☆ 4.7 Review

Target and Cell Therapy for Atherosclerosis and CVD

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Cell Biology

The Role of Macrophages in the Pathogenesis of Atherosclerosis

Alexander V. Blagov et al.

Summary: This review summarizes the involvement of various cell populations, including immune cells and endothelial cells, in the pathogenesis of atherosclerosis. Among them, macrophages are of particular importance due to their diverse effects on atherogenesis and inflammation in atherosclerosis. The significance of different phenotypes of macrophages in the progression or regression of atherosclerosis is discussed, including their ability to become foam cells, the consequences of this event, and their ability to create a pro-inflammatory or anti-inflammatory environment through cytokine production at the site of atherosclerotic lesions. In addition, therapeutic strategies aimed at modulating macrophage activity are considered, providing useful ideas for future drug developments.

CELLS (2023)

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Article Biochemistry & Molecular Biology

The Role of Cytokines in Cholesterol Accumulation in Cells and Atherosclerosis Progression

Alexander M. Markin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Cardiac & Cardiovascular Systems

Ten-Year Cardiovascular Disease Risk Score and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014

Jingkai Wei et al.

Summary: The study found that the Framingham 10-year cardiovascular disease risk score is associated with cognitive health. This association was validated in a nationally representative sample, showing that higher cardiovascular disease risk is linked to poorer cognitive function. Additionally, the effects of this association were modified by socioeconomic factors such as race or ethnicity, education, and family income.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2023)

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Review Immunology

Macrophage polarization states in atherosclerosis

Jiayong Wu et al.

Summary: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries, with macrophages playing a crucial role in the inflammatory response. Modulating macrophage polarization has shown potential in controlling the progression of atherosclerosis. This review explores the role of macrophage polarization in atherosclerosis and summarizes emerging therapies for its regulation.

FRONTIERS IN IMMUNOLOGY (2023)

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Review Cardiac & Cardiovascular Systems

The formation and consequences of cholesterol-rich deposits in atherosclerotic lesions

Frederick R. R. Maxfield et al.

Summary: Cardiovascular diseases remain the leading cause of death worldwide. The early development of atherosclerotic lesions involves the accumulation of lipoprotein-associated lipids and their interaction with macrophages. Macrophages in early plaques engage with low-density lipoproteins (LDL), ingesting large amounts of cholesterol, which is then stored in lipid droplets. Hydrolysis of cholesteryl esters occurs extracellularly, leading to the formation of unesterified (free) cholesterol. High concentrations of cholesterol can also result in the formation of cholesterol hydrate crystals, observed in atherosclerotic blood vessels. Understanding this process may lead to novel therapies for atherosclerosis prevention and treatment.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association

Connie W. Tsao et al.

Summary: The American Heart Association, in collaboration with the National Institutes of Health, releases annual statistics on heart disease, stroke, and cardiovascular risk factors. The Statistical Update provides the latest data on various heart and circulatory diseases and their outcomes, as well as information on core health behaviors and factors contributing to cardiovascular health.

CIRCULATION (2023)

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Article Cardiac & Cardiovascular Systems

The phagocytic role of macrophage following myocardial infarction

Jiahua Li et al.

Summary: Myocardial infarction (MI) is a cardiovascular disease that has a high incidence and mortality rate. The disease results in a large number of apoptotic and necrotic cells that need to be efficiently and quickly engulfed by macrophages to prevent further necrosis. Phagocytic macrophages can reduce or resolve inflammation and protect the infarcted heart. The phagocytosis of macrophages is influenced by various factors such as proteins, receptors, lncRNA, and cytokines. Understanding the mechanisms of phagocytosis can help regulate macrophage phagocytic ability for cardioprotection after MI. This review provides an overview of the phagocytic effect of macrophages and summarizes the latest reported signals that regulate phagocytosis after MI, offering new insights into phagocytosis-dependent cardiac protection after MI.

HEART FAILURE REVIEWS (2023)

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Review Biochemistry & Molecular Biology

The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases

Siarhei A. Dabravolski et al.

