: In this study, a series of new indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives were synthesized and the compound LCS1269 demonstrated significant inhibitory effects on tumor growth. LCS1269 exhibited higher antiproliferative activity against human cancer cells and caused cell cycle arrest, intrinsic apoptosis, and senescence initiation. Additionally, LCS1269 modulated multiple signaling pathways involved in cancer cell growth.

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CLINICAL SCIENCE (2022)

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Article Biochemistry & Molecular Biology

RANKL down-regulates the mast cell proliferation through inducing senescence

Jin-Ho Lim et al.

Summary: RANKL regulates mast cell proliferation by inducing cellular senescence, which has significant implications for the control of inflammatory diseases and allergic reactions.

CYTOKINE (2022)

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Article Biochemistry & Molecular Biology

The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells

Xumei Liu et al.

Summary: Small molecule inhibitors of aurora kinases are being investigated for their potential role in cancer treatment. This study focused on the effects of a reversible pan-aurora kinase inhibitor, VX-680, on normal human cells. The researchers found that VX-680 could block cell division and induce cell arrest, but a fraction of normal cells were able to resume proliferation after treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Engrailed homeobox 1 transcriptional regulation of COL22A1 inhibits nasopharyngeal carcinoma cell senescence through the G1/S phase arrest

Mao-Ling Huang et al.

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Medicine, Research & Experimental

Decreased mitophagy aggravates benign prostatic hyperplasia in aged mice through DRP1 and estrogen receptor ?

Geum-Lan Hong et al.

Summary: Benign prostatic hyperplasia (BPH) is an age-related disease with unclear etiology. This study found that mitophagy is reduced during the development of BPH in aging mice, and the downregulation of ERα may play a role in this process.

LIFE SCIENCES (2022)

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Article Cell Biology

Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes

Elisa Bientinesi et al.

Summary: Ageing is a major risk factor for age-related diseases, and targeting senescent cells with nutraceutical compounds like Quercetin could be a promising strategy for cancer treatment. Pre-treatment with Quercetin can alleviate cellular senescence induced by Doxorubicin, reduce senescent cell numbers and decrease the pro-tumour effects on osteosarcoma cells.

MECHANISMS OF AGEING AND DEVELOPMENT (2022)

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Article Biochemistry & Molecular Biology

Upregulation of PD-L1 in Senescence and Aging

Angelique Onorati et al.

Summary: Cellular senescence is associated with upregulation of the immune checkpoint molecule PD-L1, which can be induced in nonsenescent cells by secreted factors released by senescent cells via the JAK-STAT pathway. Targeting PD-L1 may provide new therapeutic opportunities in treating senescence and age-associated diseases.

MOLECULAR AND CELLULAR BIOLOGY (2022)

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Review Oncology

Targeting senescence as an anticancer therapy

Laura Bousset et al.

Summary: Cellular senescence, a stress response triggered by molecular insults, plays paradoxical roles in cancer as it limits cancer progression while also fueling recurrence and metastasis. One-two punch therapies, combining senescence induction and targeted elimination of senescent tumor cells, represent a promising new approach in cancer treatment.

MOLECULAR ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells

Ling Ma et al.

Summary: This study found that Camellia seed cake extract (CSCE) can promote the growth of balding dermal papilla cells (DPCs) and reduce the production of inflammatory factors induced by dihydrotestosterone (DHT). It also exhibits anti-apoptotic and anti-aging effects, reversing the effects of DHT on DPCs. These findings suggest that CSCE may have potential in preventing and alleviating androgenetic alopecia (AGA).

MOLECULES (2022)

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Article Multidisciplinary Sciences

Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes

Teh-Wei Wang et al.

Summary: The accumulation of senescent cells is a major cause of age-related inflammation and diseases. This study reveals that senescent cells heterogeneously express the immune checkpoint protein PD-L1 and that PD-L1(+) cells accumulate with age. PD-L1(-) cells are sensitive to T-cell surveillance, while PD-L1(+) cells are resistant. The expression of PD-L1 correlates with higher levels of SASP.

