Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the extracellular matrix and the basement membrane. Thus, these enzymes regulate airway remodeling, which is a major pathological feature of chronic obstructive pulmonary disease (COPD). Furthermore, proteolytic destruction in the lungs may lead to loss of elastin and the development of emphysema, which is associated with poor lung function in COPD patients. In this literature review, we describe and appraise evidence from the recent literature regarding the role of different MMPs in COPD, as well as how their activity is regulated by specific tissue inhibitors. Considering the importance of MMPs in COPD pathogenesis, we also discuss MMPs as potential targets for therapeutic intervention in COPD and present evidence from recent clinical trials in this regard.

Automated summary

Matrix metalloproteinases (MMPs) are proteolytic enzymes that regulate airway remodeling and may contribute to the development of emphysema in chronic obstructive pulmonary disease (COPD). This literature review examines the role of different MMPs in COPD, their regulation by tissue inhibitors, and the potential therapeutic targeting of MMPs in COPD. Recent clinical trials supporting this approach are also discussed.