4.7 Article

A Unique In Vitro Assay to Investigate ABCB4 Transport Function

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, Research & Experimental

Effects of Biliary Phospholipids on Cholesterol Crystallization and Growth in Gallstone Formation

Helen H. Wang et al.

Summary: The prevalence of cholesterol gallstone disease is increasing globally due to obesity and insulin resistance. The role of biliary phospholipids in cholesterol gallstone formation has been neglected, but their reduction or deficiency leads to abnormal bile composition that predisposes to cholesterol supersaturation. Changes in biliary phospholipid concentrations influence cholesterol crystallization, resulting in different crystallization pathways. This review summarizes the chemical structures and functions of biliary phospholipids and discusses their role in cholesterol crystallization and gallstone formation.

ADVANCES IN THERAPY (2023)

Review Genetics & Heredity

Genetic Analysis of ABCB4 Mutations and Variants Related to the Pathogenesis and Pathophysiology of Low Phospholipid-Associated Cholelithiasis

Helen H. Wang et al.

Summary: This review summarizes the role of the ABCB4 gene and its mutations in low phospholipid-associated cholelithiasis, and explores the potential of gene therapy for this disease.
Article Gastroenterology & Hepatology

ABCB4 variant is associated with hepatobiliary MR abnormalities in people with low-phospholipid-associated cholelithiasis syndrome

Moustafa Biyoukar et al.

Summary: ABCB4-related LPAC syndrome is associated with more frequent and severe hepatobiliary MR abnormalities.

JHEP REPORTS (2022)

Article Pharmacology & Pharmacy

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters

Agnes Telbisz et al.

Summary: This study examined the interactions of repurposed drugs with key human multidrug transporters, showing numerous pharmacologically relevant transporter interactions that may raise concerns about potential toxicities of these drugs in clinical settings.

PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

Laura Maria Fuhr et al.

Summary: A physiologically based pharmacokinetic model of carbamazepine and its metabolite was developed for drug-drug interaction prediction, demonstrating good performance in predicting interactions with other drugs. The model, based on plasma concentration-time profiles and urine measurements, will be freely available for use in the Open Systems Pharmacology model repository.

PHARMACEUTICS (2021)

Review Immunology

Potential of B-cell-targeting therapy in overcoming multidrug resistance and tissue invasiveness associated with P-glycoprotein expressing-B cell compartments

Shizuyo Tsujimura et al.

Summary: In patients with RA, activated B cells expressing P-gp play a crucial role in the development of drug resistance and modification of disease progression through treatment. Targeting these cells could potentially overcome refractory RA, suggesting a promising treatment strategy.

IMMUNOLOGICAL MEDICINE (2021)

Review Biotechnology & Applied Microbiology

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Richard J. Weaver et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Biochemistry & Molecular Biology

Structure of the human lipid exporter ABCB4 in a lipid environment

Jeppe A. Olsen et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Review Gastroenterology & Hepatology

Variants in ABCB4 (MDR3) across the spectrum of cholestatic liver diseases in adults

Albert Friedrich Staettermayer et al.

JOURNAL OF HEPATOLOGY (2020)

Article Pharmacology & Pharmacy

Is aspirin a substrate of MDR1/P-glycoprotein?

Renu Singh et al.

XENOBIOTICA (2020)

Article Biochemistry & Molecular Biology

Stimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid

Martin Prescher et al.

JOURNAL OF LIPID RESEARCH (2020)

Article Pharmacology & Pharmacy

Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice

Hui Wang et al.

DRUG METABOLISM AND DISPOSITION (2019)

Article Toxicology

Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI

Rosa Chan et al.

TOXICOLOGICAL SCIENCES (2018)

Article Oncology

Overexpression of ABCB4 contributes to acquired doxorubicin resistance in breast cancer cells in vitro

Jia-Feng Huang et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Drug-induced Cholestasis: Mechanisms, Models, and Markers

Sagnik Chatterjee et al.

CURRENT DRUG METABOLISM (2018)

Review Pharmacology & Pharmacy

Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies

Ranjeet Prasad Dash et al.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2017)

Article Pharmacology & Pharmacy

The drug-drug interaction of sorafenib mediated by P-glycoprotein and CYP3A4

Xianming Wang et al.

XENOBIOTICA (2016)

Article Pharmacology & Pharmacy

Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters

Vlasta Nemcova-Furstova et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis

Zainab M. Mahdi et al.

MOLECULAR PHARMACOLOGY (2016)

Article Biochemistry & Molecular Biology

Lipid flopping in the liver

Kenneth J. Linton

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

Article Pharmacology & Pharmacy

Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor

Charles E. Frost et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Article Chemistry, Medicinal

Inhibition of MDR3 Activity in Human Hepatocytes by Drugs Associated with Liver Injury

Kan He et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2015)

Review Pharmacology & Pharmacy

Asunaprevir: A Review of Preclinical and Clinical Pharmacokinetics and Drug-Drug Interactions

Timothy Eley et al.

CLINICAL PHARMACOKINETICS (2015)

Article Pharmacology & Pharmacy

Clinical drug interaction profile of idelalisib in healthy subjects

Feng Jin et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Article Otorhinolaryngology

Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells

Allen Lam et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2015)

Review Biotechnology & Applied Microbiology

Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy

Famida G. Hoosain et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Medicine, Research & Experimental

Expression of MDR1 and MDR3 gene products in paclitaxel-, doxorubicin- and vincristine-resistant cell lines

Radoslaw Januchowski et al.

BIOMEDICINE & PHARMACOTHERAPY (2014)

Article Chemistry, Medicinal

Establishment of Optimized MDCK Cell Lines for Reliable Efflux Transport Studies

Dominik Gartzke et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

Review Pharmacology & Pharmacy

The Role of Canalicular ABC Transporters in Cholestasis

Frans J. C. Cuperus et al.

DRUG METABOLISM AND DISPOSITION (2014)

Review Pharmacology & Pharmacy

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

K. L. R. Brouwer et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)

Review Pharmacology & Pharmacy

Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance

Suneet Shukla et al.

DRUG RESISTANCE UPDATES (2012)

Editorial Material Pharmacology & Pharmacy

Drug Safety Sciences and the Bottleneck in Drug Development

P. B. Watkins

CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)

Article Pharmacology & Pharmacy

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

Sagar Agarwal et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Article Gastroenterology & Hepatology

Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4

Shin-ya Morita et al.

HEPATOLOGY (2007)

Article Urology & Nephrology

Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction

D. Anglicheau et al.

KIDNEY INTERNATIONAL (2006)

Review Gastroenterology & Hepatology

Enterohepatic transport of bile salts and genetics of cholestasis

C Pauli-Magnus et al.

JOURNAL OF HEPATOLOGY (2005)

Article Pharmacology & Pharmacy

Influence of lipid lowering fibrates on P-glycoprotein activity in vitro

M Ehrhardt et al.

BIOCHEMICAL PHARMACOLOGY (2004)

Article Pharmacology & Pharmacy

Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein

C Pauli-Magnus et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2001)