NATURE (2022)

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Article Biology

The preventive effect of loganin on oxidative stress-induced cellular damage in human keratinocyte HaCaT cells

Cheol Park et al.

Summary: Loganin protects human keratinocytes from oxidative stress-induced cellular damage by inhibiting mitochondrial dysfunction, autophagy, and apoptosis.

BIOSCIENCE TRENDS (2022)

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Article Cell Biology

STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells

Je-Jung Lee et al.

Summary: In this study, the role of PD-L1 in cancer progression and its regulation of cancer prevention were investigated. It was found that PD-L1 depletion induced senescence in cancer cells by strongly inducing STING expression. Nuclear PD-L1 silencing increased STING promoter activity, indicating a negative regulation of STING expression by PD-L1 through transcriptional modulation. Furthermore, PD-L1 was shown to bind to the STING promoter region, directly controlling STING expression to promote cancer growth. Combining PD-L1 silencing with the senescence-inducing chemotherapeutic agent doxorubicin further enhanced the efficacy of PD-L1 targeting.

CELL DEATH & DISEASE (2022)

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Article Cell Biology

The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization

Quanfu Li et al.

Summary: This study identifies a novel role of mucin 1 (MUC1) in promoting mitophagy and maintaining the malignancy of cancer cells. MUC1 interacts with ATPase family AAA domain-containing 3A (ATAD3A) and induces its degradation, resulting in protection of PTEN-induced kinase 1 (Pink1) from ATAD3A-mediated cleavage. Inhibition of mitophagy suppresses MUC1-induced cancer cell activity. The findings provide a new therapeutic approach for MUC1-positive cancers.

CELL DEATH & DISEASE (2022)

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Article Multidisciplinary Sciences

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

Xu Zhang et al.

Summary: The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings suggest that senescent cell clearance could be a strategy to counter aged brain inflammation and cognitive decline. This study reveals the identities of senescent cells in the aged brain and how they exert adverse influence.

NATURE COMMUNICATIONS (2022)

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Review Oncology

HDAC6: A unique HDAC family member as a cancer target

Sumeet Kaur et al.

Summary: HDAC6 is a unique member of the HDAC family that plays important roles in various cellular functions and is associated with carcinogenesis. HDAC6 inhibitors have been shown to enhance the effectiveness of conventional chemotherapeutic drugs, highlighting their significance in cancer treatment.

CELLULAR ONCOLOGY (2022)

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Article Genetics & Heredity

Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence

Xiaoling Cui et al.

Summary: The study introduces a small chemical molecule, HCP1, that inhibits the aging of human dermal fibroblasts. By regulating the AMPK/mTOR signaling pathway and increasing lysosomal activity, HCP1 effectively suppresses cell senescence.

GENES (2022)

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Article Immunology

Extracellular vesicle-associated microRNA-30b-5p activates macrophages through the SIRT1/NF-κB pathway in cell senescence

Yu Xiao et al.

Summary: In our study, we discovered that extracellular vesicles (EVs) play a crucial role in aging, as they can induce chronic inflammation by activating immune cells. We found that EVs derived from senescent cells contain miR-30b-5p, which downregulates SIRT1 and enhances pro-inflammatory cytokine production. Additionally, we observed increased levels of miR-30b-5p in both the aging animal model and EVs harvested from tissues. EVs carrying pro-inflammatory signals can alter immune cell activity in the aging microenvironment, leading to an increase in inflammation.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics

Lea Beltzig et al.

Summary: Research has shown that certain drugs and compounds have a better ability to eliminate senescent cells in GBM cells, which may help improve the outcome of GBM therapy.

CELLS (2022)

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Article Cell Biology

Repeated Administration of Cisplatin Transforms Kidney Fibroblasts through G2/M Arrest and Cellular Senescence

Jia-Bin Yu et al.

Summary: Cisplatin, a chemotherapeutic drug, can cause kidney damage. This study established a clinically relevant model and found that cisplatin can transform kidney fibroblasts into myofibroblasts through G2/M arrest and cellular senescence.

