☆ 4.7 Review

New Insight into the Molecular Pathomechanism and Immunomodulatory Treatments of Hidradenitis Suppurativa

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Dermatology

Ustekinumab in the treatment of patients with hidradenitis suppurativa: multicenter case series and systematic review

T. Montero-Vilchez et al.

Summary: Ustekinumab may be an effective and safe option for patients with HS who do not respond to first-line therapies, as most patients showed improvement in symptoms and disease severity after treatment with ustekinumab, and no severe ustekinumab-related adverse events were reported.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Review Dermatology

Off-Label studies on anakinra in dermatology: a review

Kyle Tegtmeyer et al.

Summary: Anakinra shows potential efficacy in treating difficult-to-treat dermatologic diseases, with strong evidence for hidradenitis suppurativa, Bechet's disease, Muckle-Wells syndrome, and SAPHO syndrome. Case reports and case series data support its use in other dermatologic conditions. However, further research is needed to clarify its therapeutic role.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Letter Dermatology

Effectiveness of ustekinumab for moderate-to-severe hidradenitis suppurativa: a case series

Sandra Valenzuela-Ubina et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Letter Dermatology

Alexandrite laser as an adjuvant therapy in the management of mild to moderate hidradenitis suppurativa: A controlled prospective clinical study

Elisa Molinelli et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Dermatology

Primary alterations during the development of hidradenitis suppurativa

Z. Dajnoki et al.

Summary: The study systematically investigated inflammatory molecules involved in three stages of HS pathogenesis, revealing that epidermal changes were already detectable in non-lesional HS skin, while inflammatory reactions were more prominent in lesional HS skin.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Dermatology

An Anti-Interleukin-17A Monoclonal Antibody, Ixekizumab, in the Treatment of Resistant Hidradenitis Suppurativa: A Case Series

Pelin Esme et al.

Summary: Ixekizumab may be an effective treatment option for challenging cases of hidradenitis suppurativa, leading to improvement in symptoms within a short period of time.

SKIN APPENDAGE DISORDERS (2022)

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Letter Dermatology

International consensus definition of disease flare in hidradenitis suppurativa

Tessa M. LeWitt et al.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Dermatology

Efficacy and safety of topical resorcinol 15% versus topical clindamycin 1% in the management of mild-to-moderate hidradenitis suppurativa: A retrospective study

Elisa Molinelli et al.

Summary: Topical and systemic antibiotic therapy is the preferred treatment for mild-to-moderate hidradenitis suppurativa (HS), but antibiotic resistance in HS is becoming a concern. This study compared the efficacy of topical clindamycin and resorcinol in HS treatment and found that resorcinol can be a potential alternative to clindamycin, reducing antibiotic use and antimicrobial resistance.

DERMATOLOGIC THERAPY (2022)

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Article Biochemistry & Molecular Biology

Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions

Kacey L. Sachen et al.

Summary: This review highlights the cellular source of IL-36 cytokines, the effects of IL-36 signaling across cell types, and the association of IL-36 with a spectrum of inflammatory skin diseases.

CYTOKINE (2022)

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Article Medicine, General & Internal

The Prevalence of Periodontitis and Assessment of Oral Micro-Biota in Patients with Hidradenitis Suppurativa: A Descriptive Cross-Sectional Study

Beata Jastrzab et al.

Summary: This study found a significantly higher prevalence of periodontitis in hidradenitis suppurativa (HS) patients, and the frequency of periodontal pathogens was also higher in HS patients, suggesting a possible connection between periodontitis and the development of HS.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Infectious Diseases

The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa

Elisa Molinelli et al.

Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas in specific areas. Management is challenging, with systemic antibiotics, immunosuppressors, and biologic agents as main treatments. Dalbavancin appears to be an effective supportive therapy for selected patients with HS.

ANTIBIOTICS-BASEL (2022)

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Article Medicine, General & Internal

Impact of Hidradenitis Suppurativa Surgical Treatment on Health-Related Life Quality

Marcin Gierek et al.

Summary: This study assessed the quality of life before and after surgical treatment in patients with hidradenitis suppurativa. The results showed that surgical treatment significantly improved the patients' quality of life.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

IL-1 Family Cytokines in Inflammatory Dermatoses: Pathogenetic Role and Potential Therapeutic Implications

Helena Iznardo et al.

