4.7 Article

Lung Epithelial Cells from Obese Patients Have Impaired Control of SARS-CoV-2 Infection

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients

Nour Jalaleddine et al.

Summary: This study emphasizes the metabolic impact of obesity on COVID-19 infection and related health complications, revealing metabolic changes associated with viral infection and health complications. By measuring metabolites in the blood, researchers identified metabolic differences related to viral entry and defense mechanisms in COVID-19 obese patients.

FRONTIERS IN IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

ACE2 polymorphisms impact COVID-19 severity in obese patients

Nour Jalaleddine et al.

Summary: There is a strong association between obesity and COVID-19 complications, and ACE2 genetic polymorphisms in obese individuals may increase the severity of the disease.

SCIENTIFIC REPORTS (2022)

Article Biochemistry & Molecular Biology

Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway

Bingpeng Yan et al.

Summary: This study characterized the changes in host lipid metabolism upon SARS-CoV-2 infection using in vitro and in vivo analysis. The results showed significant downregulation of ceramides in infected cells and identified four perturbed lipid classes: ether-linked phosphatidylcholines, ether-linked phosphatidylethanolamines, phosphatidylcholines, and ceramides. The glycerophospholipid, sphingolipid, and ether lipid metabolism pathways were the most significantly perturbed host pathways, with PAP-1 identified as a potential target for intervention.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Article Cell Biology

Leptin correlates with monocytes activation and severe condition in COVID-19 patients

Jingya Wang et al.

Summary: Leptin, a cytokine found in significantly altered profiles in severe COVID-19 patients, correlates with disease severity and may exacerbate or dysregulate immune responses through activating monocytes. This study suggests a possible mechanism by which overweight COVID-19 patients have a greater tendency to develop severe conditions, providing insights into potential therapeutic strategies.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Letter Endocrinology & Metabolism

The role of obesity in inflammatory markers in COVID-19 patients

Jenna N. McNeill et al.

Summary: This study found that obese individuals hospitalized with COVID-19 exhibit a more exuberant inflammatory response and worse clinical outcomes, including higher levels of inflammatory markers and higher mortality rates.

OBESITY RESEARCH & CLINICAL PRACTICE (2021)

Review Virology

A systematic meta-analysis of immune signatures in patients with COVID-19

Kun Liu et al.

Summary: A systematic meta-analysis found significant differences in circulatory immunological signatures, with IL-6 and IL-10 showing the most significant disparities. T cell-related immune signatures and various cytokines can be utilized as robust biomarkers in predicting disease severity.

REVIEWS IN MEDICAL VIROLOGY (2021)

Review Pharmacology & Pharmacy

Interferon-beta offers promising avenues to COVID-19 treatment: a systematic review and meta-analysis of clinical trial studies

Ailar Nakhlband et al.

Summary: The study compared the efficacy of standard care protocols versus standard care plus IFN-beta in treating confirmed COVID-19 patients through systematic review and meta-analysis. It showed that early administration of IFN-beta in combination with antiviral drugs is a promising therapeutic strategy, leading to significantly reduced mortality rates and hospitalization duration.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19

Marianna Caterino et al.

Summary: This study utilized targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement to investigate the serum of COVID-19 patients with different severity degrees. The study measured serum IL-26, a cytokine involved in the IL-17 pathway, TSLP, and adiponectin, and correlated them with lipid profiles of COVID-19 patients, providing important insights for the classification of the disease and the identification of therapeutic targets.

SCIENTIFIC REPORTS (2021)

Review Immunology

Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections

Katina D. Hulme et al.

Summary: The article discusses the critical role of acute inflammation during viral infection, and how obesity impacts inflammatory response leading to increased disease severity. Obesity is recognized as a growing pandemic, contributing to both inflammation related to viral infections and increasing disease risk.

FRONTIERS IN IMMUNOLOGY (2021)

Article Virology

Correlating qRT-PCR, dPCR and Viral Titration for the Identification and Quantification of SARS-CoV-2: A New Approach for Infection Management

Martina Brandolini et al.

Summary: The study compares the performance of qRT-PCR, dPCR, and cell culture titration for the detection and quantification of SARS-CoV-2. The aim is to accurately estimate the total RNA copies and infectious viral burden, taking into account methodological errors associated with each analytical method. The results provide insights into the reliability of different testing approaches for COVID-19 diagnosis and research.

VIRUSES-BASEL (2021)

Review Medicine, Research & Experimental

Obesity and severe coronavirus disease 2019: molecular mechanisms, paths forward, and therapeutic opportunities

Tiantian Yan et al.

Summary: Obesity is associated with higher pathogenicity of SARS-CoV-2 and worsens COVID-19 outcomes due to altered physiology, impaired immunity, cytokine storm, and thrombosis, opening possibilities for host-directed therapies in this population.

THERANOSTICS (2021)

Article Biotechnology & Applied Microbiology

On the utility of RNA sample pooling to optimize cost and statistical power in RNA sequencing experiments

Alemu Takele Assefa et al.

BMC GENOMICS (2020)

Article Endocrinology & Metabolism

Increased ACE2 Expression in Bronchial Epithelium of COPD Patients who are Overweight

Andrew Higham et al.

OBESITY (2020)

Review Biochemistry & Molecular Biology

Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics

Andreas Ritter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Physiology

Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19

Saba Al Heialy et al.

FRONTIERS IN PHYSIOLOGY (2020)

Review Endocrinology & Metabolism

Obesity in patients with COVID-19: a systematic review and meta-analysis

Yi Huang et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

Review Critical Care Medicine

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

Wentao Ni et al.

CRITICAL CARE (2020)

Review Immunology

Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution

Rebekah Honce et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Cell Biology

Role of Leptin and SOCS3 in Inhibiting the Type I Interferon Response During Obesity

Eli Teran-Cabanillas et al.

INFLAMMATION (2017)

Article Immunology

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation

Gema Lorden et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations

Michele Pelosi et al.

JOURNAL OF LIPID RESEARCH (2017)

Article Agriculture, Dairy & Animal Science

Ontogenetic Expression of Lpin2 and Lpin3 Genes and Their Associations with Traits in Two Breeds of Chinese Fat-tailed Sheep

Xiao-Li Jiao et al.

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES (2016)

Article Multidisciplinary Sciences

RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes

Kai Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Immunology

Immunological complications of obesity

Thirumala-Devi Kanneganti et al.

NATURE IMMUNOLOGY (2012)

Editorial Material Immunology

Association between H1N1 Infection Severity and Obesity-Adiponectin as a Potential Etiologic Factor

C. Tsatsanis et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

Article Biochemistry & Molecular Biology

AltAnalyze and DomainGraph: analyzing and visualizing exon expression data

Dorothea Emig et al.

NUCLEIC ACIDS RESEARCH (2010)