期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms24087176
关键词
intestinal microbiota; microRNA; dysbiosis; ulcerative colitis; Crohn's disease; inflammatory bowel
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by an overactive immune response to environmental factors, including gut microbiota and dietary components. MicroRNAs (miRNAs) have been associated with various physiological processes and play a role in the regulation of inflammatory pathways. Differences in miRNA profiles can be used as a diagnostic and prognostic marker in IBD. The interaction between miRNAs and intestinal microbiota is still not fully understood, but recent studies have shown their role in modulating intestinal homeostasis.
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC) and comprises a chronic gastrointestinal tract disorder characterized by hyperactive and dysregulated immune responses to environmental factors, including gut microbiota and dietary components. An imbalance of the intestinal microbiota may contribute to the development and/or worsening of the inflammatory process. MicroRNAs (miRNAs) have been associated with various physiological processes, such as cell development and proliferation, apoptosis, and cancer. In addition, they play an important role in inflammatory processes, acting in the regulation of pro- and anti-inflammatory pathways. Differences in the profiles of miRNAs may represent a useful tool in the diagnosis of UC and CD and as a prognostic marker in both diseases. The relationship between miRNAs and the intestinal microbiota is not completely elucidated, but recently this topic has gained prominence and has become the target of several studies that demonstrate the role of miRNAs in the modulation of the intestinal microbiota and induction of dysbiosis; the microbiota, in turn, can regulate the expression of miRNAs and, consequently, alter the intestinal homeostasis. Therefore, this review aims to describe the interaction between the intestinal microbiota and miRNAs in IBD, recent discoveries, and perspectives for the future.
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