CELLS (2022)

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Article Biology

Autophagy Inhibition Enhances Anti-Glioblastoma Effects of Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors

Sofija Jovanovic Stojanov et al.

Summary: Drug resistance is a major challenge in treating glioblastoma. Autophagy plays a crucial role in drug resistance, and the use of autophagy inhibitors can enhance the effectiveness of targeted therapy. This study shows that two Src tyrosine kinase inhibitors can induce autophagy in glioblastoma cells, and inhibiting autophagy can increase the anticancer effects of these inhibitors.

LIFE-BASEL (2022)

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Article Toxicology

Bortezomib induces cellular senescence in A549 lung cancer cells by stimulating telomere shortening

Lei Wang et al.

Summary: This study found that Bortezomib (BTZ) can induce cellular senescence in non-small cell lung cancer (NSCLC) cells by stimulating telomere shortening, and regulate the expression of key proteins and genes associated with cellular senescence. This provides experimental evidence for the potential clinical application of BTZ in NSCLC treatment.

HUMAN & EXPERIMENTAL TOXICOLOGY (2022)

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Article Biochemistry & Molecular Biology

The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells

Elise Vickridge et al.

Summary: In this study, we identified the BCL11A protein's role in stimulating DNA repair and delaying cellular senescence in triple-negative breast cancer cells.

NAR CANCER (2022)

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Review Endocrinology & Metabolism

Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging

Monica Correa Alfonzo et al.

Summary: Extracellular vesicles (EVs), such as exosomes and microvesicles, play critical roles in cell-cell communication and are associated with healthy aging and age-related diseases. Senescence increases EVs secretion and facilitates the transportation of senescence-associated miRNAs, which are involved in musculoskeletal degeneration with aging. Inhibition of EV-derived, senescence-related miRNAs or increasing levels of competing endogenous long noncoding RNAs may improve musculoskeletal function with aging.

JBMR PLUS (2022)

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Article Materials Science, Biomaterials

Lapatinib- and fulvestrant-PAMAM dendrimer conjugates promote apoptosis in chemotherapy-induced senescent breast cancer cells with different receptor status

Anna Lewinska et al.

Summary: Through conjugation with PAMAM dendrimer, lapatinib and fulvestrant can enhance their cytostatic and cytotoxic effects on breast cancer cells, increase autophagy levels, and promote elimination of doxorubicin-induced senescent breast cancer cells by apoptosis regardless of receptor status. TRDMT1 RNA methyltransferase is involved in this response, and nano-drugs play a role in overcoming drug resistance in breast cancer cells.

BIOMATERIALS ADVANCES (2022)

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Article Multidisciplinary Sciences

Argonaute 2 modulates EGFR-RAS signaling to promote mutant HRAS and NRAS-driven malignancies

Ronald F. Siebenaler et al.

Summary: This study identifies the essential role of the EGFR-AGO2-RAS signaling axis in maintaining mutant HRAS and NRAS-driven malignancies. The interaction between AGO2 and RAS is regulated by EGFR-mediated phosphorylation of Y393-AGO2. Knockdown of AGO2 leads to decreased proliferation and oncogene-induced senescence (OIS) in mutant HRAS/NRAS-driven cells through induction of reactive oxygen species.

PNAS NEXUS (2022)

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Article Chemistry, Multidisciplinary

Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

Ying Zhang et al.

Summary: Oridonin, derived from traditional Chinese medicine, is identified as a novel senolytic that may activate ROS-p38 signaling and induce apoptosis in senescent cells.

CHEMICAL COMMUNICATIONS (2022)

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Article Biology

Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines

Alejandro Urdiciain et al.

Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor with poor prognosis. HDAC6 is overexpressed in GBM and its silencing inhibits proliferation, migration, and clonogenic potential in GBM cell lines, as well as reversing the mesenchymal phenotype, decreasing autophagy, inhibiting the Sonic Hedgehog pathway, and restoring primary cilia expression. These findings suggest HDAC6 may be a promising therapeutic target for GBM treatment.

BIOLOGY-BASEL (2021)

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Article Cell Biology

MicroRNA therapy confers anti-senescent effects on doxorubicin-related cardiotoxicity by intracellular and paracrine signaling

Wenzheng Xia et al.