Summary: The IL-1 family plays a crucial role in regulating the innate immune system and its dysregulation is associated with inflammatory skin diseases. Targeting IL-1 pathways through therapeutic approaches shows promising results in improving these conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Allergy

Hidradenitis suppurativa: bacteriological study in surgical treatment

Marcin Gierek et al.

Summary: This study aimed to assess the bacteriological profile of HS before surgical treatment. The results showed that the most common bacteria in HS lesions were Staphylococcus aureus and Proteus mirabilis. Some patients were found to have multi-drug-resistant bacteria.

POSTEPY DERMATOLOGII I ALERGOLOGII (2022)

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Article Biotechnology & Applied Microbiology

Co-Graft of Acellular Dermal Matrix and Split Thickness Skin Graft-A New Reconstructive Surgical Method in the Treatment of Hidradenitis Suppurativa

Marcin Gierek et al.

Summary: Hidradenitis suppurativa is a chronic disease that seriously affects patients' quality of life. This paper presents a new reconstructive surgical method using acellular dermal matrix and split thickness skin graft as a co-graft for wound closure after wide excisions in hidradenitis suppurativa surgery. The initial results are promising and show positive clinical impact.

BIOENGINEERING-BASEL (2022)

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Article Dermatology

Guselkumab in the treatment of concomitant hidradenitis suppurativa, psoriasis, and Crohn's disease

Hannah S. Berman et al.

Summary: The case report describes a 28-year-old woman with HS, psoriasis, and CD, who was successfully treated with guselkumab after failing multiple other biologic agents. Guselkumab represents a promising therapeutic option for recalcitrant HS patients with inflammatory comorbidities in which IL-23 plays a role.

JOURNAL OF DERMATOLOGICAL TREATMENT (2021)

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Article Dermatology

A Comparison of International Management Guidelines for Hidradenitis Suppurativa

Aleksi J. Hendricks et al.

Summary: This study compares and synthesizes international guidelines for the treatment of hidradenitis suppurativa (HS), finding significant overlaps in treatment recommendations. This can help to promote communication and consensus formation among different organizations.

DERMATOLOGY (2021)

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Article Dermatology

Evidence for a 'window of opportunity' in hidradenitis suppurativa treated with adalimumab: a retrospective, real-life multicentre cohort study

A. V. Marzano et al.

Summary: This study highlights the importance of early use of adalimumab in the treatment of HS, with a significant correlation between therapeutic delay and lack of clinical response at week 16. The efficacy and safety of adalimumab were confirmed, along with improvements in patients' quality of life. Previous use of immunosuppressants could negatively impact response to adalimumab.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Dermatology

Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life

T. Nguyen et al.

Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs patients' quality of life. Patients with HS often experience significant diagnostic delays and the symptoms can lead to a decrease in quality of life.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Letter Dermatology

MABp1 targeting interleukin-1α in hidradenitis suppurativa ineligible for adalimumab treatment: results of the open-label extension period

T. Kanni et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2021)

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Article Dermatology

Lymecycline vs. clindamycin plus rifampicin in hidradenitis suppurativa treatment: clinical and ultrasonography evaluation

R. D. Caposiena Caro et al.

Summary: Both lymecycline monotherapy and clindamycin plus rifampicin combination are effective treatments for moderate-severe HS. Nodular-type HS tends to respond better to lymecycline, while abscess/tunnel type HS appears to respond better to clindamycin plus rifampicin. Both groups showed significant improvements in IHS4, pain VAS, and DLQI from baseline, with a more marked improvement in Group A.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2021)

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Article Infectious Diseases

Irrelevance of Panton-Valentine leukocidin in hidradenitis suppurativa: results from a pilot, observational study

Monica Corazza et al.

Summary: The study findings suggest that Panton-Valentine leukocidin (PVL) produced by Staphylococcus aureus does not play a pathogenetic role in Hidradenitis suppurativa (HS), indicating that PVL may not be a potential target for future HS treatments.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Article Dermatology

Doppler ultrasound-based noninvasive biomarkers in hidradenitis suppurativa: evaluation of analytical and clinical validity

D. Grand et al.

Summary: This study evaluated the analytical and clinical validity of sonographic epidermal thickness, Doppler ultrasound, and dermal tunnel diameter in patients with hidradenitis suppurativa (HS). Sonographic epidermal thickness and dermal tunnel diameter showed high analytical validity in assessing HS lesions. Power Doppler intensity demonstrated significant correlation with clinical measures of disease activity, suggesting it is a valid imaging-based biomarker in HS.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Letter Dermatology

Weekly administration of brodalumab in hidradenitis suppurativa: an open-label cohort study

J. W. Frew et al.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Dermatology

Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils

S. Narla et al.

Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by painful nodules and abscesses, with neutrophil recruitment playing a crucial role in its development. Pharmacological manipulation of neutrophil recruitment pathways could help control the disease and achieve remission.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

Activity and components of the granulocyte colony-stimulating factor pathway in hidradenitis suppurativa

K. Wolk et al.

Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

Vascularization and fibrosis are important ultrasonographic tools for assessing response to adalimumab in hidradenitis suppurativa: Prospective study of 32 patients

Gianluca Nazzaro et al.

