4.7 Article

NOVAprep-miR-Cervix: New Method for Evaluation of Cervical Dysplasia Severity Based on Analysis of Six miRNAs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

miR-145 inhibits aerobic glycolysis and cell proliferation of cervical cancer by acting on MYC

Chenchen Hu et al.

Summary: In this study, it was found that miR-145 negatively correlated with metabolic reprogramming-related genes and inhibited the proliferation and metastasis of cervical cancer cell lines by impeding aerobic glycolysis. The research also showed that miR-145 affected glycolysis through its binding to the 3' UTR of MYC and suppressed tumor growth in mice.

FASEB JOURNAL (2023)

Article Genetics & Heredity

Characterization of the Genomic Landscape in Cervical Cancer by Next Generation Sequencing

Ling Qiu et al.

Summary: This study investigated the genetic landscape of Chinese cervical cancer patients using multigene next-generation sequencing (NGS) and identified several novel genetic alterations. The study highlighted the role of PIK3CA in cervical cancer and revealed that genetic variations not only affect the genetic susceptibility of cervical cancer, but also influence the resistance of cervical cancer to radiotherapy.
Article Biochemistry & Molecular Biology

MicroRNA-29a Manifests Multifaceted Features to Intensify Radiosensitivity, Escalate Apoptosis, and Revoke Cell Migration for Palliating Radioresistance-Enhanced Cervical Cancer Progression

Pei-Chin Chuang et al.

Summary: This study aimed to investigate the potential impacts of microRNA-29a (miR-29a) on the modulation of radioresistance-associated cervical cancer progression. The results showed that miR-29a enhanced radiosensitivity and triggered cell apoptosis, reducing the survival and migration abilities of radioresistant cervical cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Multidisciplinary Sciences

The clinical value of miRNA-21 in cervical cancer: A comprehensive investigation based on microarray datasets

Zhi-Min Deng et al.

Summary: This study utilized meta-analysis and bioinformatic methods to identify miR-21 as a highly sensitive and specific diagnostic marker for cervical cancer. The study also revealed the potential role of miR-21 in cancer pathways.

PLOS ONE (2022)

Review Oncology

Systematic review of circulating MICRORNAS as biomarkers of cervical carcinogenesis

Neila Pierote Gaspar Nascimento et al.

Summary: Cervical cancer is a preventable disease but remains a significant public health problem. The Pap smear has achieved great success, but has limitations, leading to the need for new approaches for early diagnosis and biomarker discovery. miRNAs have been identified as non-invasive biomarkers and have potential clinical value for early-stage cervical intraepithelial neoplasia screening. This study reviewed the expression of circulating miRNAs in the development of cervical cancer and identified potential biomarkers.

BMC CANCER (2022)

Review Biochemistry & Molecular Biology

The Complex Interplay between Vaginal Microbiota, HPV Infection, and Immunological Microenvironment in Cervical Intraepithelial Neoplasia: A Literature Review

Barbara Gardella et al.

Summary: This study reviewed the interaction between vaginal microbiota, cervical intraepithelial neoplasia (CIN), and the immune response. While some studies struggle to demonstrate the correlation between vaginal microbiota and HPV-related lesions, there is significant evidence suggesting changes in vaginal microbiota in HPV-positive women. The presence of new bacteria, pathway deregulation, and cytokine overexpression are strongly associated with the progression of cervical dysplasia and chronic inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer-An Update

Pui-Wah Choi et al.

Summary: This review focuses on the dysregulation of miRNAs in the pre-stage of cervical cancer. Several dysregulated miRNAs have been identified and found to be associated with the DNA damage response and cell growth response induced by human papillomavirus (HPV) infection. However, discrepancies in sample types, HPV status, expression measurement, and analysis methods have led to non-aligned results across studies. This review provides insight into identifying miRNAs involved in early pathogenic processes and highlights their potential as biomarkers for cervical pre-cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

MiR-95-3p acts as a prognostic marker and promotes cervical cancer progression by targeting VCAM1

Sijie Feng et al.

Summary: Our study is the first to show that miR-95-3p could serve as a prognostic biomarker of cervical cancer. Mechanistically, we discovered that miR-95-3p inhibits the expression of the cell adhesion molecule VCAM1 and thus promotes further tumor progression.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

Human papillomavirus 16 E6/E7 contributes to immune escape and progression of cervical cancer by regulating miR-142-5p/PD-L1 axis

Junjun Ling et al.

Summary: Persistent infection of human papillomavirus (HPV) and immune escape are the main causes of cervical cancer. This study identified miR-142-5p as a key player in the regulation of PD-L1 by HPV16's E6/E7, and proposed using miR-142-5p as a new strategy in cervical cancer immunotherapy.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2022)

Article Oncology

microRNA Profile Associated with Positive Lymph Node Metastasis in Early-Stage Cervical Cancer

Salim Abraham Barquet-Munoz et al.