Aging-US (2021)

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Article Cell Biology

MiR-217 promotes endothelial cell senescence through the SIRT1/p53 signaling pathway

Zhibo Wang et al.

Summary: Studies have shown that miR-217 induces vascular endothelial cell senescence by targeting the SIRT1/p53 signaling pathway, providing a new basis for research in this area.

JOURNAL OF MOLECULAR HISTOLOGY (2021)

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Article Oncology

Circadian clock protein CRY1 prevents paclitaxel-induced senescence of bladder cancer cells by promoting p53 degradation

Min Jia et al.

Summary: Bladder cancer is a common tumor type of the urinary system, and the first-line treatment is cisplatin-based combination chemotherapy, but a significant proportion of patients relapse due to drug resistance. The study found that regulating the circadian protein CRY1 can affect PTX-induced cell senescence, thus preventing the development of cisplatin-resistant bladder cancer cells.

ONCOLOGY REPORTS (2021)

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Article Oncology

Histone deacetylase 6 inhibition in urothelial cancer as a potential new strategy for cancer treatment

Hiroo Kuroki et al.

Summary: This study investigated the role of HDAC6 in urothelial cancer and found that inhibition of HDAC6 decreased cell viability and was associated with PD-L1 expression, suggesting it could be a promising novel approach for the treatment of urothelial cancer.

ONCOLOGY LETTERS (2021)

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Article Chemistry, Multidisciplinary

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

Yong Won Choi et al.

Summary: Senescent tumor cells inhibit infiltration of CD8(+) T cells by secreting CXCL12 and enhancing differentiation of monocytes into M2 macrophages, forming a cytokine barrier to protect nonsenescent tumor cells. Targeting CXCL12 in senescent tumor cells could enhance T cell infiltration and reduce tumor size in CRC, providing a new strategy to overcome immunotherapy resistance.

ADVANCED SCIENCE (2021)

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Article Oncology

Regulatory T cells promote glioma cell stemness through TGF-β-NF-κB-IL6-STAT3 signaling

Shasha Liu et al.

Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

IER2-induced senescence drives melanoma invasion through osteopontin

Lenka Kyjacova et al.

Summary: The sustained expression of IER2 drives melanoma invasion and progression through stimulating osteopontin secretion by inducing senescence in melanoma cells. Coordinate expression of IER2, p53/p21, and osteopontin in melanomas and metastases highlights the pathophysiological relevance of IER2-mediated senescence in melanoma progression.

ONCOGENE (2021)

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Article Multidisciplinary Sciences

Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells

Jieun Woo et al.

Summary: Cellular senescence results in irreversible growth arrest, with a prolonged accumulation in tissues leading to increased detrimental effects. Recent studies suggest that eliminating senescent cells can have beneficial effects on organismal aging and lifespan. Silybum marianum flower extract has been shown to selectively target and eliminate senescent cells through apoptotic mechanisms, offering potential anti-senescence strategies.

PLOS ONE (2021)

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Article Oncology

Doxorubicin-induced senescence promotes stemness and tumorigenicity in EpCAM-/CD133-nonstem cell population in hepatocellular carcinoma cell line, HuH-7

Mustafa Karabicici et al.

Summary: Therapeutic induction of senescence may increase cancer stem cell phenotype, leading to increased tumor aggressiveness and disease recurrence. In liver cancer cells, doxorubicin can induce cellular senescence, increase stem cell gene expression, and cause a shift in stem cell characteristics.

MOLECULAR ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence

Chang Youp Ok et al.

Summary: The study demonstrated that FK866 could inhibit hydrogen peroxide-induced premature senescence of human dental pulp cells by reducing senescence markers and oxidative stress induction, showing potential therapeutic effects in alleviating inflammation and cellular aging in dental pulp.

ANTIOXIDANTS (2021)

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Article Gastroenterology & Hepatology

Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy

Jindan Sheng et al.