Summary: mtDNA mutations play a role in cardiovascular diseases such as coronary artery disease and hypertension. Maternally inherited mitochondrial CVD is caused by specific mutations in mtDNA. Recent studies suggest a link between mtDNA mutations and Brugada syndrome and ischemic stroke.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cardiac & Cardiovascular Systems

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Wei Chen et al.

Summary: Nanotechnology has the potential to improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies. Targeted nanoparticles for macrophages offer more precise imaging and treatment methods. Future directions include accelerating the clinical translation of nanomedicine for the treatment of atherosclerosis.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Pharmacology & Pharmacy

Dapagliflozin exerts anti-inflammatory effects via inhibition of LPS-induced TLR-4 overexpression and NF-κB activation in human endothelial cells and differentiated macrophages

Elaheh Abdollahi et al.

Summary: Evidence suggests that the new class of anti-diabetic drugs, SGLT2 inhibitors, can have beneficial effects on atherosclerotic complications of diabetes. This study aimed to evaluate the direct anti-inflammatory effects of the SGLT2 inhibitor dapagliflozin (DAPA). The results showed that DAPA could attenuate inflammation by inhibiting the expression of TLR-4 and activation of NF-kappa B, as well as shifting macrophage polarization from an inflammatory state to an anti-inflammatory state.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Role of Endothelial Progenitor Cells in Atherosclerosis and Impact of Anti-Lipemic Treatments on Endothelial Repair

Velimir Altabas et al.

Summary: Cardiovascular complications are associated with advanced atherosclerosis. The discovery of endothelial progenitor cells (EPCs) has changed our understanding of atherosclerosis as an incurable disease. Many drugs have shown a positive effect on EPC biology, but many questions remain unanswered.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Inflammatory Mechanisms of Diabetes and Its Vascular Complications

Lyudmila V. Nedosugova et al.

Summary: The association between type 2 diabetes and cardiovascular complications is complex, primarily due to the oxidative stress and inflammation caused by hyperglycemia. Understanding the pathogenesis of type 2 diabetes and associated cardiovascular diseases can aid in the development of new diagnostic and therapeutic approaches.

BIOMEDICINES (2022)

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Review Cell Biology

Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress

Shuo Feng et al.

Summary: Hemodynamic shear stress (SS) regulates vascular homeostasis and injury through the release of endothelial microparticles (EMP), affecting physiological function of endothelial cells, inflammatory response, vascular permeability, and the coagulation system.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Recreating Tissue Structures Representative of Teratomas In Vitro Using a Combination of 3D Cell Culture Technology and Human Embryonic Stem Cells

Alejandro Hidalgo Aguilar et al.

Summary: In vitro studies using human embryonic stem cells are valuable for studying embryogenesis and tissue differentiation. Researchers have established a two-step culture method using porous scaffolds to enhance the viability and prolong the maintenance of PSC-derived embryoid bodies. They have successfully formed tissue structures similar to xenograft teratoma samples and believe this animal-free approach is a reproducible alternative for studying human tissue development.

BIOENGINEERING-BASEL (2022)

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Review Cardiac & Cardiovascular Systems

Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardioloy working Groups on Artherosclerosis and Vascular Biology, Aorta and Perirpheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis

Yvonne Alexander et al.

Summary: Endothelial cells play a crucial role in cardiovascular health, and dysfunction can be caused by cardiovascular risk factors but restored once stimuli are removed. There are various methods to measure endothelial function, with each having its pros and cons. It is recommended to adopt a consensus methodology like flow-mediated dilatation and establish reference values for different populations. Future studies should explore the integration of endothelial function measurements with patient-specific epigenetic data and other biomarkers.

CARDIOVASCULAR RESEARCH (2021)

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Review Hematology

Trained Immunity and Reactivity of Macrophages and Endothelial Cells

Charles Drummer et al.

Summary: Innate immune cells can develop trained immunity after exposure to stimuli like lipopolysaccharides and oxLDL, leading to altered responses upon subsequent challenges. This phenomenon is important for host defense and inflammation, particularly in cardiovascular and metabolic diseases. Trained immunity involves rewiring cellular metabolism and epigenetic remodeling that enhance gene transcription and proinflammatory immune responses, contributing to chronic inflammation.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Role of Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis

Jasni Viralippurath Ashraf et al.