Summary: This study confirms the efficacy of adalimumab in the treatment of Hidradenitis suppurativa (HS) and highlights the importance of ultrasound and Color Doppler in assessing vascularization and fibrosis.

DERMATOLOGIC THERAPY (2021)

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Review Biochemistry & Molecular Biology

Angiogenesis in Chronic Inflammatory Skin Disorders

Hyun Ji Lee et al.

Summary: Angiogenesis plays a critical role in chronic inflammatory skin diseases such as psoriasis, atopic dermatitis, and rosacea. Key angiogenetic factors including VEGF, angiopoietins, and various cytokines are involved in the pathogenesis of these skin disorders. Inhibition of angiogenesis may be a promising strategy for treating chronic, inflammatory skin conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Dermatology

Long-standing refractory hidradenitis suppurativa responded to a brodalumab monotherapy in a patient with psoriasis: A possible involvement of Th17 across the spectrum of both diseases

Yasuyuki Yoshida et al.

Summary: HS is a chronic inflammatory skin disease with unclear etiopathology, but recent developments in targeting cytokines have led to the exploration of biologic therapies. A 47-year-old Japanese man successfully used brodalumab, an IL-17 receptor antagonist, to treat HS and psoriasis in the first reported case of its kind.

JOURNAL OF DERMATOLOGY (2021)

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Letter Dermatology

Effectiveness of Secukinumab in the treatment of moderate-severe hidradenitis suppurativa: results from an Italian multicentric retrospective study in a real-life setting

S. Ribero et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Letter Dermatology

Tildrakizumab as a potential long-term therapeutic agent for severe Hidradenitis Suppurativa: A 15 months experience of an Australian institution

Yonatan Kok et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2021)

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Review Pharmacology & Pharmacy

A safety review of biologic therapies for the management of hidradenitis suppurativa and unmet needs

Zachary E. Holcomb et al.

Summary: Existing data support excellent short-term and long-term safety profiles for adalimumab, although caution must be taken with use in high-risk patient populations, including those with chronic infections or increased risk of malignancy. Based on their safety data for other indications, additional biologic agents appear safe in HS as well. However, further research is needed to fully understand the safety profiles of these medications in the HS population.

EXPERT OPINION ON DRUG SAFETY (2021)

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Article Medicine, General & Internal

Lymph Node Involvement in Axillary Hidradenitis Suppurativa: A Clinical, Ultrasonographic and Bacteriological Study Conducted during Radical Surgery

Silvia Vaienti et al.

Summary: The study aimed to evaluate the nodal involvement in patients with axillary hidradenitis suppurativa, but definitive conclusions could not be drawn due to the limited number of patients. Further studies are needed to confirm the preliminary results.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Serum high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin (IL)-1β, IL-17A and IL-23 levels in patients with hidradenitis suppurativa

Gonca Sarac Ozturk et al.

Summary: This study evaluated serum levels of proinflammatory cytokines and hs-CRP in HS patients, finding hs-CRP to be an indicator of treatment response and systemic inflammation. However, there is insufficient data to suggest TNF-α, IL-1β, IL-17A, and IL-23 as serum biomarkers in HS.

CYTOKINE (2021)

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Review Pharmacology & Pharmacy

Clinical Implementation of Biologics and Small Molecules in the Treatment of Hidradenitis Suppurativa

Pim Aarts et al.

Summary: Hidradenitis suppurativa is a chronic autoimmune skin disease characterized by inflammatory nodules and abscesses due to the upregulation of various immune cells and pro-inflammatory cytokines. While adalimumab is currently the only approved drug for HS, other biologics and small molecules targeting different inflammatory pathways are being researched and utilized.

