A Multi-Stage Bioprocess for the Expansion of Rodent Skin-Derived Schwann Cells in Computer-Controlled Bioreactors

Article Critical Care Medicine

Phase 1 Safety Trial of Autologous Human Schwann Cell Transplantation in Chronic Spinal Cord Injury

Katie L. Gant et al.

Summary: The study investigated the feasibility and safety of autologous human Schwann cell transplantation for patients with chronic spinal cord injury, showing that it is safe and effective within a certain range.

JOURNAL OF NEUROTRAUMA (2022)

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Review Biotechnology & Applied Microbiology

Challenges and opportunities in downstream separation processes for mesenchymal stromal cells cultured in microcarrier-based stirred suspension bioreactors

Inaara Mawji et al.

Summary: This review assesses the current state of downstream technologies for microcarrier-based MSC cultures, including harvesting, filtration, and volume reduction. A downstream process for MSCs is proposed, which can be applied to a wide range of applications.

BIOTECHNOLOGY AND BIOENGINEERING (2022)

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Article Neurosciences

Comparison of human skin- and nerve-derived Schwann cells reveals many similarities and subtle genomic and functional differences

Tak-Ho Chu et al.

Summary: Skin-derived Schwann cells (Sk-SCs) and nerve-derived Schwann cells (N-SCs) share similar gene expression profiles with subtle differences, particularly in HLA genes. In vitro experiments showed comparable functions between the two cell types, while in vivo experiments indicated that Sk-SCs may have a stronger effect on dorsal root ganglion (DRG) neurite outgrowth complexity.

GLIA (2022)

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Review Neurosciences

Systematic review of the therapeutic use of Schwann cells in the repair of peripheral nerve injuries: Advancements from animal studies to clinical trials

Frederic A. A. Vallejo et al.

Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Neurosciences

Human repair-related Schwann cells adopt functions of antigen-presenting cells in vitro

Jakob Berner et al.

Summary: This study comprehensively analyzed the immunomodulatory capacities of human repair-related Schwann cells (hrSCs), showing their phagocytic ability, expression of co-regulatory proteins, release of various chemoattractants and cytokines, and their ability to limit the activation of T cells. These findings suggest a new role of hrSCs as negative regulators of T-cell immunity during nerve regeneration.

GLIA (2022)

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Article Engineering, Biomedical

Repair of peripheral nerve defects by nerve grafts incorporated with extracellular vesicles from skin-derived precursor Schwann cells

Miaomei Yu et al.

Summary: Our study successfully demonstrated the beneficial effects of incorporating SKP-SC-EVs into nerve grafts for peripheral nerve regeneration in rats. The nerve grafts accelerated the recovery of motor, sensory, and electrophysiological functions, facilitated axon regeneration and myelination, as well as alleviated muscle atrophy. The findings suggest that SKP-SC-EVs-incorporating nerve grafts could represent a promising approach for peripheral nerve injury repair.

ACTA BIOMATERIALIA (2021)

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Review Cell & Tissue Engineering

Advances in automated cell washing and concentration

Anqi Li et al.

Summary: Successful commercialization of cell therapies requires careful planning and consideration of various factors. Automation plays a crucial role in achieving robust and reproducible manufacturing processes at an industrial scale. Understanding the characteristics and limitations of wash-and-concentrate devices is essential for optimizing cell therapy manufacturing.

CYTOTHERAPY (2021)

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Review Neurosciences

Human Schwann Cell Transplantation for Spinal Cord Injury: Prospects and Challenges in Translational Medicine

Paula Monje et al.

Summary: Research has shown the potential benefits of transplanting cultured Schwann cells for treating spinal cord injury, with human Schwann cell transplantation advancing to clinical trials. Overcoming various barriers is necessary for accessible and effective treatment, and further experimentation and data analysis are needed to understand the therapeutic value of human Schwann cell transplants.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Magnetic separation of peripheral nerve-resident cells underscores key molecular features of human Schwann cells and fibroblasts: an immunochemical and transcriptomics approach

Kaiwen Peng et al.

SCIENTIFIC REPORTS (2020)

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Review Neurosciences

The Success and Failure of the Schwann Cell Response to Nerve Injury

Kristjan R. Jessen et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Neurosciences

Skin derived precursor Schwann cell-generated acellular matrix modified chitosan/silk scaffolds for bridging rat sciatic nerve gap

Changlai Zhu et al.

NEUROSCIENCE RESEARCH (2018)

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Review Biotechnology & Applied Microbiology

Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges

Valentin Jossen et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

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Review Engineering, Biomedical

Large-scale production of stem cells utilizing microcarriers: A biomaterials engineering perspective from academic research to commercialized products

Hossein Tavassoli et al.

BIOMATERIALS (2018)

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Article Neurosciences

α6 and β1 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury

In Ae Chang et al.

NEUROSCIENCE (2018)

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Review Biotechnology & Applied Microbiology

Spinal cord injuries: how could cell therapy help?