Summary: Arteriogenesis is a primary physiological response in restoring blood flow after arterial occlusion, involving the switch in phenotype of vascular smooth muscle cells (VSMCs) between contractile and synthetic states. The timely and coordinated actions of molecular and cellular mediators are crucial in expansive remodeling of collaterals and effective restoration of blood flow to ischemic tissues. Understanding VSMC phenotype switching during arteriogenesis can lead to novel therapeutic strategies for peripheral arterial disease revascularization.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities

Xinxin Zhang et al.

Summary: The study showed that RVS treatment reduced plaque areas in the aorta inner surface and the aortic sinus of ApoE(-/-) mice with high-fat diet, improved lipid profiles, and reduced contents of inflammatory cytokines. These effects of RVS were attributed to the activation of autophagy cascades and promotion of cholesterol efflux and M2 macrophage polarization.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Review Biology

Disturbance of Mitochondrial Dynamics and Mitochondrial Therapies in Atherosclerosis

Alexander M. Markin et al.

Summary: Mitochondrial dysfunction is associated with a wide range of chronic human disorders, leading to functional impairment and energy deficiency in cells. The processes of mitochondrial turnover, involving fission and fusion, are tightly regulated and crucial for cell function. Correction of mitochondrial dynamics may offer new therapeutic approaches for various chronic diseases.

LIFE-BASEL (2021)

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Review Biochemistry & Molecular Biology

The Role of Mitochondrial Dysfunction in Vascular Disease, Tumorigenesis, and Diabetes

Olga A. Zhunina et al.

Summary: Mitochondrial dysfunction is closely associated with various human pathologies, with ROS and RNS playing a critical role in causing protein and mtDNA damage and leading to the development of diseases. Recent studies have identified numerous mtDNA mutations linked to different human pathologies, each having distinct effects in disease progression.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Cardiac & Cardiovascular Systems

New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease

Brian H. Annex et al.

Summary: PAD is a significant global cause of disability and mortality, primarily due to atherosclerotic obstructions in the large arteries to the leg(s). Despite advances in surgical and endovascular procedures, treatment outcomes may be suboptimal at times due to comorbid conditions or severe microvascular disease.

CIRCULATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Epidemiology of Peripheral Artery Disease and Polyvascular Disease

Aaron W. Aday et al.

Summary: PAD is increasingly recognized as a major cause of cardiovascular morbidity and mortality worldwide. The focus on PAD in recent years has led to new epidemiological insights and highlighted the importance of polyvascular disease in cardiovascular research and clinical practice. PAD may present similar or even greater risk compared to coronary artery disease or stroke.

CIRCULATION RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Anti-Inflammatory Therapy for Atherosclerosis: Focusing on Cytokines

Anastasia V. Poznyak et al.

Summary: Atherosclerosis is a well-known global health problem with unclear pathogenesis. Inflammation is considered the preferred target for its treatment, with studies showing efficacy in animal models but inconclusive results in clinical studies. Anti-inflammatory therapy could be part of a complex treatment for atherosclerosis prevention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medicine, General & Internal

Lower Extremity Peripheral Artery Disease Without Chronic Limb-Threatening Ischemia A Review

Tamar S. Polonsky et al.

Summary: Peripheral artery disease affects approximately 230 million people worldwide and can be diagnosed noninvasively with ABI, although some patients may not exhibit typical symptoms. PAD patients not only have an increased risk of cardiovascular events, but also a greater risk of functional decline compared to those without PAD.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Cell Biology

Structure and Function of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and Their Role in Cardiovascular Diseases

Yi Luan et al.

Summary: The abnormal function of suborganelles, such as mitochondria and endoplasmic reticulum, can lead to abnormal function of cardiomyocytes or vascular endothelial cells, resulting in cardiovascular disease (CVD). Mitochondria-associated membrane (MAM) plays a crucial role in CVD pathogenesis, mediating multiple cellular processes. The structure of MAM and its associated proteins may serve as potential therapeutic targets for CVD treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Immunology

Metformin, Macrophage Dysfunction and Atherosclerosis

Xiaojun Feng et al.