DRUGS (2021)

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Article Dermatology

Efficacy and Safety of Bimekizumab in Moderate to Severe Hidradenitis Suppurativa A Phase 2, Double-blind, Placebo-Controlled Randomized Clinical Trial

Sophie Glatt et al.

Summary: In this study, bimekizumab showed clinically meaningful improvements in patients with moderate to severe HS, demonstrating greater efficacy compared to placebo. The safety profile of bimekizumab was consistent with previous studies, supporting further evaluation for HS treatment.

JAMA DERMATOLOGY (2021)

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Article Surgery

Efficacy and Safety of Adalimumab in Conjunction With Surgery in Moderate to Severe Hidradenitis Suppurativa The SHARPS Randomized Clinical Trial

Falk G. Bechara et al.

Summary: The study investigated the efficacy and safety of adalimumab in combination with surgery for hidradenitis suppurativa, showing that adalimumab can improve clinical response by 14% across all body regions postoperatively. There was no increased risk of adverse events such as infection, complication, or hemorrhage with adalimumab compared to placebo after surgery.

JAMA SURGERY (2021)

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Review Cell Biology

Hidradenitis Suppurativa: Where We Are and Where We Are Going

Emanuele Scala et al.

Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. The pathogenesis involves follicular occlusion, immune responses, and results in an inflammatory vicious circle. Therapeutic approaches are limited, often requiring surgical interventions, presenting a challenge in treating this debilitating disease.

CELLS (2021)

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Article Dermatology

Decreased Serum Level of Interleukin-22 Correlates with Hepcidin in Patients with Hidradenitis Suppurativa

Malgorzata Ponikowska et al.

Summary: Patients with HS showed decreased levels of serum IL-22, which were not correlated with pro-inflammatory status or disease severity, but were modestly correlated with serum hepcidin levels.

ACTA DERMATO-VENEREOLOGICA (2021)

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Review Dermatology

Guselkumab: an anti-IL-23 antibody for the treatment of moderate-to-severe plaque psoriasis

Andrea Chiricozzi et al.

Summary: Guselkumab, a fully human monoclonal antibody, has been approved for the treatment of moderate-to-severe plaque psoriasis in adults by selectively inhibiting the p19 subunit of interleukin 23. Clinical trials have shown that it maintains high levels of clinical response over three years, regardless of patient characteristics, with a favorable safety profile.

EUROPEAN JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

Rapid Response to Certolizumab Pegol in Hidradenitis Suppurativa: A Case Report

Pelin Esme et al.

Summary: This case report presents a patient with hidradenitis suppurativa who had tried various treatments without success, and achieved significant improvement with certolizumab pegol. Certolizumab pegol, although only approved for plaque psoriasis, shows promise as an effective agent for challenging cases of HS.

SKIN APPENDAGE DISORDERS (2021)

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Letter Dermatology

Tildrakizumab as a potential long-term therapeutic agent for severe Hidradenitis Suppurativa: A 15 months experience of an Australian institution

Yonatan Kok et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

Ustekinumab with Intravenous Infusion: Results in Hidradenitis Suppurativa

Jorge Romani et al.

DERMATOLOGY (2020)

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Article Dermatology

Epidemiology, clinical presentation, and pathogenesis

Samantha R. Goldburg et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Dermatology

Surgical and postsurgical wound care in hidradenitis suppurativa

Marco Manfredini et al.

DERMATOLOGIC THERAPY (2020)

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Letter Dermatology

Lesional Inflammatory Profile in Hidradenitis Is Not Driven IL-1

Allard R. J. V. Vossen et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Letter Dermatology

Secukinumab in the treatment of moderate to severe hidradenitis suppurativa: Results of an open-label trial

Rachel G. Casseres et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Dermatology

The effect of subcutaneous brodalumab on clinical disease activity in hidradenitis suppurativa: An open-label cohort study

John W. Frew et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Letter Dermatology

Efficacy of oral zinc and nicotinamide as maintenance therapy for mild/moderate hidradenitis suppurativa: A controlled retrospective clinical study

Elisa Molinelli et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Medicine, General & Internal

Hidradenitis suppurativa

Robert Sabat et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Letter Dermatology

Tildrakizumab in the treatment of moderate-to-severe hidradenitis suppurativa

Yonatan Kok et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2020)

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Letter Dermatology

Efficacy and safety of topical resorcinol 15% as long-term treatment of mild-to-moderate hidradenitis suppurativa: a valid alternative to clindamycin in the panorama of antibiotic resistance

E. Molinelli et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Review Dermatology

What causes hidradenitis suppurativa ?-15 years after

Christos C. Zouboulis et al.