Summary: CDK4/6 inhibitors in combination with appropriate kinase inhibitors have the potential to effectively treat a wide range of RB1-intact cancers, including hepatocellular carcinoma. This treatment strategy has shown promising results in preclinical studies and may offer a new therapeutic approach for these malignancies.

HEPATOLOGY (2021)

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Article Cell Biology

COX2 regulates senescence secretome composition and senescence surveillance through PGE2

Susana Goncalves et al.

Summary: COX2 plays a critical role in regulating SASP composition and senescence surveillance during RAS-induced senescence. Its downstream product, prostaglandin E-2 (PGE(2)), is also implicated in tumor suppression and shaping the immune microenvironment during senescence. Loss of COX2 dysregulates immune cells and impairs senescence surveillance in early tumorigenesis.

CELL REPORTS (2021)

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Article Oncology

TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation

Yinghui Shen et al.

Summary: The study identified TET2 as a negative regulator of PD-L1 gene transcription in breast cancer cells, recruiting HDAC1/2 to the PD-L1 promoter to suppress PD-L1 gene expression through deacetylation of H3K27ac. This work provides new insights into the epigenetic mechanisms of immune evasion in breast cancer pathogenesis.

CANCERS (2021)

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Article Cell Biology

HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts

Céline Warnon et al.

Aging-US (2021)

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Article Cell Biology

CopA3 peptide induces permanent cell-cycle arrest in colorectal cancer cells

Debasish Kumar Dey et al.

Summary: CopA3 induces cell-cycle arrest in colorectal cancer cells through a ROS-mediated pathway, leading to inhibition of cell growth and proliferation.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

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Article Biochemistry & Molecular Biology

RAS induced senescence of skin keratinocytes is mediated through Rho-associated protein kinase (ROCK)

Alex J. Lee et al.

Summary: The ROCK signaling pathway plays a critical role in oncogene-induced senescence in skin carcinogenesis, highlighting its importance in counteracting transforming activities.

MOLECULAR CARCINOGENESIS (2021)

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Article Biochemistry & Molecular Biology

Human cell transformation by combined lineage conversion and oncogene expression

Biswajyoti Sahu et al.

Summary: This study demonstrates that a combination of oncogenes characteristic of liver cancer can induce senescence in cells, but reprogramming fibroblasts into liver progenitor cells makes them more sensitive to transformation by the same oncogenes, leading to the development of tumorigenic cells with gene expression signatures of liver cancer. These results highlight the importance of cell lineage and differentiation state in tumorigenesis, providing insights into the role of cell identity in transformation and establishing a paradigm for studying oncogenic drivers in human tumorigenesis.

ONCOGENE (2021)

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Article Cell Biology

One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence

Yingjie Qing et al.

Summary: Wogonin, a natural flavonoid compound, inhibits cell proliferation and induces cellular senescence in T-cell malignancies. It suppresses the transcription activity of hTERT and C-MYC, leading to the inhibition of telomerase activity, and triggers DNA damage in the aging process. Additionally, upregulation of BCL-2 in senescent cells promotes cell survival but can be counteracted by a BCL-2 inhibitor, Navitoclax, enhancing sensitivity to apoptotic cell death.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Multidisciplinary Sciences

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

Wenyu Wang et al.

Summary: The study reveals that in colorectal cancer, cancer-associated fibroblast-activated stromal signaling induces BRD4 phosphorylation, leading to resistance to BET inhibitors. Inhibiting IL6/IL8-JAK2 signaling eliminates BRD4 phosphorylation, sensitizing BET inhibitors against cancer cells.

NATURE COMMUNICATIONS (2021)

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Article Respiratory System

Histone Deacetylase 2 Suppresses Skeletal Muscle Atrophy and Senescence via NF-κB Signaling Pathway in Cigarette Smoke-Induced Mice with Emphysema

Chao Li et al.

Summary: The study found that HDAC2 plays an important role in cigarette smoke-induced skeletal muscle atrophy and senescence, possibly through the NF-kappa B pathway.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2021)

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Article Cell Biology

PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs

Nadiia Lypova et al.