Summary: Metformin can regulate the function of macrophages in atherosclerosis through various mechanisms. Future research directions may include single-cell RNA sequencing and combination drug therapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Qing Zhang et al.

Summary: This study summarized natural compounds that exert protective effects against oxidative stress in vascular endothelial cells (ECs), including phenylpropanoids, flavonoids, terpenoids, and alkaloids. These compounds alleviate EC apoptosis by activating the Nrf2/HO-1 signaling pathway, showing potential for the treatment of atherosclerosis.

JOURNAL OF ADVANCED RESEARCH (2021)

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Review Cell Biology

Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

Dan Li et al.

Summary: Cardiovascular disease (CVD) is the leading cause of death globally, with atherosclerosis as its underlying pathological basis. Mitochondrial dynamics play a crucial role in CVD progression, impacting processes such as ROS production, oxidative stress, and inflammatory responses.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Recognition of Oxidized Lipids by Macrophages and Its Role in Atherosclerosis Development

Nataliya Mushenkova et al.

Summary: Atherosclerosis is a chronic disease with inflammatory components, now recognized as an active autoimmune process involving both innate and adaptive immune pathways. One of the key factors driving this process is the presence of modified LDL, which leads to the formation of oxidation-specific epitopes recognized by immune cells. Macrophage response to these epitopes is crucial for initiating and promoting inflammation in the arteries.

BIOMEDICINES (2021)

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Review Cell & Tissue Engineering

Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients

Em Yunir et al.

Summary: This literature review compares the safety and efficacy of BMMNC and PBMNC as cell-based management in diabetic patients with PAD who are not suitable for revascularization therapy. While stem cell therapy has shown promise in reducing symptoms of PAD patients, its effectiveness in reducing major amputation rates, amputation free survival, and all-cause mortality remains inconclusive.

INTERNATIONAL JOURNAL OF STEM CELLS (2021)

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Review Hematology

Evidence-Based Medical Management of Peripheral Artery Disease

Graham H. Bevan et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Stevan D. Stojanovic et al.

EUROPEAN HEART JOURNAL (2020)

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Article Biotechnology & Applied Microbiology

Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis

Shuihua Zhang et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

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Article Multidisciplinary Sciences

In vivo priming of human mesenchymal stem cells with hepatocyte growth factor-engineered mesenchymal stem cells promotes therapeutic potential for cardiac repair

Bong-Woo Park et al.

SCIENCE ADVANCES (2020)

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Article Hematology

Epidemiology and Risk of Amputation in Patients With Diabetes Mellitus and Peripheral Artery Disease

J. Aaron Barnes et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Article Endocrinology & Metabolism

Bone regeneration is mediated by macrophage extracellular vesicles

Miya Kang et al.

BONE (2020)

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Article Cell Biology

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

Wei Tao et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Stevan D. Stojanovic et al.

EUROPEAN HEART JOURNAL (2020)

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Article Biotechnology & Applied Microbiology

Kallistatin Inhibits Atherosclerotic Inflammation by Regulating Macrophage Polarization

Bing Li et al.

HUMAN GENE THERAPY (2019)

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Article Chemistry, Medicinal

Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2-induced PSMB5 in endothelial cells

Yingchao Zhu et al.

DRUG DEVELOPMENT RESEARCH (2019)

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Review Geriatrics & Gerontology

Cell therapy to improve regeneration of skeletal muscle injuries

Taimoor H. Qazi et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

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Article Cardiac & Cardiovascular Systems

Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy

Mihai-Nicolae Podaru et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

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Review Pharmacology & Pharmacy

The role of smooth muscle cells in plaque stability: Therapeutic targeting potential

Jennifer L. Harman et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

Monocytes and macrophages in atherogenesis

Jaume Amengual et al.