Anna Badner et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2017)

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Article Biochemistry & Molecular Biology

The effect of co-transplantation of nerve fibroblasts and Schwann cells on peripheral nerve repair

Yang Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

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Article Critical Care Medicine

Safety of Autologous Human Schwann Cell Transplantation in Subacute Thoracic Spinal Cord Injury

Kim D. Anderson et al.

JOURNAL OF NEUROTRAUMA (2017)

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Article Cell & Tissue Engineering

Serum-free bioprocessing of adult human and rodent skin-derived Schwann cells: implications for cell therapy in nervous system injury

Leila Mirfeizi et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

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Article Clinical Neurology

First human experience with autologous Schwann cells to supplement sciatic nerve repair: report of 2 cases with long-term follow-up

Zachary C. Gersey et al.

NEUROSURGICAL FOCUS (2017)

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Article Neurosciences

Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve

Jo Anne Stratton et al.

ENEURO (2017)

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Review Biochemistry & Molecular Biology

The efficacy of Schwann cell transplantation on motor function recovery after spinal cord injuries in animal models: A systematic review and meta-analysis

Mostafa Hosseini et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2016)

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Article Biochemical Research Methods

Improved method to track and precisely count Schwann cells post-transplantation in a peripheral nerve injury model

Hardeep S. Gambhir et al.

JOURNAL OF NEUROSCIENCE METHODS (2016)

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Article Neurosciences

The repair Schwann cell and its function in regenerating nerves

K. R. Jessen et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

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Article Biotechnology & Applied Microbiology

Expansion, harvest and cryopreservation of human mesenchymal stem cells in a serum-free microcarrier process

Thomas R. J. Heathman et al.

BIOTECHNOLOGY AND BIOENGINEERING (2015)

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Review Neurosciences

Schwann cell transplantation and descending propriospinal regeneration after spinal cord injury

Ling-Xiao Deng et al.

BRAIN RESEARCH (2015)

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Article Engineering, Chemical

Filtration methodologies for the clarification and concentration of human mesenchymal stem cells

Barbara Cunha et al.

JOURNAL OF MEMBRANE SCIENCE (2015)

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Review Biochemistry & Molecular Biology

Injured Nerve Regeneration using Cell-Based Therapies: Current Challenges

E. S. Petrova

ACTA NATURAE (2015)

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Article Neurosciences

Combination of Engineered Schwann Cell Grafts to Secrete Neurotrophin and Chondroitinase Promotes Axonal Regeneration and Locomotion after Spinal Cord Injury

Haruo Kanno et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Clinical Neurology

Sensory recovery after cell therapy in peripheral nerve repair: effects of naive and skin precursor-derived Schwann cells

Antos Shakhbazau et al.

JOURNAL OF NEUROSURGERY (2014)

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Review Transplantation

Clinical translation of autologous Schwann cell transplantation for the treatment of spinal cord injury

James Guest et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2013)

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Article Biotechnology & Applied Microbiology

Limiting Cell Aggregation During Mesenchymal Stem Cell Expansion on Microcarriers

Caroline Ferrari et al.

BIOTECHNOLOGY PROGRESS (2012)

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Article Cell & Tissue Engineering

Fate of stem cell transplants in peripheral nerves

Sarah K. Walsh et al.

STEM CELL RESEARCH (2012)

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Review Neurosciences

Technical aspects of spinal cord injections for cell transplantation. Clinical and translational considerations

James Guest et al.

BRAIN RESEARCH BULLETIN (2011)

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Article Neurosciences

Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation

Sarah K. Walsh et al.

EXPERIMENTAL NEUROLOGY (2010)

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Article Neurosciences

SUPPLEMENTATION OF ACELLULAR NERVE GRAFTS WITH SKIN DERIVED PRECURSOR CELLS PROMOTES PERIPHERAL NERVE REGENERATION

S. Walsh et al.

NEUROSCIENCE (2009)

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Article Clinical Neurology

CERVICAL SPINAL CORD THERAPEUTICS DELIVERY: PRECLINICAL SAFETY VALIDATION OF A STABILIZED MICROINJECTION PLATFORM

Jonathan Riley et al.

NEUROSURGERY (2009)

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Article Clinical Neurology

Practical considerations concerning the use of stem cells for peripheral nerve repair

Sarah Walsh et al.

NEUROSURGICAL FOCUS (2009)

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Review Cell & Tissue Engineering

The Systematic Production of Cells for Cell Therapies

Daniel C. Kirouac et al.

CELL STEM CELL (2008)

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Article Neurosciences

Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system

Ian A. McKenzie et al.

JOURNAL OF NEUROSCIENCE (2006)

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Article Biochemical Research Methods

Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny

Jeffrey A. Biernaskie et al.

NATURE PROTOCOLS (2006)

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Article Biochemistry & Molecular Biology

cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury

DD Pearse et al.

NATURE MEDICINE (2004)

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A Multi-Stage Bioprocess for the Expansion of Rodent Skin-Derived Schwann Cells in Computer-Controlled Bioreactors

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