EXPERIMENTAL DERMATOLOGY (2020)

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Review Biochemistry & Molecular Biology

Metabolic, pharmacokinetic, and toxicological issues of biologic therapies currently used in the treatment of hidradenitis suppurativa

Elisa Molinelli et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2020)

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Review Dermatology

Hidradenitis suppurativa/acne inversa: a prospective bacteriological study and review of the literature

Valentina Benzecry et al.

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA (2020)

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Review Dermatology

Hidradenitis Suppurativa: Surgical and Postsurgical Management

Marco Manfredini et al.

SKIN APPENDAGE DISORDERS (2020)

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Review Cell Biology

IL-36 family cytokines in protective versus destructive inflammation

Yingying Han et al.

CELLULAR SIGNALLING (2020)

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Article Dermatology

Deranged Iron Status Evidenced by Iron Deficiency Characterizes Patients with Hidradenitis Suppurativa

Malgorzata Ponikowska et al.

DERMATOLOGY (2020)

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Article Dermatology

Long-term adalimumab efficacy in patients with moderate-to-severe hidradenitis suppurativa/acne inversa: 3-year results of a phase 3 open-label extension study

Christos C. Zouboulis et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Article Dermatology

Biofilm production and antibiotic susceptibility of Staphylococcus epidermidis strains from Hidradenitis Suppurativa lesions

C. B. Ardon et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Letter Dermatology

Comparison of clinical and ultrasound scores in patients with hidradenitis suppurativa: results from an Italian ultrasound working group

M. Napolitano et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Review Biochemistry & Molecular Biology

IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential

Marie-Astrid Boutet et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Dermatology

North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations Part II: Topical, intralesional, and systemic medical management

Ali Alikhan et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Letter Dermatology

Open-label, investigator-initiated, single-site exploratory trial evaluating secukinumab, an anti-interleukin-17A monoclonal antibody, for patients with moderate-to-severe hidradenitis suppurativa

L. Prussick et al.

BRITISH JOURNAL OF DERMATOLOGY (2019)

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Article Pharmacology & Pharmacy

Risankizumab: First Global Approval

Kate McKeage et al.

DRUGS (2019)

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Review Biochemistry & Molecular Biology

Metabolic, pharmacokinetic, and toxicological issues surrounding dapsone

Elisa Molinelli et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2019)

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Review Immunology

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Alberto Mantovani et al.

IMMUNITY (2019)

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Article Dermatology

Determining the optimal dose of infliximab for treatment of hidradenitis suppurativa

Ashley N. Oskardmay et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Article Dermatology

Hidradenitis suppurativa in a prepubertal case series: a call for specific guidelines

A. Offidani et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Article Dermatology

Ultrasonography in the pathway to an optimal standard of care of hidradenitis suppurativa: the Italian Ultrasound Working Group experience

F. Lacarrubba et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Article Cell Biology

Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa

Angel S. Byrd et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Pharmacodynamics OF TNF α inhibitors for the treatment of psoriasis

Anna Campanati et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2019)

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Article Dermatology

Sex-related differences of clinical features in hidradenitis suppurativa: analysis of an Italian-based cohort

L. Bianchi et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2019)

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Article Immunology

Tildrakizumab for the treatment of psoriasis

Rodney Sinclair et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2019)

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Article Dermatology

The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction

Ellen Witte-Haendel et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Letter Dermatology

Apocrine Gland-Rich Skin Has a Non-Inflammatory IL-17-RelatedImmune Milieu, that Turns to Inflammatory IL-17-Mediated Disease in Hidradenitis Suppurativa

A. Jenei et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Letter Dermatology

Guselkumab in the treatment of hidradenitis suppurativa: A retrospective chart review

Rachel G. Casseres et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Article Dermatology

Rates of antibiotic resistance/sensitivity in bacterial cultures of hidradenitis suppurativa patients

V. Bettoli et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Letter Dermatology

High-frequency ultrasound in hidradenitis suppurativa as rationale for permanent hair laser removal

Gianluca Nazzaro et al.

SKIN RESEARCH AND TECHNOLOGY (2019)

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Article Oncology

Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1 alpha antibody, in a phase III randomized study of advanced colorectal cancer

Razelle Kurzrock et al.

ONCOIMMUNOLOGY (2019)

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Article Immunology

Inherent differences in keratinocyte function in hidradenitis suppurativa: Evidence for the role of IL-22 in disease pathogenesis

Derek Jones et al.