Summary: This study identifies PFKFB3 as a mediator of erlotinib-induced autophagy in NSCLCs and demonstrates that PFKFB3 inhibition sensitizes NSCLCs to erlotinib by impairing autophagy flux. The findings reveal a novel crosstalk between PFKFB3 and EGFR in regulating erlotinib-induced autophagy and contributing to erlotinib sensitivity in NSCLCs.

CELLS (2021)

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Article Cell Biology

Etoposide Triggers Cellular Senescence by Inducing Multiple Centrosomes and Primary Cilia in Adrenocortical Tumor Cells

Yen-Ni Teng et al.

Summary: Etoposide was shown to inhibit adrenocortical tumor cell growth by inducing cellular senescence rather than apoptosis, through markers such as enlarged nuclei, elevated levels of p53 and p21, and upregulation of senescence-associated beta-galactosidase. The drug also induced multiple centrosomes and primary cilia, triggering senescence, and activated DNA-PK-Chk2 signaling pathway to facilitate autophagy, further leading to cellular senescence.

CELLS (2021)

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Review Oncology

Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment Strategies

Anindita Chakrabarty et al.

Summary: This paper focuses on chemotherapy resistance in triple negative breast cancer (TNBC) due to therapy-induced senescence (TIS). Senescent cells and the senescence-associated secretory proteome (SASP) play a role in promoting drug resistance and aggressive clones in cancer. Strategies to control TIS using evolutionary biology principles are proposed to improve therapeutic outcomes for TNBC patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

The CAGE-MiR-181b-5p-S1PR1 Axis Regulates Anticancer Drug Resistance and Autophagy in Gastric Cancer Cells

Minjeong Yeon et al.

Summary: The cancer-associated gene CAGE plays a crucial role in promoting anticancer drug resistance and autophagic flux, while also influencing invasion potential. MiR-181b-5p and S1PR1 may act as negative regulators in controlling the expression of CAGE and autophagic flux.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

Eros Di Giorgio et al.

Summary: The study investigates the regulation of class IIa HDACs in different models of senescence, revealing that HDAC4 is polyubiquitylated and degraded during all types of senescence. HDAC4 selectively binds and monitors H3K27ac levels at specific enhancers and super-enhancers, which are also monitored by AP-1/p300. Deletion of HDAC4 in transformed cells leads to the re-emergence of senescence and the activation of the AP-1/p300 epigenetic program.

GENOME BIOLOGY (2021)

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Article Materials Science, Biomaterials

A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels

Joris Pauty et al.

Summary: Aging of human tissues leads to organ dysfunction and disease. Senescent fibroblasts alter the extracellular matrix and induce angiogenesis, affecting aging and cancer research. The tissue model-on-a-chip provides a useful tool to study these changes and potential inhibitors.

BIOMATERIALS SCIENCE (2021)

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Article Biochemistry & Molecular Biology

4-phenylbutyric acid promotes migration of gastric cancer cells by histone deacetylase inhibition-mediated IL-8 upregulation

Xiaonan Shi et al.

EPIGENETICS (2020)

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Article Cell Biology

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Maria Grazia Vizioli et al.

GENES & DEVELOPMENT (2020)

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Article Cell Biology

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

Emanuela Mensa et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Biochemistry & Molecular Biology

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Marcus Ruscetti et al.

CELL (2020)

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Article Cell Biology

Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy

Norihiko Sasaki et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Biochemistry & Molecular Biology

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

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Article Oncology

Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma

Wen-Bin Yang et al.

NEURO-ONCOLOGY (2020)

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Article Oncology

Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome

Hiroshi Kikuchi et al.

CANCER RESEARCH (2020)

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Article Oncology

HDAC6 Plays a Noncanonical Role in the Regulation of Antitumor Immune Responses, Dissemination, and Invasiveness of Breast Cancer

Debarati Banik et al.

CANCER RESEARCH (2020)

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Review Cell Biology

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives

Mir Mohd Faheem et al.

CELL DEATH DISCOVERY (2020)

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Article Neurosciences

Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development

Ji-ye Kim et al.

MOLECULAR BRAIN (2020)

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Article Multidisciplinary Sciences

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Jasper Iske et al.