CURRENT OPINION IN LIPIDOLOGY (2019)

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Article Oncology

PACS2 is required for ox-LDL-induced endothelial cell apoptosis by regulating mitochondria-associated ER membrane formation and mitochondrial Ca2+ elevation

Sanjiu Yu et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Artificial High Density Lipoprotein Nanoparticles in Cardiovascular Research

Karin Kornmueller et al.

MOLECULES (2019)

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Article Immunology

Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14+CD16- Monocytes

Man K. S. Lee et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Pharmacology & Pharmacy

Immune and Smooth Muscle Cells Interactions in Atherosclerosis: How to Target a Breaking Bad Dialogue?

Damien Ramel et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Cell & Tissue Engineering

Application of Cell Therapy for Anti-Aging Facial Skin

Farshad Zarei et al.

CURRENT STEM CELL RESEARCH & THERAPY (2019)

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Article Nanoscience & Nanotechnology

Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of Gi-protein inhibitor

Monica Madalina Tucureanu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Biochemistry & Molecular Biology

Stem Cell Therapy: A New Therapeutic Option for Cardiovascular Diseases

Nasser Hashemi Goradel et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

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Article Medicine, Research & Experimental

Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the NF-κB and p38 MAPK signaling pathways

Yuliang Wu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Cardiac & Cardiovascular Systems

New Paradigms in Cell Therapy: Repeated Dosing, Intravenous Delivery, Immunomodulatory Actions, and New Cell Types

Marcin Wysoczynki et al.

CIRCULATION RESEARCH (2018)

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Article Pharmacology & Pharmacy

Cell therapy for peripheral artery disease

Nikolaos G. Frangogiannis

CURRENT OPINION IN PHARMACOLOGY (2018)

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Review Medicine, Research & Experimental

Senescent cells: a therapeutic target for cardiovascular disease

Bennett G. Childs et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Biotechnology & Applied Microbiology

Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes

Songtao An et al.

MOLECULAR THERAPY (2018)

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Review Biotechnology & Applied Microbiology

Exosomes in Myocardial Repair: Advances and Challenges in the Development of Next-Generation Therapeutics

Marta Adamiak et al.

MOLECULAR THERAPY (2018)

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Review Medical Laboratory Technology

Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

Yonggang Ma et al.

TRANSLATIONAL RESEARCH (2018)

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Article Multidisciplinary Sciences

Stem cell properties of peripheral blood endothelial progenitors are stimulated by soluble CD146 via miR-21: potential use in autologous cell therapy

Amel Essaadi et al.

SCIENTIFIC REPORTS (2018)

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Review Cardiac & Cardiovascular Systems

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

Paolo Raggi et al.

ATHEROSCLEROSIS (2018)

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Review Cell Biology

Stem Cell Therapy in Heart Diseases - Cell Types, Mechanisms and Improvement Strategies

Paula Mueller et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Hematology

Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation

Petteri Rinne et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Route of Delivery Modulates the Efficacy of Mesenchymal Stem Cell Therapy for Myocardial Infarction A Meta-Analysis of Preclinical Studies and Clinical Trials

Anthony J. Kanelidis et al.

CIRCULATION RESEARCH (2017)

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Review Cardiac & Cardiovascular Systems

Peripheral artery disease: epidemiology and global perspectives

F. Gerry R. Fowkes et al.

NATURE REVIEWS CARDIOLOGY (2017)

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Review Biotechnology & Applied Microbiology

Senescent cells: an emerging target for diseases of ageing

Bennett G. Childs et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

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Review Medicine, General & Internal

Cellular Senescence: A Translational Perspective

James L. Kirkland et al.

EBIOMEDICINE (2017)

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Review Peripheral Vascular Disease

Oxidative Stress in Atherosclerosis

Ajoe John Kattoor et al.

CURRENT ATHEROSCLEROSIS REPORTS (2017)

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Review Chemistry, Multidisciplinary

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Jacek Zielonka et al.

CHEMICAL REVIEWS (2017)

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Review Developmental Biology

Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis

Mijo Simunovic et al.