IMMUNOLOGICAL INVESTIGATIONS (2018)

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Editorial Material Dermatology

Successful Treatment of Severe Recalcitrant Hidradenitis Suppurativa with the Interleukin-17A Antibody Secukinumab

Anna Schuch et al.

ACTA DERMATO-VENEREOLOGICA (2018)

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Editorial Material Dermatology

Interleukin-36 cytokine family signalling in hidradenitis suppurativa

L. Emtestam et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Article Dermatology

Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop

S. Hessam et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Letter Dermatology

Adipokines are dysregulated in patients with hidradenitis suppurativa

A. Malara et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Article Dermatology

Incidence of hidradenitis suppurativa among tobacco smokers: a population-based retrospective analysis in the USA

A. Garg et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Article Dermatology

MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study

Theodora Kanni et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Article Cell Biology

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

Danielle M. Clancy et al.

CELL REPORTS (2018)

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Article Dermatology

Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes A Semantic Map Analysis

Rahel Thomi et al.

JAMA DERMATOLOGY (2018)

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Review Immunology

Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model

Allard R. J. V. Vossen et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

Damien Bertheloot et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2017)

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Article Immunology

Interferon-gamma (IFN-) is Elevated in Wound Exudate from Hidradenitis Suppurativa

Anirban Banerjee et al.

IMMUNOLOGICAL INVESTIGATIONS (2017)

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Article Biochemistry & Molecular Biology

Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines

Danielle M. Clancy et al.

FEBS JOURNAL (2017)

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Review Cell Biology

The critical role of macrophages in the pathogenesis of hidradenitis suppurativa

Ahmed Shah et al.

INFLAMMATION RESEARCH (2017)

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Review Medicine, General & Internal

Hidradenitis Suppurativa Advances in Diagnosis and Treatment

Ditte Marie Lindhardt Saunte et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

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Article Allergy

IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis

Andrew Johnston et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Dermatology

Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy

Barry Moran et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Dermatology

Incidence of hidradenitis suppurativa in the United States: A sex- and age-adjusted population analysis

Amit Garg et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Article Dermatology

Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents

Lukasz Matusiak et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Article Dermatology

Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa

R. Thomi et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

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Letter Allergy

Increased serum interleukin-6 levels in patients with hidradenitis suppurativa

Haoxiang Xu et al.

POSTEPY DERMATOLOGII I ALERGOLOGII (2017)

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Letter Dermatology

Canakinumab for Severe Hidradenitis Suppurativa: Preliminary Experience in 2 Cases

Carine Houriet et al.

JAMA DERMATOLOGY (2017)

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Review Immunology

Interleukin-22 in human inflammatory diseases and viral infections

Arezoo Gowhari Shabgah et al.

AUTOIMMUNITY REVIEWS (2017)

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Article Dermatology

IL-36 cytokines are increased in acne and hidradenitis suppurativa

Roberta Di Caprio et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2017)

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Review Dermatology

Hidradenitis suppurativa: from pathogenesis to diagnosis and treatment

Maddalena Napolitano et al.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2017)

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Article Dermatology

Bacterial biofilm in chronic lesions of hidradenitis suppurativa

H. C. Ring et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

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Review Dermatology

Adalimumab: A Review in Hidradenitis Suppurativa

Esther S. Kim et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2016)

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Article Dermatology

Ustekinumab in hidradenitis suppurativa: clinical results and a search for potential biomarkers in serum

J. L. Blok et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

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Article Dermatology

Antibiotic Treatment of Hidradenitis Suppurativa

Vincenzo Bettoli et al.

DERMATOLOGIC CLINICS (2016)

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Letter Gastroenterology & Hepatology

Concomitant hidradenitis suppurativa and pyostomatitis vegetans in silent ulcerative colitis successfully treated with golimumab

Antonio Tursi

DIGESTIVE AND LIVER DISEASE (2016)

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Article Dermatology

Intrinsic Defect in Keratinocyte Function Leads to Inflammation in Hidradenitis Suppurativa

Claire Hotz et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

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Review Immunology

Interleukin 1α and the inflammatory process

Nelson C. Di Paolo et al.

NATURE IMMUNOLOGY (2016)

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Article Medicine, General & Internal

Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa

Alexa B. Kimball et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Cell Biology

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

Conor M. Henry et al.