NATURE COMMUNICATIONS (2020)

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Article Immunology

Stress-induced premature senescence activated by the SENEXgene mediates apoptosis resistance of diffuse large B-cell lymphoma via promoting immunosuppressive cells and cytokines

Jiyu Wang et al.

IMMUNITY INFLAMMATION AND DISEASE (2020)

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Editorial Material Oncology

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

Tareq Saleh et al.

CANCER RESEARCH (2019)

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Article Cell Biology

Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment

Jordan Guillon et al.

CELL DEATH & DISEASE (2019)

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Article Cell Biology

Panobinostat (LBH589) inhibits Wnt/β-catenin signaling pathway via upregulating APCL expression in breast cancer

Ge Qin et al.

CELLULAR SIGNALLING (2019)

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Article Biochemistry & Molecular Biology

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

James Chapman et al.

FEBS LETTERS (2019)

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Article Multidisciplinary Sciences

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

Hubert Fleury et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

Michela Borghesan et al.

CELL REPORTS (2019)

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Article Multidisciplinary Sciences

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Priya Hari et al.

SCIENCE ADVANCES (2019)

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Article Cell Biology

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression

Qixia Xu et al.

AGING CELL (2019)

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Article Cell Biology

Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma

Xiang Lu Ji et al.

AGING-US (2019)

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Article Biochemistry & Molecular Biology

Cellular senescence is associated with reorganization of the microtubule cytoskeleton

Ossama Moujaber et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Review Physiology

Cellular senescence in the lung across the age spectrum

Pavan Parikh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4-and HIF-1α-mediated regulation of apoptosis and autophagy

Xiaofei Zhang et al.

THERANOSTICS (2019)

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Review Oncology

Unmasking senescence: context-dependent effects of SASP in cancer

Douglas V. Faget et al.

NATURE REVIEWS CANCER (2019)

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Article Multidisciplinary Sciences

Senescence-associated reprogramming promotes cancer stemness

Maja Milanovic et al.

NATURE (2018)

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Article Biochemistry & Molecular Biology

2,4-Di-tert-butylphenol, a potential HDAC6 inhibitor, induces senescence and mitotic catastrophe in human gastric adenocarcinoma AGS cells

Yeon Woo Song et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

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Article Medicine, Research & Experimental

Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-κB signaling pathway

Xian Cheng et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Oncology

Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells

Bo Chen et al.

JOURNAL OF CANCER (2018)

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Article Oncology

Autophagy Governs Protumorigenic Effects of Mitotic Slippage-induced Senescence

Rekha Jakhar et al.

MOLECULAR CANCER RESEARCH (2018)

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Article Oncology

Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression

Sawako Miyoshi et al.

ANTICANCER RESEARCH (2018)

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Article Oncology

Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53-dependent senescence and favors cell transformation

Harikrishnareddy Paluvai et al.

MOLECULAR ONCOLOGY (2018)

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Article Oncology

CAGE Binds to Beclin1, Regulates Autophagic Flux and CAGE-Derived Peptide Confers Sensitivity to Anti-cancer Drugs in Non-small Cell Lung Cancer Cells

Minjeong Yeon et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation

Audrey Lafargue et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Cell Biology

Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts

Anna Lewinska et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

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Article Oncology

The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3β and decreasing the expression of cyclinD1

Youngmi Kim et al.

ONCOTARGET (2017)

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Article Multidisciplinary Sciences

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

Leleesha Samaraweera et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

Christopher D. Wiley et al.

AGING CELL (2017)

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Article Biochemistry & Molecular Biology

Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling

Petra Grbcic et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

CELL (2017)

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Article Oncology

Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity

Qian Tan et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)

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Article Cell Biology

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts

Tasnuva D. Kabir et al.

AGING-US (2016)

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Article Oncology

Autophagy is associated with chemoresistance in neuroblastoma

Assila Belounis et al.

BMC CANCER (2016)

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Article Cell Biology

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Christopher D. Wiley et al.