DEVELOPMENT (2017)

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Article Biochemistry & Molecular Biology

Therapeutic Boosting of the Immune Response: Turning to CD14 for Help

Anne-Catherine Raby et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Effect of Repetitive Intra-Arterial Infusion of Bone Marrow Mononuclear Cells in Patients With No-Option Limb Ischemia The Randomized, Double-Blind, Placebo-Controlled Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) Trial

Martin Teraa et al.

CIRCULATION (2015)

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Article Cardiac & Cardiovascular Systems

Pathogenesis of the Limb Manifestations and Exercise Limitations in Peripheral Artery Disease

William R. Hiatt et al.

CIRCULATION RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

Mohsin Khan et al.

CIRCULATION RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

DPP-4 inhibition ameliorates atherosclerosis by priming monocytes into M2 macrophages

C. Brenner et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

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Article Cell Biology

Abnormal Accumulation of Desmin in Gastrocnemius Myofibers of Patients with Peripheral Artery Disease: Associations with Altered Myofiber Morphology and Density, Mitochondrial Dysfunction and Impaired Limb Function

Panagiotis Koutakis et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2015)

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Review Pharmacology & Pharmacy

Pericytes, mesenchymal stem cells and their contributions to tissue repair

Suet-Ping Wong et al.

PHARMACOLOGY & THERAPEUTICS (2015)

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Article Multidisciplinary Sciences

Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1

Xianjing Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

Resident c-kit+ cells in the heart are not cardiac stem cells

Nishat Sultana et al.

NATURE COMMUNICATIONS (2015)

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Article Hematology

Monocytes Are Recruited From Venules During Arteriogenesis in the Murine Spinotrapezius Ligation Model

Anthony C. Bruce et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Clusterin stimulates the chemotactic migration of macrophages through a pertussis toxin sensitive G-protein-coupled receptor and Gβγ-dependent pathways

Byeong-Ho Kang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Review Biochemistry & Molecular Biology

Immunobiology of mesenchymal stem cells

S. Ma et al.

CELL DEATH AND DIFFERENTIATION (2014)

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Article Cell & Tissue Engineering

Autologous bone marrow mononuclear cell therapy improves symptoms in patients with end-stage peripheral arterial disease and reduces inflammation-associated parameters

Nasser M. Malyar et al.

CYTOTHERAPY (2014)

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Review Cell & Tissue Engineering

Cell-based therapy approaches: the hope for incurable diseases

Ella Buzhor et al.

REGENERATIVE MEDICINE (2014)

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Review Medicine, General & Internal

Cardiovascular disease prevention

G. Van Camp

ACTA CLINICA BELGICA (2014)

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Review Physiology

Mitochondria, endothelial cell function, and vascular diseases

Xiaoqiang Tang et al.

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Mesenchymal stem cells contribute to vascular growth in skeletal muscle in response to eccentric exercise

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Review Cardiac & Cardiovascular Systems

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Tracking the Mesenchymal Stem Cell Fate After Transplantation into the Infarcted Myocardium

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FRONTIERS IN PHYSIOLOGY (2012)

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EUROPEAN HEART JOURNAL (2011)

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Therapeutic angiogenesis by transplantation of induced pluripotent stem cell-derived Flk-1 positive cells

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BMC CELL BIOLOGY (2010)

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Editorial Material Cardiac & Cardiovascular Systems

Enhancing the Outcome of Cell Therapy for Cardiac Repair Progress From Bench to Bedside and Back

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Implantation of Adipose-Derived Regenerative Cells Enhances Ischemia-Induced Angiogenesis

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Autologous adipose tissue as a new source of progenitor cells for therapeutic angiogenesis

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Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction

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CURRENT STEM CELL RESEARCH & THERAPY (2009)

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A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks

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Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction

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Induced pluripotent stem cell lines derived from human somatic cells

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Transplantation of adipose stromal cells, but not mature adipocytes, augments ischemia-induced angiogenesis

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Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Granulocytc-macrophage colony-stimulating factor stimulates arteriogenesis in a pig model of peripheral artery disease using clinically applicable infusion pumps

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VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells

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Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Bone marrow-derived cells do not incorporate into the adult growing vasculature

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Multilineage cells from human adipose tissue: Implications for cell-based therapies

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Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease

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