CELL REPORTS (2016)

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Article Dermatology

Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa A Randomized Clinical Trial

Vassiliki Tzanetakou et al.

JAMA DERMATOLOGY (2016)

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Letter Dermatology

Two cases of severe hidradenitis suppurativa with failure of anakinra therapy

D. Menis et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

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Editorial Material Dermatology

Dysregulated cytokine expression in lesional and nonlesional skin in hidradenitis suppurativa

Alex Anstey

BRITISH JOURNAL OF DERMATOLOGY (2015)

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Article Dermatology

Off-label use of TNF-alpha inhibitors in a dermatological university department: retrospective evaluation of 118 patients

Freja Laerke Sand et al.

DERMATOLOGIC THERAPY (2015)

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Article Dermatology

Pathophysiology of hidradenitis suppurativa: An update

Errol Prens et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Dermatology

New insights into the diagnosis of hidradenitis suppurativa: Clinical presentations and phenotypes

Hessel H. van der Zee et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Review Biochemistry & Molecular Biology

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future

Lisa M. Sedger et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2014)

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Review Chemistry, Medicinal

Periodontal Disease: An Oral Manifestation of Psoriasis or an Occasional Finding?

Giulia Ganzetti et al.

DRUG DEVELOPMENT RESEARCH (2014)

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Review Dermatology

Hidradenitis suppurativa: the role of immune dysregulation

Genevieve Kelly et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2014)

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Article Immunology

Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF-β-Induced Foxp3 Expression

Satoshi Ikeda et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Dermatology

An open-label study of anakinra for the treatment of moderate to severe hidradenitis suppurativa

Kieron S. Leslie et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

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Article Dermatology

Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: A chart-verified case-control analysis

Julia Shlyankevich et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

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Review Biotechnology & Applied Microbiology

Therapeutic opportunities of the IL-22-IL-22R1 system

Robert Sabat et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

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Article Multidisciplinary Sciences

IL-17/Th17 Pathway Is Activated in Acne Lesions

Hanna-Leena Kelhala et al.

PLOS ONE (2014)

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Article Dermatology

Tumour Necrosis Factor-alpha and Matrix Metalloproteinase-2 are Expressed Strongly in Hidradenitis Suppurativa

Elga Mozeika et al.

ACTA DERMATO-VENEREOLOGICA (2013)

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Article Dermatology

Myeloid marker S100A8/A9 and lymphocyte marker, soluble interleukin 2 receptor: biomarkers of hidradenitis suppurativa disease activity?

C. W. Wieland et al.

BRITISH JOURNAL OF DERMATOLOGY (2013)

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Article Dermatology

Ultrasound In-Depth Characterization and Staging of Hidradenitis Suppurativa

Ximena Wortsman et al.

DERMATOLOGIC SURGERY (2013)

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Review Dermatology

Failure of Anti-Interleukin-1 Therapy in Severe Hidradenitis Suppurativa: A Case Report

H. H. van der Zee et al.

DERMATOLOGY (2013)

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Article Immunology

IL-22 Regulates Iron Availability In Vivo through the Induction of Hepcidin

Carole L. Smith et al.

JOURNAL OF IMMUNOLOGY (2013)

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Review Immunology

Treating inflammation by blocking interleukin-1 in humans

Charles A. Dinarello et al.

SEMINARS IN IMMUNOLOGY (2013)

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Article Dermatology

Successful Treatment of Severe Hidradenitis Suppurativa With Anakinra

Kian Zarchi et al.

JAMA DERMATOLOGY (2013)

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Letter Dermatology

Pyoderma gangrenosum and concomitant hidradenitis suppurativa - rapid response to canakinumab (anti-IL-1β)

Teresa Jaeger et al.

EUROPEAN JOURNAL OF DERMATOLOGY (2013)

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Review Hematology

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

Bharat B. Aggarwal et al.

BLOOD (2012)

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Article Dermatology

Adalimumab (antitumour necrosis factor-α) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study

H. H. van der Zee et al.

BRITISH JOURNAL OF DERMATOLOGY (2012)

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Article Dermatology

Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa

V. U. Emelianov et al.

BRITISH JOURNAL OF DERMATOLOGY (2012)

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Article Dermatology

Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments

Hessel H. van der Zee et al.