Summary: This study aimed to identify a subset of miRNAs related to lymph node metastasis (LNM) in early-stage cervical cancer (CC) patients. Microarray analysis identified 36 differentially expressed miRNAs in two patient groups, and the expression of seven miRNAs was validated. These findings help identify early-stage CC patients with LNM.

CURRENT ONCOLOGY (2022)

Article

MicroRNA Levels in Cervical Cancer Samples and Relationship with Lesion Grade and HPV Infection

Carolina R. Hoelzle et al.

MicroRNA (Shariqah, United Arab Emirates) (2021)

Article Pathology

Detection of Cervical Lesions and Cancer in Air-Dried Cytologic Smears by Combined Analysis of mRNA and miRNA Expression Levels

Mikhail K. Ivanov et al.

Summary: Cervical cancer screening based on biomarker levels, including miRNAs, mRNAs, and other markers, showed promising results in predicting high-grade lesions and cancer. A combined mRNA-miRNA classifier demonstrated the best sensitivity and specificity, indicating its potential for improving screening accuracy in cervical cancer.

JOURNAL OF MOLECULAR DIAGNOSTICS (2021)

Review Cell Biology

A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression

Rhafaela Lima Causin et al.

Summary: Through a systematic review of cervical cancer microRNA studies, 26 differentially expressed microRNAs were identified in different stages of cervical cancer development. Findings suggest that some dysregulated microRNAs are associated with specific stages of cervical cancer progression, playing important roles in key cancer hallmarks. These findings also suggest potential for using stage-specific microRNAs as biomarkers for cancer classification and monitoring cervical cancer progression.
Article Cell Biology

Kruppel-like factor 5-induced overexpression of long non-coding RNA DANCR promotes the progression of cervical cancer via repressing microRNA-145-3p to target ZEB1

Chunyan Hu et al.

Summary: This study found that DANCR promotes cervical cancer (CC) progression by sponging miR-145-3p, with high DANCR expression associated with worse outcomes in CC patients. Silencing DANCR or elevating miR-145-3p can inhibit malignant behaviors of CC cells and tumor growth. The effect of DANCR knockdown on CC cells can be reversed by miR-145-3p inhibitor.

CELL CYCLE (2021)

Article Oncology

Real time quantitative methylation detection of PAX1 gene in cervical cancer screening

Haifeng Liu et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2020)

Article Oncology

Increased miR-20b Level in High Grade Cervical Intraepithelial Neoplasia

Timea Szekerczes et al.

PATHOLOGY & ONCOLOGY RESEARCH (2020)

Article Biochemistry & Molecular Biology

Reciprocal Dysregulation of MiR-146b and MiR-451 Contributes in Malignant Phenotype of Follicular Thyroid Tumor

Margarita Knyazeva et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medical Laboratory Technology

Intra- and inter-laboratory agreement of the FAM19A4/mir124-2 methylation test: Results from an international study

Arno Floore et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2019)

Article Biotechnology & Applied Microbiology

Therapeutic Delivery of miR-29b Enhances Radiosensitivity in Cervical Cancer

Tingting Zhang et al.

MOLECULAR THERAPY (2019)

Article Oncology

Frequency of HPV in oral cavity squamous cell carcinoma

Priscila Marinho de Abreu et al.

BMC CANCER (2018)

Article Pathology

Identification of clinical tumor stages related mRNAs and miRNAs in cervical squamous cell carcinoma

Chenggang Yang et al.

PATHOLOGY RESEARCH AND PRACTICE (2018)

Article Multidisciplinary Sciences

CRISPR-typing PCR (ctPCR), a new Cas9-based DNA detection method

Qiao Wang et al.

SCIENTIFIC REPORTS (2018)

Proceedings Paper Computer Science, Theory & Methods

Using Random Forest Algorithm for Breast Cancer Diagnosis

Bin Dai et al.

2018 INTERNATIONAL SYMPOSIUM ON COMPUTER, CONSUMER AND CONTROL (IS3C 2018) (2018)

Article Biochemistry & Molecular Biology

Two-tailed RT-qPCR: a novel method for highly accurate miRNA quantification

Peter Androvic et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

Distribution of miRNA expression across human tissues

Nicole Ludwig et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Obstetrics & Gynecology

Dysregulated microRNAs involved in the progression of cervical neoplasm

Kangkang Zeng et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2015)

Article Oncology

A specific miRNA signature promotes radioresistance of human cervical cancer cells

Bin Zhang et al.

CANCER CELL INTERNATIONAL (2013)

Article Medicine, Research & Experimental

MicroRNA expression and its detection in human supraglottic laryngeal squamous cell carcinoma

Xin Sun et al.

BIOMEDICAL REPORTS (2013)