CELL METABOLISM (2016)

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Article Biochemistry & Molecular Biology

Mitochondria are required for pro-ageing features of the senescent phenotype

Clara Correia-Melo et al.

EMBO JOURNAL (2016)

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Review Biochemistry & Molecular Biology

Do DNA Double-Strand Breaks Drive Aging?

Ryan R. White et al.

MOLECULAR CELL (2016)

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Article Multidisciplinary Sciences

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker et al.

NATURE (2016)

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Article Oncology

Mechanisms of skin aging induced by EGFR inhibitors

Peter Arne Gerber et al.

SUPPORTIVE CARE IN CANCER (2016)

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Article Multidisciplinary Sciences

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Megan K. Ruhland et al.

NATURE COMMUNICATIONS (2016)

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Article Oncology

Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression

Qun Wang et al.

ONCOTARGET (2016)

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Article Oncology

Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling

Shun Li et al.

TUMOR BIOLOGY (2015)

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Article Oncology

Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells

Anna E. Vilgelm et al.

CANCER RESEARCH (2015)

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Article Multidisciplinary Sciences

High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy

Tzu-Ching Chang et al.

PLOS ONE (2015)

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Article Hematology

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a-and Arf-independent manner

Lijian Shao et al.

BLOOD (2014)

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Article Oncology

Is Reliance on Mitochondrial Respiration a Chink in the Armor of Therapy-Resistant Cancer?

Dieter A. Wolf

CANCER CELL (2014)

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Review Physiology

Aging, Cellular Senescence, and Cancer

Judith Campisi

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

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Article Medicine, Research & Experimental

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-?B impairs this drug-induced senescence

Yan Liu et al.

EMBO MOLECULAR MEDICINE (2013)

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Article Biochemistry & Molecular Biology

HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity

Gang Ding et al.

FEBS LETTERS (2013)

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Article Biochemistry & Molecular Biology

miR-200b and Cancer/Testis Antigen CAGE Form a Feedback Loop to Regulate the Invasion and Tumorigenic and Angiogenic Responses of a Cancer Cell Line to Microtubule-targeting Drugs

Youngmi Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Oncology

HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS

Moon Hee Yang et al.

MOLECULAR CANCER RESEARCH (2013)

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Article Multidisciplinary Sciences

T-helper-1-cell cytokines drive cancer into senescence

Heidi Braumueller et al.

NATURE (2013)

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Article Multidisciplinary Sciences

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

Jan R. Doerr et al.

NATURE (2013)

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Article Biochemistry & Molecular Biology

SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells

C. Canino et al.

ONCOGENE (2012)

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Article Cell Biology

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells

J. Cahu et al.

CELL DEATH & DISEASE (2012)

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Article Urology & Nephrology

miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes

Xue-Yuan Bai et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

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Article Multidisciplinary Sciences

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Tae-Won Kang et al.

NATURE (2011)

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Article Oncology

miR-335 Directly Targets Rb1 (pRb/p105) in a Proximal Connection to p53-Dependent Stress Response

Michele Scarola et al.

CANCER RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Cancer/Testis Antigen CAGE Exerts Negative Regulation on p53 Expression through HDAC2 and Confers Resistance to Anti-cancer Drugs

Youngmi Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Review Oncology

Therapy-Induced Senescence in Cancer

Jonathan A. Ewald et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

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Article Cell Biology

Senescence impairs successful reprogramming to pluripotent stem cells

Ana Banito et al.

GENES & DEVELOPMENT (2009)

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Article Cell Biology

Autophagy mediates the mitotic senescence transition

Andrew R. J. Young et al.

GENES & DEVELOPMENT (2009)

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Article Cell Biology

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Francis Rodier et al.

NATURE CELL BIOLOGY (2009)

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Review Multidisciplinary Sciences

Autophagy fights disease through cellular self-digestion

Noboru Mizushima et al.

NATURE (2008)

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Article Biochemistry & Molecular Biology

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Jean-Philippe Coppe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Oncology

Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers

RS Roberson et al.

CANCER RESEARCH (2005)

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Article Biochemistry & Molecular Biology

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

CA Schmitt et al.

CELL (2002)

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