EXPERIMENTAL DERMATOLOGY (2012)

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Review Biochemistry & Molecular Biology

Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases

Toshio Tanaka et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

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Article Dermatology

Comparing treatment outcome of infliximab and adalimumab in patients with severe hidradenitis suppurativa

Dominique C. van Rappard et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2012)

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Article Dermatology

Hidradenitis suppurativa/acne inversa: bilocated epithelial hyperplasia with very different sequelae

M. von Laffert et al.

BRITISH JOURNAL OF DERMATOLOGY (2011)

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Article Dermatology

Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β

H. H. van der Zee et al.

BRITISH JOURNAL OF DERMATOLOGY (2011)

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Article Immunology

Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

Kerstin Wolk et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Dermatology

Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa

Christoph Schlapbach et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2011)

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Article Pharmacology & Pharmacy

Pharmacodynamics of TNF-α inhibitors in psoriasis

Theognosia Vergou et al.

Expert Review of Clinical Pharmacology (2011)

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Article

Treatment of Hidradenitis Suppurativa With Etanercept Injection

David R. Adams et al.

ARCHIVES OF DERMATOLOGY (2010)

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Article Dermatology

Long-term efficacy of etanercept in hidradenitis suppurativa: results from an open-label phase II prospective trial

Aimilia Pelekanou et al.

EXPERIMENTAL DERMATOLOGY (2010)

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Review Immunology

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

Reiko M. Onishi et al.

IMMUNOLOGY (2010)

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Article Dermatology

Infliximab therapy for patients with moderate to severe hidradenitis, suppurativa: A randomized, double-blind, placebo-controlled crossover trial

Annika Grant et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2010)

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Review Medicine, Research & Experimental

Certolizumab pegol

Niti Goel et al.

MABS (2010)

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Review Medicine, Research & Experimental

Canakinumab

Eugen Dhimolea

MABS (2010)

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Letter Dermatology

Etanercept for the Treatment of Hidradenitis Suppurativa

Eleni Sotiriou et al.

ACTA DERMATO-VENEREOLOGICA (2009)

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Article Dermatology

Increased Serum Tumour Necrosis Factor-alpha in Hidradenitis Suppurativa Patients: Is There a Basis for Treatment with Anti-Tumour Necrosis Factor-alpha Agents?

Lukasz Matusiak et al.

ACTA DERMATO-VENEREOLOGICA (2009)

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Review Immunology

IL-17 and Th17 Cells

Thomas Korn et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

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Article Rheumatology

Caspase 1-Independent Activation of Interleukin-1β in Neutrophil-Predominant Inflammation

Monica Guma et al.

ARTHRITIS AND RHEUMATISM (2009)

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Article Dermatology

Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity

K. Sartorius et al.

BRITISH JOURNAL OF DERMATOLOGY (2009)

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Letter Dermatology

VEGF, survivin and NOS overexpression in psoriatic skin: Critical role of nitric oxide synthases

Oriana Simonetti et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2009)

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Article Genetics & Heredity

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

Kerstin Wolk et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2009)

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Article Dermatology

Human β-defensin-2 and psoriasin are overexpressed in lesions of acne inversa

Christoph Schlapbach et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2009)

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Review Dermatology

Hidradenitis suppurativa: A comprehensive review

Ali Alikhan et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2009)

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Review Dermatology

What causes hidradenitis suppurativa?

H. Kurzen et al.

EXPERIMENTAL DERMATOLOGY (2008)

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Editorial Material Dermatology

What causes acne inversa (or hidradenitis suppurativa)? - the debate continues

Klaus Sellheyer et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2008)

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Review Pharmacology & Pharmacy

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

Daniel Tracey et al.

PHARMACOLOGY & THERAPEUTICS (2008)

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Article Dermatology

Long-term efficacy of a single course of infliximab in hidradenitis suppurativa

J. R. Mekkes et al.

BRITISH JOURNAL OF DERMATOLOGY (2008)

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Review Medicine, Research & Experimental

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Takashi Kadowaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Article Dermatology

Etanercept: effective in the management of hidradenitis suppurativa

C Cusack et al.

BRITISH JOURNAL OF DERMATOLOGY (2006)

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Review Dermatology

Biology of tumor necrosis factor-α -: implications for psoriasis

AJG Schottelius et al.

EXPERIMENTAL DERMATOLOGY (2004)

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Article Gastroenterology & Hepatology

Hidradenitis suppurativa and Crohn's disease:: Response to treatment with infliximab

F Martínez et al.

INFLAMMATORY BOWEL DISEASES (2001)

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Article Multidisciplinary Sciences

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

FKM Chan et al.

SCIENCE (2000)

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